RU2010148420A - Производные аминопиридина - Google Patents
Производные аминопиридина Download PDFInfo
- Publication number
- RU2010148420A RU2010148420A RU2010148420/04A RU2010148420A RU2010148420A RU 2010148420 A RU2010148420 A RU 2010148420A RU 2010148420/04 A RU2010148420/04 A RU 2010148420/04A RU 2010148420 A RU2010148420 A RU 2010148420A RU 2010148420 A RU2010148420 A RU 2010148420A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- ylmethyl
- carbamoyl
- aminopyridin
- ethyl
- Prior art date
Links
- 150000003927 aminopyridines Chemical class 0.000 title 1
- -1 aryl (C1-C4) alkyl Chemical group 0.000 claims abstract 39
- 125000003118 aryl group Chemical group 0.000 claims abstract 24
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 21
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims abstract 19
- 229910052736 halogen Inorganic materials 0.000 claims abstract 18
- 150000002367 halogens Chemical group 0.000 claims abstract 18
- 125000001424 substituent group Chemical group 0.000 claims abstract 15
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims abstract 13
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims abstract 13
- 150000001875 compounds Chemical class 0.000 claims abstract 13
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 12
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 11
- 125000004429 atom Chemical group 0.000 claims abstract 10
- 125000005842 heteroatom Chemical group 0.000 claims abstract 9
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims abstract 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 9
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims abstract 8
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 7
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 7
- 229910052799 carbon Inorganic materials 0.000 claims abstract 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract 5
- 125000002619 bicyclic group Chemical group 0.000 claims abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 3
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 2
- 208000010668 atopic eczema Diseases 0.000 claims 14
- 230000000172 allergic effect Effects 0.000 claims 12
- 208000006673 asthma Diseases 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 9
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 8
- 101000605522 Homo sapiens Kallikrein-1 Proteins 0.000 claims 8
- 102100038297 Kallikrein-1 Human genes 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 8
- 206010011224 Cough Diseases 0.000 claims 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 6
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 4
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 claims 4
- 206010010741 Conjunctivitis Diseases 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 4
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 4
- 206010039085 Rhinitis allergic Diseases 0.000 claims 4
- 201000010105 allergic rhinitis Diseases 0.000 claims 4
- 206010003246 arthritis Diseases 0.000 claims 4
- 230000001684 chronic effect Effects 0.000 claims 4
- 230000005713 exacerbation Effects 0.000 claims 4
- 230000002757 inflammatory effect Effects 0.000 claims 4
- 230000004054 inflammatory process Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 208000005615 Interstitial Cystitis Diseases 0.000 claims 2
- 208000005647 Mumps Diseases 0.000 claims 2
- 208000007101 Muscle Cramp Diseases 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 206010033647 Pancreatitis acute Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 208000036071 Rhinorrhea Diseases 0.000 claims 2
- 206010039101 Rhinorrhoea Diseases 0.000 claims 2
- 208000005392 Spasm Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 208000024780 Urticaria Diseases 0.000 claims 2
- 201000003229 acute pancreatitis Diseases 0.000 claims 2
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 208000010805 mumps infectious disease Diseases 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 208000028169 periodontal disease Diseases 0.000 claims 2
- 210000002307 prostate Anatomy 0.000 claims 2
- 230000000306 recurrent effect Effects 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 206010039083 rhinitis Diseases 0.000 claims 2
- 201000009890 sinusitis Diseases 0.000 claims 2
- 208000017520 skin disease Diseases 0.000 claims 2
- 210000002460 smooth muscle Anatomy 0.000 claims 2
- 206010044008 tonsillitis Diseases 0.000 claims 2
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 2
- MLRBBTOYORQYNK-LPJMZDSDSA-N (2S)-2-amino-N-[(6-aminopyridin-3-yl)methyl]-3-(3,4-difluorophenyl)propanamide (2R)-1-(2-methylpropyl)pyrrolidine-2-carboxylic acid Chemical compound CC(C)CN1CCC[C@@H]1C(O)=O.C([C@H](N)C(=O)NCC=1C=NC(N)=CC=1)C1=CC=C(F)C(F)=C1 MLRBBTOYORQYNK-LPJMZDSDSA-N 0.000 claims 1
- UMFBAWNSXKASMF-AZUAARDMSA-N (2r)-n-[(2s)-1-[(6-aminopyridin-3-yl)methylamino]-3-(3,4-dichlorophenyl)-1-oxopropan-2-yl]-2-(dimethylamino)-3-methylbutanamide Chemical compound C([C@H](NC(=O)[C@H](N(C)C)C(C)C)C(=O)NCC=1C=NC(N)=CC=1)C1=CC=C(Cl)C(Cl)=C1 UMFBAWNSXKASMF-AZUAARDMSA-N 0.000 claims 1
- SHHYWMRZINUSMU-PKOBYXMFSA-N (2r)-n-[(2s)-1-[(6-aminopyridin-3-yl)methylamino]-3-(3,4-dichlorophenyl)-1-oxopropan-2-yl]-3-methyl-2-(methylamino)butanamide Chemical compound C([C@H](NC(=O)[C@@H](C(C)C)NC)C(=O)NCC=1C=NC(N)=CC=1)C1=CC=C(Cl)C(Cl)=C1 SHHYWMRZINUSMU-PKOBYXMFSA-N 0.000 claims 1
- LTFSFTYAXJRGHD-ICSRJNTNSA-N (2r)-n-[(2s)-1-[(6-aminopyridin-3-yl)methylamino]-3-(3,4-difluorophenyl)-1-oxopropan-2-yl]-2-(dimethylamino)-3,3-dimethylbutanamide Chemical compound C([C@H](NC(=O)[C@H](N(C)C)C(C)(C)C)C(=O)NCC=1C=NC(N)=CC=1)C1=CC=C(F)C(F)=C1 LTFSFTYAXJRGHD-ICSRJNTNSA-N 0.000 claims 1
- ZBJBLJBCRBJSOH-LIRRHRJNSA-N (2s)-n-[(6-aminopyridin-3-yl)methyl]-2-[[(2s)-2-(diethylamino)propanoyl]amino]-3-(3,4-difluorophenyl)propanamide Chemical compound C([C@H](NC(=O)[C@H](C)N(CC)CC)C(=O)NCC=1C=NC(N)=CC=1)C1=CC=C(F)C(F)=C1 ZBJBLJBCRBJSOH-LIRRHRJNSA-N 0.000 claims 1
- SGYFOTNBVHRQND-LPHOPBHVSA-N (2s)-n-[(6-aminopyridin-3-yl)methyl]-3-cyclohexyl-2-[[(2s)-2-(diethylamino)propanoyl]amino]propanamide Chemical compound C([C@H](NC(=O)[C@H](C)N(CC)CC)C(=O)NCC=1C=NC(N)=CC=1)C1CCCCC1 SGYFOTNBVHRQND-LPHOPBHVSA-N 0.000 claims 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
- TZPYUTJMVLCBKD-UHFFFAOYSA-N 3,5-dimethyl-1h-pyrrole-2-carboxamide Chemical compound CC1=CC(C)=C(C(N)=O)N1 TZPYUTJMVLCBKD-UHFFFAOYSA-N 0.000 claims 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001721 carbon Chemical class 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 230000008718 systemic inflammatory response Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7143108P | 2008-04-29 | 2008-04-29 | |
| GB0807828.9 | 2008-04-29 | ||
| GBGB0807828.9A GB0807828D0 (en) | 2008-04-29 | 2008-04-29 | Aminopyridine derivatives |
| US61/071,431 | 2008-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010148420A true RU2010148420A (ru) | 2012-06-10 |
Family
ID=39522782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010148420/04A RU2010148420A (ru) | 2008-04-29 | 2009-04-28 | Производные аминопиридина |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20100076015A1 (enExample) |
| EP (1) | EP2300428A1 (enExample) |
| JP (1) | JP2011519845A (enExample) |
| KR (1) | KR20110014161A (enExample) |
| CN (1) | CN102076666A (enExample) |
| AR (1) | AR071514A1 (enExample) |
| AU (1) | AU2009241906A1 (enExample) |
| BR (1) | BRPI0911443A2 (enExample) |
| CA (1) | CA2722648A1 (enExample) |
| CO (1) | CO6321287A2 (enExample) |
| EC (1) | ECSP10010648A (enExample) |
| GB (1) | GB0807828D0 (enExample) |
| IL (1) | IL208812A0 (enExample) |
| MX (1) | MX2010011896A (enExample) |
| NZ (1) | NZ588635A (enExample) |
| RU (1) | RU2010148420A (enExample) |
| WO (1) | WO2009133348A1 (enExample) |
| ZA (1) | ZA201007615B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011006169A (es) * | 2008-12-12 | 2011-06-27 | Univ Vanderbilt | Inhibidores 3.3.0-biciclicos de giyt1 y metodos para hacer y utilizar los mismos. |
| GB0918922D0 (en) * | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminopyridine derivatives |
| US9290485B2 (en) | 2010-08-04 | 2016-03-22 | Novartis Ag | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides |
| EP3512839A4 (en) | 2016-09-18 | 2020-03-25 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | AGAINST INTERACTION OF YAP1 WITH YCT1 INHIBITORS |
| WO2019178401A1 (en) | 2018-03-14 | 2019-09-19 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Yap1 inhibitors that target the interaction of yap1 with oct4 |
| WO2021032933A1 (en) * | 2019-08-21 | 2021-02-25 | Kalvista Pharmaceuticals Limited | Enzyme inhibitors |
| EP4066896A4 (en) * | 2019-11-27 | 2024-03-27 | Riken | G9A INHIBITOR |
| WO2022255399A1 (ja) * | 2021-06-01 | 2022-12-08 | 国立研究開発法人理化学研究所 | Ｇ９ａ阻害剤 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5187157A (en) * | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| US5464820A (en) * | 1993-06-22 | 1995-11-07 | The University Hospital | Specific inhibitors of tissue kallikrein |
| NZ547626A (en) * | 2000-08-11 | 2007-10-26 | Wilex Ag | Non-covalent inhibitors of urokinase and blood vessel formation |
| FR2819254B1 (fr) * | 2001-01-08 | 2003-04-18 | Fournier Lab Sa | Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques |
| FR2836143B1 (fr) * | 2002-02-21 | 2004-04-16 | Servier Lab | Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2557858A1 (en) * | 2004-03-02 | 2005-09-15 | Merck & Co., Inc. | Amino cyclopropane carboxamide derivatives as bradykinin antagonists |
| JP4775259B2 (ja) * | 2004-03-31 | 2011-09-21 | 味の素株式会社 | アニリン誘導体 |
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2008
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- 2009-04-28 AR ARP090101507A patent/AR071514A1/es unknown
- 2009-04-28 NZ NZ588635A patent/NZ588635A/en not_active IP Right Cessation
- 2009-04-28 RU RU2010148420/04A patent/RU2010148420A/ru unknown
- 2009-04-28 AU AU2009241906A patent/AU2009241906A1/en not_active Abandoned
- 2009-04-28 MX MX2010011896A patent/MX2010011896A/es not_active Application Discontinuation
- 2009-04-28 CN CN2009801248942A patent/CN102076666A/zh active Pending
- 2009-04-28 BR BRPI0911443A patent/BRPI0911443A2/pt not_active IP Right Cessation
- 2009-04-28 US US12/431,114 patent/US20100076015A1/en not_active Abandoned
- 2009-04-28 EP EP09738378A patent/EP2300428A1/en not_active Withdrawn
- 2009-04-28 JP JP2011506764A patent/JP2011519845A/ja active Pending
- 2009-04-28 WO PCT/GB2009/001062 patent/WO2009133348A1/en not_active Ceased
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- 2010-11-29 EC EC2010010648A patent/ECSP10010648A/es unknown
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| MX2010011896A (es) | 2010-11-30 |
| ZA201007615B (en) | 2011-08-31 |
| CA2722648A1 (en) | 2009-11-05 |
| ECSP10010648A (es) | 2011-01-31 |
| EP2300428A1 (en) | 2011-03-30 |
| JP2011519845A (ja) | 2011-07-14 |
| CN102076666A (zh) | 2011-05-25 |
| BRPI0911443A2 (pt) | 2015-10-06 |
| CO6321287A2 (es) | 2011-09-20 |
| WO2009133348A1 (en) | 2009-11-05 |
| AR071514A1 (es) | 2010-06-23 |
| IL208812A0 (en) | 2011-01-31 |
| AU2009241906A1 (en) | 2009-11-05 |
| US20100076015A1 (en) | 2010-03-25 |
| KR20110014161A (ko) | 2011-02-10 |
| NZ588635A (en) | 2011-09-30 |
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