RU2003119972A - Препараты циклодекстрина - Google Patents
Препараты циклодекстрина Download PDFInfo
- Publication number
- RU2003119972A RU2003119972A RU2003119972/15A RU2003119972A RU2003119972A RU 2003119972 A RU2003119972 A RU 2003119972A RU 2003119972/15 A RU2003119972/15 A RU 2003119972/15A RU 2003119972 A RU2003119972 A RU 2003119972A RU 2003119972 A RU2003119972 A RU 2003119972A
- Authority
- RU
- Russia
- Prior art keywords
- cyclodextrin
- ebselen
- aqueous solution
- aqueous
- hydroxypropyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
- C07D293/10—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D293/12—Selenazoles; Hydrogenated selenazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medical Informatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (13)
1. Водный жидкий лекарственный препарат, включающий эбселен и циклодекстрин.
2. Водный раствор, включающий эбселен и циклодекстрин.
3. Водный раствор в соответствии с п.2, в котором циклодекстрин представляет собой натриевую соль простого сульфобутилового эфира β–циклодекстрина или гидроксипропил-β-циклодекстрин.
4. Водный раствор по п.2 или 3, в котором молярное отношение циклодекстрина к эбселену составляет от 1:2 до 1:50.
5. Инъекционный раствор, включающий водный раствор, содержащий эбселен и циклодекстрин.
6. Инъекционный раствор по п.5, в котором циклодекстрин представляет собой натриевую соль простого сульфобутилового эфира β–циклодекстрина или гидроксипропил-β-циклодекстрин.
7. Раствор для внутривенного капельного вливания, включающий водный раствор, содержащий эбселен и циклодекстрин.
8. Раствор для внутривенного капельного вливания по п.7, в котором циклодекстрин представляет собой натриевую соль простого сульфобутилового эфира β–циклодекстрина или гидроксипропил-β-циклодекстрин.
9. Способ получения водного раствора, содержащего эбселен и циклодекстрин, включающий растворение эбселена в смешивающемся с водой органическом растворителе и отдельное растворением циклодекстрина в водном растворителе, смешивание обоих растворов, затем высушивание смеси и смешивание полученного высушенного продукта с водным растворителем.
10. Способ по п.9, в котором смешивающийся с водой органический растворитель представляет собой этанол, метанол или смесь метанола с хлороформом.
11. Высушенный препарат, включающий эбселен и циклодекстрин.
12. Высушенный препарат по п.11, в котором циклодекстрин представляет собой натриевую соль простого сульфобутилового эфира β–циклодекстрина или гидроксипропил-β-циклодекстрин.
13. Способ получения раствора, содержащего эбселен и циклодекстрин, включающий растворение эбселена в смешивающемся с водой органическом растворителе и отдельное растворение циклодекстрина в водном растворителе и смешивание обоих растворов.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001000247 | 2001-01-04 | ||
JP2001-247 | 2001-01-04 | ||
JP2001-16022 | 2001-01-24 | ||
JP2001016022 | 2001-01-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2003119972A true RU2003119972A (ru) | 2004-12-27 |
Family
ID=26607336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2003119972/15A RU2003119972A (ru) | 2001-01-04 | 2001-12-17 | Препараты циклодекстрина |
Country Status (12)
Country | Link |
---|---|
US (1) | US20040053888A1 (ru) |
EP (1) | EP1348432A4 (ru) |
JP (1) | JPWO2002055076A1 (ru) |
KR (1) | KR20030068203A (ru) |
CN (1) | CN1492760A (ru) |
AR (1) | AR032386A1 (ru) |
BR (1) | BR0116658A (ru) |
CA (1) | CA2434077A1 (ru) |
MX (1) | MXPA03006071A (ru) |
NO (1) | NO20033042L (ru) |
RU (1) | RU2003119972A (ru) |
WO (1) | WO2002055076A1 (ru) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2451680C1 (ru) * | 2011-02-21 | 2012-05-27 | Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" | Клатратный комплекс циклодекстрина или арабиногалактана с 9-фенил-симм-октагидроселеноксантеном, способ его получения (варианты), фармацевтическая композиция и лекарственное средство |
RU2481830C2 (ru) * | 2007-01-16 | 2013-05-20 | Бипар Сайенсиз, Инк. | Лекарственные препараты для лечения рака |
WO2021054863A1 (ru) * | 2019-09-18 | 2021-03-25 | Рахимджан Ахметджанович РОЗИЕВ | Стимулятор процессов репаративной регенерации тестикулярной ткани |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2368484A1 (en) | 1999-03-31 | 2000-10-05 | Daiichi Pharmaceutical Co., Ltd. | Substrates for thioredoxin reductase |
CN1853627B (zh) * | 2005-04-25 | 2011-08-10 | 曾慧慧 | 双苯并异硒唑乙烷环糊精或环糊精衍生物包合物及其制备方法和其用途 |
SG164368A1 (en) | 2005-07-18 | 2010-09-29 | Bipar Sciences Inc | Treatment of cancer |
JP4886233B2 (ja) * | 2005-07-21 | 2012-02-29 | 独立行政法人物質・材料研究機構 | エブセレンの可溶化方法 |
CN100503647C (zh) * | 2005-11-02 | 2009-06-24 | 南京师范大学 | 羟丙基-磺丁基-β-环糊精及其制备方法、分析方法以及在药学上的应用 |
EP1795183B1 (en) * | 2005-12-09 | 2009-07-15 | Teva Pharmaceutical Industries, Inc. | Aqueous dispersions and solutions of difficult to dissolve compounds and methods of their preparation |
US20100160442A1 (en) * | 2006-07-18 | 2010-06-24 | Ossovskaya Valeria S | Formulations for cancer treatment |
WO2008030891A2 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof |
CA2662517A1 (en) | 2006-09-05 | 2008-03-13 | Jerome Moore | Treatment of cancer |
CN100486645C (zh) * | 2006-09-12 | 2009-05-13 | 南京师范大学 | 含有环糊精紫杉醇包合物的药物组合物及其制备方法 |
CN100411688C (zh) * | 2006-09-12 | 2008-08-20 | 南京师范大学 | 含有环糊精/多烯紫杉醇包合物的药物组合物及其制备方法 |
US7732491B2 (en) | 2007-11-12 | 2010-06-08 | Bipar Sciences, Inc. | Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents |
AU2010210636A1 (en) * | 2009-02-04 | 2011-09-22 | Bipar Sciences, Inc. | Treatment of lung cancer with a nitrobenzamide compound in combination with a growth factor inhibitor |
GB201102248D0 (en) | 2011-02-09 | 2011-03-23 | Isis Innovation | Treatment of bipolar disorder |
WO2015042170A1 (en) | 2013-09-17 | 2015-03-26 | Wayne State University | Compositions and uses of combinations of dim-related indoles and selected anti-androgen compounds |
WO2015071841A1 (en) | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
US10058542B1 (en) | 2014-09-12 | 2018-08-28 | Thioredoxin Systems Ab | Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith |
US10576086B2 (en) | 2015-06-12 | 2020-03-03 | University Of Greenwich | Triazine derivatives as interferon-gamma inhibitors |
TWI830180B (zh) * | 2017-06-30 | 2024-01-21 | 財團法人工業技術研究院 | 化合物之液體劑型的醫藥配方 |
WO2023240094A1 (en) * | 2022-06-06 | 2023-12-14 | Sound Pharmaceuticals Inc. | Amorphous dosage form containing ebselen |
WO2024181358A1 (ja) * | 2023-02-27 | 2024-09-06 | 国立大学法人東北大学 | 医薬組成物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01131113A (ja) * | 1987-08-27 | 1989-05-24 | Dai Ichi Seiyaku Co Ltd | 脳障害治療剤 |
US5288734A (en) * | 1988-10-29 | 1994-02-22 | A. Nattermann & Cie Gmbh | Stable parenteral solution of 2-phenyl-1.2-benzisoselenazol-3(2H)-one and process for producing the same |
AU5780696A (en) * | 1995-06-02 | 1996-12-18 | Takeda Chemical Industries Ltd. | Stabilized composition comprising an antiulcerative benzimid azole |
US6596706B1 (en) * | 1997-11-07 | 2003-07-22 | Daiichi Pharmaceutical Co., Ltd. | Piperazine-cyclodextrin complexes |
AU1411600A (en) * | 1998-11-30 | 2000-06-19 | Sankyo Company Limited | Immunoglobulin preparations |
-
2001
- 2001-12-17 BR BR0116658-1A patent/BR0116658A/pt not_active Application Discontinuation
- 2001-12-17 JP JP2002555810A patent/JPWO2002055076A1/ja active Pending
- 2001-12-17 CA CA002434077A patent/CA2434077A1/en not_active Abandoned
- 2001-12-17 CN CNA018228720A patent/CN1492760A/zh active Pending
- 2001-12-17 RU RU2003119972/15A patent/RU2003119972A/ru not_active Application Discontinuation
- 2001-12-17 EP EP01273183A patent/EP1348432A4/en not_active Withdrawn
- 2001-12-17 KR KR10-2003-7009050A patent/KR20030068203A/ko not_active Application Discontinuation
- 2001-12-17 MX MXPA03006071A patent/MXPA03006071A/es unknown
- 2001-12-17 WO PCT/JP2001/011048 patent/WO2002055076A1/ja not_active Application Discontinuation
- 2001-12-17 US US10/250,472 patent/US20040053888A1/en not_active Abandoned
-
2002
- 2002-01-02 AR ARP020100001A patent/AR032386A1/es unknown
-
2003
- 2003-07-02 NO NO20033042A patent/NO20033042L/no not_active Application Discontinuation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2481830C2 (ru) * | 2007-01-16 | 2013-05-20 | Бипар Сайенсиз, Инк. | Лекарственные препараты для лечения рака |
RU2451680C1 (ru) * | 2011-02-21 | 2012-05-27 | Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" | Клатратный комплекс циклодекстрина или арабиногалактана с 9-фенил-симм-октагидроселеноксантеном, способ его получения (варианты), фармацевтическая композиция и лекарственное средство |
WO2021054863A1 (ru) * | 2019-09-18 | 2021-03-25 | Рахимджан Ахметджанович РОЗИЕВ | Стимулятор процессов репаративной регенерации тестикулярной ткани |
Also Published As
Publication number | Publication date |
---|---|
NO20033042L (no) | 2003-09-04 |
EP1348432A4 (en) | 2005-08-10 |
BR0116658A (pt) | 2003-12-30 |
CA2434077A1 (en) | 2002-07-18 |
WO2002055076A1 (fr) | 2002-07-18 |
JPWO2002055076A1 (ja) | 2004-05-13 |
NO20033042D0 (no) | 2003-07-02 |
KR20030068203A (ko) | 2003-08-19 |
AR032386A1 (es) | 2003-11-05 |
US20040053888A1 (en) | 2004-03-18 |
MXPA03006071A (es) | 2004-02-26 |
EP1348432A1 (en) | 2003-10-01 |
CN1492760A (zh) | 2004-04-28 |
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Legal Events
Date | Code | Title | Description |
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FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20011217 |