RU2003133446A - Пероральная фармацевтическая композиция для лечения и профилактики сердечных заболеваний и заболеваний, протекающих с расстройством кровообращения - Google Patents
Пероральная фармацевтическая композиция для лечения и профилактики сердечных заболеваний и заболеваний, протекающих с расстройством кровообращения Download PDFInfo
- Publication number
- RU2003133446A RU2003133446A RU2003133446/15A RU2003133446A RU2003133446A RU 2003133446 A RU2003133446 A RU 2003133446A RU 2003133446/15 A RU2003133446/15 A RU 2003133446/15A RU 2003133446 A RU2003133446 A RU 2003133446A RU 2003133446 A RU2003133446 A RU 2003133446A
- Authority
- RU
- Russia
- Prior art keywords
- carvedilol
- hours
- released
- pharmaceutical composition
- oral pharmaceutical
- Prior art date
Links
- 239000008203 oral pharmaceutical composition Substances 0.000 title claims 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 9
- 208000019622 heart disease Diseases 0.000 title claims 6
- 201000010099 disease Diseases 0.000 title claims 5
- 230000002265 prevention Effects 0.000 title claims 5
- NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 claims 64
- 229960004195 carvedilol Drugs 0.000 claims 64
- 238000000034 method Methods 0.000 claims 12
- 230000036470 plasma concentration Effects 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims 7
- 238000004090 dissolution Methods 0.000 claims 6
- 239000012530 fluid Substances 0.000 claims 6
- 230000000968 intestinal effect Effects 0.000 claims 6
- 150000002148 esters Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 4
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 230000001105 regulatory effect Effects 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 230000008961 swelling Effects 0.000 claims 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- 239000002250 absorbent Substances 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000001276 controlling effect Effects 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920003176 water-insoluble polymer Polymers 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Packaging Frangible Articles (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN464MU2001 IN191028B (index.php) | 2001-05-17 | 2001-05-17 | |
| IN464/MUM/2001 | 2001-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2003133446A true RU2003133446A (ru) | 2005-03-10 |
Family
ID=11097247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003133446/15A RU2003133446A (ru) | 2001-05-17 | 2002-05-10 | Пероральная фармацевтическая композиция для лечения и профилактики сердечных заболеваний и заболеваний, протекающих с расстройством кровообращения |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20030035836A1 (index.php) |
| EP (1) | EP1395258A1 (index.php) |
| JP (1) | JP2004534031A (index.php) |
| KR (1) | KR20040037026A (index.php) |
| CN (1) | CN1525855A (index.php) |
| AU (1) | AU2002314515B2 (index.php) |
| BE (1) | BE1014328A7 (index.php) |
| BR (1) | BR0210976A (index.php) |
| CA (1) | CA2447005A1 (index.php) |
| HU (1) | HUP0400607A3 (index.php) |
| IN (1) | IN191028B (index.php) |
| MX (1) | MXPA03010501A (index.php) |
| PL (1) | PL370589A1 (index.php) |
| RU (1) | RU2003133446A (index.php) |
| WO (1) | WO2002092078A1 (index.php) |
| ZA (1) | ZA200309724B (index.php) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1067910B1 (en) | 1998-04-03 | 2004-05-26 | Egalet A/S | Controlled release composition |
| EP2957281A1 (en) | 2001-09-21 | 2015-12-23 | Egalet Ltd. | Polymer release system |
| WO2003024430A1 (en) | 2001-09-21 | 2003-03-27 | Egalet A/S | Morphine polymer release system |
| ES2298401T3 (es) * | 2001-09-21 | 2008-05-16 | Egalet A/S | Dispersiones solidas de liberacion controlada de carvedilol. |
| US8101209B2 (en) * | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| AU2003231283A1 (en) * | 2002-04-30 | 2003-11-17 | Sb Pharmco Puerto Rico Inc. | Carvedilol monocitrate monohydrate |
| US20050261355A1 (en) | 2002-06-27 | 2005-11-24 | Sb Pharmco Puerto Rico Inc., | Carvedilol hydobromide |
| CN103254114A (zh) | 2002-06-27 | 2013-08-21 | 史密斯克莱.比奇曼（科克）有限公司 | 卡维地洛磷酸盐和/或其溶剂合物相应的组合物和/或治疗方法 |
| US20040151772A1 (en) | 2002-11-08 | 2004-08-05 | Egalet A/S | Controlled release carvedilol compositions |
| WO2004047837A2 (en) * | 2002-11-22 | 2004-06-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Beta-blockers having antioxidant and nitric oxide-donor activity |
| US8298581B2 (en) * | 2003-03-26 | 2012-10-30 | Egalet A/S | Matrix compositions for controlled delivery of drug substances |
| EP1610767B1 (en) | 2003-03-26 | 2011-01-19 | Egalet A/S | Morphine controlled release system |
| EP1615626B1 (en) * | 2003-04-24 | 2009-10-14 | Jagotec Ag | Tablet with coloured core |
| US7260685B2 (en) | 2003-06-20 | 2007-08-21 | Micron Technology, Inc. | Memory hub and access method having internal prefetch buffers |
| PT2821067T (pt) * | 2003-09-12 | 2017-12-01 | Amgen Inc | Formulação de cinacalcet de dissolução rápida |
| US7120743B2 (en) | 2003-10-20 | 2006-10-10 | Micron Technology, Inc. | Arbitration system and method for memory responses in a hub-based memory system |
| WO2005051322A2 (en) | 2003-11-25 | 2005-06-09 | Sb Pharmco Puerto Rico Inc. | Controlled release pharmaceutical formulations comprising carvedilol, free based and its salts |
| JP2007512350A (ja) * | 2003-11-25 | 2007-05-17 | エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド | カルベジロール組成物の治療および送達方法 |
| US7750036B2 (en) | 2003-11-25 | 2010-07-06 | Sb Pharmco Puerto Rico Inc. | Carvedilol salts, corresponding compositions, methods of delivery and/or treatment |
| EP1750717B1 (en) * | 2004-02-11 | 2017-07-19 | Rubicon Research Private Limited | Controlled release pharmaceutical compositions with improved bioavailability |
| US20090274759A1 (en) * | 2005-06-03 | 2009-11-05 | Egalet A/S | Solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids |
| US8367112B2 (en) * | 2006-02-28 | 2013-02-05 | Alkermes Pharma Ireland Limited | Nanoparticulate carverdilol formulations |
| US8703804B2 (en) | 2006-03-26 | 2014-04-22 | Uti Limited Partnership | Ryanodine receptor inhibitors and methods relating thereto |
| SG10201503411QA (en) | 2006-08-03 | 2015-06-29 | Nitec Pharma Ag | Delayed-release glucocorticoid treatment of rheumatoid disease |
| WO2008070072A2 (en) * | 2006-12-01 | 2008-06-12 | Mutual Pharmaceutical Company, Inc. | Carvedilol forms, compositions, and methods of preparation thereof |
| US20090028935A1 (en) * | 2006-12-01 | 2009-01-29 | Kristin Arnold | Carvedilol forms, compositions, and methods of preparation thereof |
| EP2104493A2 (en) * | 2007-01-16 | 2009-09-30 | Egalet A/S | Use of i) a polyglycol and n) an active drug substance for the preparation of a pharmaceutical composition for i) mitigating the risk of alcohol induced dose dumping and/or ii) reducing the risk of drug abuse |
| WO2008114276A1 (en) * | 2007-03-16 | 2008-09-25 | Lupin Limited | Novel oral controlled release composition of carvedilol |
| BRPI0701904A2 (pt) * | 2007-04-27 | 2008-12-09 | Libbs Farmaceutica Ltda | forma farmacÊutica de liberaÇço controlada de princÍpios ativos com solubilidade dependente do baixo ph do meio e processo para preparar a forma farmacÊutica |
| WO2008148798A2 (en) | 2007-06-04 | 2008-12-11 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
| CA2749646A1 (en) * | 2009-01-26 | 2010-07-29 | Nitec Pharma Ag | Delayed-release glucocorticoid treatment of asthma |
| CA2751667C (en) | 2009-02-06 | 2016-12-13 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
| NZ597283A (en) | 2009-06-24 | 2013-07-26 | Egalet Ltd | Controlled release formulations |
| TWI415604B (zh) * | 2009-09-29 | 2013-11-21 | Tsh Biopharm Corp Ltd | 調控釋放卡菲蒂羅劑型 |
| ES2600894T3 (es) * | 2010-02-22 | 2017-02-13 | Daiichi Sankyo Company, Limited | Preparación sólida de liberación sostenida para uso oral |
| JP5749247B2 (ja) | 2010-02-22 | 2015-07-15 | 第一三共株式会社 | 経口用徐放性固形製剤 |
| MX2014015880A (es) | 2012-07-06 | 2015-08-05 | Egalet Ltd | Composiciones farmaceuticas disuasivas de abuso para liberacion controlada. |
| BR112015004190A2 (pt) | 2012-09-03 | 2017-07-04 | Daiichi Sankyo Co Ltd | composição farmacêutica de liberação sustentada, e, método para produzir uma composição farmacêutica de liberação sustentada |
| KR102241487B1 (ko) | 2013-02-20 | 2021-04-16 | 주식회사 종근당 | 제어방출 펠릿으로 된 약제학적 조성물 |
| KR102158339B1 (ko) | 2016-02-05 | 2020-09-21 | 삼진제약주식회사 | 인습성이 개선된 카르베딜롤 속방성 제제 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US5972389A (en) * | 1996-09-19 | 1999-10-26 | Depomed, Inc. | Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter |
| JP2001514651A (ja) * | 1997-03-11 | 2001-09-11 | ダーウィン・ディスカバリー・リミテッド | Ｒ−およびｓ−エナンチオマーの別の部分を含む製剤 |
| IE970588A1 (en) * | 1997-08-01 | 2000-08-23 | Elan Corp Plc | Controlled release pharmaceutical compositions containing tiagabine |
| US20020054911A1 (en) * | 2000-05-11 | 2002-05-09 | Boehringer Mannheim Pharmaceutical Corporation-Sm Ithkline Beckman Corporation, Limited Partnershi | Novel oral dosage form for carvedilol |
| PE20001302A1 (es) * | 1998-11-27 | 2000-11-30 | Hoffmann La Roche | Preparaciones de una combinacion farmaceutica que contiene carvedilol e hidroclorotiazida |
| WO2001035958A1 (en) * | 1999-11-15 | 2001-05-25 | Smithkline Beecham Corporation | Carvedilol methanesulfonate |
| US6491949B2 (en) * | 2000-01-14 | 2002-12-10 | Osmotica Corp. | Osmotic device within an osmotic device |
| US6352721B1 (en) * | 2000-01-14 | 2002-03-05 | Osmotica Corp. | Combined diffusion/osmotic pumping drug delivery system |
| AU2001263813A1 (en) * | 2000-04-03 | 2001-10-15 | F.Hoffmann-La Roche Ag | Concentrated solutions of carvedilol |
| AU2001297631A1 (en) * | 2000-10-24 | 2002-09-04 | Smithkline Beecham Corporation | Novel formulations of carvedilol |
-
2001
- 2001-05-17 IN IN464MU2001 patent/IN191028B/en unknown
-
2002
- 2002-05-10 KR KR10-2003-7014987A patent/KR20040037026A/ko not_active Ceased
- 2002-05-10 JP JP2002588995A patent/JP2004534031A/ja active Pending
- 2002-05-10 PL PL02370589A patent/PL370589A1/xx not_active Application Discontinuation
- 2002-05-10 CN CNA028101294A patent/CN1525855A/zh active Pending
- 2002-05-10 AU AU2002314515A patent/AU2002314515B2/en not_active Ceased
- 2002-05-10 HU HU0400607A patent/HUP0400607A3/hu unknown
- 2002-05-10 MX MXPA03010501A patent/MXPA03010501A/es unknown
- 2002-05-10 RU RU2003133446/15A patent/RU2003133446A/ru unknown
- 2002-05-10 BR BR0210976-0A patent/BR0210976A/pt not_active IP Right Cessation
- 2002-05-10 CA CA002447005A patent/CA2447005A1/en not_active Abandoned
- 2002-05-10 WO PCT/IN2002/000118 patent/WO2002092078A1/en not_active Ceased
- 2002-05-10 EP EP02741152A patent/EP1395258A1/en active Pending
- 2002-05-16 BE BE2002/0322A patent/BE1014328A7/fr not_active IP Right Cessation
- 2002-08-19 US US10/146,670 patent/US20030035836A1/en not_active Abandoned
-
2003
- 2003-12-15 ZA ZA2003/09724A patent/ZA200309724B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040037026A (ko) | 2004-05-04 |
| CA2447005A1 (en) | 2002-11-21 |
| HUP0400607A2 (hu) | 2004-07-28 |
| US20030035836A1 (en) | 2003-02-20 |
| CN1525855A (zh) | 2004-09-01 |
| IN191028B (index.php) | 2003-09-13 |
| BE1014328A7 (fr) | 2003-08-05 |
| AU2002314515B2 (en) | 2007-08-16 |
| MXPA03010501A (es) | 2004-03-02 |
| EP1395258A1 (en) | 2004-03-10 |
| ZA200309724B (en) | 2005-05-25 |
| BR0210976A (pt) | 2004-10-05 |
| JP2004534031A (ja) | 2004-11-11 |
| WO2002092078A1 (en) | 2002-11-21 |
| PL370589A1 (en) | 2005-05-30 |
| HUP0400607A3 (en) | 2005-07-28 |
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