RU2008114360A - Производные диацилиндазола как ингибиторы липаз и фосфолипаз - Google Patents
Производные диацилиндазола как ингибиторы липаз и фосфолипаз Download PDFInfo
- Publication number
- RU2008114360A RU2008114360A RU2008114360/04A RU2008114360A RU2008114360A RU 2008114360 A RU2008114360 A RU 2008114360A RU 2008114360/04 A RU2008114360/04 A RU 2008114360/04A RU 2008114360 A RU2008114360 A RU 2008114360A RU 2008114360 A RU2008114360 A RU 2008114360A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- different
- hydrogen
- heterocycle
- phenyl
- Prior art date
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- 239000003112 inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 22
- 150000001875 compounds Chemical class 0.000 claims abstract 21
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 18
- 239000001257 hydrogen Substances 0.000 claims abstract 18
- 229910052736 halogen Inorganic materials 0.000 claims abstract 15
- 150000002367 halogens Chemical class 0.000 claims abstract 15
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 14
- 125000004122 cyclic group Chemical group 0.000 claims abstract 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 13
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 11
- 125000002619 bicyclic group Chemical group 0.000 claims abstract 10
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 10
- 125000004429 atom Chemical group 0.000 claims abstract 9
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 9
- -1 pentafluorosulfanyl Chemical group 0.000 claims abstract 8
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims abstract 5
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims abstract 5
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims abstract 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 5
- 125000002950 monocyclic group Chemical group 0.000 claims abstract 5
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 5
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 4
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims abstract 4
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims abstract 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims abstract 2
- 125000003118 aryl group Chemical group 0.000 claims abstract 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims abstract 2
- 238000011282 treatment Methods 0.000 claims 8
- 230000002265 prevention Effects 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 102100031375 Endothelial lipase Human genes 0.000 claims 2
- 101710087274 Endothelial lipase Proteins 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 206010022489 Insulin Resistance Diseases 0.000 claims 2
- 102000000019 Sterol Esterase Human genes 0.000 claims 2
- 108010055297 Sterol Esterase Proteins 0.000 claims 2
- AOGYCOYQMAVAFD-UHFFFAOYSA-N chlorocarbonic acid Chemical compound OC(Cl)=O AOGYCOYQMAVAFD-UHFFFAOYSA-N 0.000 claims 2
- 125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- ODIGIKRIUKFKHP-UHFFFAOYSA-N (n-propan-2-yloxycarbonylanilino) acetate Chemical compound CC(C)OC(=O)N(OC(C)=O)C1=CC=CC=C1 ODIGIKRIUKFKHP-UHFFFAOYSA-N 0.000 claims 1
- MWAGUKZCDDRDCS-UHFFFAOYSA-N 1-nitro-4-(4-nitrophenoxy)benzene Chemical compound C1=CC([N+](=O)[O-])=CC=C1OC1=CC=C([N+]([O-])=O)C=C1 MWAGUKZCDDRDCS-UHFFFAOYSA-N 0.000 claims 1
- CKDWPUIZGOQOOM-UHFFFAOYSA-N Carbamyl chloride Chemical class NC(Cl)=O CKDWPUIZGOQOOM-UHFFFAOYSA-N 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 230000003143 atherosclerotic effect Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 230000004190 glucose uptake Effects 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 150000002513 isocyanates Chemical class 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- SMYMDRJWEFCCCI-UHFFFAOYSA-N trichloro(trichloromethoxy)methane Chemical compound ClC(Cl)(Cl)OC(Cl)(Cl)Cl SMYMDRJWEFCCCI-UHFFFAOYSA-N 0.000 claims 1
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 1
- 0 *N(*)C(N(C1=C2****1)N(C(N(*)*)=O)C2=O)=O Chemical compound *N(*)C(N(C1=C2****1)N(C(N(*)*)=O)C2=O)=O 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005048897.8 | 2005-10-12 | ||
| DE102005048897A DE102005048897A1 (de) | 2005-10-12 | 2005-10-12 | Diacylindazol-derivate als Inhibitoren von Lipasen und Phospholipasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008114360A true RU2008114360A (ru) | 2009-10-20 |
Family
ID=37813518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008114360/04A RU2008114360A (ru) | 2005-10-12 | 2006-10-04 | Производные диацилиндазола как ингибиторы липаз и фосфолипаз |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7772268B2 (https=) |
| EP (1) | EP1937648B1 (https=) |
| JP (1) | JP2009511517A (https=) |
| KR (1) | KR20080048062A (https=) |
| CN (1) | CN101282939A (https=) |
| AR (1) | AR056686A1 (https=) |
| AU (1) | AU2006301591A1 (https=) |
| BR (1) | BRPI0617222A2 (https=) |
| CA (1) | CA2625546A1 (https=) |
| DE (1) | DE102005048897A1 (https=) |
| IL (1) | IL190672A0 (https=) |
| MA (1) | MA29856B1 (https=) |
| NO (1) | NO20081878L (https=) |
| RU (1) | RU2008114360A (https=) |
| TW (1) | TW200728285A (https=) |
| UY (1) | UY29853A1 (https=) |
| WO (1) | WO2007042178A1 (https=) |
| ZA (1) | ZA200802105B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010500300A (ja) | 2006-08-08 | 2010-01-07 | サノフィ−アベンティス | アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用 |
| EP2002835A1 (en) | 2007-06-04 | 2008-12-17 | GenKyo Tex | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
| EP2000176A1 (en) | 2007-06-04 | 2008-12-10 | GenKyo Tex | Tetrahydroindole derivatives as NADPH Oxidase inhibitors |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| CA2704266A1 (en) | 2007-11-02 | 2009-06-11 | Vertex Pharmaceuticals Incorporated | [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| EP2166010A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
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| US6372421B1 (en) * | 2000-06-13 | 2002-04-16 | Eastman Kodak Company | Photothermographic imaging element having improved contrast and methods of image formation |
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2005
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2006
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- 2006-10-04 WO PCT/EP2006/009577 patent/WO2007042178A1/de not_active Ceased
- 2006-10-04 CA CA002625546A patent/CA2625546A1/en not_active Abandoned
- 2006-10-04 RU RU2008114360/04A patent/RU2008114360A/ru not_active Application Discontinuation
- 2006-10-04 CN CNA2006800376850A patent/CN101282939A/zh active Pending
- 2006-10-04 BR BRPI0617222-9A patent/BRPI0617222A2/pt not_active IP Right Cessation
- 2006-10-04 EP EP06806017.7A patent/EP1937648B1/de active Active
- 2006-10-05 TW TW095136995A patent/TW200728285A/zh unknown
- 2006-10-10 AR ARP060104444A patent/AR056686A1/es not_active Application Discontinuation
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| US8357698B2 (en) | 2013-01-22 |
| UY29853A1 (es) | 2007-05-31 |
| MA29856B1 (fr) | 2008-10-03 |
| AR056686A1 (es) | 2007-10-17 |
| JP2009511517A (ja) | 2009-03-19 |
| US20080287448A1 (en) | 2008-11-20 |
| US20100286133A1 (en) | 2010-11-11 |
| CA2625546A1 (en) | 2007-04-19 |
| TW200728285A (en) | 2007-08-01 |
| WO2007042178A1 (de) | 2007-04-19 |
| EP1937648B1 (de) | 2014-11-26 |
| BRPI0617222A2 (pt) | 2011-07-19 |
| IL190672A0 (en) | 2008-11-03 |
| CN101282939A (zh) | 2008-10-08 |
| EP1937648A1 (de) | 2008-07-02 |
| KR20080048062A (ko) | 2008-05-30 |
| US7772268B2 (en) | 2010-08-10 |
| AU2006301591A1 (en) | 2007-04-19 |
| DE102005048897A1 (de) | 2007-04-19 |
| NO20081878L (no) | 2008-04-18 |
| ZA200802105B (en) | 2009-09-30 |
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