ATE299490T1 - Multizyklische verbindungen zur hemmung der durch vla-4 vermittelten leukozytenadhäsion - Google Patents

Multizyklische verbindungen zur hemmung der durch vla-4 vermittelten leukozytenadhäsion

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Publication number
ATE299490T1
ATE299490T1 AT00911619T AT00911619T ATE299490T1 AT E299490 T1 ATE299490 T1 AT E299490T1 AT 00911619 T AT00911619 T AT 00911619T AT 00911619 T AT00911619 T AT 00911619T AT E299490 T1 ATE299490 T1 AT E299490T1
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Austria
Prior art keywords
leukocyte adhesion
mediated leukocyte
multicyclic compounds
inhibiting vla
vla
Prior art date
Application number
AT00911619T
Other languages
English (en)
Inventor
Francine S Grant
Bradley S Johnson
Michael A Pleiss
Eugene D Thorsett
Original Assignee
Elan Pharm Inc
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Publication of ATE299490T1 publication Critical patent/ATE299490T1/de

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    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/84—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a saturated carbon skeleton containing rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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AT00911619T 1999-01-22 2000-01-21 Multizyklische verbindungen zur hemmung der durch vla-4 vermittelten leukozytenadhäsion ATE299490T1 (de)

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