MA26850A1 - 4-pyrimidinyle- n- acyl- l- phenylalanines - Google Patents

4-pyrimidinyle- n- acyl- l- phenylalanines

Info

Publication number
MA26850A1
MA26850A1 MA26673A MA26673A MA26850A1 MA 26850 A1 MA26850 A1 MA 26850A1 MA 26673 A MA26673 A MA 26673A MA 26673 A MA26673 A MA 26673A MA 26850 A1 MA26850 A1 MA 26850A1
Authority
MA
Morocco
Prior art keywords
pyrimidinyle
phenylalanines
acyl
Prior art date
Application number
MA26673A
Other languages
English (en)
Inventor
Jefferson Wright Tilley
Achyutharao Sidduri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA26850A1 publication Critical patent/MA26850A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MA26673A 1999-12-06 2002-06-05 4-pyrimidinyle- n- acyl- l- phenylalanines MA26850A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16908999P 1999-12-06 1999-12-06

Publications (1)

Publication Number Publication Date
MA26850A1 true MA26850A1 (fr) 2004-12-20

Family

ID=22614222

Family Applications (1)

Application Number Title Priority Date Filing Date
MA26673A MA26850A1 (fr) 1999-12-06 2002-06-05 4-pyrimidinyle- n- acyl- l- phenylalanines

Country Status (35)

Country Link
EP (1) EP1237878B1 (fr)
JP (1) JP3824935B2 (fr)
KR (1) KR100522344B1 (fr)
CN (1) CN1218943C (fr)
AR (1) AR034401A1 (fr)
AT (1) ATE357433T1 (fr)
AU (1) AU783348B2 (fr)
BR (1) BR0016195A (fr)
CA (1) CA2392570C (fr)
CO (1) CO5080772A1 (fr)
CY (1) CY1106626T1 (fr)
CZ (1) CZ303435B6 (fr)
DE (1) DE60034061T2 (fr)
DK (1) DK1237878T3 (fr)
EG (1) EG24361A (fr)
ES (1) ES2282162T3 (fr)
HK (1) HK1054384B (fr)
HR (1) HRP20020468B1 (fr)
HU (1) HU229105B1 (fr)
IL (2) IL149617A0 (fr)
JO (1) JO2283B1 (fr)
MA (1) MA26850A1 (fr)
MX (1) MXPA02005564A (fr)
MY (1) MY126972A (fr)
NO (1) NO322866B1 (fr)
NZ (1) NZ518828A (fr)
PE (1) PE20010961A1 (fr)
PL (1) PL207160B1 (fr)
PT (1) PT1237878E (fr)
RS (1) RS50371B (fr)
RU (1) RU2266901C2 (fr)
SI (1) SI1237878T1 (fr)
TW (1) TWI256387B (fr)
WO (1) WO2001042225A2 (fr)
ZA (1) ZA200203533B (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960597B2 (en) 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
YU12203A (sh) * 2000-08-18 2006-03-03 Ajinomoto Co.Inc. Novi derivati fenilalanina
AR033765A1 (es) * 2001-05-22 2004-01-07 Syngenta Participations Ag Procedimiento para la preparacion de derivados 3-alquil-3h-isobenzofuran-1-ona 7-sustituidos.
WO2003053926A1 (fr) 2001-12-13 2003-07-03 Ajinomoto Co.,Inc. Nouveau derive de phenylalanine
KR20110098980A (ko) 2003-12-22 2011-09-02 아지노모토 가부시키가이샤 신규한 페닐알라닌 유도체
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
US7776891B2 (en) * 2004-08-16 2010-08-17 Merck Sharp & Dohme Corp. VLA-4 antagonists
JP4784224B2 (ja) 2004-09-24 2011-10-05 味の素株式会社 糖鎖転移方法および糖鎖転移酵素
US20090137601A1 (en) * 2005-11-23 2009-05-28 Astrazeneca Ab L-Phenylalanine Derivatives
AR059224A1 (es) * 2006-01-31 2008-03-19 Jerini Ag Compuestos para la inhibicion de integrinas y uso de estas
CN101379028A (zh) * 2006-02-09 2009-03-04 阿斯利康(瑞典)有限公司 化学化合物
ES2384400T3 (es) * 2006-06-19 2012-07-04 Toray Industries, Inc. Agente terapéutico o profiláctico para la esclerosis múltiple
NZ618277A (en) 2007-09-17 2015-07-31 Abbvie Bahamas Ltd Uracil or thymine derivative for treating hepatitis c
EP2639226B1 (fr) 2007-09-17 2016-08-31 AbbVie Bahamas Ltd. Pyrimidines anti-infectieuses et leurs utilisations
ATE512954T1 (de) 2007-09-17 2011-07-15 Abbott Lab Als inhibitoren des hepatitis-c-virus (hcv) geeignete n-phenyldioxohydropyrimidine
KR101701395B1 (ko) * 2008-12-22 2017-02-01 아이씨엘-아이피 아메리카 아이엔씨. 비스포스페이트를 정제하기 위한 수용성 용매 기반 정제 방법
US9216952B2 (en) 2010-03-23 2015-12-22 Abbvie Inc. Process for preparing antiviral compound
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
EA201790723A1 (ru) 2010-07-16 2017-12-29 ЭббВи Айэленд Анлимитед Компани Способ получения противовирусных соединений
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
KR101774742B1 (ko) 2010-07-16 2017-09-11 애브비 아일랜드 언리미티드 컴퍼니 촉매 반응용 포스핀 리간드
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
CA2854254A1 (fr) * 2012-01-27 2013-08-01 F. Hoffmann-La Roche Ag Conjugues d'antagonistes d'integrine pour cibler des cellules exprimant le vla-4
US9447035B2 (en) * 2012-01-27 2016-09-20 Hoffmann-La Roche Inc. Integrin antagonist conjugates for targeted delivery to cells expressing VLA-4
AU2014324426A1 (en) 2013-09-30 2016-04-21 The Regents Of The University Of California Anti-alphavbeta1 integrin compounds and methods
PL3064491T3 (pl) * 2013-10-29 2020-04-30 Ea Pharma Co., Ltd. Pochodna sulfonamidowa i jej zastosowanie medyczne
CA2981371A1 (fr) 2015-03-10 2016-09-15 The Regents Of The University Of California Inhibiteurs anti-integrine alphavbeta1 et methodes d'utilisation associees
EP3873897B1 (fr) 2018-10-30 2024-08-14 Gilead Sciences, Inc. Dérivés de n-benzoyl-phénylalanine en tant qu'inhibiteurs d'integrin alpha4béta7 pour le traitement de maladies inflammatoires
US11179383B2 (en) 2018-10-30 2021-11-23 Gilead Sciences, Inc. Compounds for inhibition of α4β7 integrin
EP3873900A1 (fr) 2018-10-30 2021-09-08 Gilead Sciences, Inc. Dérivés d'imidazopyridine utilisés en tant qu'inhibiteurs de l'intégrine alpha4bêta7
WO2020092375A1 (fr) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Dérivés de quinoléine utilisés en tant qu'inhibiteurs de l'intégrine alpha4bêta7
CN114222730B (zh) 2019-08-14 2024-09-10 吉利德科学公司 用于抑制α4β7整合素的化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002512625A (ja) * 1997-05-29 2002-04-23 メルク エンド カンパニー インコーポレーテッド 細胞接着阻害薬としての複素環アミド化合物
DE69833654T2 (de) * 1997-05-29 2006-12-14 Merck & Co., Inc. (A New Jersey Corp.) Biarylalkansäuren in der verwendung als zelladhäsionsinhibitoren
JP3555876B2 (ja) * 1997-08-22 2004-08-18 エフ．ホフマン−ラ ロシュ アーゲー Ｎ−アロイルフェニルアラニン誘導体
CN1276785A (zh) * 1997-08-22 2000-12-13 霍夫曼-拉罗奇有限公司 N－烷酰基苯丙氨酸衍生物
ATE299490T1 (de) * 1999-01-22 2005-07-15 Elan Pharm Inc Multizyklische verbindungen zur hemmung der durch vla-4 vermittelten leukozytenadhäsion

Also Published As

Publication number Publication date
AU783348B2 (en) 2005-10-20
JO2283B1 (en) 2005-09-12
SI1237878T1 (sl) 2007-08-31
HRP20020468A2 (en) 2004-04-30
ZA200203533B (en) 2003-08-04
AR034401A1 (es) 2004-02-25
CN1218943C (zh) 2005-09-14
RU2002117422A (ru) 2004-03-10
PE20010961A1 (es) 2001-09-26
PT1237878E (pt) 2007-06-18
PL357601A1 (en) 2004-07-26
ATE357433T1 (de) 2007-04-15
IL149617A (en) 2007-10-31
CZ20022351A3 (cs) 2003-04-16
CY1106626T1 (el) 2012-01-25
MXPA02005564A (es) 2002-09-02
CA2392570C (fr) 2010-05-11
NO20022633L (no) 2002-06-04
CO5080772A1 (es) 2001-09-25
HRP20020468B1 (en) 2009-02-28
NO20022633D0 (no) 2002-06-04
ES2282162T3 (es) 2007-10-16
WO2001042225A8 (fr) 2002-06-06
DK1237878T3 (da) 2007-07-30
DE60034061D1 (de) 2007-05-03
HUP0204081A2 (en) 2003-05-28
HUP0204081A3 (en) 2003-07-28
JP2003516396A (ja) 2003-05-13
NZ518828A (en) 2004-03-26
EP1237878A2 (fr) 2002-09-11
CZ303435B6 (cs) 2012-09-12
IL149617A0 (en) 2002-11-10
CN1407972A (zh) 2003-04-02
RS50371B (sr) 2009-11-10
KR20020063906A (ko) 2002-08-05
HU229105B1 (en) 2013-07-29
YU40402A (sh) 2005-03-15
HK1054384B (zh) 2005-12-09
AU2669601A (en) 2001-06-18
CA2392570A1 (fr) 2001-06-14
WO2001042225A2 (fr) 2001-06-14
PL207160B1 (pl) 2010-11-30
EG24361A (en) 2009-03-04
MY126972A (en) 2006-11-30
WO2001042225A3 (fr) 2002-02-21
EP1237878B1 (fr) 2007-03-21
BR0016195A (pt) 2002-08-13
JP3824935B2 (ja) 2006-09-20
TWI256387B (en) 2006-06-11
NO322866B1 (no) 2006-12-18
HK1054384A1 (en) 2003-11-28
DE60034061T2 (de) 2007-12-13
KR100522344B1 (ko) 2005-10-20
RU2266901C2 (ru) 2005-12-27

Similar Documents

Publication Publication Date Title
DE50010505D1 (de) Gurtaufrollersystem
DE122007000064I1 (de) Erythropoietinkonjugate
DE19983871T1 (de) Fönvorrichtung
DE10084676T1 (de) Einmallanzettvorrichtung
ATA51899A (de) Handstempel
DK1237878T3 (da) 4-pyrimidinyl-N-acyl-L-phenylanin
NO20013680D0 (no) Ketolidantibiotika
ATE297895T1 (de) 4-pyridinyl-n-acyl-l-phenylalanine
DE59909346D1 (de) Zylinderkopfdichtung
DE50007953D1 (de) Beleuchtungsanordung
DE59910286D1 (de) Kniehebel-spannvorrichtung
DE50009570D1 (de) Wechselcorrugator
DE50008613D1 (de) Sicherungsring
DE60000107D1 (de) Formschliessvorrichtung
DE50006899D1 (de) Antistatikum
DE10085008T1 (de) Oberflächenbehandlungsdüse
DE50003660D1 (de) Diacylhydrazinderivate
DE50006013D1 (de) Anschlagpuffer
DE50003259D1 (de) Textilie
DE19983890T1 (de) Ventiltaktgebungsjustiereinrichtung
DE50001640D1 (de) Nahfeldoptische untersuchungsvorrichtung
DE50008429D1 (de) Kraftstofffraktioniereinrichtung
IS5192A (is) Manumél
DE60000485D1 (de) Kulturgefass
DE50009208D1 (de) Hydroxyphenylvinylthiazole