RS50371B - 4-pirimidinil-n-acil-l-fenilalanini - Google Patents

4-pirimidinil-n-acil-l-fenilalanini

Info

Publication number
RS50371B
RS50371B YUP-404/02A YUP40402A RS50371B RS 50371 B RS50371 B RS 50371B YU P40402 A YUP40402 A YU P40402A RS 50371 B RS50371 B RS 50371B
Authority
RS
Serbia
Prior art keywords
alkyl
aryl
hydrogen
denotes
substituted
Prior art date
Application number
YUP-404/02A
Other languages
English (en)
Inventor
Achyutharao SIDDURI
Jefferson Wright Tilley
Null Null
Original Assignee
F. Hoffmann-La Roche Ag.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag., filed Critical F. Hoffmann-La Roche Ag.,
Publication of YU40402A publication Critical patent/YU40402A/sh
Publication of RS50371B publication Critical patent/RS50371B/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
YUP-404/02A 1999-12-06 2000-11-28 4-pirimidinil-n-acil-l-fenilalanini RS50371B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16908999P 1999-12-06 1999-12-06

Publications (2)

Publication Number Publication Date
YU40402A YU40402A (sh) 2005-03-15
RS50371B true RS50371B (sr) 2009-11-10

Family

ID=22614222

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-404/02A RS50371B (sr) 1999-12-06 2000-11-28 4-pirimidinil-n-acil-l-fenilalanini

Country Status (35)

Country Link
EP (1) EP1237878B1 (sr)
JP (1) JP3824935B2 (sr)
KR (1) KR100522344B1 (sr)
CN (1) CN1218943C (sr)
AR (1) AR034401A1 (sr)
AT (1) ATE357433T1 (sr)
AU (1) AU783348B2 (sr)
BR (1) BR0016195A (sr)
CA (1) CA2392570C (sr)
CO (1) CO5080772A1 (sr)
CY (1) CY1106626T1 (sr)
CZ (1) CZ303435B6 (sr)
DE (1) DE60034061T2 (sr)
DK (1) DK1237878T3 (sr)
EG (1) EG24361A (sr)
ES (1) ES2282162T3 (sr)
HK (1) HK1054384B (sr)
HR (1) HRP20020468B1 (sr)
HU (1) HU229105B1 (sr)
IL (2) IL149617A0 (sr)
JO (1) JO2283B1 (sr)
MA (1) MA26850A1 (sr)
MX (1) MXPA02005564A (sr)
MY (1) MY126972A (sr)
NO (1) NO322866B1 (sr)
NZ (1) NZ518828A (sr)
PE (1) PE20010961A1 (sr)
PL (1) PL207160B1 (sr)
PT (1) PT1237878E (sr)
RS (1) RS50371B (sr)
RU (1) RU2266901C2 (sr)
SI (1) SI1237878T1 (sr)
TW (1) TWI256387B (sr)
WO (1) WO2001042225A2 (sr)
ZA (1) ZA200203533B (sr)

Families Citing this family (32)

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US6960597B2 (en) 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
WO2002016329A1 (fr) * 2000-08-18 2002-02-28 Ajinomoto Co., Inc. Nouveaux derives de phenylalanine
AR033765A1 (es) * 2001-05-22 2004-01-07 Syngenta Participations Ag Procedimiento para la preparacion de derivados 3-alquil-3h-isobenzofuran-1-ona 7-sustituidos.
WO2003053926A1 (fr) 2001-12-13 2003-07-03 Ajinomoto Co.,Inc. Nouveau derive de phenylalanine
CN103784458B (zh) 2003-12-22 2015-10-14 味之素株式会社 苯基丙氨酸衍生物
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
AU2005277634B2 (en) * 2004-08-16 2011-02-17 Merck Sharp & Dohme Corp. VLA-4 antagonists
JP4784224B2 (ja) 2004-09-24 2011-10-05 味の素株式会社 糖鎖転移方法および糖鎖転移酵素
CN101360711A (zh) * 2005-11-23 2009-02-04 阿斯利康(瑞典)有限公司 L-苯丙氨酸衍生物及其作为整联蛋白拮抗剂的用途
AR059224A1 (es) * 2006-01-31 2008-03-19 Jerini Ag Compuestos para la inhibicion de integrinas y uso de estas
CN101379028A (zh) * 2006-02-09 2009-03-04 阿斯利康(瑞典)有限公司 化学化合物
WO2007148648A1 (ja) * 2006-06-19 2007-12-27 Toray Industries, Inc. 多発性硬化症の治療又は予防剤
AU2008302448B2 (en) * 2007-09-17 2014-11-06 Abbvie Ireland Unlimited Company Uracil or thymine derivative for treating hepatitis C
RU2014147354A (ru) 2007-09-17 2015-07-10 Эббви Бахамаз Лтд. Пиримидины, которые могут быть использованы в качестве противоинфекционных средств, и их применения
HRP20110632T1 (hr) 2007-09-17 2011-10-31 Abbott Laboratories N-fenil-diokso-hidropirimidini korisni kao inhibitori virusa hepatitisa c (hcv)
EP2382222B1 (en) * 2008-12-22 2013-05-01 Icl-ip America Inc. Water miscible solvent based process for purifying a bisphosphate
US9216952B2 (en) 2010-03-23 2015-12-22 Abbvie Inc. Process for preparing antiviral compound
EA030228B1 (ru) 2010-07-16 2018-07-31 ЭббВи Айэленд Анлимитед Компани Фосфиновые лиганды для каталитических реакций
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
CN103097360B (zh) 2010-07-16 2016-02-10 艾伯维巴哈马有限公司 用于制备抗病毒化合物的方法
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
KR20140127234A (ko) * 2012-01-27 2014-11-03 에프. 호프만-라 로슈 아게 Vla-4 발현 세포로의 표적화된 전달을 위한 인테그린 안타고니스트 접합체
US9447035B2 (en) * 2012-01-27 2016-09-20 Hoffmann-La Roche Inc. Integrin antagonist conjugates for targeted delivery to cells expressing VLA-4
EP3052515A4 (en) 2013-09-30 2017-03-15 The Regents of the University of California Anti-alphavbeta1 integrin compounds and methods
CA2928619C (en) * 2013-10-29 2019-04-02 Ajinomoto Co., Inc. Sulfonamide derivative and pharmaceutical use thereof
JP2018515424A (ja) 2015-03-10 2018-06-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗アルファvベータ1インテグリン阻害剤及び使用方法
WO2020092375A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Quinoline derivatives as alpha4beta7 integrin inhibitors
CN112969504B (zh) 2018-10-30 2024-04-09 吉利德科学公司 用于抑制α4β7整合素的化合物
PL3873900T3 (pl) 2018-10-30 2025-06-02 Gilead Sciences, Inc. Imidazo[1,2-a]pirydynowe pochodne jako inhibitory integryny alpha4beta7 do leczenia chorób zapalnych
WO2020092383A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
CA3148613A1 (en) 2019-08-14 2021-02-18 Gilead Sciences, Inc. Phenylalanine derived compounds and their use as inhinitors of alpha 4 beta 7 integrin

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
CH516578A (de) * 1967-11-02 1971-12-15 Bayer Ag Verfahren zur Herstellung von heterocyclische Acylaminogruppen enthaltenden Arylsulfonylharnstoffen mit blutdrucksenkender Wirkung
CA2291778A1 (en) * 1997-05-29 1998-12-03 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
ES2257808T3 (es) * 1997-05-29 2006-08-01 MERCK & CO., INC. (A NEW JERSEY CORP.) Acidos biarilalcanoicos como inhibidores de adhesion celular.
DK1005446T3 (da) * 1997-08-22 2004-06-07 Hoffmann La Roche N-aroylphenylalaninderivater
AU739511B2 (en) * 1997-08-22 2001-10-11 F. Hoffmann-La Roche Ag N-aroylphenylalanine derivatives
HK1045495A1 (zh) * 1999-01-22 2002-11-29 依兰制药公司 抑制vla-4介导的白细胞粘着的多环化合物

Also Published As

Publication number Publication date
ZA200203533B (en) 2003-08-04
AU2669601A (en) 2001-06-18
YU40402A (sh) 2005-03-15
JO2283B1 (en) 2005-09-12
AU783348B2 (en) 2005-10-20
EP1237878A2 (en) 2002-09-11
HK1054384A1 (en) 2003-11-28
HRP20020468B1 (en) 2009-02-28
EG24361A (en) 2009-03-04
WO2001042225A2 (en) 2001-06-14
CZ303435B6 (cs) 2012-09-12
MY126972A (en) 2006-11-30
NO322866B1 (no) 2006-12-18
DK1237878T3 (da) 2007-07-30
NZ518828A (en) 2004-03-26
IL149617A (en) 2007-10-31
EP1237878B1 (en) 2007-03-21
JP3824935B2 (ja) 2006-09-20
HRP20020468A2 (en) 2004-04-30
NO20022633L (no) 2002-06-04
ES2282162T3 (es) 2007-10-16
PT1237878E (pt) 2007-06-18
BR0016195A (pt) 2002-08-13
MA26850A1 (fr) 2004-12-20
CA2392570A1 (en) 2001-06-14
ATE357433T1 (de) 2007-04-15
HK1054384B (zh) 2005-12-09
IL149617A0 (en) 2002-11-10
SI1237878T1 (sl) 2007-08-31
CN1218943C (zh) 2005-09-14
HUP0204081A3 (en) 2003-07-28
CA2392570C (en) 2010-05-11
PL357601A1 (en) 2004-07-26
AR034401A1 (es) 2004-02-25
CY1106626T1 (el) 2012-01-25
DE60034061D1 (de) 2007-05-03
CO5080772A1 (es) 2001-09-25
WO2001042225A8 (en) 2002-06-06
DE60034061T2 (de) 2007-12-13
RU2002117422A (ru) 2004-03-10
PL207160B1 (pl) 2010-11-30
PE20010961A1 (es) 2001-09-26
NO20022633D0 (no) 2002-06-04
KR20020063906A (ko) 2002-08-05
TWI256387B (en) 2006-06-11
MXPA02005564A (es) 2002-09-02
HUP0204081A2 (en) 2003-05-28
JP2003516396A (ja) 2003-05-13
KR100522344B1 (ko) 2005-10-20
RU2266901C2 (ru) 2005-12-27
WO2001042225A3 (en) 2002-02-21
HU229105B1 (en) 2013-07-29
CZ20022351A3 (cs) 2003-04-16
CN1407972A (zh) 2003-04-02

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