RS51227B - Makrociklički inhibitori virusa hepatitisa c - Google Patents
Makrociklički inhibitori virusa hepatitisa cInfo
- Publication number
- RS51227B RS51227B RSP-2010/0183A RSP20100183A RS51227B RS 51227 B RS51227 B RS 51227B RS P20100183 A RSP20100183 A RS P20100183A RS 51227 B RS51227 B RS 51227B
- Authority
- RS
- Serbia
- Prior art keywords
- c6alkyl
- independently
- c3alkylene
- c6alkoxy
- alkylenecarbocyclyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Jedinjenje formule I:i N-oksidi, soli i stereoizomeri od toga, naznačeno time da: A je OR1, NHS(=O)pR2; u čemu;R1 je vodonik, C1-C6alkil, C0-C3alkilenkarbociklil. C0-C3alkilenheterociklil; R2 je C1-C6alkil, C0-C3alkilenkarbociklil C0-C3alkilenheterociklil; p je nezavisno 1 ili 2; n je 3, 4, 5 ili 6;-----označava dvostruku vezu po izboru;L je N ili CRz;Rz je H ili formira dvostruku vezu sa ugljenikom obeleženim asteriskom; Rq je H ili kada L je CRz, Rq može također da bude C1-C6alkil;Rr je kvinazolinil, po izboru supstituisan sa jednim, dva ili tri supstituenta, vaki nezavisno izabran između C1-C6alkil, C1-C6alkoksi. hidroksil, halo, haloC1-C6alkil, amino, mono- ili dialkilamino, mono- ili dialkilaminokarboni1, C1-C6alkilkarbonilamino, C0-C3alkilenkarbociklil i C0-C3 alkilenheterociklil;R5 je vodonik, C1-C6alkil, C1-C6alkoksiC1-C6alkiL ili C3-C7cikloalkil; i u čemusvaki C1-C6alkil, C0-C3alkilenkarbocikil ili C0-C3alkilenheterociklil je po izboru supstituisan sa 1 do 3 supstituenta nezavisno izabrana iz grupe koja se sastoji od halo, okso, nitril, azido, nitro, C1-C6alkil, C0-C3alkilenkarbociklil, C0-C3alkilen-heterociklil, NH2C(=O)-, Y-NRaRb, Y-O-Rb, Y-C(=O)Rb, Y-(C=O)NRaRb, Y-NRaC(=O)Rb. Y-NHS(=Op)Rb. Y-S(=O)pRb i Y-S(=O)pNRaRb, Y-C(=O)ORb, Y-NRaC(=O)ORb;Y je nezavisno veza ili C1-C3alkilen; Ra je nezavisno H, C1-C6alkoksi, C1-C3alkil ili:Rb je nezavisno H, C1-C6alkil, C1-C6alkoksi. C0-C3alkilen-karbociklil ili C0-C3alkilenheterociklil;ili Ra i Rb zajedno sa azotom na kojeg su vezani formiraju heterociklilnu grupu.Prijava sadrži još 27 zavisnih patentnih zahteva.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05107057 | 2005-07-29 | ||
| EP06113097 | 2006-04-25 | ||
| PCT/EP2006/064822 WO2007014927A2 (en) | 2005-07-29 | 2006-07-28 | Macrocyclic inhibitors of hepatitis c virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS51227B true RS51227B (sr) | 2010-12-31 |
Family
ID=37708968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RSP-2010/0183A RS51227B (sr) | 2005-07-29 | 2006-07-28 | Makrociklički inhibitori virusa hepatitisa c |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US7659245B2 (sr) |
| EP (1) | EP1912981B1 (sr) |
| JP (1) | JP5230418B2 (sr) |
| KR (1) | KR101083631B1 (sr) |
| AP (1) | AP2585A (sr) |
| AR (1) | AR057702A1 (sr) |
| AT (1) | ATE455775T1 (sr) |
| AU (1) | AU2006274866B2 (sr) |
| BR (1) | BRPI0614153A2 (sr) |
| CA (1) | CA2617103C (sr) |
| CY (1) | CY1110008T1 (sr) |
| DE (1) | DE602006011905D1 (sr) |
| DK (1) | DK1912981T3 (sr) |
| EA (1) | EA014188B1 (sr) |
| ES (1) | ES2339702T3 (sr) |
| GT (1) | GT200600343A (sr) |
| HK (1) | HK1116488A1 (sr) |
| HR (1) | HRP20100209T1 (sr) |
| IL (1) | IL188320A (sr) |
| ME (1) | ME01454B (sr) |
| MY (1) | MY151026A (sr) |
| NO (1) | NO20081075L (sr) |
| NZ (1) | NZ564540A (sr) |
| PE (1) | PE20070343A1 (sr) |
| PL (1) | PL1912981T3 (sr) |
| PT (1) | PT1912981E (sr) |
| RS (1) | RS51227B (sr) |
| SI (1) | SI1912981T1 (sr) |
| SV (1) | SV2008002641A (sr) |
| TW (1) | TWI387597B (sr) |
| UY (1) | UY29704A1 (sr) |
| WO (1) | WO2007014927A2 (sr) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| ATE461209T1 (de) | 2004-01-30 | 2010-04-15 | Medivir Ab | Hcv ns-3 serine protease inhibitoren |
| WO2007014925A1 (en) | 2005-07-29 | 2007-02-08 | Tibotec Pharmaceuticals Ltd. | Macrocylic inhibitors of hepatitis c virus |
| AR057704A1 (es) | 2005-07-29 | 2007-12-12 | Tibotec Pharm Ltd | Inhibidores macrociclicos del virus de la hepatitis c, composicion farmaceutica y proceso de preparacion del compuesto |
| JO2768B1 (en) * | 2005-07-29 | 2014-03-15 | تيبوتيك فارماسيوتيكالز ليمتد | Large cyclic inhibitors of hepatitis C virus |
| PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
| GEP20104956B (en) | 2005-10-11 | 2010-04-12 | Array Biopharma Inc | Compounds for inhibiting hepatitis c viral replication and use thereof |
| US7741281B2 (en) | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| KR20090024834A (ko) | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | Ｃ형 간염 바이러스 복제의 신규 억제제 |
| US7935670B2 (en) | 2006-07-11 | 2011-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7906619B2 (en) | 2006-07-13 | 2011-03-15 | Achillion Pharmaceuticals, Inc. | 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication |
| US8343477B2 (en) | 2006-11-01 | 2013-01-01 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
| US7772180B2 (en) | 2006-11-09 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8003604B2 (en) | 2006-11-16 | 2011-08-23 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7888464B2 (en) | 2006-11-16 | 2011-02-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7763584B2 (en) | 2006-11-16 | 2010-07-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| KR20090079881A (ko) * | 2006-11-17 | 2009-07-22 | 티보텍 파마슈티칼즈 리미티드 | Ｃ형 간염 바이러스의 마크로사이클릭 억제제 |
| US8212043B2 (en) * | 2007-02-01 | 2012-07-03 | Janssen R&D Ireland | Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV |
| CN101641349A (zh) * | 2007-02-08 | 2010-02-03 | 泰博特克药品有限公司 | 嘧啶取代的大环抑制剂 |
| ITMI20071616A1 (it) | 2007-08-03 | 2009-02-04 | Cosmo Spa | Processo enzimatico per l'ottenimento di 17-alfa monoesteri del cortexolone e/o suoi 9,11-deidroderivati. |
| WO2009042668A2 (en) * | 2007-09-24 | 2009-04-02 | Achillion Pharmaceuticals, Inc. | Urea-containing peptides as inhibitors of viral replication |
| US8383583B2 (en) | 2007-10-26 | 2013-02-26 | Enanta Pharmaceuticals, Inc. | Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors |
| US8426360B2 (en) * | 2007-11-13 | 2013-04-23 | Enanta Pharmaceuticals, Inc. | Carbocyclic oxime hepatitis C virus serine protease inhibitors |
| WO2009070692A1 (en) | 2007-11-29 | 2009-06-04 | Enanta Pharmaceuticals, Inc. | C5-substituted, proline-derived, macrocyclic hepatitis c serine protease inhibitors |
| US8202996B2 (en) | 2007-12-21 | 2012-06-19 | Bristol-Myers Squibb Company | Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide |
| EP2226315A4 (en) | 2007-12-28 | 2012-01-25 | Carna Biosciences Inc | 2-AMINOQUINAZOLINE DERIVATIVE |
| JP5490778B2 (ja) | 2008-03-20 | 2014-05-14 | エナンタ ファーマシューティカルズ インコーポレイテッド | Ｃ型肝炎ウイルス阻害剤としてのフッ素化大環状化合物 |
| US8163921B2 (en) | 2008-04-16 | 2012-04-24 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2300491B1 (en) | 2008-05-29 | 2016-01-06 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| US7964560B2 (en) | 2008-05-29 | 2011-06-21 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8207341B2 (en) | 2008-09-04 | 2012-06-26 | Bristol-Myers Squibb Company | Process or synthesizing substituted isoquinolines |
| UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
| US8044087B2 (en) | 2008-09-29 | 2011-10-25 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8563505B2 (en) | 2008-09-29 | 2013-10-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2010068760A2 (en) | 2008-12-10 | 2010-06-17 | Achillion Pharmaceuticals, Inc. | New 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication |
| US8283310B2 (en) | 2008-12-15 | 2012-10-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CA2898529C (en) * | 2009-02-27 | 2017-10-17 | Peter Jozef Maria Van Remoortere | Amorphous sodium salt of tmc435 inhibitor of hcv |
| WO2010118078A1 (en) | 2009-04-08 | 2010-10-14 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors |
| US20120129875A1 (en) * | 2009-05-29 | 2012-05-24 | Syngenta Crop Protection, Llc | Substituted quinazolines as fungicides |
| WO2011017389A1 (en) | 2009-08-05 | 2011-02-10 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv |
| MX2013007698A (es) | 2010-12-30 | 2013-08-15 | Abbvie Inc | Inhibidores de serina proteasa de hepatitis c macrociclicos de fenantridina. |
| EP2658859A4 (en) | 2010-12-30 | 2014-07-30 | Enanta Pharm Inc | MACROCYCLIC HEPATITIS C SERIN PROTEASE INHIBITORS |
| US9353100B2 (en) | 2011-02-10 | 2016-05-31 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections |
| US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CN104203940B (zh) | 2011-12-28 | 2017-01-18 | 爱尔兰詹森科学公司 | 作为hcv抑制剂的杂双环衍生物 |
| CA2886973C (en) * | 2012-10-15 | 2017-08-15 | Albemarle Corporation | Processes for the synthesis of 2-amino-4,6-dimethoxybenzamide and other benzamide compounds |
| RS55592B1 (sr) | 2012-10-19 | 2017-06-30 | Bristol Myers Squibb Co | 9-metil supstituisani heksadekahidrociklopropa(e)pirolo(1,2-a)(1,4)diazaciklopentadecinil karbamat derivati kao nestrukturalni 3 (ns3) proteazni inhibitori za lečenje infekcijavirusom hepatitisa c |
| WO2014070964A1 (en) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2014071007A1 (en) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| EP2914614B1 (en) | 2012-11-05 | 2017-08-16 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| WO2014137869A1 (en) | 2013-03-07 | 2014-09-12 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| US9085607B2 (en) | 2013-03-15 | 2015-07-21 | Achillion Pharmaceuticals, Inc. | ACH-0142684 sodium salt polymorph, composition including the same, and method of manufacture thereof |
| US9006423B2 (en) | 2013-03-15 | 2015-04-14 | Achillion Pharmaceuticals Inc. | Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof |
| WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
| EP3108879A1 (en) | 2015-06-25 | 2016-12-28 | Cassiopea S.p.A. | High concentration formulation |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| UA74546C2 (en) * | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
| US6867185B2 (en) * | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
| JP2005535574A (ja) | 2002-04-11 | 2005-11-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | セリンプロテアーゼ、特にｈｃｖｎｓ３−ｎｓ４ａプロテアーゼのインヒビター |
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| WO2004072243A2 (en) * | 2003-02-07 | 2004-08-26 | Enanta Pharmaceuticals, Inc. | Macrocyclic hepatitis c serine protease inhibitors |
| US20040180815A1 (en) * | 2003-03-07 | 2004-09-16 | Suanne Nakajima | Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors |
| ES2386161T3 (es) * | 2003-04-16 | 2012-08-10 | Bristol-Myers Squibb Company | Proceso para separar una mezcla de enantiómeros de éster alquílico usando una enzima |
| US7125845B2 (en) * | 2003-07-03 | 2006-10-24 | Enanta Pharmaceuticals, Inc. | Aza-peptide macrocyclic hepatitis C serine protease inhibitors |
| US7642235B2 (en) * | 2003-09-22 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| ATE461209T1 (de) * | 2004-01-30 | 2010-04-15 | Medivir Ab | Hcv ns-3 serine protease inhibitoren |
| AR054882A1 (es) * | 2005-07-29 | 2007-07-25 | Tibotec Pharm Ltd | Inhibidores macrociclicos del virus de la hepatitis c |
| PE20070211A1 (es) * | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
| BRPI0613933A2 (pt) * | 2005-07-29 | 2011-02-22 | Medivir Ab | inibidores macrocìlicos do vìrus da hepatite c |
| AR055105A1 (es) * | 2005-07-29 | 2007-08-08 | Tibotec Pharm Ltd | Inhibidores macrociclicos del virus de la hepatitis c |
-
2006
- 2006-07-26 PE PE2006000903A patent/PE20070343A1/es not_active Application Discontinuation
- 2006-07-28 AR ARP060103303A patent/AR057702A1/es not_active Application Discontinuation
- 2006-07-28 TW TW095127585A patent/TWI387597B/zh not_active IP Right Cessation
- 2006-07-28 ME MEP-2012-119A patent/ME01454B/me unknown
- 2006-07-28 KR KR1020087004894A patent/KR101083631B1/ko not_active IP Right Cessation
- 2006-07-28 AT AT06764268T patent/ATE455775T1/de active
- 2006-07-28 NZ NZ564540A patent/NZ564540A/en not_active IP Right Cessation
- 2006-07-28 SI SI200630627T patent/SI1912981T1/sl unknown
- 2006-07-28 JP JP2008523383A patent/JP5230418B2/ja not_active Expired - Fee Related
- 2006-07-28 AU AU2006274866A patent/AU2006274866B2/en not_active Ceased
- 2006-07-28 ES ES06764268T patent/ES2339702T3/es active Active
- 2006-07-28 DK DK06764268.6T patent/DK1912981T3/da active
- 2006-07-28 US US11/995,900 patent/US7659245B2/en not_active Expired - Fee Related
- 2006-07-28 CA CA2617103A patent/CA2617103C/en not_active Expired - Fee Related
- 2006-07-28 AP AP2008004306A patent/AP2585A/xx active
- 2006-07-28 GT GT200600343A patent/GT200600343A/es unknown
- 2006-07-28 BR BRPI0614153-6A patent/BRPI0614153A2/pt not_active Application Discontinuation
- 2006-07-28 EP EP06764268A patent/EP1912981B1/en active Active
- 2006-07-28 UY UY29704A patent/UY29704A1/es unknown
- 2006-07-28 DE DE602006011905T patent/DE602006011905D1/de active Active
- 2006-07-28 RS RSP-2010/0183A patent/RS51227B/sr unknown
- 2006-07-28 PT PT06764268T patent/PT1912981E/pt unknown
- 2006-07-28 PL PL06764268T patent/PL1912981T3/pl unknown
- 2006-07-28 MY MYPI20063670 patent/MY151026A/en unknown
- 2006-07-28 WO PCT/EP2006/064822 patent/WO2007014927A2/en active Application Filing
- 2006-07-28 EA EA200800482A patent/EA014188B1/ru not_active IP Right Cessation
- 2006-07-29 SV SV2006002641A patent/SV2008002641A/es unknown
-
2007
- 2007-12-20 IL IL188320A patent/IL188320A/en not_active IP Right Cessation
-
2008
- 2008-02-29 NO NO20081075A patent/NO20081075L/no not_active Application Discontinuation
- 2008-06-20 HK HK08106903.5A patent/HK1116488A1/xx not_active IP Right Cessation
-
2010
- 2010-04-14 HR HR20100209T patent/HRP20100209T1/hr unknown
- 2010-04-20 CY CY20101100355T patent/CY1110008T1/el unknown
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