RS56617B1 - Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’,-dihidro-3’h-spiro[cikloheksan-1,1’-pirano’[3,4.b]indol]-4-amin i paracetamol ili propacetamol - Google Patents

Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’,-dihidro-3’h-spiro[cikloheksan-1,1’-pirano’[3,4.b]indol]-4-amin i paracetamol ili propacetamol

Info

Publication number
RS56617B1
RS56617B1 RS20171229A RSP20171229A RS56617B1 RS 56617 B1 RS56617 B1 RS 56617B1 RS 20171229 A RS20171229 A RS 20171229A RS P20171229 A RSP20171229 A RS P20171229A RS 56617 B1 RS56617 B1 RS 56617B1
Authority
RS
Serbia
Prior art keywords
pharmacologically active
active ingredient
pharmaceutical dosage
dosage form
pain
Prior art date
Application number
RS20171229A
Other languages
English (en)
Serbian (sr)
Inventor
Stefanie Frosch
Klaus Linz
Klaus Schiene
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of RS56617B1 publication Critical patent/RS56617B1/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
RS20171229A 2012-05-18 2013-05-16 Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’,-dihidro-3’h-spiro[cikloheksan-1,1’-pirano’[3,4.b]indol]-4-amin i paracetamol ili propacetamol RS56617B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12003897 2012-05-18
EP13723674.1A EP2849740B1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano'[3,4,b]indol]-4-amine and paracetamol or propacetamol
PCT/EP2013/001468 WO2013170969A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano'[3,4,b]indol]-4-amine and paracetamol or propacetamol

Publications (1)

Publication Number Publication Date
RS56617B1 true RS56617B1 (sr) 2018-02-28

Family

ID=48468208

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20171229A RS56617B1 (sr) 2012-05-18 2013-05-16 Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’,-dihidro-3’h-spiro[cikloheksan-1,1’-pirano’[3,4.b]indol]-4-amin i paracetamol ili propacetamol

Country Status (22)

Country Link
US (3) US20130310435A1 (enExample)
EP (1) EP2849740B1 (enExample)
JP (1) JP6116676B2 (enExample)
CN (2) CN108524498A (enExample)
AU (1) AU2013262075B2 (enExample)
BR (1) BR112014028561A2 (enExample)
CA (1) CA2873644A1 (enExample)
CY (1) CY1119610T1 (enExample)
DK (1) DK2849740T3 (enExample)
EA (1) EA026949B1 (enExample)
ES (1) ES2650441T3 (enExample)
HR (1) HRP20171438T1 (enExample)
HU (1) HUE034676T2 (enExample)
IL (1) IL235651B (enExample)
LT (1) LT2849740T (enExample)
MX (1) MX352596B (enExample)
NO (1) NO2849740T3 (enExample)
PL (1) PL2849740T3 (enExample)
PT (1) PT2849740T (enExample)
RS (1) RS56617B1 (enExample)
SI (1) SI2849740T1 (enExample)
WO (1) WO2013170969A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201791662A1 (ru) 2015-01-23 2017-12-29 Грюненталь Гмбх Цебранопадол для лечения от боли субъектов с нарушенной печеночной и/или нарушенной почечной функцией
CN109069483A (zh) 2016-02-29 2018-12-21 格吕伦塔尔有限公司 西博帕多的滴定

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068838B1 (en) 1981-06-26 1986-09-17 The Upjohn Company Analgesic process and composition
US4389393A (en) 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4404208A (en) 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and tiflamizole
IE55189B1 (en) 1982-07-08 1990-06-20 Wyeth John & Brother Ltd Pharmaceutical compositions
US4612008A (en) 1983-05-11 1986-09-16 Alza Corporation Osmotic device with dual thermodynamic activity
US4765989A (en) 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
US4783337A (en) 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
ATE46265T1 (de) 1985-01-23 1989-09-15 Asta Pharma Ag Synergistische kombination von flupirtin und nicht-steroidalen antiphlogistika.
EP0473655B1 (en) 1989-05-22 1997-01-15 Biochemical Veterinary Research Pty. Ltd. Divalent metal salts of indomethacin
EP0661050A1 (en) 1991-07-04 1995-07-05 Taisho Pharmaceutical Co. Ltd Analgesic
JPH05221857A (ja) * 1992-02-14 1993-08-31 Arakusu:Kk 配合解熱鎮痛剤
US5472711A (en) 1992-07-30 1995-12-05 Edward Mendell Co., Inc. Agglomerated hydrophilic complexes with multi-phasic release characteristics
US5330761A (en) 1993-01-29 1994-07-19 Edward Mendell Co. Inc. Bioadhesive tablet for non-systemic use products
CA2163995A1 (en) 1993-06-07 1994-12-22 Malcolm Maccoss Spiro-substituted azacycles as neurokinin antagonists
US5455046A (en) 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5399362A (en) 1994-04-25 1995-03-21 Edward Mendell Co., Inc. Once-a-day metoprolol oral dosage form
US5914129A (en) 1996-07-23 1999-06-22 Mauskop; Alexander Analgesic composition for treatment of migraine headaches
RS49982B (sr) 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
DE69905380T2 (de) 1998-09-10 2003-11-27 Nycomed Danmark A/S, Roskilde Pharmazeutische zusammensetzungen mit schneller freisetzung von wirkstoffen
CA2350531A1 (en) 1998-11-13 2000-05-25 Smriti Iyengar Method for treating pain
EP1219304B1 (de) 2000-12-28 2004-10-20 Fresenius Kabi Austria GmbH Stabile Infusionslösung von Diclofenac-Salzen, deren Herstellung und Verwendung
WO2003064425A1 (en) 2002-01-28 2003-08-07 Pfizer Japan Inc. N-substituted spiropiperidine compounds as ligands for orl-1 receptor
PT1374906E (pt) 2002-06-17 2007-07-24 Chiesi Farma Spa Um processo para a preparação de compostos de inclusão de piroxicam: beta-ciclodextrina
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10257824B4 (de) 2002-12-10 2004-11-11 Kochem, Hans-Günter, Dr. Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen
US20100297252A1 (en) 2003-03-03 2010-11-25 Elan Pharma International Ltd. Nanoparticulate meloxicam formulations
US7132452B2 (en) 2003-03-10 2006-11-07 Fang-Yu Lee Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
WO2006134486A2 (en) 2005-06-17 2006-12-21 Pfizer Japan Inc. Alpha-(aryl-or heteroaryl-methyl)-beta piperidino propanamide compounds as orl1-receptor antagonists
NZ571939A (en) 2006-04-28 2011-10-28 Gruenenthal Chemie Pharmaceutical combination comprising 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol and an NSAID
JP5496653B2 (ja) 2006-04-28 2014-05-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ３−（３−ジメチルアミノ−１−エチル−２−メチル−プロピル）−フェノール、およびパラセタモールを含む医薬の組合せ
CN101147735A (zh) * 2006-09-19 2008-03-26 沈阳华泰药物研究有限公司 注射用药物组合物及其药盒
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
DE102006056458A1 (de) * 2006-11-28 2008-05-29 Grünenthal GmbH Arzneimittelzubereitung von Tramadol und Acetaminophen
WO2009046801A1 (en) 2007-10-09 2009-04-16 Merck Patent Gmbh Pharmaceutical compositions containing benfotiamine and one or one more pharmaceutically active agents for the treatment of pain conditions of neuropathic origin
CN100560061C (zh) 2008-06-20 2009-11-18 海南锦瑞制药股份有限公司 一种氯诺昔康冻干粉针剂及其制备方法
CN105520924B (zh) 2008-09-05 2019-04-09 格吕伦塔尔有限公司 3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚和抗癫痫药的联合药物
AU2009289824A1 (en) * 2008-09-05 2010-03-11 Grunenthal Gmbh Pharmaceutical combination comprising 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3 diol and Paracetamol
BRPI0918919A2 (pt) 2008-09-05 2015-12-01 Gruenenthal Gmbh composição farmaceutica compreendendo 6-dimetilaminometil-1-(3-metoxifenil)-ciclo-hexano-1,3-diol e um nsaid
BR112013002696A2 (pt) * 2010-08-04 2016-05-31 Gruenenthal Gmbh forma de dosagem farmacêutica compreendendo 6'-fluor-(n-metil- ou n,n-dimetil-)4-fenil-4',9'-diidro-3'h-espiro[cicloexano-1,-1'-pirano[3,4-b]indol]-4 amina 13''
NZ604662A (en) * 2010-08-04 2014-08-29 Gruenenthal Gmbh Pharmaceutical dosage form comprising 6’-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4’,9’-dihydro-3’h-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine
RU2631481C2 (ru) * 2010-08-04 2017-09-22 Грюненталь Гмбх ЛЕКАРСТВЕННАЯ ДОЗИРОВАННАЯ ФОРМА, КОТОРАЯ СОДЕРЖИТ 6'-ФТОР-(N-МЕТИЛ-ИЛИ N, N-ДИМЕТИЛ-)-4-ФЕНИЛ-4', 9'-ДИГИДРО-3' Н-СПИРО[ЦИКЛОГЕКСАН-1, 1'-ПИРАНО[3, 4, b] ИНДОЛ]-4-АМИН ДЛЯ ЛЕЧЕНИЯ НОЦИЦЕПТИВНОЙ БОЛИ
US9320729B2 (en) 2012-05-18 2016-04-26 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative

Also Published As

Publication number Publication date
HRP20171438T1 (hr) 2017-11-03
AU2013262075B2 (en) 2017-10-26
DK2849740T3 (da) 2017-11-20
JP6116676B2 (ja) 2017-04-19
EA201401272A1 (ru) 2015-05-29
CY1119610T1 (el) 2018-04-04
US20190350884A1 (en) 2019-11-21
AU2013262075A1 (en) 2015-01-22
CN104302282A (zh) 2015-01-21
US20180092867A1 (en) 2018-04-05
US20130310435A1 (en) 2013-11-21
ES2650441T3 (es) 2018-01-18
HK1204940A1 (en) 2015-12-11
PT2849740T (pt) 2017-12-13
IL235651B (en) 2018-08-30
BR112014028561A2 (pt) 2017-07-25
US11311504B2 (en) 2022-04-26
HUE034676T2 (hu) 2018-02-28
MX352596B (es) 2017-11-30
SI2849740T1 (en) 2018-01-31
EA026949B1 (ru) 2017-06-30
JP2015516449A (ja) 2015-06-11
WO2013170969A1 (en) 2013-11-21
PL2849740T3 (pl) 2018-03-30
IL235651A0 (en) 2015-01-29
CA2873644A1 (en) 2013-11-21
LT2849740T (lt) 2017-12-27
EP2849740B1 (en) 2017-09-13
NO2849740T3 (enExample) 2018-02-10
CN108524498A (zh) 2018-09-14
EP2849740A1 (en) 2015-03-25
MX2014012723A (es) 2015-01-15

Similar Documents

Publication Publication Date Title
RS56771B1 (sr) Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’-dihidro-3’h-spiro[cikloheksan-1,1’-pirano-[3,4,b]indol]-4-amin i ibuprofen
RS55905B1 (sr) Farmaceutska kompozicija koja sadrži (1r,4r)-6'-fluoro-n, n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano [3,4,b]indol]-4-amin i antikonvulziv
RS56788B1 (sr) Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’-dihidro-3’h-spiro[cikloheksan-1,1’-pirano[3,4,b]indol]-4-amin i neki nsar
RS56799B1 (sr) Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’-dihidro-3’h-spiro[cikloheksan-1,1’-pirano [3,4,b]indol]-4-amin i neki gabapentinoid
RS56617B1 (sr) Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’,-dihidro-3’h-spiro[cikloheksan-1,1’-pirano’[3,4.b]indol]-4-amin i paracetamol ili propacetamol
RS56830B1 (sr) Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’-dihidro-3’h-spiro[cikloheksan-1,1’-pirano [3,4,b]indol]-4-amin i meloksikam
RS56856B1 (sr) Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’-dihidro-3’h-spiro[cikloheksan-1,1’-pirano[3,4,b]indol]-4-amin i duloksetin
JP6116675B2 (ja) （１ｒ，４ｒ）−６’−フルオロ−Ｎ，Ｎ−ジメチル−４−フェニル−４’，９’−ジヒドロ−３’Ｈ−スピロ［シクロヘキサン−１，１’−ピラノ［３，４，ｂ］インドール］−４−アミンおよびサリチル酸成分を含む医薬組成物
HK1204940B (en) Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano'[3,4,b]indol]-4-amine and paracetamol or propacetamol
HK1204938B (en) Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and a nsar