EA026949B1 - ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ (1r,4r)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО-3'H-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО-[3,4,b]ИНДОЛ]-4-АМИН И ПАРАЦЕТАМОЛ ИЛИ ПРОПАЦЕТАМОЛ - Google Patents
ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ (1r,4r)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО-3'H-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО-[3,4,b]ИНДОЛ]-4-АМИН И ПАРАЦЕТАМОЛ ИЛИ ПРОПАЦЕТАМОЛ Download PDFInfo
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- EA026949B1 EA026949B1 EA201401272A EA201401272A EA026949B1 EA 026949 B1 EA026949 B1 EA 026949B1 EA 201401272 A EA201401272 A EA 201401272A EA 201401272 A EA201401272 A EA 201401272A EA 026949 B1 EA026949 B1 EA 026949B1
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- Eurasian Patent Office
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- pharmacologically active
- active ingredient
- pharmaceutical dosage
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
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- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12003897 | 2012-05-18 | ||
| PCT/EP2013/001468 WO2013170969A1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano'[3,4,b]indol]-4-amine and paracetamol or propacetamol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201401272A1 EA201401272A1 (ru) | 2015-05-29 |
| EA026949B1 true EA026949B1 (ru) | 2017-06-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201401272A EA026949B1 (ru) | 2012-05-18 | 2013-05-16 | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ (1r,4r)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО-3'H-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО-[3,4,b]ИНДОЛ]-4-АМИН И ПАРАЦЕТАМОЛ ИЛИ ПРОПАЦЕТАМОЛ |
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| BR (1) | BR112014028561A2 (enExample) |
| CA (1) | CA2873644A1 (enExample) |
| CY (1) | CY1119610T1 (enExample) |
| DK (1) | DK2849740T3 (enExample) |
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| ES (1) | ES2650441T3 (enExample) |
| HR (1) | HRP20171438T1 (enExample) |
| HU (1) | HUE034676T2 (enExample) |
| IL (1) | IL235651B (enExample) |
| LT (1) | LT2849740T (enExample) |
| MX (1) | MX352596B (enExample) |
| NO (1) | NO2849740T3 (enExample) |
| PL (1) | PL2849740T3 (enExample) |
| PT (1) | PT2849740T (enExample) |
| RS (1) | RS56617B1 (enExample) |
| SI (1) | SI2849740T1 (enExample) |
| WO (1) | WO2013170969A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201791662A1 (ru) | 2015-01-23 | 2017-12-29 | Грюненталь Гмбх | Цебранопадол для лечения от боли субъектов с нарушенной печеночной и/или нарушенной почечной функцией |
| JP7373904B2 (ja) | 2016-02-29 | 2023-11-06 | パーク・セラピューティクス・インコーポレイテッド | セブラノパドールの滴定 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005066183A1 (de) * | 2003-12-23 | 2005-07-21 | Grünenthal GmbH | Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor |
| CN101147735A (zh) * | 2006-09-19 | 2008-03-26 | 沈阳华泰药物研究有限公司 | 注射用药物组合物及其药盒 |
| DE102006056458A1 (de) * | 2006-11-28 | 2008-05-29 | Grünenthal GmbH | Arzneimittelzubereitung von Tramadol und Acetaminophen |
| US20080125475A1 (en) * | 2006-09-29 | 2008-05-29 | Grunenthal Gmbh | Mixed ORL1/mu-agonists for the treatment of pain |
| US20110319440A1 (en) * | 2002-11-11 | 2011-12-29 | Gruenenthal Gmbh | Process for Preparing Spirocyclic Cyclohexane Compounds, Compositions Containing Such Compounds and Method of Using Such Compounds |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3273329D1 (en) | 1981-06-26 | 1986-10-23 | Upjohn Co | Analgesic process and composition |
| US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4404208A (en) | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and tiflamizole |
| IE55189B1 (en) | 1982-07-08 | 1990-06-20 | Wyeth John & Brother Ltd | Pharmaceutical compositions |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| DE3665538D1 (en) | 1985-01-23 | 1989-10-19 | Asta Pharma Ag | Synergistic combination of flupirtin and non-steroidal anti-phlogistics |
| DK0473655T3 (da) | 1989-05-22 | 1997-02-10 | Biochemical Veterinary Res | Divalente metalsalte af indomethacin |
| WO1993000895A1 (fr) | 1991-07-04 | 1993-01-21 | Taisho Pharmaceutical Co., Ltd. | Analgesique |
| JPH05221857A (ja) * | 1992-02-14 | 1993-08-31 | Arakusu:Kk | 配合解熱鎮痛剤 |
| US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| JPH08511522A (ja) | 1993-06-07 | 1996-12-03 | メルク エンド カンパニー インコーポレーテッド | ニューロキニンアンタゴニストとしてのスピロ置換アザ環 |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
| US5914129A (en) | 1996-07-23 | 1999-06-22 | Mauskop; Alexander | Analgesic composition for treatment of migraine headaches |
| RS49982B (sr) | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
| JP5026635B2 (ja) | 1998-09-10 | 2012-09-12 | ニュコメデ ダンマルク アンパーツセルスカブ | 医薬物質の迅速放出医薬組成物 |
| JP2002529499A (ja) | 1998-11-13 | 2002-09-10 | イーライ・リリー・アンド・カンパニー | 痛みの治療方法 |
| ATE279920T1 (de) | 2000-12-28 | 2004-11-15 | Fresenius Kabi Austria Gmbh | Stabile infusionslösung von diclofenac-salzen, deren herstellung und verwendung |
| JP2005519921A (ja) | 2002-01-28 | 2005-07-07 | ファイザー株式会社 | Ｏｒｌ−１受容体リガンドとしてのｎ置換スピロピペリジン化合物 |
| PT1374906E (pt) | 2002-06-17 | 2007-07-24 | Chiesi Farma Spa | Um processo para a preparação de compostos de inclusão de piroxicam: beta-ciclodextrina |
| DE10257824B4 (de) | 2002-12-10 | 2004-11-11 | Kochem, Hans-Günter, Dr. | Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen |
| US20100297252A1 (en) | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
| US7132452B2 (en) | 2003-03-10 | 2006-11-07 | Fang-Yu Lee | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection |
| EP1893610A2 (en) | 2005-06-17 | 2008-03-05 | Pfizer, Inc. | Alpha-(aryl-or heteroaryl-methyl)-beta piperidino propanamide compounds as orl1-receptor antagonists |
| NZ571442A (en) * | 2006-04-28 | 2011-09-30 | Gruenenthal Chemie | Pharmaceutical combination comprising 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol and paracetamol for treating pain |
| CN102671195B (zh) | 2006-04-28 | 2016-01-20 | 格吕伦塔尔有限公司 | 包含3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚和nsaid的药物组合物 |
| CA2701838A1 (en) | 2007-10-09 | 2009-04-16 | Merck Patent Gmbh | Pharmaceutical compositions containing benfotiamine and one or more pharmaceutically active agents for the treatment of pain conditions of neuropathic origin |
| CN100560061C (zh) | 2008-06-20 | 2009-11-18 | 海南锦瑞制药股份有限公司 | 一种氯诺昔康冻干粉针剂及其制备方法 |
| US20100069501A1 (en) * | 2008-09-05 | 2010-03-18 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol and Paracetamol |
| WO2010025931A2 (en) | 2008-09-05 | 2010-03-11 | Grünenthal GmbH | Pharmaceutical combination |
| AU2009289736A1 (en) | 2008-09-05 | 2010-03-11 | Grunenthal Gmbh | Pharmaceutical combination comprising 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol and an NSAID |
| DK2600851T3 (en) * | 2010-08-04 | 2018-06-25 | Gruenenthal Gmbh | PHARMACEUTICAL DOSAGE FORM CONTAINING 6'-FLUORO- (N-METHYL OR N, N-DIMETHYL -) - 4-PHENYL-4 ', 9'-DIHYDRO-3'H-SPIRO [CYCLOHEXAN-1,1'-PYRANO [3,4, B] INDOL] -4-AMINE FOR TREATMENT OF NEUROPATHIC PAIN |
| SI2600846T1 (sl) * | 2010-08-04 | 2016-02-29 | Gruenenthal Gmbh | Farmacevtska odmerna oblika, ki obsega 6'-fluoro-(N-metil- ali N,N-dimetil-)-4-fenil-4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano (3,4,b)indol)-4-amin |
| BR112013004055A2 (pt) * | 2010-08-04 | 2018-04-24 | Gruenenthal Gmbh | Forma de dosagem farmacêutica compreendendo 6'-fluor-(n-metil- ou n, n-dimetil-)-4-fenil-4',9'-di- hidro-3'h-espiro[cicloexano-1,1'-pirano[3,4-b]indol]-4 -amina. |
| US9320729B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
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- 2013-05-16 ES ES13723674.1T patent/ES2650441T3/es active Active
- 2013-05-16 HU HUE13723674A patent/HUE034676T2/hu unknown
- 2013-05-16 CN CN201810706944.9A patent/CN108524498A/zh active Pending
- 2013-05-16 EP EP13723674.1A patent/EP2849740B1/en not_active Not-in-force
- 2013-05-16 WO PCT/EP2013/001468 patent/WO2013170969A1/en not_active Ceased
- 2013-05-16 JP JP2015511955A patent/JP6116676B2/ja active Active
- 2013-05-16 CA CA2873644A patent/CA2873644A1/en not_active Abandoned
- 2013-05-16 DK DK13723674.1T patent/DK2849740T3/da active
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- 2013-05-16 PL PL13723674T patent/PL2849740T3/pl unknown
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- 2013-05-16 EA EA201401272A patent/EA026949B1/ru not_active IP Right Cessation
- 2013-05-16 BR BR112014028561A patent/BR112014028561A2/pt not_active IP Right Cessation
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- 2013-05-16 CN CN201380025683.XA patent/CN104302282A/zh active Pending
- 2013-05-16 SI SI201330870T patent/SI2849740T1/en unknown
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- 2014-11-12 IL IL235651A patent/IL235651B/en active IP Right Grant
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- 2017-10-06 US US15/726,761 patent/US20180092867A1/en not_active Abandoned
- 2017-11-20 CY CY20171101212T patent/CY1119610T1/el unknown
-
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- 2019-07-03 US US16/502,651 patent/US11311504B2/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110319440A1 (en) * | 2002-11-11 | 2011-12-29 | Gruenenthal Gmbh | Process for Preparing Spirocyclic Cyclohexane Compounds, Compositions Containing Such Compounds and Method of Using Such Compounds |
| WO2005066183A1 (de) * | 2003-12-23 | 2005-07-21 | Grünenthal GmbH | Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor |
| CN101147735A (zh) * | 2006-09-19 | 2008-03-26 | 沈阳华泰药物研究有限公司 | 注射用药物组合物及其药盒 |
| US20080125475A1 (en) * | 2006-09-29 | 2008-05-29 | Grunenthal Gmbh | Mixed ORL1/mu-agonists for the treatment of pain |
| DE102006056458A1 (de) * | 2006-11-28 | 2008-05-29 | Grünenthal GmbH | Arzneimittelzubereitung von Tramadol und Acetaminophen |
Also Published As
| Publication number | Publication date |
|---|---|
| LT2849740T (lt) | 2017-12-27 |
| CN108524498A (zh) | 2018-09-14 |
| HRP20171438T1 (hr) | 2017-11-03 |
| IL235651A0 (en) | 2015-01-29 |
| NO2849740T3 (enExample) | 2018-02-10 |
| AU2013262075A1 (en) | 2015-01-22 |
| US20190350884A1 (en) | 2019-11-21 |
| MX352596B (es) | 2017-11-30 |
| EP2849740A1 (en) | 2015-03-25 |
| JP2015516449A (ja) | 2015-06-11 |
| WO2013170969A1 (en) | 2013-11-21 |
| PL2849740T3 (pl) | 2018-03-30 |
| US11311504B2 (en) | 2022-04-26 |
| HK1204940A1 (en) | 2015-12-11 |
| US20180092867A1 (en) | 2018-04-05 |
| RS56617B1 (sr) | 2018-02-28 |
| AU2013262075B2 (en) | 2017-10-26 |
| DK2849740T3 (da) | 2017-11-20 |
| HUE034676T2 (hu) | 2018-02-28 |
| US20130310435A1 (en) | 2013-11-21 |
| PT2849740T (pt) | 2017-12-13 |
| CN104302282A (zh) | 2015-01-21 |
| IL235651B (en) | 2018-08-30 |
| EA201401272A1 (ru) | 2015-05-29 |
| BR112014028561A2 (pt) | 2017-07-25 |
| CY1119610T1 (el) | 2018-04-04 |
| MX2014012723A (es) | 2015-01-15 |
| ES2650441T3 (es) | 2018-01-18 |
| EP2849740B1 (en) | 2017-09-13 |
| CA2873644A1 (en) | 2013-11-21 |
| SI2849740T1 (en) | 2018-01-31 |
| JP6116676B2 (ja) | 2017-04-19 |
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