RU2009116835A - Слоистые фармацевтические соединения, включающие промежуточный быстрорастворимый слой - Google Patents
Слоистые фармацевтические соединения, включающие промежуточный быстрорастворимый слой Download PDFInfo
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Abstract
1. Слоистый фармацевтический состав для введения двух или более фармацевтически активных компонентов, включающий ! первый фармацевтический слой, включающий первый фармацевтически активный компонент; ! второй фармацевтический слой, включающий второй фармацевтически активный компонент; и ! быстро высвобождающийся промежуточный слой, расположенный между указанным первым и указанным вторым фармацевтическими слоями, где указанный быстро высвобождающийся промежуточный слой формируется таким образом, чтобы быстро растворяться in vivo, а оставшиеся указанный первый и указанный второй фармацевтические слои оставались интактными, но физически разделенными. ! 2. Слоистый фармацевтический состав по пп.1, где указанный первый фармацевтический слой имеет профиль растворения, подобный профилю растворения одиночной спрессованной таблетки такого же состава, и где указанный второй фармацевтический слой имеет профиль растворения, подобный профилю растворения одиночной спрессованной таблетки такого же состава. ! 3. Слоистый фармацевтический состав по пп.1, где указанный первый фармацевтический слой включает другую фармацевтическую композицию, нежели указанный второй фармацевтический слой. ! 4. Слоистый фармацевтический состав по 1, где указанный первый фармацевтический слой включает другой фармацевтически активный компонент, нежели указанный второй фармацевтический слой. ! 5. Слоистый фармацевтический состав по пп.1, где указанный первый фармацевтический слой и указанный второй фармацевтический слой включают один и тот же фармацевтически активный компонент. ! 6. Слоистый фармацевтический состав по одному любому и
Claims (20)
1. Слоистый фармацевтический состав для введения двух или более фармацевтически активных компонентов, включающий
первый фармацевтический слой, включающий первый фармацевтически активный компонент;
второй фармацевтический слой, включающий второй фармацевтически активный компонент; и
быстро высвобождающийся промежуточный слой, расположенный между указанным первым и указанным вторым фармацевтическими слоями, где указанный быстро высвобождающийся промежуточный слой формируется таким образом, чтобы быстро растворяться in vivo, а оставшиеся указанный первый и указанный второй фармацевтические слои оставались интактными, но физически разделенными.
2. Слоистый фармацевтический состав по пп.1, где указанный первый фармацевтический слой имеет профиль растворения, подобный профилю растворения одиночной спрессованной таблетки такого же состава, и где указанный второй фармацевтический слой имеет профиль растворения, подобный профилю растворения одиночной спрессованной таблетки такого же состава.
3. Слоистый фармацевтический состав по пп.1, где указанный первый фармацевтический слой включает другую фармацевтическую композицию, нежели указанный второй фармацевтический слой.
4. Слоистый фармацевтический состав по 1, где указанный первый фармацевтический слой включает другой фармацевтически активный компонент, нежели указанный второй фармацевтический слой.
5. Слоистый фармацевтический состав по пп.1, где указанный первый фармацевтический слой и указанный второй фармацевтический слой включают один и тот же фармацевтически активный компонент.
6. Слоистый фармацевтический состав по одному любому из пп.1-5, где, по крайней мере, один из указанного первого и указанного второго фармацевтических слоев включает бупропион.
7. Слоистый фармацевтический состав по одному любому из пп.1-5, где, по крайней мере, один EG указанного первого и указанного второго фармацевтических слоев включает зонисамид.
8. Слоистый фармацевтический состав по одному любому из пп.1-5, где, по крайней мере, один из указанного первого и указанного второго фармацевтических слоев включает налтрексон.
9. Слоистый фармацевтический состав по одному любому из пп.1-4, где указанный первый фармацевтический слой включает зонисамид, и указанный второй фармацевтический слой включает бупропион.
10. Слоистый фармацевтический состав по одному любому из пп.1-4, где указанный первый фармацевтический слой включает налтрексон, и указанный второй фармацевтический слой включает бупропион.
11. Слоистый фармацевтический состав по одному любому из пп.1-5, где, по крайней мере, один из указанного первого слоя и указанного второго слоя включает состав с длительным высвобождением.
12. Слоистый фармацевтический состав по одному любому из пп.1-5, где указанный быстро высвобождающийся промежуточный слой включает, по крайней мере, один моносахаридный сахар, дисахаридный сахар или крахмал.
13. Слоистый фармацевтический состав по пп.12, где указанный быстро высвобождающийся промежуточный слой включает лактозу.
14. Способ снижения веса, подавления аппетита и/или лечения связанного с ожирением состояния у пациента, включающий
идентификацию пациента, страдающего от связанного с ожирением состояния; и
предоставление пациенту первого соединения и второго соединения в препарате слоистого фармацевтического состава по одному любому из пп.1-5.
15. Слоистый фармацевтический состав по п.9, где, по крайней мере, один из указанного первого слоя и указанного второго слоя включает состав с длительным высвобождением.
16. Слоистый фармацевтический состав по пп.15, где указанный быстро высвобождающийся промежуточный слой включает, по крайней мере, один моносахаридный сахар, дисахаридный сахар или крахмал.
17. Способ снижения веса, подавления аппетита и/или лечения, связанного с ожирением состояния у пациента, включающий
идентификацию пациента, страдающего от связанного с ожирением состояния; и
предоставление пациенту первого соединения и второго соединения в препарате слоистого фармацевтического состава по пп.15.
18. Слоистый фармацевтический состав по пп.10, где, по крайней мере, один из указанного первого слоя и указанного второго слоя включает состав с длительным высвобождением.
19. Слоистый фармацевтический состав по пп.18, где указанный быстро высвобождающийся промежуточный слой включает, по крайней мере, один моносахаридный сахар, дисахаридный сахар или крахмал.
20. Способ снижения веса, подавления аппетита и/или лечения, связанного с ожирением состояния у пациента, включающий
идентификацию пациента, страдающего от связанного с ожирением состояния; и
предоставление пациенту первого соединения и второго соединения в препарате слоистого фармацевтического состава по пп.18.
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