HRP20020468B1 - 4-pyrimidinyl-n-acyl-l-phenylalanines - Google Patents
4-pyrimidinyl-n-acyl-l-phenylalaninesInfo
- Publication number
- HRP20020468B1 HRP20020468B1 HR20020468A HRP20020468A HRP20020468B1 HR P20020468 B1 HRP20020468 B1 HR P20020468B1 HR 20020468 A HR20020468 A HR 20020468A HR P20020468 A HRP20020468 A HR P20020468A HR P20020468 B1 HRP20020468 B1 HR P20020468B1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- hydrogen
- aryl
- substituted
- group
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 16
- 229910052739 hydrogen Inorganic materials 0.000 abstract 12
- 239000001257 hydrogen Substances 0.000 abstract 12
- 125000003118 aryl group Chemical group 0.000 abstract 11
- 150000002431 hydrogen Chemical class 0.000 abstract 9
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 3
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate Chemical compound [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 125000001960 7 membered carbocyclic group Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16908999P | 1999-12-06 | 1999-12-06 | |
| PCT/EP2000/011884 WO2001042225A2 (en) | 1999-12-06 | 2000-11-28 | 4-pyrimidinyl-n-acyl-l-phenylalanines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20020468A2 HRP20020468A2 (en) | 2004-04-30 |
| HRP20020468B1 true HRP20020468B1 (en) | 2009-02-28 |
Family
ID=22614222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20020468A HRP20020468B1 (en) | 1999-12-06 | 2002-05-28 | 4-pyrimidinyl-n-acyl-l-phenylalanines |
Country Status (35)
| Country | Link |
|---|---|
| EP (1) | EP1237878B1 (xx) |
| JP (1) | JP3824935B2 (xx) |
| KR (1) | KR100522344B1 (xx) |
| CN (1) | CN1218943C (xx) |
| AR (1) | AR034401A1 (xx) |
| AT (1) | ATE357433T1 (xx) |
| AU (1) | AU783348B2 (xx) |
| BR (1) | BR0016195A (xx) |
| CA (1) | CA2392570C (xx) |
| CO (1) | CO5080772A1 (xx) |
| CY (1) | CY1106626T1 (xx) |
| CZ (1) | CZ303435B6 (xx) |
| DE (1) | DE60034061T2 (xx) |
| DK (1) | DK1237878T3 (xx) |
| EG (1) | EG24361A (xx) |
| ES (1) | ES2282162T3 (xx) |
| HK (1) | HK1054384B (xx) |
| HR (1) | HRP20020468B1 (xx) |
| HU (1) | HU229105B1 (xx) |
| IL (2) | IL149617A0 (xx) |
| JO (1) | JO2283B1 (xx) |
| MA (1) | MA26850A1 (xx) |
| MX (1) | MXPA02005564A (xx) |
| MY (1) | MY126972A (xx) |
| NO (1) | NO322866B1 (xx) |
| NZ (1) | NZ518828A (xx) |
| PE (1) | PE20010961A1 (xx) |
| PL (1) | PL207160B1 (xx) |
| PT (1) | PT1237878E (xx) |
| RS (1) | RS50371B (xx) |
| RU (1) | RU2266901C2 (xx) |
| SI (1) | SI1237878T1 (xx) |
| TW (1) | TWI256387B (xx) |
| WO (1) | WO2001042225A2 (xx) |
| ZA (1) | ZA200203533B (xx) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| EP1288205B1 (en) * | 2000-08-18 | 2011-02-02 | Ajinomoto Co., Inc. | Novel phenylalanine derivatives |
| AR033765A1 (es) * | 2001-05-22 | 2004-01-07 | Syngenta Participations Ag | Procedimiento para la preparacion de derivados 3-alquil-3h-isobenzofuran-1-ona 7-sustituidos. |
| JP4452899B2 (ja) | 2001-12-13 | 2010-04-21 | 味の素株式会社 | 新規フェニルアラニン誘導体 |
| RU2390520C2 (ru) | 2003-12-22 | 2010-05-27 | Адзиномото Ко., Инк. | Новые производные фенилаланина |
| US7618981B2 (en) * | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| EP1781686B1 (en) * | 2004-08-16 | 2009-05-06 | Merck & Co., Inc. | Vla-4 antagonists |
| JP4784224B2 (ja) | 2004-09-24 | 2011-10-05 | 味の素株式会社 | 糖鎖転移方法および糖鎖転移酵素 |
| JP2009516729A (ja) * | 2005-11-23 | 2009-04-23 | アストラゼネカ アクチボラグ | Ｌ−フェニルアラニン誘導体 |
| AR059224A1 (es) * | 2006-01-31 | 2008-03-19 | Jerini Ag | Compuestos para la inhibicion de integrinas y uso de estas |
| WO2007091046A1 (en) * | 2006-02-09 | 2007-08-16 | Astrazeneca Ab | Chemical compounds |
| ES2384400T3 (es) * | 2006-06-19 | 2012-07-04 | Toray Industries, Inc. | Agente terapéutico o profiláctico para la esclerosis múltiple |
| EP2548873A1 (en) | 2007-09-17 | 2013-01-23 | Abbott Laboratories | N-phenyl-dioxo-hydropyrimidines useful as hepatitis c virus (hcv) inhibitors |
| WO2009039127A1 (en) | 2007-09-17 | 2009-03-26 | Abbott Laboratories | Uracil or thymine derivative for treating hepatitis c |
| PT2639226T (pt) | 2007-09-17 | 2016-12-09 | Abbvie Bahamas Ltd | Pirimidinas anti-infeciosas e suas utilizações |
| JP5689813B2 (ja) * | 2008-12-22 | 2015-03-25 | アイシーエル−アイピー アメリカ インコーポレイテッド | ビスホスフェートを精製するための水混和性溶媒ベースのプロセス |
| US9216952B2 (en) | 2010-03-23 | 2015-12-22 | Abbvie Inc. | Process for preparing antiviral compound |
| US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
| MY167881A (en) | 2010-07-16 | 2018-09-26 | Abbvie Bahamas Ltd | Process for preparing antiviral compounds |
| US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
| MX338725B (es) | 2010-07-16 | 2016-04-28 | Abbvie Bahamas Ltd | Ligando de fosfina para reacciones cataliticas. |
| US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
| CA2854254A1 (en) * | 2012-01-27 | 2013-08-01 | F. Hoffmann-La Roche Ag | Integrin antagonist conjugates for targeted delivery to cells expressing vla-4 |
| US9447035B2 (en) * | 2012-01-27 | 2016-09-20 | Hoffmann-La Roche Inc. | Integrin antagonist conjugates for targeted delivery to cells expressing VLA-4 |
| WO2015048819A1 (en) | 2013-09-30 | 2015-04-02 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
| EP3064491B1 (en) | 2013-10-29 | 2020-01-08 | EA Pharma Co., Ltd. | Sulfonamide derivative and medicinal use thereof |
| CA2981371A1 (en) | 2015-03-10 | 2016-09-15 | The Regents Of The University Of California | Anti-alphavbeta1 integrin inhibitors and methods of use |
| CR20210213A (es) | 2018-10-30 | 2021-06-24 | Gilead Sciences Inc | Derivados de quinolina como inhibidores de la integrina alfa4beta7 |
| US11179383B2 (en) | 2018-10-30 | 2021-11-23 | Gilead Sciences, Inc. | Compounds for inhibition of α4β7 integrin |
| US11174256B2 (en) | 2018-10-30 | 2021-11-16 | Gilead Sciences, Inc. | Imidazopyridine derivatives |
| AU2019373242B2 (en) | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| AU2020329207B2 (en) | 2019-08-14 | 2024-02-29 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998053817A1 (en) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Biarylalkanoic acids as cell adhesion inhibitors |
| WO1998053814A1 (en) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| WO1999010313A1 (en) * | 1997-08-22 | 1999-03-04 | F.Hoffmann-La Roche Ag | N-aroylphenylalanine derivatives |
| WO1999010312A1 (en) * | 1997-08-22 | 1999-03-04 | F. Hoffmann-La Roche Ag | N-alkanoylphenylalanine derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR035838A1 (es) * | 1999-01-22 | 2004-07-21 | Elan Pharm Inc | Compuestos multiciclicos que inhiben la adhesion de leucocitos mediada por vla-4 y el uso de los mismos para la preparacion de un medicamento |
-
2000
- 2000-11-28 JP JP2001543526A patent/JP3824935B2/ja not_active Expired - Fee Related
- 2000-11-28 RS YUP-404/02A patent/RS50371B/sr unknown
- 2000-11-28 AT AT00989906T patent/ATE357433T1/de active
- 2000-11-28 EP EP00989906A patent/EP1237878B1/en not_active Expired - Lifetime
- 2000-11-28 CA CA2392570A patent/CA2392570C/en not_active Expired - Fee Related
- 2000-11-28 PL PL357601A patent/PL207160B1/pl unknown
- 2000-11-28 KR KR10-2002-7007175A patent/KR100522344B1/ko not_active IP Right Cessation
- 2000-11-28 HU HU0204081A patent/HU229105B1/hu not_active IP Right Cessation
- 2000-11-28 NZ NZ518828A patent/NZ518828A/en not_active IP Right Cessation
- 2000-11-28 RU RU2002117422/04A patent/RU2266901C2/ru not_active IP Right Cessation
- 2000-11-28 WO PCT/EP2000/011884 patent/WO2001042225A2/en active IP Right Grant
- 2000-11-28 DK DK00989906T patent/DK1237878T3/da active
- 2000-11-28 DE DE60034061T patent/DE60034061T2/de not_active Expired - Lifetime
- 2000-11-28 PT PT00989906T patent/PT1237878E/pt unknown
- 2000-11-28 IL IL14961700A patent/IL149617A0/xx active IP Right Grant
- 2000-11-28 MX MXPA02005564A patent/MXPA02005564A/es active IP Right Grant
- 2000-11-28 ES ES00989906T patent/ES2282162T3/es not_active Expired - Lifetime
- 2000-11-28 CN CNB008167958A patent/CN1218943C/zh not_active Expired - Fee Related
- 2000-11-28 BR BR0016195-0A patent/BR0016195A/pt active Search and Examination
- 2000-11-28 AU AU26696/01A patent/AU783348B2/en not_active Ceased
- 2000-11-28 CZ CZ20022351A patent/CZ303435B6/cs not_active IP Right Cessation
- 2000-11-28 SI SI200030948T patent/SI1237878T1/sl unknown
- 2000-11-29 JO JO2000190A patent/JO2283B1/en active
- 2000-12-03 EG EG20001502A patent/EG24361A/xx active
- 2000-12-04 AR ARP000106415A patent/AR034401A1/es not_active Application Discontinuation
- 2000-12-04 MY MYPI20005690A patent/MY126972A/en unknown
- 2000-12-05 TW TW089125890A patent/TWI256387B/zh not_active IP Right Cessation
- 2000-12-05 PE PE2000001293A patent/PE20010961A1/es not_active Application Discontinuation
- 2000-12-05 CO CO00092691A patent/CO5080772A1/es unknown
-
2002
- 2002-05-03 ZA ZA200203533A patent/ZA200203533B/en unknown
- 2002-05-13 IL IL149617A patent/IL149617A/en not_active IP Right Cessation
- 2002-05-28 HR HR20020468A patent/HRP20020468B1/xx not_active IP Right Cessation
- 2002-06-04 NO NO20022633A patent/NO322866B1/no not_active IP Right Cessation
- 2002-06-05 MA MA26673A patent/MA26850A1/fr unknown
-
2003
- 2003-09-16 HK HK03106628.4A patent/HK1054384B/zh not_active IP Right Cessation
-
2007
- 2007-05-29 CY CY20071100715T patent/CY1106626T1/el unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998053817A1 (en) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Biarylalkanoic acids as cell adhesion inhibitors |
| WO1998053814A1 (en) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| WO1999010313A1 (en) * | 1997-08-22 | 1999-03-04 | F.Hoffmann-La Roche Ag | N-aroylphenylalanine derivatives |
| WO1999010312A1 (en) * | 1997-08-22 | 1999-03-04 | F. Hoffmann-La Roche Ag | N-alkanoylphenylalanine derivatives |
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Legal Events
| Date | Code | Title | Description |
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