RU2009138351A - Биарильные и бигетероарильные соединения, применяемые при лечении нарушений баланса железа - Google Patents
Биарильные и бигетероарильные соединения, применяемые при лечении нарушений баланса железа Download PDFInfo
- Publication number
- RU2009138351A RU2009138351A RU2009138351/04A RU2009138351A RU2009138351A RU 2009138351 A RU2009138351 A RU 2009138351A RU 2009138351/04 A RU2009138351/04 A RU 2009138351/04A RU 2009138351 A RU2009138351 A RU 2009138351A RU 2009138351 A RU2009138351 A RU 2009138351A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- optionally substituted
- independently
- hydrogen
- haloalkyl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract 71
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims 6
- 229910052742 iron Inorganic materials 0.000 title claims 3
- 150000005347 biaryls Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 290
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 238
- 239000001257 hydrogen Substances 0.000 claims abstract 238
- 150000002431 hydrogen Chemical class 0.000 claims abstract 149
- 125000001188 haloalkyl group Chemical group 0.000 claims abstract 142
- 229910052736 halogen Inorganic materials 0.000 claims abstract 93
- 150000002367 halogens Chemical class 0.000 claims abstract 93
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 89
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 63
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 58
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 52
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims abstract 49
- 125000002947 alkylene group Chemical group 0.000 claims abstract 49
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims abstract 49
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 39
- 125000000304 alkynyl group Chemical group 0.000 claims abstract 39
- 125000003107 substituted aryl group Chemical group 0.000 claims abstract 36
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims abstract 36
- 125000003118 aryl group Chemical group 0.000 claims abstract 27
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims abstract 21
- 125000004475 heteroaralkyl group Chemical group 0.000 claims abstract 9
- 125000001424 substituent group Chemical group 0.000 claims abstract 4
- -1 (6,6'-dimethylbiphenyl-2,2'-diyl) bis (methylene) Chemical class 0.000 claims 42
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 28
- 125000000753 cycloalkyl group Chemical group 0.000 claims 22
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 22
- 150000002541 isothioureas Chemical class 0.000 claims 13
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- HSUFRFVNRNOTOR-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)phenyl]sulfanylphenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1SC1=CC=CC=C1CSC(N)=N HSUFRFVNRNOTOR-UHFFFAOYSA-N 0.000 claims 2
- PWWSSIYVTQUJQQ-UHFFFAOYSA-N distearyl thiodipropionate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCSCCC(=O)OCCCCCCCCCCCCCCCCCC PWWSSIYVTQUJQQ-UHFFFAOYSA-N 0.000 claims 2
- WTXHVCTVIQDVOV-UHFFFAOYSA-N 1-[2-[2-(1-carbamimidoylsulfanylethyl)phenoxy]phenyl]ethyl carbamimidothioate Chemical compound NC(=N)SC(C)C1=CC=CC=C1OC1=CC=CC=C1C(C)SC(N)=N WTXHVCTVIQDVOV-UHFFFAOYSA-N 0.000 claims 1
- KEBXKALGJXAQTF-UHFFFAOYSA-N 2-[[2-[2-[(diaminomethylideneamino)methyl]phenyl]sulfanylphenyl]methyl]guanidine Chemical compound NC(=N)NCC1=CC=CC=C1SC1=CC=CC=C1CNC(N)=N KEBXKALGJXAQTF-UHFFFAOYSA-N 0.000 claims 1
- QMZOQMNTUCMHLC-UHFFFAOYSA-N C1=CC=C(C(=C1)C2=CC=CC=C2C(=O)OCSC(=N)N)C(=O)O Chemical compound C1=CC=C(C(=C1)C2=CC=CC=C2C(=O)OCSC(=N)N)C(=O)O QMZOQMNTUCMHLC-UHFFFAOYSA-N 0.000 claims 1
- BDDPRJLXXZPCPO-UHFFFAOYSA-N [2-[1-(carbamimidoylsulfanylmethyl)naphthalen-2-yl]sulfanyl-5-fluorophenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC(F)=CC=C1SC1=CC=C(C=CC=C2)C2=C1CSC(N)=N BDDPRJLXXZPCPO-UHFFFAOYSA-N 0.000 claims 1
- OAGRFSWUPPEWOG-UHFFFAOYSA-N [2-[1-(carbamimidoylsulfanylmethyl)naphthalen-2-yl]sulfanylphenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1SC1=CC=C(C=CC=C2)C2=C1CSC(N)=N OAGRFSWUPPEWOG-UHFFFAOYSA-N 0.000 claims 1
- YDJXWMJZIDNNJW-UHFFFAOYSA-N [2-[2,6-bis(carbamimidoylsulfanylmethyl)phenyl]-3-(carbamimidoylsulfanylmethyl)phenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC(CSC(N)=N)=C1C1=C(CSC(N)=N)C=CC=C1CSC(N)=N YDJXWMJZIDNNJW-UHFFFAOYSA-N 0.000 claims 1
- CKOPRHWLMDTTQR-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)-3-chlorophenoxy]-5-fluorophenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC(F)=CC=C1OC1=CC=CC(Cl)=C1CSC(N)=N CKOPRHWLMDTTQR-UHFFFAOYSA-N 0.000 claims 1
- CMMRFQALGJBNQE-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)-4,5-difluorophenyl]sulfanylphenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1SC1=CC(F)=C(F)C=C1CSC(N)=N CMMRFQALGJBNQE-UHFFFAOYSA-N 0.000 claims 1
- VHLNBLUSPLVOGG-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)-4-(ethylamino)phenyl]sulfanylphenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC(NCC)=CC=C1SC1=CC=CC=C1CSC(N)=N VHLNBLUSPLVOGG-UHFFFAOYSA-N 0.000 claims 1
- PBSCISQPVBETEK-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)-4-(trifluoromethyl)phenyl]sulfanylphenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1SC1=CC=C(C(F)(F)F)C=C1CSC(N)=N PBSCISQPVBETEK-UHFFFAOYSA-N 0.000 claims 1
- MJOORKVVDZCKMJ-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)-4-chlorobenzoyl]phenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1C(=O)C1=CC=C(Cl)C=C1CSC(N)=N MJOORKVVDZCKMJ-UHFFFAOYSA-N 0.000 claims 1
- DXAKSZOTWNBXRP-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)-4-chlorophenoxy]-5-fluorophenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC(F)=CC=C1OC1=CC=C(Cl)C=C1CSC(N)=N DXAKSZOTWNBXRP-UHFFFAOYSA-N 0.000 claims 1
- LUTKZCHGIBGYGY-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)-4-chlorophenyl]sulfanylphenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1SC1=CC=C(Cl)C=C1CSC(N)=N LUTKZCHGIBGYGY-UHFFFAOYSA-N 0.000 claims 1
- OXJUBBYOLNTDQU-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)-4-fluorobenzoyl]phenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1C(=O)C1=CC=C(F)C=C1CSC(N)=N OXJUBBYOLNTDQU-UHFFFAOYSA-N 0.000 claims 1
- NAGNVZUDILOUCT-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)-4-fluorophenoxy]-4-fluorophenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=C(F)C=C1OC1=CC=C(F)C=C1CSC(N)=N NAGNVZUDILOUCT-UHFFFAOYSA-N 0.000 claims 1
- OXAGDHOUNYGFBJ-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)-4-fluorophenoxy]-5-fluorophenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC(F)=CC=C1OC1=CC=C(F)C=C1CSC(N)=N OXAGDHOUNYGFBJ-UHFFFAOYSA-N 0.000 claims 1
- PVODIKFSJIQMMH-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)-4-fluorophenyl]sulfanylphenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1SC1=CC=C(F)C=C1CSC(N)=N PVODIKFSJIQMMH-UHFFFAOYSA-N 0.000 claims 1
- CXRHXJYNKBOVOY-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)-4-methoxyphenyl]sulfanylphenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC(OC)=CC=C1SC1=CC=CC=C1CSC(N)=N CXRHXJYNKBOVOY-UHFFFAOYSA-N 0.000 claims 1
- BHQRWNYLGUZQNK-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)-4-methylphenyl]sulfanylphenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC(C)=CC=C1SC1=CC=CC=C1CSC(N)=N BHQRWNYLGUZQNK-UHFFFAOYSA-N 0.000 claims 1
- WOJXWAUYLHOFCS-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)-6-methylphenyl]sulfanylphenyl]methyl carbamimidothioate Chemical compound CC1=CC=CC(CSC(N)=N)=C1SC1=CC=CC=C1CSC(N)=N WOJXWAUYLHOFCS-UHFFFAOYSA-N 0.000 claims 1
- OKNAEBOMLWDZOB-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)benzoyl]-4-chlorophenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1C(=O)C1=CC(Cl)=CC=C1CSC(N)=N OKNAEBOMLWDZOB-UHFFFAOYSA-N 0.000 claims 1
- PCGCPEDEXIPNAO-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)benzoyl]-4-fluorophenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1C(=O)C1=CC(F)=CC=C1CSC(N)=N PCGCPEDEXIPNAO-UHFFFAOYSA-N 0.000 claims 1
- NONDOVCWISGVGK-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)benzoyl]phenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1C(=O)C1=CC=CC=C1CSC(N)=N NONDOVCWISGVGK-UHFFFAOYSA-N 0.000 claims 1
- NVPQZZSXWUTRKL-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)phenoxy]phenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1OC1=CC=CC=C1CSC(N)=N NVPQZZSXWUTRKL-UHFFFAOYSA-N 0.000 claims 1
- OFWJXPLLFCTWLR-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)phenyl]phenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1C1=CC=CC=C1CSC(N)=N OFWJXPLLFCTWLR-UHFFFAOYSA-N 0.000 claims 1
- WFIYATQCWXRHSR-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)phenyl]sulfanyl-4-chlorophenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1SC1=CC(Cl)=CC=C1CSC(N)=N WFIYATQCWXRHSR-UHFFFAOYSA-N 0.000 claims 1
- FCADQHISGWXHMC-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)phenyl]sulfanyl-4-fluorophenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1SC1=CC(F)=CC=C1CSC(N)=N FCADQHISGWXHMC-UHFFFAOYSA-N 0.000 claims 1
- GMONPOQPZDXTSE-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)phenyl]sulfanyl-4-methylphenyl]methyl carbamimidothioate Chemical compound CC1=CC=C(CSC(N)=N)C(SC=2C(=CC=CC=2)CSC(N)=N)=C1 GMONPOQPZDXTSE-UHFFFAOYSA-N 0.000 claims 1
- QGIIHEYHAPPAGG-UHFFFAOYSA-N [2-[2-(carbamimidoylsulfanylmethyl)phenyl]sulfonylphenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1S(=O)(=O)C1=CC=CC=C1CSC(N)=N QGIIHEYHAPPAGG-UHFFFAOYSA-N 0.000 claims 1
- QHFIEZHJPCSFSO-UHFFFAOYSA-N [2-[4-amino-2-(carbamimidoylsulfanylmethyl)phenyl]sulfanylphenyl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=CC=C1SC1=CC=C(N)C=C1CSC(N)=N QHFIEZHJPCSFSO-UHFFFAOYSA-N 0.000 claims 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 claims 1
- 239000012965 benzophenone Substances 0.000 claims 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- NHPWICWOYKASEE-UHFFFAOYSA-N n-(diaminomethylidene)-2-[2-(diaminomethylidenecarbamoyl)phenyl]sulfanylbenzamide Chemical compound NC(N)=NC(=O)C1=CC=CC=C1SC1=CC=CC=C1C(=O)N=C(N)N NHPWICWOYKASEE-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89566207P | 2007-03-19 | 2007-03-19 | |
| US60/895,662 | 2007-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009138351A true RU2009138351A (ru) | 2011-04-27 |
Family
ID=39551662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009138351/04A RU2009138351A (ru) | 2007-03-19 | 2008-03-19 | Биарильные и бигетероарильные соединения, применяемые при лечении нарушений баланса железа |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080234384A1 (enExample) |
| EP (1) | EP2061754A1 (enExample) |
| JP (1) | JP2010522197A (enExample) |
| CN (1) | CN101622227A (enExample) |
| AR (1) | AR065785A1 (enExample) |
| AU (1) | AU2008228898A1 (enExample) |
| BR (1) | BRPI0809272A2 (enExample) |
| CA (1) | CA2678949A1 (enExample) |
| CL (1) | CL2008000794A1 (enExample) |
| MX (1) | MX2009010083A (enExample) |
| RU (1) | RU2009138351A (enExample) |
| TW (1) | TW200843733A (enExample) |
| WO (1) | WO2008115999A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010005851A1 (en) * | 2008-07-08 | 2010-01-14 | Xenon Pharmaceuticals Inc. | Combination therapy for treating iron disorders |
| GB0903482D0 (en) * | 2009-02-27 | 2009-04-08 | Ucl Business Plc | New compounds |
| WO2010098866A1 (en) | 2009-02-27 | 2010-09-02 | Supergen, Inc. | Cyclopentathiophene/cyclohexathiophene dna methyltransferase inhibitors |
| AR077892A1 (es) | 2009-08-20 | 2011-09-28 | Vifor Int Ag | Quinolinas antagonistas de la hepcidina |
| AR077958A1 (es) | 2009-08-27 | 2011-10-05 | Vifor Int Ag | Quinoxalinonas antagonistas de la hepcidina |
| AR077999A1 (es) | 2009-09-02 | 2011-10-05 | Vifor Int Ag | Antagonistas de pirimidin y triazin-hepcidina |
| TW201113274A (en) | 2009-09-07 | 2011-04-16 | Vifor Int Ag | Novel ethanediamine hepcidine antagonists |
| AR078278A1 (es) | 2009-09-09 | 2011-10-26 | Vifor Int Ag | Antagonistas de la tiazol y oxazol hepcidina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de anemias y enfermedades asociadas a deficiencias de hierro. |
| US20120214803A1 (en) | 2011-02-18 | 2012-08-23 | Vifor (International) Ag | Novel Sulfonaminoquinoline Hepcidin Antagonists |
| CN103073528A (zh) * | 2012-12-21 | 2013-05-01 | 北京万全德众医药生物技术有限公司 | 草酸艾司西酞普兰杂质a的制备方法 |
| CN104370784B (zh) * | 2014-12-11 | 2017-02-22 | 北京彤程创展科技有限公司 | 一种环烷基硫化锌化合物及其制备方法 |
| JP6810988B2 (ja) | 2015-10-23 | 2021-01-13 | ヴィフォール （インターナショナル） アクチェンゲゼルシャフトＶｉｆｏｒ （Ｉｎｔｅｒｎａｔｉｏｎａｌ） ＡＧ | 新規なフェロポーチン阻害剤 |
| JOP20180036A1 (ar) | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| TW202102478A (zh) | 2019-04-01 | 2021-01-16 | 瑞士商威佛（國際）股份有限公司 | 新穎的鐵螯合物 |
| WO2024035268A2 (en) * | 2022-08-10 | 2024-02-15 | Qatar Foundation For Education, Science And Community Development | Tau pathway modulators |
| WO2025050066A1 (en) * | 2023-09-01 | 2025-03-06 | Board Of Regents, The University Of Texas System | Compositions including small-molecule tert activator compounds and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2906773A (en) * | 1957-08-01 | 1959-09-29 | Dow Chemical Co | 2, 2'-oxybis (p-phenylenemethylene) bis (2-thiopseudourea) compounds |
| US3247035A (en) * | 1962-09-28 | 1966-04-19 | Standard Oil Co | Ammonium nitrate propellants containing a nitro-aminocarboxy-alkali metal phenolate combustion catalyst |
| NL134627C (enExample) * | 1966-10-27 | |||
| FR1541946A (fr) * | 1966-10-27 | 1968-10-11 | Geigy Ag J R | Amines et produits d'entretien des surfaces contenant ces amines |
| US3636109A (en) * | 1969-02-05 | 1972-01-18 | Dow Chemical Co | 2 2'-isopropylidenebis((6 - lower alkoxy-m-phenylene)methylene)bis(2 - thiopseudourea) dihydrochlori |
| JPH0791260B2 (ja) * | 1986-12-27 | 1995-10-04 | 第一製薬株式会社 | グアニジン誘導体及びその塩 |
| IL95548A0 (en) * | 1989-09-15 | 1991-06-30 | Fujisawa Pharmaceutical Co | Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same |
| DE19603425A1 (de) * | 1996-01-31 | 1997-08-07 | Hoechst Ag | Substituierte Diaryldicarbonsäure-diguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE10024319A1 (de) * | 2000-05-17 | 2001-11-22 | Merck Patent Gmbh | Bisacylguanidine |
| WO2002012224A2 (en) * | 2000-08-08 | 2002-02-14 | Ortho Mcneil Pharmaceutical, Inc. | Bicyclic compounds as h3 receptor ligands |
| CA2688547A1 (en) * | 2007-06-05 | 2008-12-11 | Xenon Pharmaceuticals, Inc. | Aromatic and heteroaromatic compounds useful in treating iron disorders |
-
2008
- 2008-03-18 AR ARP080101125A patent/AR065785A1/es not_active Application Discontinuation
- 2008-03-19 EP EP08744072A patent/EP2061754A1/en not_active Withdrawn
- 2008-03-19 CN CN200880006800A patent/CN101622227A/zh active Pending
- 2008-03-19 TW TW097109658A patent/TW200843733A/zh unknown
- 2008-03-19 CA CA002678949A patent/CA2678949A1/en not_active Abandoned
- 2008-03-19 RU RU2009138351/04A patent/RU2009138351A/ru not_active Application Discontinuation
- 2008-03-19 AU AU2008228898A patent/AU2008228898A1/en not_active Abandoned
- 2008-03-19 MX MX2009010083A patent/MX2009010083A/es unknown
- 2008-03-19 BR BRPI0809272-9A2A patent/BRPI0809272A2/pt not_active IP Right Cessation
- 2008-03-19 JP JP2009554715A patent/JP2010522197A/ja not_active Withdrawn
- 2008-03-19 CL CL200800794A patent/CL2008000794A1/es unknown
- 2008-03-19 WO PCT/US2008/057519 patent/WO2008115999A1/en not_active Ceased
- 2008-03-19 US US12/051,741 patent/US20080234384A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200843733A (en) | 2008-11-16 |
| WO2008115999A8 (en) | 2008-12-24 |
| AR065785A1 (es) | 2009-07-01 |
| JP2010522197A (ja) | 2010-07-01 |
| MX2009010083A (es) | 2009-10-12 |
| CL2008000794A1 (es) | 2008-05-30 |
| CA2678949A1 (en) | 2008-09-25 |
| EP2061754A1 (en) | 2009-05-27 |
| US20080234384A1 (en) | 2008-09-25 |
| CN101622227A (zh) | 2010-01-06 |
| WO2008115999A1 (en) | 2008-09-25 |
| AU2008228898A1 (en) | 2008-09-25 |
| BRPI0809272A2 (pt) | 2014-10-14 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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