JP2010522197A - 鉄障害を治療するのに有用なビアリール化合物およびヘテロビアリール化合物 - Google Patents

鉄障害を治療するのに有用なビアリール化合物およびヘテロビアリール化合物 Download PDF

Info

Publication number
JP2010522197A
JP2010522197A JP2009554715A JP2009554715A JP2010522197A JP 2010522197 A JP2010522197 A JP 2010522197A JP 2009554715 A JP2009554715 A JP 2009554715A JP 2009554715 A JP2009554715 A JP 2009554715A JP 2010522197 A JP2010522197 A JP 2010522197A
Authority
JP
Japan
Prior art keywords
alkyl
optionally substituted
independently
haloalkyl
independently hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2009554715A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010522197A5 (enExample
Inventor
ミカエル チャフィーブ，
ナガスリー チャッカ，
ジャン−ジャック シャデュー，
チアンミン フー，
ラジェンダー カンボイ，
ヴィシュヌムルティ コドュムル，
ジョナサン ランギル，
シーフェン リュー，
チアンユー サン，
セルゲイ スヴィリドフ，
チャイホイ チャン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenon Pharmaceuticals Inc
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of JP2010522197A publication Critical patent/JP2010522197A/ja
Publication of JP2010522197A5 publication Critical patent/JP2010522197A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2009554715A 2007-03-19 2008-03-19 鉄障害を治療するのに有用なビアリール化合物およびヘテロビアリール化合物 Withdrawn JP2010522197A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89566207P 2007-03-19 2007-03-19
PCT/US2008/057519 WO2008115999A1 (en) 2007-03-19 2008-03-19 Biaryl and biheteroaryl compounds useful in treating iron disorders

Publications (2)

Publication Number Publication Date
JP2010522197A true JP2010522197A (ja) 2010-07-01
JP2010522197A5 JP2010522197A5 (enExample) 2012-05-24

Family

ID=39551662

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009554715A Withdrawn JP2010522197A (ja) 2007-03-19 2008-03-19 鉄障害を治療するのに有用なビアリール化合物およびヘテロビアリール化合物

Country Status (13)

Country Link
US (1) US20080234384A1 (enExample)
EP (1) EP2061754A1 (enExample)
JP (1) JP2010522197A (enExample)
CN (1) CN101622227A (enExample)
AR (1) AR065785A1 (enExample)
AU (1) AU2008228898A1 (enExample)
BR (1) BRPI0809272A2 (enExample)
CA (1) CA2678949A1 (enExample)
CL (1) CL2008000794A1 (enExample)
MX (1) MX2009010083A (enExample)
RU (1) RU2009138351A (enExample)
TW (1) TW200843733A (enExample)
WO (1) WO2008115999A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010005851A1 (en) * 2008-07-08 2010-01-14 Xenon Pharmaceuticals Inc. Combination therapy for treating iron disorders
TW201035088A (en) 2009-02-27 2010-10-01 Supergen Inc Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
GB0903482D0 (en) * 2009-02-27 2009-04-08 Ucl Business Plc New compounds
AR077892A1 (es) 2009-08-20 2011-09-28 Vifor Int Ag Quinolinas antagonistas de la hepcidina
AR077958A1 (es) 2009-08-27 2011-10-05 Vifor Int Ag Quinoxalinonas antagonistas de la hepcidina
AR077999A1 (es) 2009-09-02 2011-10-05 Vifor Int Ag Antagonistas de pirimidin y triazin-hepcidina
WO2011026959A1 (de) 2009-09-07 2011-03-10 Vifor (International) Ag Neue ethandiamin-hepcidin-antagonisten
AR078278A1 (es) 2009-09-09 2011-10-26 Vifor Int Ag Antagonistas de la tiazol y oxazol hepcidina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de anemias y enfermedades asociadas a deficiencias de hierro.
US20120214803A1 (en) 2011-02-18 2012-08-23 Vifor (International) Ag Novel Sulfonaminoquinoline Hepcidin Antagonists
CN103073528A (zh) * 2012-12-21 2013-05-01 北京万全德众医药生物技术有限公司 草酸艾司西酞普兰杂质a的制备方法
CN104370784B (zh) * 2014-12-11 2017-02-22 北京彤程创展科技有限公司 一种环烷基硫化锌化合物及其制备方法
AU2016342310B2 (en) 2015-10-23 2020-08-27 Vifor (International) Ag Novel ferroportin inhibitors
JOP20180036A1 (ar) 2017-04-18 2019-01-30 Vifor Int Ag أملاح لمثبطات فروبورتين جديدة
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
TW202102478A (zh) 2019-04-01 2021-01-16 瑞士商威佛（國際）股份有限公司 新穎的鐵螯合物
WO2024035268A2 (en) * 2022-08-10 2024-02-15 Qatar Foundation For Education, Science And Community Development Tau pathway modulators
WO2025050066A1 (en) * 2023-09-01 2025-03-06 Board Of Regents, The University Of Texas System Compositions including small-molecule tert activator compounds and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2906773A (en) * 1957-08-01 1959-09-29 Dow Chemical Co 2, 2'-oxybis (p-phenylenemethylene) bis (2-thiopseudourea) compounds
US3247035A (en) * 1962-09-28 1966-04-19 Standard Oil Co Ammonium nitrate propellants containing a nitro-aminocarboxy-alkali metal phenolate combustion catalyst
NL134627C (enExample) * 1966-10-27
FR1541946A (fr) * 1966-10-27 1968-10-11 Geigy Ag J R Amines et produits d'entretien des surfaces contenant ces amines
US3636109A (en) * 1969-02-05 1972-01-18 Dow Chemical Co 2 2'-isopropylidenebis((6 - lower alkoxy-m-phenylene)methylene)bis(2 - thiopseudourea) dihydrochlori
JPH0791260B2 (ja) * 1986-12-27 1995-10-04 第一製薬株式会社 グアニジン誘導体及びその塩
IL95548A0 (en) * 1989-09-15 1991-06-30 Fujisawa Pharmaceutical Co Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same
DE19603425A1 (de) * 1996-01-31 1997-08-07 Hoechst Ag Substituierte Diaryldicarbonsäure-diguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10024319A1 (de) * 2000-05-17 2001-11-22 Merck Patent Gmbh Bisacylguanidine
EP1311499B1 (en) * 2000-08-08 2006-04-12 Ortho-McNeil Pharmaceutical, Inc. Bicyclic compounds as h3 receptor ligands
US20100240713A1 (en) * 2007-06-05 2010-09-23 Xenon Pharmaceuticals Inc. Aromatic and heteroaromatic compounds useful in treating iron disorders

Also Published As

Publication number Publication date
US20080234384A1 (en) 2008-09-25
BRPI0809272A2 (pt) 2014-10-14
CL2008000794A1 (es) 2008-05-30
AR065785A1 (es) 2009-07-01
AU2008228898A1 (en) 2008-09-25
MX2009010083A (es) 2009-10-12
CA2678949A1 (en) 2008-09-25
EP2061754A1 (en) 2009-05-27
RU2009138351A (ru) 2011-04-27
TW200843733A (en) 2008-11-16
WO2008115999A1 (en) 2008-09-25
WO2008115999A8 (en) 2008-12-24
CN101622227A (zh) 2010-01-06

Similar Documents

Publication Publication Date Title
JP2010522197A (ja) 鉄障害を治療するのに有用なビアリール化合物およびヘテロビアリール化合物
US20080234327A1 (en) Dihydroindazole compounds useful in treating iron disorders
US20100240713A1 (en) Aromatic and heteroaromatic compounds useful in treating iron disorders
US20090069408A1 (en) Tricyclic compounds useful in treating iron disorders
JP5632612B2 (ja) ラクタム化合物又はその塩及びｐｐａｒ活性化剤
WO2008121861A2 (en) Pyrazole and pyrrole compounds useful in treating iron disorders
JP4926473B2 (ja) 生体内リン輸送を阻害する化合物およびそれを含んでなる医薬
US20080261917A1 (en) Isoindolin-1-One Derivatives
CZ282503B6 (cs) Amidy, způsob jejich přípravy a farmaceutické komposice tyto amidy obsahující
BG65834B1 (bg) Производни на аминокарбоксилни киселини с фармацевтични свойства
WO2000047577A1 (en) Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
KR20030097618A (ko) 치료용 치환 구아니딘류
KR20050111314A (ko) 천식 및 알레르기성 염증 조절제들
WO2000023407A2 (en) Ureido-thiobutyric acid derivatives as ppar-agonists
JP2021514963A (ja) ニューロトロフィンに関連する疾患を治療するためのトリアジン誘導体
US7750019B2 (en) Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same
BRPI0618745A2 (pt) composto ou um sal do mesmo, composição farmacêutica, e, uso de um composto ou um sal do mesmo
US20100041657A1 (en) Haloalkylsulfone substituted compounds useful for treating obesity and diabetes
RU2648242C2 (ru) Производное имидазопиридина, используемое для лечения сахарного диабета
CS255856B2 (en) Process for preparing alkylendiaryl derivatives
US20070142441A1 (en) AMPA receptor potentiators
JP2001507001A (ja) アルドースレダクターゼ阻害剤としてのニトロメチルチオベンゼン誘導体
JPH069544A (ja) 中枢神経系抗虚血剤

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110308

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110308

A072 Dismissal of procedure [no reply to invitation to correct request for examination]

Free format text: JAPANESE INTERMEDIATE CODE: A073

Effective date: 20120718

A300 Application deemed to be withdrawn because no request for examination was validly filed

Free format text: JAPANESE INTERMEDIATE CODE: A300

Effective date: 20120807