RU2011103451A - Гетероциклические производные в качестве модуляторов ионных каналов - Google Patents
Гетероциклические производные в качестве модуляторов ионных каналов Download PDFInfo
- Publication number
- RU2011103451A RU2011103451A RU2011103451/04A RU2011103451A RU2011103451A RU 2011103451 A RU2011103451 A RU 2011103451A RU 2011103451/04 A RU2011103451/04 A RU 2011103451/04A RU 2011103451 A RU2011103451 A RU 2011103451A RU 2011103451 A RU2011103451 A RU 2011103451A
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- RU
- Russia
- Prior art keywords
- pain
- compound according
- acute
- syndrome
- chronic
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims abstract 54
- 229910052736 halogen Inorganic materials 0.000 claims abstract 8
- 125000001931 aliphatic group Chemical group 0.000 claims abstract 6
- 150000002367 halogens Chemical class 0.000 claims abstract 5
- 125000005843 halogen group Chemical group 0.000 claims abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 208000002193 Pain Diseases 0.000 claims 42
- 230000036407 pain Effects 0.000 claims 35
- 238000000034 method Methods 0.000 claims 8
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- 230000001684 chronic effect Effects 0.000 claims 6
- 208000021722 neuropathic pain Diseases 0.000 claims 5
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 claims 3
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- 208000007514 Herpes zoster Diseases 0.000 claims 2
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- 208000008765 Sciatica Diseases 0.000 claims 2
- 108010052164 Sodium Channels Proteins 0.000 claims 2
- 102000018674 Sodium Channels Human genes 0.000 claims 2
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- 201000011510 cancer Diseases 0.000 claims 2
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
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- YMRFWDLKXKZAPU-LFABVHOISA-N O=C([C@H](CC1)N(CC2)CC2c(cc2)ccc2Cl)N1c(cc1)ccc1S(Nc1ncc[s]1)(=O)=O Chemical compound O=C([C@H](CC1)N(CC2)CC2c(cc2)ccc2Cl)N1c(cc1)ccc1S(Nc1ncc[s]1)(=O)=O YMRFWDLKXKZAPU-LFABVHOISA-N 0.000 description 1
- YGHCKDOMNUKAHH-FXMQYSIJSA-N O=C([C@H](CC1)N(CC2)CC2c2cc(Cl)cc(Cl)c2)N1c(cc1)ccc1S(Nc1ncc[s]1)(=O)=O Chemical compound O=C([C@H](CC1)N(CC2)CC2c2cc(Cl)cc(Cl)c2)N1c(cc1)ccc1S(Nc1ncc[s]1)(=O)=O YGHCKDOMNUKAHH-FXMQYSIJSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7722008P | 2008-07-01 | 2008-07-01 | |
| US61/077,220 | 2008-07-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2011103451A true RU2011103451A (ru) | 2012-08-10 |
Family
ID=41464851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011103451/04A RU2011103451A (ru) | 2008-07-01 | 2009-07-01 | Гетероциклические производные в качестве модуляторов ионных каналов |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7846954B2 (https=) |
| EP (1) | EP2307412A2 (https=) |
| JP (1) | JP2011526919A (https=) |
| KR (1) | KR20110025855A (https=) |
| CN (1) | CN102099356A (https=) |
| AU (1) | AU2009266979A1 (https=) |
| CA (1) | CA2729681A1 (https=) |
| IL (1) | IL210412A0 (https=) |
| MX (1) | MX2010014193A (https=) |
| RU (1) | RU2011103451A (https=) |
| WO (1) | WO2010002956A2 (https=) |
| ZA (1) | ZA201009128B (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| MX2008003337A (es) * | 2005-09-09 | 2008-09-26 | Vertex Pharma | Derivados biciclicos como modulares de canales ionicos regulados por voltaje. |
| EP1948597A1 (en) * | 2005-10-21 | 2008-07-30 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| AU2008256937A1 (en) | 2007-05-25 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| EP2231655B1 (en) | 2007-11-13 | 2011-08-31 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivatives and related compounds as modulators of ion channels for the treatment of pain |
| CN101910166A (zh) * | 2007-11-13 | 2010-12-08 | 沃泰克斯药物股份有限公司 | 用作钠离子通道调节剂的杂环衍生物 |
| US9056201B1 (en) | 2008-01-07 | 2015-06-16 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| US10022558B1 (en) | 2008-01-07 | 2018-07-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| US8602959B1 (en) | 2010-05-21 | 2013-12-10 | Robert Park | Methods and devices for delivery of radiation to the posterior portion of the eye |
| DK2227257T3 (da) | 2008-01-07 | 2013-09-30 | Salutaris Medical Devices Inc | Anordninger til minimal-invasiv ekstraokular afgivelse af stråling til den posteriore del af øjet |
| US9873001B2 (en) | 2008-01-07 | 2018-01-23 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| US8608632B1 (en) | 2009-07-03 | 2013-12-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye |
| WO2009133641A1 (ja) * | 2008-04-30 | 2009-11-05 | シャープ株式会社 | 照明装置、及び表示装置 |
| USD691267S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
| USD691270S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
| USD691269S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
| USD691268S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
| US8956346B2 (en) | 2010-05-14 | 2015-02-17 | Rainbow Medical, Ltd. | Reflectance-facilitated ultrasound treatment and monitoring |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
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| US2324013A (en) * | 1941-07-31 | 1943-07-13 | Sharp & Dohme Inc | Amino-substituents of sulphanil-amide derivatives |
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- 2009-07-01 MX MX2010014193A patent/MX2010014193A/es not_active Application Discontinuation
- 2009-07-01 AU AU2009266979A patent/AU2009266979A1/en not_active Abandoned
- 2009-07-01 US US12/495,880 patent/US7846954B2/en active Active
- 2009-07-01 EP EP09774406A patent/EP2307412A2/en not_active Withdrawn
- 2009-07-01 KR KR1020117002162A patent/KR20110025855A/ko not_active Withdrawn
- 2009-07-01 WO PCT/US2009/049346 patent/WO2010002956A2/en not_active Ceased
- 2009-07-01 JP JP2011516842A patent/JP2011526919A/ja active Pending
- 2009-07-01 CA CA2729681A patent/CA2729681A1/en not_active Abandoned
- 2009-07-01 CN CN200980127869XA patent/CN102099356A/zh active Pending
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| WO2010002956A2 (en) | 2010-01-07 |
| AU2009266979A1 (en) | 2010-01-07 |
| US8143297B2 (en) | 2012-03-27 |
| IL210412A0 (en) | 2011-03-31 |
| EP2307412A2 (en) | 2011-04-13 |
| JP2011526919A (ja) | 2011-10-20 |
| WO2010002956A3 (en) | 2010-06-10 |
| CN102099356A (zh) | 2011-06-15 |
| US7846954B2 (en) | 2010-12-07 |
| US20110098328A1 (en) | 2011-04-28 |
| KR20110025855A (ko) | 2011-03-11 |
| US20100004300A1 (en) | 2010-01-07 |
| US8343763B2 (en) | 2013-01-01 |
| ZA201009128B (en) | 2012-03-28 |
| MX2010014193A (es) | 2011-02-22 |
| CA2729681A1 (en) | 2010-01-07 |
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