RU1825378C - Способ разделени рацемической смеси (его варианты) и способ отделени хирального продукта от ахирального предшественника - Google Patents

Способ разделени рацемической смеси (его варианты) и способ отделени хирального продукта от ахирального предшественника

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Publication number
RU1825378C
RU1825378C SU894742278A SU4742278A RU1825378C RU 1825378 C RU1825378 C RU 1825378C SU 894742278 A SU894742278 A SU 894742278A SU 4742278 A SU4742278 A SU 4742278A RU 1825378 C RU1825378 C RU 1825378C
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Russia
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membrane
enzyme
stream
organic
racemic
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SU894742278A
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English (en)
Russian (ru)
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Л.Мэтсон Стефен
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Сепракор, Инк
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2475—Membrane reactors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/10—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of a carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • C07C305/10—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/18—Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087—Acrylic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00159—Controlling the temperature controlling multiple zones along the direction of flow, e.g. pre-heating and after-cooling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00162—Controlling or regulating processes controlling the pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00177—Controlling or regulating processes controlling the pH

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
SU894742278A 1987-04-01 1989-09-29 Способ разделени рацемической смеси (его варианты) и способ отделени хирального продукта от ахирального предшественника RU1825378C (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/033,962 US4800162A (en) 1987-04-01 1987-04-01 Method for resolution of steroisomers in multiphase and extractive membrane reactors
PCT/US1988/001098 WO1988007582A1 (en) 1987-04-01 1988-03-31 Method for resolution of stereoisomers in multiphase and extractive membrane reactors

Publications (1)

Publication Number Publication Date
RU1825378C true RU1825378C (ru) 1993-06-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SU894742278A RU1825378C (ru) 1987-04-01 1989-09-29 Способ разделени рацемической смеси (его варианты) и способ отделени хирального продукта от ахирального предшественника

Country Status (14)

Country Link
US (2) US4800162A (enExample)
EP (1) EP0353248B1 (enExample)
JP (1) JP2677403B2 (enExample)
KR (1) KR970005052B1 (enExample)
AT (1) ATE120495T1 (enExample)
AU (1) AU605589B2 (enExample)
BR (1) BR8807438A (enExample)
CA (1) CA1266248A (enExample)
DE (1) DE3853478T2 (enExample)
DK (1) DK481889A (enExample)
IL (1) IL85938A (enExample)
IN (1) IN166947B (enExample)
RU (1) RU1825378C (enExample)
WO (1) WO1988007582A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7129274B1 (en) 1999-11-05 2006-10-31 Emisphere Technologies Inc. Phenoxy carboxylic acid compounds and compositions for delivering active agents

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244791A (en) * 1984-05-29 1993-09-14 Genecor International, Inc. Methods of ester hydrolysis
DE3638760A1 (de) * 1986-11-13 1988-05-26 Schering Ag Verfahren zur herstellung von optisch aktiven bicyclo(3.3.0)octandioncarbonsaeureestern
US4800162A (en) * 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
US5116741A (en) * 1988-04-12 1992-05-26 Genex Corporation Biosynthetic uses of thermostable proteases
US6521445B1 (en) * 1988-10-26 2003-02-18 Sepracor, Inc. Process for preparing optically active glycidate esters
AU4826890A (en) * 1988-12-19 1990-07-10 Sepracor, Inc. Method and apparatus for catalyst containment in multiphase membrane reactor systems
US4948732A (en) * 1989-02-10 1990-08-14 Schering Corporation Microbiological chiral reduction of carbonyl groups
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
CA2076972A1 (en) * 1990-02-26 1991-08-27 Animesh Goswami Stereospecific resolution by hydrolysis of esters of 2-arylpropionic acids by liver enzymes
US5175100A (en) * 1990-02-26 1992-12-29 Rhone-Poulenc, Inc. Stereospecific resolution by hydrolysis of esters of 2-arylpropionic acids by liver enzymes
DE59106876D1 (de) * 1990-03-16 1995-12-21 Forschungszentrum Juelich Gmbh Verfahren zur enzymatischen Herstellung optisch aktiver Cyanhydrine.
US5275950A (en) * 1990-05-11 1994-01-04 Abbott Laboratories Process for the preparation of a renin inhibiting compound
US5080795A (en) * 1990-05-23 1992-01-14 Research Corporation Technologies, Inc. Supported chiral liquid membrane for the separation of enantiomers
DK0549710T3 (da) 1990-09-20 1996-03-18 Du Pont Fremgangsmåde til fremstilling af enantiomere 2-alkansyrer
US5593871A (en) * 1990-09-20 1997-01-14 E. I. Du Pont De Nemours And Company Process for the preparation of enantiometric 2-alkanoic acid amides from nitriles
SG48037A1 (en) * 1990-11-14 1998-04-17 Nitto Chemical Industry Co Ltd Biology process for production-alpha-hydroxyamide or alpha-hydroxy acid
HUT59692A (en) * 1990-11-15 1992-06-29 Puetter Medice Chem Pharm Process for producing complexes containing s/+/-phenyl-alkanoic acids and aminosugars
US5106736A (en) * 1991-04-23 1992-04-21 E.R. Squibb & Sons, Inc. Enzymatic process for enantiomer-specific perparation of mercapto alkanoic acid compounds
IT1247533B (it) * 1991-04-26 1994-12-17 Mini Ricerca Scient Tecnolog Processo per la separazione degli isomeri ottici di acidi carbossilici alfa-sostitutivi
AT398081B (de) * 1991-04-29 1994-09-26 Chemie Linz Gmbh Verfahren zur enzymatischen hydrolyse eines carbonsäurederivates
US5262313A (en) * 1991-06-14 1993-11-16 Andcare, Inc. Carrageeman-immobilized esterase
JP2816777B2 (ja) * 1991-08-03 1998-10-27 鐘淵化学工業株式会社 共重合体及びその製造方法
JP2777757B2 (ja) * 1991-09-17 1998-07-23 鐘淵化学工業株式会社 共重合体およびその製造方法
EP0538693A3 (en) * 1991-10-23 1994-08-17 Squibb & Sons Inc Stereoselective preparation of halophenyl alcohols
US5198117A (en) * 1991-12-02 1993-03-30 The Dow Chemical Company Method and apparatus for preparing an epoxide by anionic dialysis
US5177242A (en) * 1991-12-17 1993-01-05 Fmc Corporation Process for preparing optically active cyanohydrins with enzymes
JP3409353B2 (ja) * 1992-04-30 2003-05-26 住友化学工業株式会社 アミド化合物の製造方法および使用される微生物
US5324662A (en) * 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
JP3319628B2 (ja) * 1992-07-08 2002-09-03 ロンザ リミテッド ５−ヒドロキシピラジンカルボン酸を製造するための微生物学的方法
US5273895A (en) * 1992-10-26 1993-12-28 Sepracor, Inc. Enantioselective production of chiral carboxylic acids
US5420337A (en) * 1992-11-12 1995-05-30 E. R. Squibb & Sons, Inc. Enzymatic reduction method for the preparation of compounds useful for preparing taxanes
US5457051A (en) * 1993-03-09 1995-10-10 Sepracor, Inc. Enantioselective hydrolysis of ketoprofen esters by beauveria bassiana and enzymes derived therefrom
US5500352A (en) * 1993-03-24 1996-03-19 Sepracor, Inc. Membrane filtration process for 6-aminopenicillanic acid
NL9300715A (nl) * 1993-04-27 1994-11-16 Inst Voor Agrotech Onderzoek Werkwijze voor het uitvoeren van een enzymatische en/of katalytische omzetting respectievelijk voor het uitvoeren van een scheiding van een mengsel van optische isomeren, membraan waarop en/of waarin enzym en/of katalysator geimmobiliseerd alsmede membraanreactor, die een of meer van dergelijke membranen bevat.
JPH0762030A (ja) * 1993-08-31 1995-03-07 Daicel Chem Ind Ltd 光学活性アセチレンポリマー及びその膜、並びにそれを用いた光学分割方法
US5443824A (en) * 1994-03-14 1995-08-22 Piacquadio; Daniel J. Topical thalidomide compositions for surface or mucosal wounds, ulcerations, and lesions
US5602272A (en) * 1994-06-21 1997-02-11 Bristol-Myers Squibb Company Reduction and resolution methods for the preparation of compounds useful as intemediates for preparing taxanes
DE4436149A1 (de) * 1994-10-11 1996-04-18 Forschungszentrum Juelich Gmbh Verfahren zur kontinuierlichen enzymkatalytischen Gewinnung hydrophober Produkte
US6469009B1 (en) 1996-04-08 2002-10-22 Ucb, S.A. Pharmaceutical compositions for the treatment of rhinitis
US5958714A (en) 1996-10-02 1999-09-28 Safety Associates, Inc. Test kits for determining at least two specific analytes in foods and other complex matrices
FR2755143B1 (fr) * 1996-10-25 1998-11-27 Rhone Poulenc Nutrition Animal Procede de preparation de l'acide 2-hydroxy-4-methylthio-butyrique par utilisation d'une nitrilase
KR100517776B1 (ko) * 1997-07-22 2005-09-28 론자 아게 아미드의 제조 방법
US6884842B2 (en) * 1997-10-14 2005-04-26 Alnis Biosciences, Inc. Molecular compounds having complementary surfaces to targets
US6136327A (en) 1997-12-01 2000-10-24 Alza Corporation Stereospecific delivery of a drug using electrotransport
AU2241799A (en) * 1998-01-26 1999-08-09 Pharm-Eco Laboratories, Inc. Enzyme activated supports for enantiomeric separations
DE19807972A1 (de) * 1998-02-25 1999-08-26 Hoechst Marion Roussel De Gmbh Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung
US6194431B1 (en) 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
HK1040059A1 (zh) 1998-06-15 2002-05-24 塞普拉科有限公司 光学纯度(-)-降西沙必利对治疗呼吸暂停、贪食症和其它疾病的用途
IL140118A0 (en) 1998-06-15 2002-02-10 Sepracor Inc Use of optically pure (+) norcisapride for treating apnea, bulimia and other disorders
US6265615B1 (en) * 1998-07-01 2001-07-24 The Regents Of The University Of California Chiral recognition polymer and its use to separate enantiomers
DK1119635T3 (da) * 1998-10-09 2012-08-20 Althea Technologies Inc Ikke-homogene systemer til spaltning af enantiomerblandinger
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
US6353005B1 (en) 1999-03-02 2002-03-05 Sepracor, Inc. Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
US6362202B1 (en) 1999-03-02 2002-03-26 Sepracor Inc. Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
DE19913862C2 (de) * 1999-03-26 2003-04-10 Forschungszentrum Juelich Gmbh Verfahren zur biokatalysierten Umsetzung schlecht wasserlöslicher Substanzen
US6602719B1 (en) 1999-03-26 2003-08-05 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
US6511814B1 (en) 1999-03-26 2003-01-28 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
US6551842B1 (en) 1999-03-26 2003-04-22 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
US7279597B1 (en) 1999-11-05 2007-10-09 Emisphere Technologies, Inc. Phenyl amine carboxylic acid compounds and compositions for delivering active agents
US6355666B1 (en) 2000-06-23 2002-03-12 Medinox, Inc. Protected forms of pharmacologically active agents and uses therefor
US6485650B1 (en) 2000-08-28 2002-11-26 Facilichem, Inc. Liquid membrane separation of enantiomers
US7001526B1 (en) * 2002-02-28 2006-02-21 Hla Ngwe Tin Optical isomer separation method
US7101947B2 (en) * 2002-06-14 2006-09-05 Florida State University Research Foundation, Inc. Polyelectrolyte complex films for analytical and membrane separation of chiral compounds
US20040019300A1 (en) * 2002-07-26 2004-01-29 Leonard Leslie Anne Microfluidic blood sample separations
JP2008538351A (ja) 2005-03-21 2008-10-23 メタボレックス インコーポレーティッド 癌を含むＰＰＡＲγ反応性疾患の処置または予防における浮腫を回避するための方法
US20070282010A1 (en) * 2006-05-30 2007-12-06 Bridge Pharma, Inc. Methods of Accelerating Muscle Growth, Decreasing Fat Deposits and Improving Feed Efficiency in Livestock Animals
WO2007143336A2 (en) * 2006-05-30 2007-12-13 Stirling Products Limited Use of ractopamine enantiomers
WO2008080138A1 (en) * 2006-12-22 2008-07-03 Richmond Chemical Corporation Stereoinversion of amino acids
US20090124506A1 (en) * 2007-11-02 2009-05-14 Technion Research & Development Foundation Ltd. Membrane computing
AU2008331928B2 (en) 2007-12-03 2012-08-16 Bridge Pharma, Inc. Use of RR/SR-ractopamine
US8617856B2 (en) * 2010-01-07 2013-12-31 Wisconsin Alumni Research Foundation Fatty acid-producing hosts
WO2013022803A1 (en) * 2011-08-06 2013-02-14 Biocee, Inc. Structured biological materials and related products and methods
US9023856B2 (en) 2011-11-04 2015-05-05 Cymabay Therapeutics, Inc. Methods for treating hyperuricemia in patients with gout using halofenate or halogenic acid and a second urate-lowering agent
US9060987B2 (en) 2011-11-04 2015-06-23 Cymabay Therapeutics, Inc. Methods for treating gout flares
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR101407403B1 (ko) * 2012-02-02 2014-06-17 한국과학기술연구원 막 증류용 분리막 모듈 장치
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형
BR112017009223B1 (pt) 2014-11-02 2022-03-22 Biocheminsights, Inc Dispositivo para a produção de um produto e método de produção de um produto desejado a partir de um substrato
WO2017160793A1 (en) 2016-03-14 2017-09-21 Biocheminsights, Inc. Improved method for using electrochemical bioreactor module with recovery of cofactor
US10258929B2 (en) * 2016-06-30 2019-04-16 Uop Llc Stable facilitated transport membranes for olefin/paraffin separations
CN107080972B (zh) * 2017-06-20 2019-06-21 中国科学院青岛生物能源与过程研究所 一种提高膜萃取效率的方法
CN110257443B (zh) * 2018-03-12 2023-04-07 江苏扬农化工股份有限公司 一种超滤膜在右反de菊酸的连续化拆分中的应用方法
CN108486170A (zh) * 2018-03-12 2018-09-04 江苏扬农化工股份有限公司 一种右旋反式二氯菊酸的制备方法
CN108486171A (zh) * 2018-03-12 2018-09-04 江苏扬农化工股份有限公司 一种右旋反式第一菊酸的制备方法
CN113122445A (zh) * 2021-05-06 2021-07-16 南京普瑞特生物科技有限公司 固定化酶法拆分制备光学纯1-(1-萘基)乙胺的设备及使用方法
EP4404767A2 (en) * 2021-11-16 2024-07-31 Firmenich Incorporated Amide compounds and their use as flavor modifiers
WO2023126186A1 (en) 2021-12-29 2023-07-06 Universite D'aix-Marseille Method for simultaneous preparation of separated enantiomeric products from racemic or scalemic substrates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5233194B2 (enExample) * 1973-04-24 1977-08-26
US4251631A (en) * 1978-02-23 1981-02-17 Research Products Rehovot Ltd. Cross-linked enzyme membrane
JPS59154999A (ja) * 1983-02-21 1984-09-04 Shoichi Shimizu 生物化学反応方法および生物化学反応装置
DE3318932C1 (de) * 1983-05-25 1984-06-07 Degussa Ag, 6000 Frankfurt Verfahren zur Gewinnung von reinem L-Leucin
AU587366B2 (en) * 1983-07-27 1989-08-17 Imperial Chemical Industries Plc Process for producing optically active aryloxypropionic acids and derivatives thereof
JPS6178397A (ja) * 1984-09-22 1986-04-21 Kao Corp 酵素及び微生物の反応方法
US5002871A (en) * 1986-08-18 1991-03-26 The Coca-Cola Company Enzymatic membrane method for the synthesis and separation of peptides
EP0273679A2 (en) * 1986-12-29 1988-07-06 EASTMAN KODAK COMPANY (a New Jersey corporation) Improved method for effecting enzymatic reactions and an enzymatic reactor useful therein
US4800162A (en) * 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Патент US №4565782, кл.С12Р 17/12, 1986. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7129274B1 (en) 1999-11-05 2006-10-31 Emisphere Technologies Inc. Phenoxy carboxylic acid compounds and compositions for delivering active agents
US7951971B1 (en) 1999-11-05 2011-05-31 Emisphere Technologies, Inc. Phenoxy carboxylic acid compounds and compositions for delivering active agents

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US5077217A (en) 1991-12-31
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IL85938A0 (en) 1988-09-30
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