ATE299490T1 - Multizyklische verbindungen zur hemmung der durch vla-4 vermittelten leukozytenadhäsion - Google Patents
Multizyklische verbindungen zur hemmung der durch vla-4 vermittelten leukozytenadhäsionInfo
- Publication number
- ATE299490T1 ATE299490T1 AT00911619T AT00911619T ATE299490T1 AT E299490 T1 ATE299490 T1 AT E299490T1 AT 00911619 T AT00911619 T AT 00911619T AT 00911619 T AT00911619 T AT 00911619T AT E299490 T1 ATE299490 T1 AT E299490T1
- Authority
- AT
- Austria
- Prior art keywords
- leukocyte adhesion
- mediated leukocyte
- multicyclic compounds
- inhibiting vla
- vla
- Prior art date
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- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/84—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a saturated carbon skeleton containing rings
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- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11673599P | 1999-01-22 | 1999-01-22 | |
US11774399P | 1999-01-29 | 1999-01-29 | |
PCT/US2000/001604 WO2000043354A2 (en) | 1999-01-22 | 2000-01-21 | Multicyclic compounds which inhibit leukocyte adhesion mediated by vla-4 |
Publications (1)
Publication Number | Publication Date |
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ATE299490T1 true ATE299490T1 (de) | 2005-07-15 |
Family
ID=26814561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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AT00911619T ATE299490T1 (de) | 1999-01-22 | 2000-01-21 | Multizyklische verbindungen zur hemmung der durch vla-4 vermittelten leukozytenadhäsion |
Country Status (11)
Country | Link |
---|---|
US (3) | US6465513B1 (de) |
EP (1) | EP1144364B1 (de) |
JP (1) | JP2002535304A (de) |
CN (1) | CN1231212C (de) |
AR (1) | AR035838A1 (de) |
AT (1) | ATE299490T1 (de) |
AU (1) | AU3348800A (de) |
CA (1) | CA2357781A1 (de) |
DE (1) | DE60021251D1 (de) |
HK (1) | HK1045495A1 (de) |
WO (1) | WO2000043354A2 (de) |
Families Citing this family (22)
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ATE299490T1 (de) * | 1999-01-22 | 2005-07-15 | Elan Pharm Inc | Multizyklische verbindungen zur hemmung der durch vla-4 vermittelten leukozytenadhäsion |
PL207160B1 (pl) * | 1999-12-06 | 2010-11-30 | Hoffmann La Roche | Pochodne 4-pirymidynylo-N-acylo-L-fenyloalaniny, związki pośrednie, środek farmaceutyczny i ich zastosowanie |
CN1196682C (zh) * | 1999-12-06 | 2005-04-13 | 霍夫曼-拉罗奇有限公司 | 4-吡啶基-n-酰基-l-苯丙氨酸 |
US6388084B1 (en) | 1999-12-06 | 2002-05-14 | Hoffmann-La Roche Inc. | 4-pyridinyl-n-acyl-l-phenylalanines |
US6380387B1 (en) | 1999-12-06 | 2002-04-30 | Hoffmann-La Roche Inc. | 4-Pyrimidinyl-n-acyl-l phenylalanines |
EP1244656A1 (de) | 1999-12-28 | 2002-10-02 | Pfizer Products Inc. | Nicht-peptidische inhibitoren vla-4 abhängiger zellbindung nützlich für die behandlung von entzündungs- autoimmun- und atemwegserkrankungen |
US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
JP2002201168A (ja) * | 2000-12-28 | 2002-07-16 | Kaken Pharmaceut Co Ltd | シクロヘキサン誘導体 |
EP1539744A4 (de) * | 2002-07-11 | 2007-06-06 | Vicuron Pharm Inc | N-hydroxyamidderivate mit antibakterieller wirkung |
US20050176755A1 (en) * | 2003-10-31 | 2005-08-11 | Dyatkin Alexey B. | Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists |
US7419666B1 (en) | 2004-02-23 | 2008-09-02 | Massachusetts Eye And Ear Infirmary | Treatment of ocular disorders |
WO2006052962A2 (en) | 2004-11-10 | 2006-05-18 | Janssen Pharmaceutica, N.V. | Bicyclic triazole a4 integrin inhibitors |
EP1935420A1 (de) | 2006-12-21 | 2008-06-25 | Merck Sante | 2-Adamantyl-Butyramid Derivate als selektive 11Beta-HSD1 Inhibitoren |
US9480747B2 (en) | 2012-01-24 | 2016-11-01 | Bvw Holding Ag | Class of anti-adhesion hydrogels with healing aspects |
US20150045435A1 (en) * | 2013-08-06 | 2015-02-12 | Indiana University Research And Technology Corporation | Compounds and methods for treating diabetes |
WO2017192753A1 (en) | 2016-05-03 | 2017-11-09 | Bvw Holding Ag | Multiphase gel |
US20230033021A1 (en) | 2018-06-20 | 2023-02-02 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
US11174256B2 (en) | 2018-10-30 | 2021-11-16 | Gilead Sciences, Inc. | Imidazopyridine derivatives |
PE20211866A1 (es) | 2018-10-30 | 2021-09-21 | Gilead Sciences Inc | Derivados de quinolina como inhibidores de la integrina alfa4beta7 |
WO2020092401A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN |
EP3873897B1 (de) | 2018-10-30 | 2024-08-14 | Gilead Sciences, Inc. | N-benzoyl-phenylalanin-derivate als alpha4beta7 integrin-inhibitoren zur behandlung von entzündlichen erkrankungen |
WO2021030438A1 (en) | 2019-08-14 | 2021-02-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
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JPS5727454B2 (de) | 1975-02-21 | 1982-06-10 | ||
DE2742173A1 (de) | 1977-09-20 | 1979-03-29 | Bayer Ag | Phenoxy-pyridinyl(pyrimidinyl)-alkanole, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide |
IT1211096B (it) | 1981-08-20 | 1989-09-29 | Lpb Ist Farm | Pirimidine e s.triazinici adattivita' ipolipidemizzante. |
US4672065A (en) | 1982-11-19 | 1987-06-09 | Chevron Research Company | N-substituted phenoxyacetamide fungicides |
DE3322720A1 (de) | 1983-06-24 | 1985-01-03 | Chemische Werke Hüls AG, 4370 Marl | Verwendung von in 2-stellung mit (substituierten) aminogruppen substituierten 4-dl-alkylester-(alpha)-alaninyl-6-chlor-s-triazinen als herbizide, insbesondere gegen flughafer |
US4505910A (en) | 1983-06-30 | 1985-03-19 | American Home Products Corporation | Amino-pyrimidine derivatives, compositions and use |
PH22520A (en) | 1984-11-12 | 1988-10-17 | Yamanouchi Pharma Co Ltd | Heterocyclic compounds having 4-lover alkyl-3-hydroxy-2-lower alkyl phenoxy-lower alkylene-y-group, and process of producing them |
US4959364A (en) | 1985-02-04 | 1990-09-25 | G. D. Searle & Co. | Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides |
EP0330506A3 (de) | 1988-02-26 | 1990-06-20 | Dana Farber Cancer Institute | VLA-Proteine |
DE3904931A1 (de) | 1989-02-17 | 1990-08-23 | Bayer Ag | Pyridyl-substituierte acrylsaeureester |
US5030644A (en) | 1989-07-31 | 1991-07-09 | Merck & Co., Inc. | Imidazole compounds and their use as transglutaminase inhibitors |
US4992439A (en) | 1990-02-13 | 1991-02-12 | Bristol-Myers Squibb Company | Pyridazine carboxylic acids and esters |
NZ239846A (en) | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
DE4108029A1 (de) | 1991-03-13 | 1992-09-17 | Bayer Ag | Triazinyl-substituierte acrylsaeureester |
IT1247509B (it) | 1991-04-19 | 1994-12-17 | Univ Cagliari | Composti di sintesi atti all'impiego nella terapia delle infezioni da rhinovirus |
EP0633881B1 (de) | 1992-03-11 | 2003-10-29 | Narhex Limited | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
DE4227748A1 (de) | 1992-08-21 | 1994-02-24 | Bayer Ag | Pyridyloxy-acrylsäureester |
JP2848232B2 (ja) | 1993-02-19 | 1999-01-20 | 武田薬品工業株式会社 | アルデヒド誘導体 |
US5770573A (en) * | 1993-12-06 | 1998-06-23 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
US5821231A (en) * | 1993-12-06 | 1998-10-13 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using same |
TW530047B (en) | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
US5510332A (en) | 1994-07-07 | 1996-04-23 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor |
DE69530392D1 (de) | 1994-07-11 | 2003-05-22 | Athena Neurosciences Inc | Inhibitoren der leukozytenadhäsion |
IL117659A (en) | 1995-04-13 | 2000-12-06 | Dainippon Pharmaceutical Co | Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same |
ZA968183B (en) | 1995-09-29 | 1997-04-25 | Sankyo Co | 13-Substituted milbemycin 5-oxime derivatives their preparation and their use against insects and other pests |
DE19629817A1 (de) | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
DE19647317A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Schering Agrevo Gmbh | Substituierte Stickstoff-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
DE19713000A1 (de) | 1997-03-27 | 1998-10-01 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
PT1005446E (pt) | 1997-08-22 | 2004-06-30 | Hoffmann La Roche | Derivados de n-aroilfenilalanina |
IL134550A (en) | 1997-08-22 | 2005-12-18 | Hoffmann La Roche | History of N - aroylphenylalanine, their use in drug preparation and as a drug |
TR200100141T2 (tr) | 1998-04-16 | 2001-06-21 | Texas Biotechnology Corporation | İntegrinlerin reseptörlerine bağlanmasını engelleyen bileşikler |
GB9812088D0 (en) | 1998-06-05 | 1998-08-05 | Celltech Therapeutics Ltd | Chemical compounds |
ATE299490T1 (de) * | 1999-01-22 | 2005-07-15 | Elan Pharm Inc | Multizyklische verbindungen zur hemmung der durch vla-4 vermittelten leukozytenadhäsion |
-
2000
- 2000-01-21 AT AT00911619T patent/ATE299490T1/de not_active IP Right Cessation
- 2000-01-21 CN CNB008029423A patent/CN1231212C/zh not_active Expired - Fee Related
- 2000-01-21 DE DE60021251T patent/DE60021251D1/de not_active Expired - Lifetime
- 2000-01-21 AU AU33488/00A patent/AU3348800A/en not_active Abandoned
- 2000-01-21 EP EP00911619A patent/EP1144364B1/de not_active Expired - Lifetime
- 2000-01-21 CA CA002357781A patent/CA2357781A1/en not_active Abandoned
- 2000-01-21 US US09/489,157 patent/US6465513B1/en not_active Expired - Lifetime
- 2000-01-21 AR ARP000100267A patent/AR035838A1/es unknown
- 2000-01-21 JP JP2000594772A patent/JP2002535304A/ja active Pending
- 2000-01-21 WO PCT/US2000/001604 patent/WO2000043354A2/en active IP Right Grant
-
2002
- 2002-09-16 US US10/243,731 patent/US7115768B2/en not_active Expired - Fee Related
- 2002-09-20 HK HK02106864.8A patent/HK1045495A1/zh unknown
-
2005
- 2005-11-22 US US11/285,889 patent/US20060074110A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1231212C (zh) | 2005-12-14 |
AU3348800A (en) | 2000-08-07 |
AR035838A1 (es) | 2004-07-21 |
EP1144364A2 (de) | 2001-10-17 |
US7115768B2 (en) | 2006-10-03 |
WO2000043354A3 (en) | 2000-11-23 |
DE60021251D1 (de) | 2005-08-18 |
CN1344247A (zh) | 2002-04-10 |
EP1144364B1 (de) | 2005-07-13 |
WO2000043354A2 (en) | 2000-07-27 |
JP2002535304A (ja) | 2002-10-22 |
HK1045495A1 (zh) | 2002-11-29 |
CA2357781A1 (en) | 2000-07-27 |
US20030134874A1 (en) | 2003-07-17 |
US6465513B1 (en) | 2002-10-15 |
US20060074110A1 (en) | 2006-04-06 |
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