LT3700902T - Trpc6 inhibitoriai - Google Patents

Trpc6 inhibitoriai

Info

Publication number
LT3700902T
LT3700902T LTEPPCT/EP2018/079276T LTEP2018079276T LT3700902T LT 3700902 T LT3700902 T LT 3700902T LT EP2018079276 T LTEP2018079276 T LT EP2018079276T LT 3700902 T LT3700902 T LT 3700902T
Authority
LT
Lithuania
Prior art keywords
trpc6
inhibitors
Prior art date
Application number
LTEPPCT/EP2018/079276T
Other languages
English (en)
Inventor
Thierry Bouyssou
Dirk Gottschling
Niklas Heine
Lana Louise Smith Keenan
Michael D. Lowe
Hossein Razavi
Christopher Ronald Sarko
Simon Surprenant
Hidenori Takahashi
Michael Robert Turner
Xinyuan Wu
Original Assignee
Boehringer Ingelheim International Gmbh
Hydra Biosciences, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International Gmbh, Hydra Biosciences, Llc filed Critical Boehringer Ingelheim International Gmbh
Publication of LT3700902T publication Critical patent/LT3700902T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
LTEPPCT/EP2018/079276T 2017-10-27 2018-10-25 Trpc6 inhibitoriai LT3700902T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762577883P 2017-10-27 2017-10-27
US201862628313P 2018-02-09 2018-02-09
PCT/EP2018/079276 WO2019081637A1 (en) 2017-10-27 2018-10-25 CARBONYL PYRIDINE DERIVATIVES AND THEIR THERAPEUTIC USES AS TRPC6 INHIBITORS

Publications (1)

Publication Number Publication Date
LT3700902T true LT3700902T (lt) 2023-06-26

Family

ID=64270818

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEPPCT/EP2018/079276T LT3700902T (lt) 2017-10-27 2018-10-25 Trpc6 inhibitoriai
LTEP20197194.2T LT3786160T (lt) 2017-10-27 2018-10-25 Piridino dariniai ir jų terapinis panaudojimas kaip trpc6 inhibitorių

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTEP20197194.2T LT3786160T (lt) 2017-10-27 2018-10-25 Piridino dariniai ir jų terapinis panaudojimas kaip trpc6 inhibitorių

Country Status (30)

Country Link
US (4) US10800757B2 (lt)
EP (2) EP3786160B1 (lt)
JP (2) JP7217273B6 (lt)
KR (2) KR20200095467A (lt)
CN (1) CN111527078B (lt)
AU (2) AU2018355743B2 (lt)
BR (1) BR112020007818A2 (lt)
CA (1) CA3078769A1 (lt)
CL (2) CL2020001097A1 (lt)
CY (1) CY1126109T1 (lt)
DK (2) DK3700902T3 (lt)
ES (2) ES2924933T3 (lt)
FI (1) FI3700902T3 (lt)
HR (2) HRP20220991T1 (lt)
HU (2) HUE062460T2 (lt)
IL (2) IL274039B (lt)
LT (2) LT3700902T (lt)
MX (1) MX2020004283A (lt)
PE (1) PE20210154A1 (lt)
PH (1) PH12020550503A1 (lt)
PL (2) PL3700902T3 (lt)
PT (2) PT3786160T (lt)
RS (2) RS63535B1 (lt)
SA (1) SA520411843B1 (lt)
SG (2) SG10202011632RA (lt)
SI (2) SI3700902T1 (lt)
TW (2) TWI780246B (lt)
UA (1) UA128474C2 (lt)
WO (1) WO2019081637A1 (lt)
ZA (1) ZA202002372B (lt)

Families Citing this family (12)

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PL3700902T3 (pl) * 2017-10-27 2023-09-04 Boehringer Ingelheim International Gmbh Inhibitory trpc6
US11485740B2 (en) * 2018-02-15 2022-11-01 Boehringer Ingelheim International Gmbh Inhibitors of TRPC6
JP7301861B2 (ja) * 2018-02-16 2023-07-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｔｒｐｃ６の阻害剤
IL315313A (en) * 2018-08-24 2024-10-01 Xeniopro GmbH Aromatic molecules for use in the treatment of pathological conditions
EP3959206A1 (en) * 2019-04-12 2022-03-02 Boehringer Ingelheim International GmbH Inhibitors of trpc6
JP2021070688A (ja) * 2019-10-24 2021-05-06 国立大学法人大阪大学 難聴の予防および／または治療用医薬組成物
US20230137816A1 (en) 2020-02-11 2023-05-04 Deutsches Herzzentrum Muenchen Des Freistaates Bayern Administration of calcium channel trpc6 inhibitors using balloons, stents or other medical devices
KR20230004650A (ko) * 2020-04-16 2023-01-06 베링거 인겔하임 인터내셔날 게엠베하 호흡기 병태를 치료하기 위한 trpc6의 억제제
AR121846A1 (es) * 2020-04-16 2022-07-13 Teijin Pharma Ltd Derivado de arilo o heteroarilo
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WO2023106421A1 (ja) * 2021-12-06 2023-06-15 国立大学法人熊本大学 Trpc6の発現を抑制する方法

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Also Published As

Publication number Publication date
USRE49699E1 (en) 2023-10-17
HRP20220991T1 (hr) 2022-11-11
US20210163449A1 (en) 2021-06-03
AU2018355743B2 (en) 2022-04-14
IL277493A (en) 2020-11-30
HUE059450T2 (hu) 2022-11-28
PL3786160T3 (pl) 2022-10-24
KR20200095467A (ko) 2020-08-10
FI3700902T3 (fi) 2023-05-25
ES2946274T3 (es) 2023-07-14
PT3786160T (pt) 2022-08-19
SA520411843B1 (ar) 2024-01-27
CN111527078A (zh) 2020-08-11
US10800757B2 (en) 2020-10-13
CY1126109T1 (el) 2023-11-15
ZA202002372B (en) 2023-10-25
US20190169167A1 (en) 2019-06-06
DK3700902T3 (en) 2023-05-22
RS64271B1 (sr) 2023-07-31
CN111527078B (zh) 2023-06-02
SG11202003367TA (en) 2020-05-28
TW202120494A (zh) 2021-06-01
PL3700902T3 (pl) 2023-09-04
BR112020007818A2 (pt) 2020-10-20
JP2021500390A (ja) 2021-01-07
IL277493B (en) 2022-02-01
WO2019081637A1 (en) 2019-05-02
DK3786160T3 (da) 2022-08-22
PE20210154A1 (es) 2021-01-26
SI3700902T1 (sl) 2023-10-30
PT3700902T (pt) 2023-05-30
EP3700902A1 (en) 2020-09-02
JP2021008503A (ja) 2021-01-28
EP3700902B8 (en) 2023-08-02
AU2018355743A1 (en) 2020-05-14
AU2020250185B2 (en) 2022-04-14
JP6979502B2 (ja) 2021-12-15
EP3700902B1 (en) 2023-03-08
HUE062460T2 (hu) 2023-11-28
MX2020004283A (es) 2021-10-21
HRP20230502T1 (hr) 2023-09-15
ES2924933T3 (es) 2022-10-11
KR20200125758A (ko) 2020-11-04
JP7217273B2 (ja) 2023-02-02
RS63535B1 (sr) 2022-09-30
CL2020002562A1 (es) 2021-01-15
AU2020250185A1 (en) 2020-11-12
TW201930294A (zh) 2019-08-01
IL274039A (en) 2020-06-30
TWI780246B (zh) 2022-10-11
SI3786160T1 (sl) 2022-11-30
SG10202011632RA (en) 2021-01-28
PH12020550503A1 (en) 2021-03-22
IL274039B (en) 2021-08-31
JP7217273B6 (ja) 2024-02-08
UA128474C2 (uk) 2024-07-24
US20190169168A1 (en) 2019-06-06
CA3078769A1 (en) 2019-05-02
EP3786160A1 (en) 2021-03-03
TWI780511B (zh) 2022-10-11
US10889568B2 (en) 2021-01-12
EP3786160B1 (en) 2022-07-13
CL2020001097A1 (es) 2020-08-28
LT3786160T (lt) 2022-09-26

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