RU2006102867A - Производные 5-замещенного хиназолинона - Google Patents

Производные 5-замещенного хиназолинона Download PDF

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RU2006102867A
RU2006102867A RU2006102867/04A RU2006102867A RU2006102867A RU 2006102867 A RU2006102867 A RU 2006102867A RU 2006102867/04 A RU2006102867/04 A RU 2006102867/04A RU 2006102867 A RU2006102867 A RU 2006102867A RU 2006102867 A RU2006102867 A RU 2006102867A
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Элберт ЧИНЬ (US)
Элберт ЧИНЬ
Ричард Лео КУРНОЙЕР (US)
Ричард Лео КУРНОЙЕР
Пол Франсис КАЙТЦ (US)
Пол Франсис КАЙТЦ
Ын Ке ЛИ (US)
Ын Ке ЛИ
Франсиско-Хавьер ЛОПЕС-ТАПИА (US)
Франсиско-Хавьер ЛОПЕС-ТАПИА
Крис Ричард МЕЛВИЛЛ (US)
Крис Ричард МЕЛВИЛЛ
Фернандо ПАДИЛЛА (US)
Фернандо ПАДИЛЛА
Клаус Курт ВАЙНХАРДТ (US)
Клаус Курт ВАЙНХАРДТ
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Ф.Хоффманн-Ля Рош Аг (Ch)
Ф.Хоффманн-Ля Рош Аг
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Claims (8)

1. Соединение формулы I
Figure 00000001
где Z означает -С(=O)- или -S(=O)2-,
R и R′ означают (низш.)алкокси,
R5 выбирают из группы, включающей галоген, циано, гидрокси, необязательно замещенный фенил, -R6 и -OR6,
R6 означает алкил, алкоксиалкил, гидроксиалкил, необязательно замещенный бензилоксиалкокси, необязательно замещенный фенокси, аминоалкил, необязательно замещенный арил, необязательно замещенный гетероарил, циклоалкил или циклоалкилокси, и
Q означает моноциклический или бициклический гетероциклический цикл, выбранный из групп (S), (Т), (U) и (V)
Figure 00000002
,
Figure 00000003
,
Figure 00000004
и
Figure 00000005
где В означает необязательно замещенный конденсированный арильный или гетероарильный цикл,
R7 присоединен к любому доступному атому углерода пиперидинильного или пиперазинильного цикла и в каждом случае является независимо выбранным из группы, включающей алкил, замещенный алкил, галоген, циано, гидрокси, алкокси, галогеналкокси, амино и алкиламино, или в другом варианте, если Q означает цикл (Т), то две группы R7, присоединенные к разным атомам углерода, вместе образуют углерод-углеродный мостик, содержащий в своем составе от одного до двух атомов углерода,
R8 означает - K-R14,
R9 и R10 (1) независимо выбирают из -L-R15, или в другом варианте, (2) R9 и R10 вместе образуют необязательно замещенный спироциклический цикл,
К и L независимо выбирают из группы, включающей химическую связь, необязательно замещенный С1-С4алкилен, -M1-O-М2-, -M1-C(=O)-M2-, -M1-С(O)2-М2-, -M1-C(=O)NR16-M2- и -M1-NR16-M2-, где M1 и M2 выбирают из группы, включающей химическую связь и необязательно замещенный С1-С4алкилен,
R14 и R15 независимо выбирают из группы, включающей водород, необязательно замещенный алкил, арил, гетероарил, циклоалкил или гетероциклил, при условии, если К или L означает химическую связь или -NR16-, то R14 и R15 не означают фенил, пиридил или пиримидинил, содержащий заместитель в пара-положении, который означает CO2R22, где R22 выбирают из группы, включающей водород, алкил, арил, арилалкил, гуанидинил, гидрокси, алкокси, арилокси и арилалкилокси,
R16 выбирают из группы, включающей водород и алкил,
m равно 0, 1, 2, 3 или 4,
n равно 0 или 1,
р равно 0, 1 или 2,
q равно 0 или 1, или
его изомер, или фармацевтически приемлемая соль, гидрат или пролекарство.
2. Соединение по п.1, выбранное из группы, включающей
2-[4-(1Н-имидазол-2-ил)пиперазин-1-ил]-5,6,7-триметокси-1Н-хиназолин-4-он,
2-[4-(2-имидазол-1-илэтил)пиперидин-1-ил]-6,7-диметокси-5-метил-1Н-хиназолин-4-он,
4-(4-фторфенил)-9-(5,6,7-триметокси-4-оксо-1,4-дигидрохиназолин-2-ил)-1-окса-4,9-диазаспиро[5.5]ундекан-3-он и
N-[2-(6,7-диметокси-5-метил-4-оксо-1,4-дигидрохиназолин-2-ил)-1,2,3,4-тетрагидроизохинолин-5-илметил]-N-метил-2-метиламиноацетамид.
3. Соединение по п.1 для применения в качестве терапевтически активного вещества.
4. Фармацевтическая композиция, включающая терапевтически эффективное количество по меньшей мере одного соединения по п.1 и по меньшей мере один фармацевтически приемлемый носитель.
5. Способ лечения патологического состояния у пациента, которое модулируется α-1A/B-адренорецептором, причем указанный способ включает введение субъекту, который нуждается в таком лечении, терапевтически эффективного количества по меньшей мере одного соединения по п.1.
6. Способ по п.5, где патологическое состояние выбирают из нарушений и симптомов заболевания мочевых путей, сексуальной дисфункции, доброкачественной гипертрофии предстательной железы и боли.
7. Применение соединения по п.1 для получения лекарственного средства, включающего соединение по п.1, предназначенного для лечения патологического состояния у пациента, которое модулируется г α-1А/В-адренорецептором.
8. Способ получения соединения по п.1.
RU2006102867/04A 2003-07-02 2004-06-29 Производные 5-замещенного хиназолинона RU2006102867A (ru)

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US20040048853A1 (en) * 2002-08-21 2004-03-11 Gustave Bergnes Compounds, compositions, and methods
US7402596B2 (en) 2005-03-24 2008-07-22 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
CN1884262B (zh) * 2005-06-24 2014-06-25 中国人民解放军军事医学科学院毒物药物研究所 4-氨基哌啶类化合物及其医药用途
WO2007110868A2 (en) 2006-03-28 2007-10-04 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
CN101225083A (zh) 2007-01-16 2008-07-23 北京摩力克科技有限公司 四氢喹唑啉酮类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
MY146924A (en) 2007-06-21 2012-10-15 Cara Therapeutics Inc Substituted imidazoheterocycles
US8859538B2 (en) * 2007-06-21 2014-10-14 Cara Therapeutics, Inc. Uses of substituted imidazoheterocycles
US9353067B2 (en) 2011-04-10 2016-05-31 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
BR112014031375A2 (pt) 2012-06-20 2017-06-27 Novartis Ag moduladores da série de reação complementar e usos dos mesmos
CN114716390A (zh) * 2015-04-07 2022-07-08 Ela制药有限公司 用于治疗和/或预防细胞或组织坏死的组合物和方法
AU2016295693B2 (en) * 2015-07-17 2020-05-21 Sunshine Lake Pharma Co., Ltd. Substituted quinazoline compounds and preparation and uses thereof
WO2017164707A1 (ko) * 2016-03-24 2017-09-28 주식회사 케미메디 전립선 비대증에서 기인한 방광출구폐색에 의해 2차적인 방광 변성으로 유발된 과민성 방광의 예방 또는 치료용 의약 조성물 및 건강기능식품
JP7288161B2 (ja) 2017-12-27 2023-06-07 国立研究開発法人理化学研究所 新規ジヒドロキナゾリノン系化合物又はその薬理学的に許容される塩、及び細胞増殖阻害剤
CN113754594A (zh) * 2021-09-16 2021-12-07 中国药科大学 喹唑啉酮类化合物或其可药用的盐、异构体及其制备方法、药物组合物和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084457A (en) * 1990-07-23 1992-01-28 American Cyanamid Company Benzoylaminoquinazolinones
US5756502A (en) * 1994-08-08 1998-05-26 Warner-Lambert Company Quinazolinone derivatives as cholyecystokinin (CCK) ligands
GB9700504D0 (en) * 1997-01-11 1997-02-26 Pfizer Ltd Pharmaceutical compounds
US6156758A (en) * 1999-09-08 2000-12-05 Isis Pharmaceuticals, Inc. Antibacterial quinazoline compounds
CN1237060C (zh) * 2001-01-02 2006-01-18 弗·哈夫曼-拉罗切有限公司 用作α1A/B肾上腺素能受体拮抗剂的喹唑酮衍生物
US6900220B2 (en) * 2001-01-02 2005-05-31 Syntex (U.S.A.) Llc Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
GB0206033D0 (en) * 2002-03-14 2002-04-24 Pfizer Ltd Compounds useful in therapy

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CN1845908A (zh) 2006-10-11
AR045006A1 (es) 2005-10-12
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EP1644343B1 (en) 2007-07-04
DE602004007387T2 (de) 2008-03-06
US20050124607A1 (en) 2005-06-09
ES2290726T3 (es) 2008-02-16
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JP2009513504A (ja) 2009-04-02
EP1644343A1 (en) 2006-04-12
BRPI0412163A (pt) 2006-08-22
CA2530450A1 (en) 2005-01-20
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