CN1486318A - 用于碳青霉烯合成的改进方法 - Google Patents
用于碳青霉烯合成的改进方法 Download PDFInfo
- Publication number
- CN1486318A CN1486318A CNA028037421A CN02803742A CN1486318A CN 1486318 A CN1486318 A CN 1486318A CN A028037421 A CNA028037421 A CN A028037421A CN 02803742 A CN02803742 A CN 02803742A CN 1486318 A CN1486318 A CN 1486318A
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- CN
- China
- Prior art keywords
- record
- compound
- general formula
- alcohol
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (43)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26193301P | 2001-01-16 | 2001-01-16 | |
US60/261,933 | 2001-01-16 | ||
US29344001P | 2001-05-24 | 2001-05-24 | |
US60/293,440 | 2001-05-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1486318A true CN1486318A (zh) | 2004-03-31 |
CN1249065C CN1249065C (zh) | 2006-04-05 |
Family
ID=26948925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB028037421A Expired - Fee Related CN1249065C (zh) | 2001-01-16 | 2002-01-11 | 用于碳青霉烯合成的改进方法 |
Country Status (29)
Country | Link |
---|---|
US (1) | US7071330B2 (zh) |
EP (1) | EP1353923B1 (zh) |
JP (1) | JP4098626B2 (zh) |
KR (1) | KR100827562B1 (zh) |
CN (1) | CN1249065C (zh) |
AR (1) | AR035728A1 (zh) |
AT (1) | ATE278691T1 (zh) |
AU (1) | AU2002234240B2 (zh) |
BR (1) | BR0206372A (zh) |
CA (1) | CA2433874C (zh) |
CZ (1) | CZ301440B6 (zh) |
DE (1) | DE60201498T2 (zh) |
DK (1) | DK1353923T3 (zh) |
EA (1) | EA006098B1 (zh) |
EG (1) | EG23993A (zh) |
ES (1) | ES2227423T3 (zh) |
HR (1) | HRP20030566B1 (zh) |
HU (1) | HUP0302764A3 (zh) |
IL (2) | IL156507A0 (zh) |
MX (1) | MXPA03006322A (zh) |
NZ (1) | NZ527191A (zh) |
PL (1) | PL362912A1 (zh) |
PT (1) | PT1353923E (zh) |
RS (1) | RS50494B (zh) |
SI (1) | SI1353923T1 (zh) |
SK (1) | SK287350B6 (zh) |
TW (1) | TWI318627B (zh) |
UA (1) | UA74870C2 (zh) |
WO (1) | WO2002057266A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101367807B (zh) * | 2007-06-28 | 2011-01-12 | 山东轩竹医药科技有限公司 | 被巯基吡咯烷甲酰胺基吡啶取代的培南衍生物 |
CN101357920B (zh) * | 2007-06-22 | 2011-01-12 | 山东轩竹医药科技有限公司 | 含有巯基吡咯烷甲酰胺基三嗪的培南化合物 |
WO2011150679A1 (zh) * | 2010-06-03 | 2011-12-08 | 山东轩竹医药科技有限公司 | 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途 |
US9012628B2 (en) | 2010-12-31 | 2015-04-21 | Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. Ltd. | Crystalline form of ertapenem sodium and preparation method therefor |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040198973A1 (en) * | 2001-08-13 | 2004-10-07 | Tsujii Masahiko | Process for preparation of carbapenem antibiotics |
USRE40794E1 (en) | 2001-09-26 | 2009-06-23 | Merck & Co., Inc. | Crystalline forms of carbapenem antibiotics and methods of preparation |
ES2368997T3 (es) * | 2001-09-26 | 2011-11-24 | Merck Sharp & Dohme Corp. | Procedimiento de fabricación de compuestos de carbapenem. |
CN1608066A (zh) * | 2001-11-16 | 2005-04-20 | 兰贝克赛实验室有限公司 | 结晶亚胺培南的制备方法 |
US7538212B2 (en) * | 2002-11-13 | 2009-05-26 | Kaneka Corporation | Intermediate for carbapenem compound for oral administration and process for producing the same |
DE102005025899A1 (de) * | 2005-06-06 | 2006-12-07 | Basf Ag | Verfahren zur Aufbereitung eines Alkoxycarbonylaminotriazin enthaltenden Reaktionsgemisches |
WO2007031858A2 (en) * | 2005-09-15 | 2007-03-22 | Orchid Chemicals And Pharmaceuticals Limited | An improved process for the preparation of beta-lactam antibiotic |
WO2007111328A1 (ja) * | 2006-03-28 | 2007-10-04 | Kaneka Corporation | カルバペネム化合物の改良された製造方法 |
US8293894B2 (en) | 2006-11-20 | 2012-10-23 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of carbapenem antibiotic |
KR101694506B1 (ko) | 2009-04-30 | 2017-01-10 | 씨에스피씨 종콰이 팔마씨우티컬 테크놀로지 (스자좡) 컴퍼니 리미티드 | 에르타페넴의 중간체, 이를 포함하는 조성물 및 이의 제조 방법 |
US20130079322A1 (en) * | 2010-05-21 | 2013-03-28 | Xuanzhu Pharama Co., Ltd. | Crystalline of carbapenem derivative or its hydrate, preparation methods and uses thereof |
WO2012038979A2 (en) * | 2010-09-24 | 2012-03-29 | Sequent Anti Biotics Private Limited | A process for preparation of ertapenem |
WO2013121279A2 (en) * | 2012-02-14 | 2013-08-22 | Aurobindo Pharma Limited | Process to prepare ertapenem |
WO2014097221A1 (en) * | 2012-12-21 | 2014-06-26 | Ranbaxy Laboratories Limited | Process for the purification of biapenem |
CN110922405A (zh) * | 2014-03-27 | 2020-03-27 | 庄信万丰股份有限公司 | 制备碳青霉烯抗生素的方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE794554A (fr) * | 1972-01-31 | 1973-07-26 | Lilly Co Eli | Nouveaux derives de penicilline et de cephalusporine |
US3925372A (en) * | 1973-02-23 | 1975-12-09 | Lilly Co Eli | Alpha-aminoacyl-3-halo cephalosporins |
US3897424A (en) * | 1973-07-23 | 1975-07-29 | Lilly Co Eli | Process for 7-{62 -amino-7-{60 -methoxy-cephalosporanic acid esters and related compounds |
AR207327A1 (es) * | 1974-02-06 | 1976-09-30 | Lilly Co Eli | Un procedimiento para preparar acidos 3-cefem 3-sulfonatos y sus esteres |
US4001226A (en) * | 1974-12-04 | 1977-01-04 | Eli Lilly And Company | 3-(substituted)carbonylamino cephem derivatives |
US3992377A (en) * | 1974-12-13 | 1976-11-16 | Eli Lilly And Company | 3-Thio-substituted cephalosporin antibiotics |
US3985746A (en) * | 1975-03-25 | 1976-10-12 | E. R. Squibb & Sons, Inc. | 7-(α-Cyanomethylthio)acetamido-3-cephem carboxylates |
US4217453A (en) * | 1978-07-24 | 1980-08-12 | Merck & Co., Inc. | 6-Amido-3-substituted-amino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid |
US4656263A (en) * | 1979-03-05 | 1987-04-07 | Pfizer Inc. | 6-β-substituted penicillanic acid compound free of the 6-α-epimer |
US4299954A (en) * | 1979-11-05 | 1981-11-10 | Eli Lilly And Company | Cephalosporin vinyl halides |
US4269772A (en) * | 1980-01-14 | 1981-05-26 | Merck & Co., Inc. | Synthesis of thienamycin via trans-3-carboxymethylene-4-carboxy-5-methyl-Δ2 -isoxazoline |
US4414155A (en) * | 1980-01-14 | 1983-11-08 | Merck & Co., Inc. | Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid |
US4369187A (en) * | 1980-02-06 | 1983-01-18 | Merck & Co., Inc. | 3-Substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid |
US4383946A (en) * | 1980-03-27 | 1983-05-17 | Merck & Co., Inc. | Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals |
US4501741A (en) * | 1983-04-12 | 1985-02-26 | Eli Lilly And Company | Cephalosporin antibiotics |
US4783453A (en) * | 1985-06-10 | 1988-11-08 | Merck & Co., Inc. | 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids |
JPS6475488A (en) * | 1987-09-17 | 1989-03-22 | Sumitomo Pharma | Production of beta-lactam compound |
US5034384A (en) * | 1990-08-01 | 1991-07-23 | Merck & Co., Inc. | 2-(9-fluorenonyl)-carbapenem antibacterial agents |
GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
CA2091309A1 (en) | 1992-03-26 | 1993-09-27 | Frederic H. Jung | Antibiotic compounds |
UA62920C2 (en) * | 1996-05-28 | 2004-01-15 | Merck & Co Inc | Carbapeneme antibiotic, a composition and a method for the preparation |
HRP970281B1 (en) | 1996-05-28 | 2002-04-30 | Merck & Co Inc | Carbapenem antibiotic, composition and method of preparation |
US6180783B1 (en) * | 1997-06-16 | 2001-01-30 | Merck & Co., Inc. | Stabilized carbapenem intermediates and improved process for carbapenem synthesis |
US6063931A (en) * | 1997-07-09 | 2000-05-16 | Merck & Co., Inc. | Process for synthesizing carbapenem side chain intermediates |
US5872250A (en) * | 1997-07-30 | 1999-02-16 | Merck & Co., Inc. | Process for synthesizing carbapenem antibiotics |
EP1060180B1 (en) * | 1998-03-02 | 2006-03-29 | Merck & Co., Inc. | Process for synthesizing carbapenem antibiotics |
-
2002
- 2002-01-09 AR ARP020100062A patent/AR035728A1/es active IP Right Grant
- 2002-01-11 KR KR1020037009510A patent/KR100827562B1/ko not_active IP Right Cessation
- 2002-01-11 US US10/466,876 patent/US7071330B2/en not_active Expired - Fee Related
- 2002-01-11 JP JP2002557943A patent/JP4098626B2/ja not_active Expired - Lifetime
- 2002-01-11 ES ES02701042T patent/ES2227423T3/es not_active Expired - Lifetime
- 2002-01-11 PL PL02362912A patent/PL362912A1/xx not_active Application Discontinuation
- 2002-01-11 PT PT02701042T patent/PT1353923E/pt unknown
- 2002-01-11 CA CA002433874A patent/CA2433874C/en not_active Expired - Fee Related
- 2002-01-11 EP EP02701042A patent/EP1353923B1/en not_active Expired - Lifetime
- 2002-01-11 BR BR0206372-7A patent/BR0206372A/pt active Search and Examination
- 2002-01-11 RS YUP-550/03A patent/RS50494B/sr unknown
- 2002-01-11 IL IL15650702A patent/IL156507A0/xx unknown
- 2002-01-11 HU HU0302764A patent/HUP0302764A3/hu unknown
- 2002-01-11 SK SK897-2003A patent/SK287350B6/sk not_active IP Right Cessation
- 2002-01-11 NZ NZ527191A patent/NZ527191A/en not_active IP Right Cessation
- 2002-01-11 DE DE60201498T patent/DE60201498T2/de not_active Expired - Lifetime
- 2002-01-11 CZ CZ20031911A patent/CZ301440B6/cs not_active IP Right Cessation
- 2002-01-11 WO PCT/US2002/000821 patent/WO2002057266A1/en active IP Right Grant
- 2002-01-11 AU AU2002234240A patent/AU2002234240B2/en not_active Ceased
- 2002-01-11 CN CNB028037421A patent/CN1249065C/zh not_active Expired - Fee Related
- 2002-01-11 AT AT02701042T patent/ATE278691T1/de active
- 2002-01-11 SI SI200230039T patent/SI1353923T1/xx unknown
- 2002-01-11 MX MXPA03006322A patent/MXPA03006322A/es active IP Right Grant
- 2002-01-11 DK DK02701042T patent/DK1353923T3/da active
- 2002-01-11 EA EA200300804A patent/EA006098B1/ru not_active IP Right Cessation
- 2002-01-12 EG EG20020034A patent/EG23993A/xx active
- 2002-01-15 TW TW091100466A patent/TWI318627B/zh not_active IP Right Cessation
- 2002-11-01 UA UA2003087771A patent/UA74870C2/uk unknown
-
2003
- 2003-06-18 IL IL156507A patent/IL156507A/en not_active IP Right Cessation
- 2003-07-11 HR HR20030566A patent/HRP20030566B1/xx not_active IP Right Cessation
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101357920B (zh) * | 2007-06-22 | 2011-01-12 | 山东轩竹医药科技有限公司 | 含有巯基吡咯烷甲酰胺基三嗪的培南化合物 |
CN101367807B (zh) * | 2007-06-28 | 2011-01-12 | 山东轩竹医药科技有限公司 | 被巯基吡咯烷甲酰胺基吡啶取代的培南衍生物 |
WO2011150679A1 (zh) * | 2010-06-03 | 2011-12-08 | 山东轩竹医药科技有限公司 | 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途 |
CN103025733A (zh) * | 2010-06-03 | 2013-04-03 | 山东轩竹医药科技有限公司 | 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途 |
US8822445B2 (en) | 2010-06-03 | 2014-09-02 | Xuanzhu Pharma Co., Ltd. | Crystalline form of carbapenem derivative or its hydrates and preparation methods and uses thereof |
CN103025733B (zh) * | 2010-06-03 | 2015-11-25 | 山东轩竹医药科技有限公司 | 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途 |
US9012628B2 (en) | 2010-12-31 | 2015-04-21 | Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. Ltd. | Crystalline form of ertapenem sodium and preparation method therefor |
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