BRPI0809272A2 - Compostos de biaril e biheteroaril no tratamento de distúrbios do ferro - Google Patents
Compostos de biaril e biheteroaril no tratamento de distúrbios do ferroInfo
- Publication number
- BRPI0809272A2 BRPI0809272A2 BRPI0809272-9A2A BRPI0809272A BRPI0809272A2 BR PI0809272 A2 BRPI0809272 A2 BR PI0809272A2 BR PI0809272 A BRPI0809272 A BR PI0809272A BR PI0809272 A2 BRPI0809272 A2 BR PI0809272A2
- Authority
- BR
- Brazil
- Prior art keywords
- biheteroaril
- biaril
- compounds
- treatment
- iron disorders
- Prior art date
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 1
- 229910052742 iron Inorganic materials 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89566207P | 2007-03-19 | 2007-03-19 | |
| PCT/US2008/057519 WO2008115999A1 (en) | 2007-03-19 | 2008-03-19 | Biaryl and biheteroaryl compounds useful in treating iron disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0809272A2 true BRPI0809272A2 (pt) | 2014-10-14 |
Family
ID=39551662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0809272-9A2A BRPI0809272A2 (pt) | 2007-03-19 | 2008-03-19 | Compostos de biaril e biheteroaril no tratamento de distúrbios do ferro |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080234384A1 (enExample) |
| EP (1) | EP2061754A1 (enExample) |
| JP (1) | JP2010522197A (enExample) |
| CN (1) | CN101622227A (enExample) |
| AR (1) | AR065785A1 (enExample) |
| AU (1) | AU2008228898A1 (enExample) |
| BR (1) | BRPI0809272A2 (enExample) |
| CA (1) | CA2678949A1 (enExample) |
| CL (1) | CL2008000794A1 (enExample) |
| MX (1) | MX2009010083A (enExample) |
| RU (1) | RU2009138351A (enExample) |
| TW (1) | TW200843733A (enExample) |
| WO (1) | WO2008115999A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010005851A1 (en) * | 2008-07-08 | 2010-01-14 | Xenon Pharmaceuticals Inc. | Combination therapy for treating iron disorders |
| GB0903482D0 (en) * | 2009-02-27 | 2009-04-08 | Ucl Business Plc | New compounds |
| WO2010098866A1 (en) | 2009-02-27 | 2010-09-02 | Supergen, Inc. | Cyclopentathiophene/cyclohexathiophene dna methyltransferase inhibitors |
| AR077892A1 (es) | 2009-08-20 | 2011-09-28 | Vifor Int Ag | Quinolinas antagonistas de la hepcidina |
| AR077958A1 (es) | 2009-08-27 | 2011-10-05 | Vifor Int Ag | Quinoxalinonas antagonistas de la hepcidina |
| AR077999A1 (es) | 2009-09-02 | 2011-10-05 | Vifor Int Ag | Antagonistas de pirimidin y triazin-hepcidina |
| TW201113274A (en) | 2009-09-07 | 2011-04-16 | Vifor Int Ag | Novel ethanediamine hepcidine antagonists |
| AR078278A1 (es) | 2009-09-09 | 2011-10-26 | Vifor Int Ag | Antagonistas de la tiazol y oxazol hepcidina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de anemias y enfermedades asociadas a deficiencias de hierro. |
| US20120214803A1 (en) | 2011-02-18 | 2012-08-23 | Vifor (International) Ag | Novel Sulfonaminoquinoline Hepcidin Antagonists |
| CN103073528A (zh) * | 2012-12-21 | 2013-05-01 | 北京万全德众医药生物技术有限公司 | 草酸艾司西酞普兰杂质a的制备方法 |
| CN104370784B (zh) * | 2014-12-11 | 2017-02-22 | 北京彤程创展科技有限公司 | 一种环烷基硫化锌化合物及其制备方法 |
| JP6810988B2 (ja) | 2015-10-23 | 2021-01-13 | ヴィフォール （インターナショナル） アクチェンゲゼルシャフトＶｉｆｏｒ （Ｉｎｔｅｒｎａｔｉｏｎａｌ） ＡＧ | 新規なフェロポーチン阻害剤 |
| JOP20180036A1 (ar) | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| TW202102478A (zh) | 2019-04-01 | 2021-01-16 | 瑞士商威佛（國際）股份有限公司 | 新穎的鐵螯合物 |
| WO2024035268A2 (en) * | 2022-08-10 | 2024-02-15 | Qatar Foundation For Education, Science And Community Development | Tau pathway modulators |
| WO2025050066A1 (en) * | 2023-09-01 | 2025-03-06 | Board Of Regents, The University Of Texas System | Compositions including small-molecule tert activator compounds and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2906773A (en) * | 1957-08-01 | 1959-09-29 | Dow Chemical Co | 2, 2'-oxybis (p-phenylenemethylene) bis (2-thiopseudourea) compounds |
| US3247035A (en) * | 1962-09-28 | 1966-04-19 | Standard Oil Co | Ammonium nitrate propellants containing a nitro-aminocarboxy-alkali metal phenolate combustion catalyst |
| NL134627C (enExample) * | 1966-10-27 | |||
| FR1541946A (fr) * | 1966-10-27 | 1968-10-11 | Geigy Ag J R | Amines et produits d'entretien des surfaces contenant ces amines |
| US3636109A (en) * | 1969-02-05 | 1972-01-18 | Dow Chemical Co | 2 2'-isopropylidenebis((6 - lower alkoxy-m-phenylene)methylene)bis(2 - thiopseudourea) dihydrochlori |
| JPH0791260B2 (ja) * | 1986-12-27 | 1995-10-04 | 第一製薬株式会社 | グアニジン誘導体及びその塩 |
| IL95548A0 (en) * | 1989-09-15 | 1991-06-30 | Fujisawa Pharmaceutical Co | Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same |
| DE19603425A1 (de) * | 1996-01-31 | 1997-08-07 | Hoechst Ag | Substituierte Diaryldicarbonsäure-diguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE10024319A1 (de) * | 2000-05-17 | 2001-11-22 | Merck Patent Gmbh | Bisacylguanidine |
| WO2002012224A2 (en) * | 2000-08-08 | 2002-02-14 | Ortho Mcneil Pharmaceutical, Inc. | Bicyclic compounds as h3 receptor ligands |
| CA2688547A1 (en) * | 2007-06-05 | 2008-12-11 | Xenon Pharmaceuticals, Inc. | Aromatic and heteroaromatic compounds useful in treating iron disorders |
-
2008
- 2008-03-18 AR ARP080101125A patent/AR065785A1/es not_active Application Discontinuation
- 2008-03-19 EP EP08744072A patent/EP2061754A1/en not_active Withdrawn
- 2008-03-19 CN CN200880006800A patent/CN101622227A/zh active Pending
- 2008-03-19 TW TW097109658A patent/TW200843733A/zh unknown
- 2008-03-19 CA CA002678949A patent/CA2678949A1/en not_active Abandoned
- 2008-03-19 RU RU2009138351/04A patent/RU2009138351A/ru not_active Application Discontinuation
- 2008-03-19 AU AU2008228898A patent/AU2008228898A1/en not_active Abandoned
- 2008-03-19 MX MX2009010083A patent/MX2009010083A/es unknown
- 2008-03-19 BR BRPI0809272-9A2A patent/BRPI0809272A2/pt not_active IP Right Cessation
- 2008-03-19 JP JP2009554715A patent/JP2010522197A/ja not_active Withdrawn
- 2008-03-19 CL CL200800794A patent/CL2008000794A1/es unknown
- 2008-03-19 WO PCT/US2008/057519 patent/WO2008115999A1/en not_active Ceased
- 2008-03-19 US US12/051,741 patent/US20080234384A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200843733A (en) | 2008-11-16 |
| RU2009138351A (ru) | 2011-04-27 |
| WO2008115999A8 (en) | 2008-12-24 |
| AR065785A1 (es) | 2009-07-01 |
| JP2010522197A (ja) | 2010-07-01 |
| MX2009010083A (es) | 2009-10-12 |
| CL2008000794A1 (es) | 2008-05-30 |
| CA2678949A1 (en) | 2008-09-25 |
| EP2061754A1 (en) | 2009-05-27 |
| US20080234384A1 (en) | 2008-09-25 |
| CN101622227A (zh) | 2010-01-06 |
| WO2008115999A1 (en) | 2008-09-25 |
| AU2008228898A1 (en) | 2008-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |