RS63535B1 - Derivati piridina i njihove terapeutske primene kao trpc6 inhibitora - Google Patents
Derivati piridina i njihove terapeutske primene kao trpc6 inhibitoraInfo
- Publication number
- RS63535B1 RS63535B1 RS20220752A RSP20220752A RS63535B1 RS 63535 B1 RS63535 B1 RS 63535B1 RS 20220752 A RS20220752 A RS 20220752A RS P20220752 A RSP20220752 A RS P20220752A RS 63535 B1 RS63535 B1 RS 63535B1
- Authority
- RS
- Serbia
- Prior art keywords
- therapeutic uses
- pyridine derivatives
- trpc6
- inhibitors
- trpc6 inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000003222 pyridines Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762577883P | 2017-10-27 | 2017-10-27 | |
US201862628313P | 2018-02-09 | 2018-02-09 | |
EP20197194.2A EP3786160B1 (en) | 2017-10-27 | 2018-10-25 | Pyridine derivatives and therapeutic uses thereof as trpc6 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
RS63535B1 true RS63535B1 (sr) | 2022-09-30 |
Family
ID=64270818
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20220752A RS63535B1 (sr) | 2017-10-27 | 2018-10-25 | Derivati piridina i njihove terapeutske primene kao trpc6 inhibitora |
RS20230382A RS64271B1 (sr) | 2017-10-27 | 2018-10-25 | Inhibitori trpc6 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20230382A RS64271B1 (sr) | 2017-10-27 | 2018-10-25 | Inhibitori trpc6 |
Country Status (30)
Country | Link |
---|---|
US (4) | US10889568B2 (sr) |
EP (2) | EP3786160B1 (sr) |
JP (2) | JP7217273B6 (sr) |
KR (2) | KR20200125758A (sr) |
CN (1) | CN111527078B (sr) |
AU (2) | AU2018355743B2 (sr) |
BR (1) | BR112020007818A2 (sr) |
CA (1) | CA3078769A1 (sr) |
CL (2) | CL2020001097A1 (sr) |
CY (1) | CY1126109T1 (sr) |
DK (2) | DK3700902T3 (sr) |
ES (2) | ES2946274T3 (sr) |
FI (1) | FI3700902T3 (sr) |
HR (2) | HRP20230502T1 (sr) |
HU (2) | HUE062460T2 (sr) |
IL (2) | IL274039B (sr) |
LT (2) | LT3786160T (sr) |
MX (1) | MX2020004283A (sr) |
PE (1) | PE20210154A1 (sr) |
PH (1) | PH12020550503A1 (sr) |
PL (2) | PL3786160T3 (sr) |
PT (2) | PT3700902T (sr) |
RS (2) | RS63535B1 (sr) |
SA (1) | SA520411843B1 (sr) |
SG (2) | SG10202011632RA (sr) |
SI (2) | SI3700902T1 (sr) |
TW (2) | TWI780511B (sr) |
UA (1) | UA128474C2 (sr) |
WO (1) | WO2019081637A1 (sr) |
ZA (1) | ZA202002372B (sr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3700902T1 (sl) * | 2017-10-27 | 2023-10-30 | Boehringer Ingelheim International Gmbh | Inhibitorji trpc6 |
WO2019158572A1 (en) * | 2018-02-15 | 2019-08-22 | Boehringer Ingelheim International Gmbh | Inhibitors of trpc6 |
US11370771B2 (en) * | 2018-02-16 | 2022-06-28 | Boehringer Ingelheim International Gmbh | Inhibitors of TRPC6 |
CN112955439A (zh) * | 2018-08-24 | 2021-06-11 | 赛尼欧普罗有限责任公司 | 用于治疗病理状况的芳族分子 |
US20220152023A1 (en) * | 2019-04-12 | 2022-05-19 | Boehringer Ingelheim International Gmbh | Inhibitors of trpc6 |
WO2021079962A1 (ja) * | 2019-10-24 | 2021-04-29 | 国立大学法人大阪大学 | 難聴の予防および/または治療用医薬組成物 |
WO2021160625A1 (en) | 2020-02-11 | 2021-08-19 | Klinikum Rechts Der Isar | Administration of calcium channel trpc6 inhibitors using balloons, stents or other medical devices |
AR121846A1 (es) * | 2020-04-16 | 2022-07-13 | Teijin Pharma Ltd | Derivado de arilo o heteroarilo |
CA3173616A1 (en) * | 2020-04-16 | 2021-10-21 | Boehringer Ingelheim International Gmbh | Use of pyridine carbonyl derivatives as inhibitors of trpc6 for treating respiratory conditions |
CN113105318B (zh) * | 2021-02-23 | 2022-05-20 | 中山大学 | 一种2,2-二氟环丁烷-1-羧酸的制备方法及应用 |
KR20240093600A (ko) | 2021-10-15 | 2024-06-24 | 베링거 인겔하임 인터내셔날 게엠베하 | 패혈증 치료를 위한 trpc6 억제 화합물 |
WO2023106421A1 (ja) * | 2021-12-06 | 2023-06-15 | 国立大学法人熊本大学 | Trpc6の発現を抑制する方法 |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991009594A1 (en) | 1989-12-28 | 1991-07-11 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
PT100639A (pt) | 1991-06-27 | 1993-09-30 | Univ Virginia Commonwealth | Metodo para o tratamento terapeutico com compostos que sao ligandos ao receptor sigma e compostos ai utilizados, nomeadamente derivados fenilalquil-amina, aminotetralina,piperazina e piperidina |
WO1994012461A1 (en) | 1992-12-02 | 1994-06-09 | Pfizer Inc. | Catechol diethers as selective pdeiv inhibitors |
CA2345146C (en) | 1998-09-22 | 2010-02-23 | Yamanouchi Pharmaceutical Co., Ltd. | Cyanophenyl derivative |
WO2001064643A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa |
NZ523526A (en) | 2000-07-20 | 2004-10-29 | Neurogen Corp | Diaryl piperazines as capsaicin receptor ligands |
WO2002102778A1 (fr) | 2001-06-15 | 2002-12-27 | Yamanouchi Pharmaceutical Co., Ltd. | Derive de phenylpyridinecarbonylpiperazine |
JP4186518B2 (ja) * | 2001-06-15 | 2008-11-26 | アステラス製薬株式会社 | フェニルピリジン誘導体 |
NI200300045A (es) | 2002-04-26 | 2005-07-08 | Pfizer Prod Inc | Inhibidores de triariloxiariloxipirimidin-2,4,6-triona de metaloproteinasa. |
DE10222291A1 (de) | 2002-05-18 | 2003-11-27 | Schlafhorst & Co W | Faserbandzuführeinrichtung |
CN1150176C (zh) | 2002-05-22 | 2004-05-19 | 上海医药工业研究院 | 芳烷酮哌嗪衍生物及其应用 |
EP1809626A2 (en) | 2004-10-13 | 2007-07-25 | Neurogen Corporation | Aryl substituted 8-azabicyclo[3.2.1]octane compounds as ligands of the melanin concentrating hormone receptor |
DE102005044814A1 (de) * | 2005-05-19 | 2006-11-23 | Grünenthal GmbH | Substituierte Sprio-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
PE20070795A1 (es) | 2005-10-28 | 2007-08-24 | Lilly Co Eli | Compuestos pirazol-urea-heterociclicos como inhibidores de cinasa |
WO2007075629A2 (en) | 2005-12-21 | 2007-07-05 | Schering Corporation | Phenoxypiperidines and analogs thereof useful as histamine h3 antagonists |
JP5019768B2 (ja) | 2006-03-23 | 2012-09-05 | 独立行政法人科学技術振興機構 | 新規低分子化合物およびその製造方法 |
MY156814A (en) | 2007-03-15 | 2016-03-31 | Novartis Ag | Organic compounds and their uses |
JP5082538B2 (ja) | 2007-03-28 | 2012-11-28 | Dic株式会社 | ピペラジン化合物 |
EP2379524A1 (en) | 2008-12-18 | 2011-10-26 | Boehringer Ingelheim International GmbH | Serotonin 5-ht2b receptor inhibitors |
US20100234603A1 (en) | 2009-03-13 | 2010-09-16 | Xin Linghu | Process for Making Substituted Aryl Sulfone Intermediates |
US20110039850A1 (en) | 2009-08-12 | 2011-02-17 | Mhairi Copland | Leukemia Treatment |
CN102686579A (zh) | 2009-10-09 | 2012-09-19 | Irm责任有限公司 | 作为gpr119活性调节剂的化合物和组合物 |
MX2012005695A (es) | 2009-11-18 | 2012-06-13 | Novartis Ag | Metodos y composiciones para el tratamiento de tumores solidos y otras malignidades. |
RU2581367C2 (ru) | 2010-03-01 | 2016-04-20 | Джи Ти Икс, ИНК. | Соединения для лечения рака |
DK2565182T3 (en) | 2010-04-27 | 2017-12-04 | Mitsubishi Tanabe Pharma Corp | New amide derivative and its use as a drug |
KR101564806B1 (ko) | 2010-05-13 | 2015-10-30 | 암젠 인크 | Pde10 저해제로서 유용한 질소 헤테로시클릭 화합물 |
MX338707B (es) | 2010-07-29 | 2016-04-28 | Rigel Pharmaceuticals Inc | Compuestos heterociclicos activadores de proteina cinasa activada por 5'-amp (ampk) y metodos para emplearlos. |
US9586928B2 (en) | 2011-05-16 | 2017-03-07 | The Scripps Research Institute | Modulators of the nuclear hormone receptor ROR |
JP5800786B2 (ja) | 2011-10-26 | 2015-10-28 | 田辺三菱製薬株式会社 | 新規アミド誘導体を有効成分として含有する医薬組成物 |
WO2013066714A1 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
CN103360343B (zh) | 2012-03-30 | 2017-04-19 | 凯惠药业(上海)有限公司 | 一种哌嗪酰胺类化合物的制备方法 |
WO2014139144A1 (en) | 2013-03-15 | 2014-09-18 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
MX366678B (es) * | 2013-05-27 | 2019-07-19 | Hoffmann La Roche | Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. |
US20150087673A1 (en) | 2013-09-26 | 2015-03-26 | Rigel Pharmaceuticals, Inc. | Methods for using and biomarkers for ampk-activating compounds |
EP3092236B1 (en) | 2014-01-06 | 2020-08-26 | Rhizen Pharmaceuticals S.A. | Novel glutaminase inhibitors |
WO2015199206A1 (ja) * | 2014-06-27 | 2015-12-30 | 塩野義製薬株式会社 | Trpv4阻害活性を有する6員環誘導体 |
UY36391A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
MA41598A (fr) | 2015-02-25 | 2018-01-02 | Constellation Pharmaceuticals Inc | Composés thérapeutiques de pyridazine et leurs utilisations |
US20180305334A1 (en) | 2015-10-14 | 2018-10-25 | Aquinnah Pharmaceuticals, Inc. | Compounds, compositions and methods of use against stress granules |
CN107176927B (zh) | 2016-03-12 | 2020-02-18 | 福建金乐医药科技有限公司 | 组蛋白去甲基化酶lsd1抑制剂 |
CN114539284A (zh) | 2016-03-16 | 2022-05-27 | 库拉肿瘤学公司 | 经取代的menin-mll抑制剂及使用方法 |
MX2018015990A (es) | 2016-06-20 | 2019-10-07 | Univ Rutgers | Compuestos terapeuticos. |
CN107540636A (zh) | 2016-06-29 | 2018-01-05 | 成都贝斯凯瑞生物科技有限公司 | 一种含氮杂环衍生物及其应用 |
CN106317050B (zh) * | 2016-08-24 | 2018-11-23 | 烟台大学 | 一种苯基噻唑衍生物及其制备方法与应用 |
JPWO2018159827A1 (ja) | 2017-03-03 | 2020-01-09 | 国立大学法人京都大学 | 植物ステロイドホルモン(ブラシノライド)様活性をもつ非ステロイド化合物の創製 |
WO2018170225A1 (en) | 2017-03-15 | 2018-09-20 | Athenex, Inc. | Biaryl piperidine amide compounds and methods of use thereof |
SI3700902T1 (sl) | 2017-10-27 | 2023-10-30 | Boehringer Ingelheim International Gmbh | Inhibitorji trpc6 |
US11225493B2 (en) * | 2017-11-16 | 2022-01-18 | Principia Biopharma Inc. | Immunoproteasome inhibitors |
WO2019158572A1 (en) * | 2018-02-15 | 2019-08-22 | Boehringer Ingelheim International Gmbh | Inhibitors of trpc6 |
US11370771B2 (en) * | 2018-02-16 | 2022-06-28 | Boehringer Ingelheim International Gmbh | Inhibitors of TRPC6 |
-
2018
- 2018-10-25 SI SI201830924T patent/SI3700902T1/sl unknown
- 2018-10-25 US US16/170,178 patent/US10889568B2/en active Active
- 2018-10-25 DK DK18800513.6T patent/DK3700902T3/da active
- 2018-10-25 SG SG10202011632RA patent/SG10202011632RA/en unknown
- 2018-10-25 JP JP2020523445A patent/JP7217273B6/ja active Active
- 2018-10-25 SI SI201830732T patent/SI3786160T1/sl unknown
- 2018-10-25 LT LTEP20197194.2T patent/LT3786160T/lt unknown
- 2018-10-25 BR BR112020007818-2A patent/BR112020007818A2/pt unknown
- 2018-10-25 HU HUE18800513A patent/HUE062460T2/hu unknown
- 2018-10-25 AU AU2018355743A patent/AU2018355743B2/en active Active
- 2018-10-25 PL PL20197194.2T patent/PL3786160T3/pl unknown
- 2018-10-25 WO PCT/EP2018/079276 patent/WO2019081637A1/en active Application Filing
- 2018-10-25 ES ES18800513T patent/ES2946274T3/es active Active
- 2018-10-25 UA UAA202003145A patent/UA128474C2/uk unknown
- 2018-10-25 KR KR1020207031025A patent/KR20200125758A/ko not_active Application Discontinuation
- 2018-10-25 DK DK20197194.2T patent/DK3786160T3/da active
- 2018-10-25 CA CA3078769A patent/CA3078769A1/en active Pending
- 2018-10-25 TW TW109138850A patent/TWI780511B/zh active
- 2018-10-25 US US16/170,154 patent/US10800757B2/en not_active Ceased
- 2018-10-25 RS RS20220752A patent/RS63535B1/sr unknown
- 2018-10-25 SG SG11202003367TA patent/SG11202003367TA/en unknown
- 2018-10-25 HU HUE20197194A patent/HUE059450T2/hu unknown
- 2018-10-25 TW TW107137733A patent/TWI780246B/zh active
- 2018-10-25 FI FIEP18800513.6T patent/FI3700902T3/fi active
- 2018-10-25 KR KR1020207014013A patent/KR20200095467A/ko active IP Right Grant
- 2018-10-25 HR HRP20230502TT patent/HRP20230502T1/hr unknown
- 2018-10-25 RS RS20230382A patent/RS64271B1/sr unknown
- 2018-10-25 PL PL18800513.6T patent/PL3700902T3/pl unknown
- 2018-10-25 PE PE2020000424A patent/PE20210154A1/es unknown
- 2018-10-25 CN CN201880070122.4A patent/CN111527078B/zh active Active
- 2018-10-25 MX MX2020004283A patent/MX2020004283A/es unknown
- 2018-10-25 PT PT188005136T patent/PT3700902T/pt unknown
- 2018-10-25 EP EP20197194.2A patent/EP3786160B1/en active Active
- 2018-10-25 HR HRP20220991TT patent/HRP20220991T1/hr unknown
- 2018-10-25 ES ES20197194T patent/ES2924933T3/es active Active
- 2018-10-25 EP EP18800513.6A patent/EP3700902B8/en active Active
- 2018-10-25 PT PT201971942T patent/PT3786160T/pt unknown
- 2018-10-25 LT LTEPPCT/EP2018/079276T patent/LT3700902T/lt unknown
-
2020
- 2020-04-19 IL IL274039A patent/IL274039B/en unknown
- 2020-04-23 CL CL2020001097A patent/CL2020001097A1/es unknown
- 2020-04-26 SA SA520411843A patent/SA520411843B1/ar unknown
- 2020-04-27 PH PH12020550503A patent/PH12020550503A1/en unknown
- 2020-05-04 ZA ZA2020/02372A patent/ZA202002372B/en unknown
- 2020-09-22 IL IL277493A patent/IL277493B/en unknown
- 2020-10-02 CL CL2020002562A patent/CL2020002562A1/es unknown
- 2020-10-06 AU AU2020250185A patent/AU2020250185B2/en active Active
- 2020-10-08 JP JP2020170563A patent/JP6979502B2/ja active Active
- 2020-12-08 US US17/115,667 patent/US20210163449A1/en not_active Abandoned
-
2021
- 2021-05-28 US US17/334,097 patent/USRE49699E1/en active Active
-
2023
- 2023-06-07 CY CY20231100270T patent/CY1126109T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SI3786160T1 (sl) | Piridinski derivati in njihova terapevtska uporaba kot inhibitorjev TRPC6 | |
IL253712A0 (en) | Mysterlein derivatives for coupling and healing | |
PL3287443T3 (pl) | 6-członowa pochodna heterocykliczna i kompozycja farmaceutyczna ją zawierająca | |
EP3310376A4 (en) | MODIFIED THERAPEUTIC AGENTS AND COMPOSITIONS THEREOF | |
IL258978B (en) | The use of pyrimidine and pyridine derivatives in the treatment of multiple sclerosis | |
IL255530A (en) | Efflux-pump inhibitors and therapeutic uses thereof | |
HK1250161B (zh) | 6-嗎啉基-2-吡唑基-9h-嘌呤衍生物及其作為pi3k抑制劑的用途 | |
PT3487851T (pt) | Derivados de aminopiridina e a sua utilização como inibidores seletivos de alk-2 | |
HK1250028A1 (zh) | 2-苯基-6-咪唑基-吡啶-4-甲酰胺衍生物及其作為eaat3抑制劑的用途 | |
IL261645A (en) | History of dioxo-hexahydroisoindolyl and their use as cyclophilin inhibitors | |
IL274722A (en) | History of pyridinones and their use as selective inhibitors of ALK-2 | |
EP3302530A4 (en) | Cdh26 based therapeutic agents and their use | |
IL258690A (en) | Pyridone derivatives and their use as kinase inhibitors | |
EP3253734A4 (en) | Glucosylceramide synthase inhibitors and therapeutic methods using the same | |
ZA202000959B (en) | Adamantylmethylamine derivative and use thereof as pharmaceutical | |
IL261644A (en) | Oxalyl derivatives and their use as cyclophilin inhibitors |