CO5080772A1 - 4-pirimidinil-n-acil-l-fenilalaninas - Google Patents
4-pirimidinil-n-acil-l-fenilalaninasInfo
- Publication number
- CO5080772A1 CO5080772A1 CO00092691A CO00092691A CO5080772A1 CO 5080772 A1 CO5080772 A1 CO 5080772A1 CO 00092691 A CO00092691 A CO 00092691A CO 00092691 A CO00092691 A CO 00092691A CO 5080772 A1 CO5080772 A1 CO 5080772A1
- Authority
- CO
- Colombia
- Prior art keywords
- molecular weight
- low molecular
- weight alkyl
- formula
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un compuesto de la fórmula I:<EMI FILE="00092691_1" ID="1" IMF=JPEG >en la que R1 es un grupo de la fórmula Y-1<EMI FILE="00092691_2" ID="2" IMF=JPEG >en la que R22 y R23 , con independencia entre sí, son hidrógeno, alquilo de bajo peso molecular, alcoxi de bajo peso molecular, cicloalquilo, arilo, arilalquilo, nitro, ciano, (alquilo de bajo peso molecular)-tio, (alquilo de bajo peso molecular)-sulfinilo, (alquilo de bajo peso molecular)-sulfonilo, alcanoílo de bajo peso molecular, halógeno o perfluor-(alquilo de bajo peso molecular), y por lo menos uno de R22 y R23 es diferente del hidrógeno, y R24 es hidrógeno, alquilo de bajo peso molecular, alcoxi de bajo peso molecular, arilo, nitro, ciano, (alquilo de bajo peso molecular)-sulfonilo o halógeno, o bienR1 es un grupo de la fórmula Y-2, que es un anillo heteroaromático de cinco a seis eslabones, unido a través del átomo de carbono al carbonilo de la amida, dicho anillo contiene uno, dos, o tres heteroátomos elegidos entre N, O y S y uno o dos átomos de dicho anillo están sustituidos con independencia entre sí por alquilo de bajo peso molecular, cicloalquilo, halógeno, ciano, perfluoralquilo o arilo y por lo menos uno de dichos átomos sustituidos está adyacente al átomo de carbono unido al carbonilo de la amida, o bien R1 es un grupo de la fórmula Y-3 que es un anillo de 3-7 eslabones de la fórmula<EMI FILE="00092691_3" ID="3" IMF=JPEG >en la que R25 es alquilo de bajo peso molecular, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16908999P | 1999-12-06 | 1999-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5080772A1 true CO5080772A1 (es) | 2001-09-25 |
Family
ID=22614222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00092691A CO5080772A1 (es) | 1999-12-06 | 2000-12-05 | 4-pirimidinil-n-acil-l-fenilalaninas |
Country Status (35)
| Country | Link |
|---|---|
| EP (1) | EP1237878B1 (es) |
| JP (1) | JP3824935B2 (es) |
| KR (1) | KR100522344B1 (es) |
| CN (1) | CN1218943C (es) |
| AR (1) | AR034401A1 (es) |
| AT (1) | ATE357433T1 (es) |
| AU (1) | AU783348B2 (es) |
| BR (1) | BR0016195A (es) |
| CA (1) | CA2392570C (es) |
| CO (1) | CO5080772A1 (es) |
| CY (1) | CY1106626T1 (es) |
| CZ (1) | CZ303435B6 (es) |
| DE (1) | DE60034061T2 (es) |
| DK (1) | DK1237878T3 (es) |
| EG (1) | EG24361A (es) |
| ES (1) | ES2282162T3 (es) |
| HK (1) | HK1054384B (es) |
| HR (1) | HRP20020468B1 (es) |
| HU (1) | HU229105B1 (es) |
| IL (2) | IL149617A0 (es) |
| JO (1) | JO2283B1 (es) |
| MA (1) | MA26850A1 (es) |
| MX (1) | MXPA02005564A (es) |
| MY (1) | MY126972A (es) |
| NO (1) | NO322866B1 (es) |
| NZ (1) | NZ518828A (es) |
| PE (1) | PE20010961A1 (es) |
| PL (1) | PL207160B1 (es) |
| PT (1) | PT1237878E (es) |
| RS (1) | RS50371B (es) |
| RU (1) | RU2266901C2 (es) |
| SI (1) | SI1237878T1 (es) |
| TW (1) | TWI256387B (es) |
| WO (1) | WO2001042225A2 (es) |
| ZA (1) | ZA200203533B (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| CN1325480C (zh) | 2000-08-18 | 2007-07-11 | 味之素株式会社 | 苯基丙氨酸衍生物 |
| AR033765A1 (es) * | 2001-05-22 | 2004-01-07 | Syngenta Participations Ag | Procedimiento para la preparacion de derivados 3-alquil-3h-isobenzofuran-1-ona 7-sustituidos. |
| AU2002354224A1 (en) | 2001-12-13 | 2003-07-09 | Ajinomoto Co., Inc. | Novel phenylalanine derivative |
| RU2390520C2 (ru) | 2003-12-22 | 2010-05-27 | Адзиномото Ко., Инк. | Новые производные фенилаланина |
| US7618981B2 (en) * | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| BRPI0514415A (pt) * | 2004-08-16 | 2008-06-10 | Merck & Co Inc | composto, composição farmacêutica, e, uso de um composto |
| JP4784224B2 (ja) | 2004-09-24 | 2011-10-05 | 味の素株式会社 | 糖鎖転移方法および糖鎖転移酵素 |
| JP2009516729A (ja) * | 2005-11-23 | 2009-04-23 | アストラゼネカ アクチボラグ | Ｌ−フェニルアラニン誘導体 |
| AR059224A1 (es) * | 2006-01-31 | 2008-03-19 | Jerini Ag | Compuestos para la inhibicion de integrinas y uso de estas |
| WO2007091046A1 (en) * | 2006-02-09 | 2007-08-16 | Astrazeneca Ab | Chemical compounds |
| EP2039687B1 (en) | 2006-06-19 | 2012-05-02 | Toray Industries, Inc. | Therapeutic or prophylactic agent for multiple sclerosis |
| SI2368882T1 (sl) | 2007-09-17 | 2015-02-27 | Abbvie Bahamas Ltd. | Antiinfekcijski pirimidini in njihove uporabe |
| RU2542099C2 (ru) | 2007-09-17 | 2015-02-20 | Эббви Бахамаз Лтд. | N-фенил-диоксо-гидропиримидины, используемые в качестве ингибитора вируса гепатита с (hcv) |
| RU2543620C2 (ru) | 2007-09-17 | 2015-03-10 | Эббви Бахамаз Лтд. | Производные урацила или тимина для лечения гепатита с |
| TWI448470B (zh) * | 2008-12-22 | 2014-08-11 | Icl Ip America Inc | 基於水互溶性溶劑的方法 |
| US9216952B2 (en) | 2010-03-23 | 2015-12-22 | Abbvie Inc. | Process for preparing antiviral compound |
| AU2011278926B2 (en) | 2010-07-16 | 2014-09-25 | Abbvie Ireland Unlimited Company | Phosphine ligands for catalytic reactions |
| US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
| US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
| UA115025C2 (uk) | 2010-07-16 | 2017-09-11 | Еббві Айрленд Анлімітед Компані | Спосіб одержання противірусних сполук |
| US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
| US9447035B2 (en) * | 2012-01-27 | 2016-09-20 | Hoffmann-La Roche Inc. | Integrin antagonist conjugates for targeted delivery to cells expressing VLA-4 |
| RU2624731C2 (ru) * | 2012-01-27 | 2017-07-06 | Ф. Хоффманн-Ля Рош Аг | Конъюгаты антагонистов интегрина для нацеленной доставки к клеткам, экспрессирующим vla-4 |
| EP3052515A4 (en) | 2013-09-30 | 2017-03-15 | The Regents of the University of California | Anti-alphavbeta1 integrin compounds and methods |
| CN106414413A (zh) * | 2013-10-29 | 2017-02-15 | Ea制药株式会社 | 磺酰胺衍生物及其药物用途 |
| EP3268369A4 (en) | 2015-03-10 | 2018-08-08 | The Regents of The University of California | Anti-alphavbeta1 integrin inhibitors and methods of use |
| US11224600B2 (en) | 2018-10-30 | 2022-01-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| WO2020092401A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN |
| CA3114240C (en) | 2018-10-30 | 2023-09-05 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| EP3873884A1 (en) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Quinoline derivatives as alpha4beta7 integrin inhibitors |
| JP7491996B2 (ja) | 2019-08-14 | 2024-05-28 | ギリアード サイエンシーズ， インコーポレイテッド | α４β７インテグリンの阻害のための化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2291778A1 (en) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| DE69833654T2 (de) * | 1997-05-29 | 2006-12-14 | Merck & Co., Inc. (A New Jersey Corp.) | Biarylalkansäuren in der verwendung als zelladhäsionsinhibitoren |
| HU229362B1 (en) * | 1997-08-22 | 2013-11-28 | Hoffmann La Roche | N-alkanoylphenylalanine derivatives |
| ES2214728T3 (es) * | 1997-08-22 | 2004-09-16 | F. Hoffmann-La Roche Ag | Derivados de n-aroilfenilalanina. |
| CN1231212C (zh) * | 1999-01-22 | 2005-12-14 | 依兰制药公司 | 抑制vla－4介导的白细胞粘着的多环化合物 |
-
2000
- 2000-11-28 DK DK00989906T patent/DK1237878T3/da active
- 2000-11-28 PL PL357601A patent/PL207160B1/pl unknown
- 2000-11-28 AU AU26696/01A patent/AU783348B2/en not_active Ceased
- 2000-11-28 KR KR10-2002-7007175A patent/KR100522344B1/ko not_active IP Right Cessation
- 2000-11-28 WO PCT/EP2000/011884 patent/WO2001042225A2/en active IP Right Grant
- 2000-11-28 CN CNB008167958A patent/CN1218943C/zh not_active Expired - Fee Related
- 2000-11-28 ES ES00989906T patent/ES2282162T3/es not_active Expired - Lifetime
- 2000-11-28 HU HU0204081A patent/HU229105B1/hu not_active IP Right Cessation
- 2000-11-28 RS YUP-404/02A patent/RS50371B/sr unknown
- 2000-11-28 JP JP2001543526A patent/JP3824935B2/ja not_active Expired - Fee Related
- 2000-11-28 IL IL14961700A patent/IL149617A0/xx active IP Right Grant
- 2000-11-28 RU RU2002117422/04A patent/RU2266901C2/ru not_active IP Right Cessation
- 2000-11-28 SI SI200030948T patent/SI1237878T1/sl unknown
- 2000-11-28 NZ NZ518828A patent/NZ518828A/en not_active IP Right Cessation
- 2000-11-28 CA CA2392570A patent/CA2392570C/en not_active Expired - Fee Related
- 2000-11-28 PT PT00989906T patent/PT1237878E/pt unknown
- 2000-11-28 EP EP00989906A patent/EP1237878B1/en not_active Expired - Lifetime
- 2000-11-28 AT AT00989906T patent/ATE357433T1/de active
- 2000-11-28 MX MXPA02005564A patent/MXPA02005564A/es active IP Right Grant
- 2000-11-28 BR BR0016195-0A patent/BR0016195A/pt active Search and Examination
- 2000-11-28 DE DE60034061T patent/DE60034061T2/de not_active Expired - Lifetime
- 2000-11-28 CZ CZ20022351A patent/CZ303435B6/cs not_active IP Right Cessation
- 2000-11-29 JO JO2000190A patent/JO2283B1/en active
- 2000-12-03 EG EG20001502A patent/EG24361A/xx active
- 2000-12-04 AR ARP000106415A patent/AR034401A1/es not_active Application Discontinuation
- 2000-12-04 MY MYPI20005690A patent/MY126972A/en unknown
- 2000-12-05 TW TW089125890A patent/TWI256387B/zh not_active IP Right Cessation
- 2000-12-05 PE PE2000001293A patent/PE20010961A1/es not_active Application Discontinuation
- 2000-12-05 CO CO00092691A patent/CO5080772A1/es unknown
-
2002
- 2002-05-03 ZA ZA200203533A patent/ZA200203533B/en unknown
- 2002-05-13 IL IL149617A patent/IL149617A/en not_active IP Right Cessation
- 2002-05-28 HR HR20020468A patent/HRP20020468B1/xx not_active IP Right Cessation
- 2002-06-04 NO NO20022633A patent/NO322866B1/no not_active IP Right Cessation
- 2002-06-05 MA MA26673A patent/MA26850A1/fr unknown
-
2003
- 2003-09-16 HK HK03106628.4A patent/HK1054384B/zh not_active IP Right Cessation
-
2007
- 2007-05-29 CY CY20071100715T patent/CY1106626T1/el unknown
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