CN101622227A - 用于治疗铁失调的二芳基及二杂芳基化合物 - Google Patents

用于治疗铁失调的二芳基及二杂芳基化合物 Download PDF

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Publication number
CN101622227A
CN101622227A CN200880006800A CN200880006800A CN101622227A CN 101622227 A CN101622227 A CN 101622227A CN 200880006800 A CN200880006800 A CN 200880006800A CN 200880006800 A CN200880006800 A CN 200880006800A CN 101622227 A CN101622227 A CN 101622227A
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CN
China
Prior art keywords
alkyl
independently
another
replaces
hydrogen
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Pending
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CN200880006800A
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English (en)
Chinese (zh)
Inventor
麦克海里·乔威夫
纳加斯瑞·柴卡
琼-杰克库·卡迪厄
傅健民
拉金德·坎博日
维什努墨西·库德穆鲁
乔纳森·朗吉乐
刘世峰
孙建宇
塞尔戈·斯维里多夫
张载辉
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Xenon Pharmaceuticals Inc
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Xenon Pharmaceuticals Inc
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Publication of CN101622227A publication Critical patent/CN101622227A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200880006800A 2007-03-19 2008-03-19 用于治疗铁失调的二芳基及二杂芳基化合物 Pending CN101622227A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89566207P 2007-03-19 2007-03-19
US60/895,662 2007-03-19

Publications (1)

Publication Number Publication Date
CN101622227A true CN101622227A (zh) 2010-01-06

Family

ID=39551662

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880006800A Pending CN101622227A (zh) 2007-03-19 2008-03-19 用于治疗铁失调的二芳基及二杂芳基化合物

Country Status (13)

Country Link
US (1) US20080234384A1 (enExample)
EP (1) EP2061754A1 (enExample)
JP (1) JP2010522197A (enExample)
CN (1) CN101622227A (enExample)
AR (1) AR065785A1 (enExample)
AU (1) AU2008228898A1 (enExample)
BR (1) BRPI0809272A2 (enExample)
CA (1) CA2678949A1 (enExample)
CL (1) CL2008000794A1 (enExample)
MX (1) MX2009010083A (enExample)
RU (1) RU2009138351A (enExample)
TW (1) TW200843733A (enExample)
WO (1) WO2008115999A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103073528A (zh) * 2012-12-21 2013-05-01 北京万全德众医药生物技术有限公司 草酸艾司西酞普兰杂质a的制备方法
CN104370784A (zh) * 2014-12-11 2015-02-25 北京彤程创展科技有限公司 一种环烷基硫化锌化合物及其制备方法

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WO2010005851A1 (en) * 2008-07-08 2010-01-14 Xenon Pharmaceuticals Inc. Combination therapy for treating iron disorders
TW201035088A (en) 2009-02-27 2010-10-01 Supergen Inc Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
GB0903482D0 (en) * 2009-02-27 2009-04-08 Ucl Business Plc New compounds
WO2011020886A1 (de) 2009-08-20 2011-02-24 Vifor (International) Ag Neue chinolin-hepcidin-antagonisten
AR077958A1 (es) 2009-08-27 2011-10-05 Vifor Int Ag Quinoxalinonas antagonistas de la hepcidina
AR077999A1 (es) 2009-09-02 2011-10-05 Vifor Int Ag Antagonistas de pirimidin y triazin-hepcidina
JP2013503835A (ja) 2009-09-07 2013-02-04 ヴィフォール （インターナショナル） アクチェンゲゼルシャフト 新規なエタンジアミン系ヘプシジン拮抗薬
TW201111379A (en) 2009-09-09 2011-04-01 Vifor Int Ag Novel thiazole-and oxazole-hepcidine-antagonists
US20120214803A1 (en) 2011-02-18 2012-08-23 Vifor (International) Ag Novel Sulfonaminoquinoline Hepcidin Antagonists
JP6810988B2 (ja) 2015-10-23 2021-01-13 ヴィフォール （インターナショナル） アクチェンゲゼルシャフトＶｉｆｏｒ （Ｉｎｔｅｒｎａｔｉｏｎａｌ） ＡＧ 新規なフェロポーチン阻害剤
JOP20180036A1 (ar) 2017-04-18 2019-01-30 Vifor Int Ag أملاح لمثبطات فروبورتين جديدة
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
TW202102478A (zh) 2019-04-01 2021-01-16 瑞士商威佛（國際）股份有限公司 新穎的鐵螯合物
WO2024035268A2 (en) * 2022-08-10 2024-02-15 Qatar Foundation For Education, Science And Community Development Tau pathway modulators
WO2025050066A1 (en) * 2023-09-01 2025-03-06 Board Of Regents, The University Of Texas System Compositions including small-molecule tert activator compounds and uses thereof

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US2906773A (en) * 1957-08-01 1959-09-29 Dow Chemical Co 2, 2'-oxybis (p-phenylenemethylene) bis (2-thiopseudourea) compounds
US3247035A (en) * 1962-09-28 1966-04-19 Standard Oil Co Ammonium nitrate propellants containing a nitro-aminocarboxy-alkali metal phenolate combustion catalyst
NL134627C (enExample) * 1966-10-27
FR1541946A (fr) * 1966-10-27 1968-10-11 Geigy Ag J R Amines et produits d'entretien des surfaces contenant ces amines
US3636109A (en) * 1969-02-05 1972-01-18 Dow Chemical Co 2 2'-isopropylidenebis((6 - lower alkoxy-m-phenylene)methylene)bis(2 - thiopseudourea) dihydrochlori
JPH0791260B2 (ja) * 1986-12-27 1995-10-04 第一製薬株式会社 グアニジン誘導体及びその塩
IL95548A0 (en) * 1989-09-15 1991-06-30 Fujisawa Pharmaceutical Co Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same
DE19603425A1 (de) * 1996-01-31 1997-08-07 Hoechst Ag Substituierte Diaryldicarbonsäure-diguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10024319A1 (de) * 2000-05-17 2001-11-22 Merck Patent Gmbh Bisacylguanidine
AU2001281119A1 (en) * 2000-08-08 2002-02-18 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic compounds as h3 receptor ligands
US20100240713A1 (en) * 2007-06-05 2010-09-23 Xenon Pharmaceuticals Inc. Aromatic and heteroaromatic compounds useful in treating iron disorders

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103073528A (zh) * 2012-12-21 2013-05-01 北京万全德众医药生物技术有限公司 草酸艾司西酞普兰杂质a的制备方法
CN104370784A (zh) * 2014-12-11 2015-02-25 北京彤程创展科技有限公司 一种环烷基硫化锌化合物及其制备方法

Also Published As

Publication number Publication date
CA2678949A1 (en) 2008-09-25
BRPI0809272A2 (pt) 2014-10-14
CL2008000794A1 (es) 2008-05-30
AR065785A1 (es) 2009-07-01
US20080234384A1 (en) 2008-09-25
WO2008115999A8 (en) 2008-12-24
EP2061754A1 (en) 2009-05-27
AU2008228898A1 (en) 2008-09-25
MX2009010083A (es) 2009-10-12
WO2008115999A1 (en) 2008-09-25
JP2010522197A (ja) 2010-07-01
RU2009138351A (ru) 2011-04-27
TW200843733A (en) 2008-11-16

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Application publication date: 20100106