RS50494B - Poboljšani postupak za sintezu karbapenema - Google Patents

Poboljšani postupak za sintezu karbapenema

Info

Publication number
RS50494B
RS50494B YUP-550/03A YUP55003A RS50494B RS 50494 B RS50494 B RS 50494B YU P55003 A YUP55003 A YU P55003A RS 50494 B RS50494 B RS 50494B
Authority
RS
Serbia
Prior art keywords
formula
compound
improved process
hydrogenolysis
heteroaryl
Prior art date
Application number
YUP-550/03A
Other languages
English (en)
Inventor
John M. Williams
Renato Skerlj
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of YU55003A publication Critical patent/YU55003A/sh
Publication of RS50494B publication Critical patent/RS50494B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Postupak za sintetisanje jedinjenja predstavljenog formulomili njegove farmaceutski prihvatljive soli, naznačen time, što su R1 i R2 nezavisno H, C1-10 alkil, aril ili heteroaril, pomenuti alkil, aril ili heteroaril su supstituisani ili nesupstituisani, koji uključuje deprotektovanje jedinjenja formule II:hidrogenolizom u prisustvu preredukovanog metalnog katalizatora i baze da se dobije jednjenje formule I, praćeno prečišćavanjem i izlovanjem jedinjenja formule I, gde je P karboksilna protektivna grupa, P*je H2+, ili protektivna grupa koja može da se ukloni hidrogenolizom, i R1 i R2 su kako je opisano gore.Prijava sadrži još 42 zahteva.
YUP-550/03A 2001-01-16 2002-01-11 Poboljšani postupak za sintezu karbapenema RS50494B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26193301P 2001-01-16 2001-01-16
US29344001P 2001-05-24 2001-05-24

Publications (2)

Publication Number Publication Date
YU55003A YU55003A (sh) 2006-05-25
RS50494B true RS50494B (sr) 2010-03-02

Family

ID=26948925

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-550/03A RS50494B (sr) 2001-01-16 2002-01-11 Poboljšani postupak za sintezu karbapenema

Country Status (29)

Country Link
US (1) US7071330B2 (sr)
EP (1) EP1353923B1 (sr)
JP (1) JP4098626B2 (sr)
KR (1) KR100827562B1 (sr)
CN (1) CN1249065C (sr)
AR (1) AR035728A1 (sr)
AT (1) ATE278691T1 (sr)
AU (1) AU2002234240B2 (sr)
BR (1) BR0206372A (sr)
CA (1) CA2433874C (sr)
CZ (1) CZ301440B6 (sr)
DE (1) DE60201498T2 (sr)
DK (1) DK1353923T3 (sr)
EA (1) EA006098B1 (sr)
EG (1) EG23993A (sr)
ES (1) ES2227423T3 (sr)
HR (1) HRP20030566B1 (sr)
HU (1) HUP0302764A3 (sr)
IL (2) IL156507A0 (sr)
MX (1) MXPA03006322A (sr)
NZ (1) NZ527191A (sr)
PL (1) PL362912A1 (sr)
PT (1) PT1353923E (sr)
RS (1) RS50494B (sr)
SI (1) SI1353923T1 (sr)
SK (1) SK287350B6 (sr)
TW (1) TWI318627B (sr)
UA (1) UA74870C2 (sr)
WO (1) WO2002057266A1 (sr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040198973A1 (en) * 2001-08-13 2004-10-07 Tsujii Masahiko Process for preparation of carbapenem antibiotics
KR100628676B1 (ko) * 2001-09-26 2006-09-27 머크 앤드 캄파니 인코포레이티드 카바페넴 화합물의 제조방법
EP1442038A4 (en) * 2001-09-26 2005-01-05 Merck & Co Inc CRYSTALLINE FORMS OF CARBAPENEM ANTIBIOTICS AND MANUFACTURING METHOD
WO2003042215A1 (en) * 2001-11-16 2003-05-22 Ranbaxy Laboratories Limited Process for the preparation of crystalline imipenem
AU2003284545A1 (en) * 2002-11-13 2004-06-03 Kaneka Corporation Novel intermediate for carbapenem compound for oral administration and process for producing the same
DE102005025899A1 (de) * 2005-06-06 2006-12-07 Basf Ag Verfahren zur Aufbereitung eines Alkoxycarbonylaminotriazin enthaltenden Reaktionsgemisches
EP1934221A4 (en) * 2005-09-15 2011-10-26 Orchid Chemicals & Pharm Ltd IMPROVED METHOD FOR THE PRODUCTION OF BETA LACTAM ANTIBIOTICS
CN101410398B (zh) * 2006-03-28 2013-01-23 株式会社钟化 碳青霉素烯化合物的改良制备方法
US8293894B2 (en) 2006-11-20 2012-10-23 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
CN101357920B (zh) * 2007-06-22 2011-01-12 山东轩竹医药科技有限公司 含有巯基吡咯烷甲酰胺基三嗪的培南化合物
CN101367807B (zh) * 2007-06-28 2011-01-12 山东轩竹医药科技有限公司 被巯基吡咯烷甲酰胺基吡啶取代的培南衍生物
CN101875665B (zh) 2009-04-30 2013-02-06 石药集团中奇制药技术（石家庄）有限公司 一种厄他培南中间体、含其的组合物及其制备方法
WO2011143935A1 (zh) * 2010-05-21 2011-11-24 山东轩竹医药科技有限公司 碳青霉烯衍生物或其水合物的晶型及其制备方法与用途
WO2011150679A1 (zh) * 2010-06-03 2011-12-08 山东轩竹医药科技有限公司 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途
WO2012038979A2 (en) * 2010-09-24 2012-03-29 Sequent Anti Biotics Private Limited A process for preparation of ertapenem
CN102558182B (zh) 2010-12-31 2015-02-11 石药集团中奇制药技术（石家庄）有限公司 一种厄他培南钠晶型及其制备方法
WO2013121279A2 (en) * 2012-02-14 2013-08-22 Aurobindo Pharma Limited Process to prepare ertapenem
WO2014097221A1 (en) * 2012-12-21 2014-06-26 Ranbaxy Laboratories Limited Process for the purification of biapenem
GB2529738B (en) * 2014-03-27 2018-10-17 Johnson Matthey Plc Process for preparing a carbapenem antibiotic

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794554A (fr) * 1972-01-31 1973-07-26 Lilly Co Eli Nouveaux derives de penicilline et de cephalusporine
US3925372A (en) * 1973-02-23 1975-12-09 Lilly Co Eli Alpha-aminoacyl-3-halo cephalosporins
US3897424A (en) * 1973-07-23 1975-07-29 Lilly Co Eli Process for 7-{62 -amino-7-{60 -methoxy-cephalosporanic acid esters and related compounds
AR207327A1 (es) * 1974-02-06 1976-09-30 Lilly Co Eli Un procedimiento para preparar acidos 3-cefem 3-sulfonatos y sus esteres
US4001226A (en) * 1974-12-04 1977-01-04 Eli Lilly And Company 3-(substituted)carbonylamino cephem derivatives
US3992377A (en) * 1974-12-13 1976-11-16 Eli Lilly And Company 3-Thio-substituted cephalosporin antibiotics
US3985746A (en) * 1975-03-25 1976-10-12 E. R. Squibb & Sons, Inc. 7-(α-Cyanomethylthio)acetamido-3-cephem carboxylates
US4217453A (en) * 1978-07-24 1980-08-12 Merck & Co., Inc. 6-Amido-3-substituted-amino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid
US4656263A (en) * 1979-03-05 1987-04-07 Pfizer Inc. 6-β-substituted penicillanic acid compound free of the 6-α-epimer
US4299954A (en) * 1979-11-05 1981-11-10 Eli Lilly And Company Cephalosporin vinyl halides
US4414155A (en) 1980-01-14 1983-11-08 Merck & Co., Inc. Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
US4269772A (en) 1980-01-14 1981-05-26 Merck & Co., Inc. Synthesis of thienamycin via trans-3-carboxymethylene-4-carboxy-5-methyl-Δ2 -isoxazoline
US4369187A (en) * 1980-02-06 1983-01-18 Merck & Co., Inc. 3-Substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid
US4383946A (en) 1980-03-27 1983-05-17 Merck & Co., Inc. Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals
US4501741A (en) * 1983-04-12 1985-02-26 Eli Lilly And Company Cephalosporin antibiotics
US4783453A (en) * 1985-06-10 1988-11-08 Merck & Co., Inc. 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
JPS6475488A (en) * 1987-09-17 1989-03-22 Sumitomo Pharma Production of beta-lactam compound
US5034384A (en) 1990-08-01 1991-07-23 Merck & Co., Inc. 2-(9-fluorenonyl)-carbapenem antibacterial agents
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
CA2091309A1 (en) * 1992-03-26 1993-09-27 Frederic H. Jung Antibiotic compounds
HRP970281B1 (en) 1996-05-28 2002-04-30 Merck & Co Inc Carbapenem antibiotic, composition and method of preparation
UA62920C2 (en) 1996-05-28 2004-01-15 Merck & Co Inc Carbapeneme antibiotic, a composition and a method for the preparation
US6180783B1 (en) 1997-06-16 2001-01-30 Merck & Co., Inc. Stabilized carbapenem intermediates and improved process for carbapenem synthesis
US6063931A (en) 1997-07-09 2000-05-16 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
US5872250A (en) 1997-07-30 1999-02-16 Merck & Co., Inc. Process for synthesizing carbapenem antibiotics
DE69930616T2 (de) * 1998-03-02 2006-11-23 Merck & Co., Inc. Verfahren zur synthese von carbapenem-antibiotika

Also Published As

Publication number Publication date
SK287350B6 (sk) 2010-08-09
US20040063931A1 (en) 2004-04-01
DE60201498D1 (de) 2004-11-11
UA74870C2 (en) 2006-02-15
EG23993A (en) 2008-03-10
YU55003A (sh) 2006-05-25
KR100827562B1 (ko) 2008-05-07
TWI318627B (en) 2009-12-21
HRP20030566A2 (en) 2005-06-30
SI1353923T1 (en) 2005-02-28
DK1353923T3 (da) 2005-01-31
DE60201498T2 (de) 2005-11-17
HRP20030566B1 (en) 2011-08-31
AU2002234240B2 (en) 2006-04-27
EA200300804A1 (ru) 2003-12-25
CZ301440B6 (cs) 2010-03-03
JP4098626B2 (ja) 2008-06-11
EP1353923B1 (en) 2004-10-06
JP2004518672A (ja) 2004-06-24
NZ527191A (en) 2004-04-30
EA006098B1 (ru) 2005-08-25
CA2433874C (en) 2009-08-11
KR20040007438A (ko) 2004-01-24
PT1353923E (pt) 2005-01-31
PL362912A1 (en) 2004-11-02
BR0206372A (pt) 2003-12-23
ES2227423T3 (es) 2005-04-01
CN1486318A (zh) 2004-03-31
IL156507A0 (en) 2004-01-04
HUP0302764A2 (hu) 2003-11-28
CZ20031911A3 (cs) 2003-10-15
CA2433874A1 (en) 2002-07-25
IL156507A (en) 2010-06-30
WO2002057266A1 (en) 2002-07-25
SK8972003A3 (en) 2003-10-07
US7071330B2 (en) 2006-07-04
HUP0302764A3 (en) 2005-11-28
EP1353923A1 (en) 2003-10-22
ATE278691T1 (de) 2004-10-15
CN1249065C (zh) 2006-04-05
MXPA03006322A (es) 2003-10-06
AR035728A1 (es) 2004-07-07

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