RO92607A - Procedeu pentru prepararea unor derivati de dihidropiridazinona - Google Patents

Procedeu pentru prepararea unor derivati de dihidropiridazinona

Info

Publication number
RO92607A
RO92607A RO85120090A RO12009085A RO92607A RO 92607 A RO92607 A RO 92607A RO 85120090 A RO85120090 A RO 85120090A RO 12009085 A RO12009085 A RO 12009085A RO 92607 A RO92607 A RO 92607A
Authority
RO
Romania
Prior art keywords
preparation
compounds
formula
dihydropyridazinone derivatives
dihydropyridazinone
Prior art date
Application number
RO85120090A
Other languages
English (en)
French (fr)
Romanian (ro)
Inventor
Robert A Slater
Original Assignee
Smith Kline & French Laboratories Ltd,Gb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline & French Laboratories Ltd,Gb filed Critical Smith Kline & French Laboratories Ltd,Gb
Publication of RO92607A publication Critical patent/RO92607A/ro

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22Nitrogen and oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Hydrogenated Pyridines (AREA)
RO85120090A 1984-01-13 1985-09-12 Procedeu pentru prepararea unor derivati de dihidropiridazinona RO92607A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848400863A GB8400863D0 (en) 1984-01-13 1984-01-13 Chemical compounds

Publications (1)

Publication Number Publication Date
RO92607A true RO92607A (ro) 1987-11-30

Family

ID=10554924

Family Applications (1)

Application Number Title Priority Date Filing Date
RO85120090A RO92607A (ro) 1984-01-13 1985-09-12 Procedeu pentru prepararea unor derivati de dihidropiridazinona

Country Status (31)

Country Link
US (1) US4654342A (enEXAMPLES)
EP (1) EP0150937B1 (enEXAMPLES)
JP (3) JPS60158181A (enEXAMPLES)
KR (1) KR920006781B1 (enEXAMPLES)
CN (1) CN85101722A (enEXAMPLES)
AT (1) ATE37179T1 (enEXAMPLES)
AU (1) AU572252B2 (enEXAMPLES)
CA (2) CA1251209A (enEXAMPLES)
CS (1) CS248731B2 (enEXAMPLES)
DD (1) DD231350A5 (enEXAMPLES)
DE (1) DE3564941D1 (enEXAMPLES)
DK (1) DK162519C (enEXAMPLES)
ES (3) ES8607949A1 (enEXAMPLES)
FI (1) FI850140L (enEXAMPLES)
GB (1) GB8400863D0 (enEXAMPLES)
GR (1) GR850068B (enEXAMPLES)
HU (1) HU193591B (enEXAMPLES)
IE (1) IE57969B1 (enEXAMPLES)
IL (1) IL74031A (enEXAMPLES)
JO (1) JO1351B1 (enEXAMPLES)
MY (1) MY100124A (enEXAMPLES)
NO (1) NO850129L (enEXAMPLES)
NZ (1) NZ210816A (enEXAMPLES)
PH (1) PH22136A (enEXAMPLES)
PL (1) PL147123B1 (enEXAMPLES)
PT (1) PT79819B (enEXAMPLES)
RO (1) RO92607A (enEXAMPLES)
SU (1) SU1396963A3 (enEXAMPLES)
WO (1) WO1985003076A1 (enEXAMPLES)
ZA (1) ZA85251B (enEXAMPLES)
ZW (1) ZW385A1 (enEXAMPLES)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
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CA1251448A (en) * 1985-03-27 1989-03-21 William J. Coates Pyridazinone derivatives
AU581324B2 (en) * 1985-07-05 1989-02-16 Smith Kline & French Laboratories Limited Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones
GB8603780D0 (en) * 1986-02-15 1986-03-19 Smith Kline French Lab Chemical compounds
GB8722776D0 (en) * 1987-09-28 1987-11-04 Smith Kline French Lab Chemical compounds
NZ229828A (en) * 1988-08-09 1992-03-26 Squibb & Sons Inc Aryl cyanoguanidine derivatives and pharmaceutical compositions
US5011837A (en) * 1988-08-09 1991-04-30 E. R. Squibb & Sons, Inc. Aryl cyanoguanidines: potassium channel activators and method of making same
AU2002254124A1 (en) * 2001-02-27 2002-09-12 Mitokor Aryl-n-cyanoguanidines and methods related thereto
ES2268157T3 (es) * 2001-11-05 2007-03-16 Merck Patent Gmbh Hidrazono-malonitrilos.
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DE102004011512B4 (de) * 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische Zubereitung enthaltend Pimobendan
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
TWI435729B (zh) 2005-11-09 2014-05-01 Combinatorx Inc 治療病症之方法,組合物及套組
CN101309685A (zh) * 2005-11-14 2008-11-19 贝林格尔·英格海姆维特梅迪卡有限公司 磷酸二酯酶ⅲ型抑制剂或者钙增敏剂用于治疗无症状(潜隐性)心力衰竭的用途
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
NZ592927A (en) 2008-11-25 2013-07-26 Boehringer Ingelheim Vetmed PHOSPHODIESTERASE TYPE III (PDE III) INHIBITORS OR CA2+-SENSITIZING AGENTS such as pimobendan FOR THE TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN107090016A (zh) 2011-03-01 2017-08-25 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2013135852A1 (en) 2012-03-15 2013-09-19 Boehringer Ingelheim Vetmedica Gmbh Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
CA2915445C (en) 2013-07-19 2024-04-23 Boehringer Ingelheim Vetmedica Gmbh Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
AU2014359427B2 (en) 2013-12-04 2017-04-20 Boehringer Ingelheim Vetmedica Gmbh Improved pharmaceutical compositions of pimobendan
CN104987310A (zh) * 2015-06-03 2015-10-21 青岛农业大学 左西孟旦的合成工艺
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN110117257B (zh) * 2018-02-05 2022-12-06 安徽省新星药物开发有限责任公司 一种含胍基的p2y12受体拮抗剂、制备方法及其用途
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3822260A (en) * 1970-10-09 1974-07-02 American Cyanamid Co 6-(cyanophenyl)-4,5-dihydro-3(2h)-pyridazinones
BE791539A (fr) * 1971-11-19 1973-05-17 Basf Ag Dihydropyridazones, leur preparation et leurs utilisations therapeutiques
DE3063196D1 (en) * 1979-12-05 1983-06-16 Morishita Pharma Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them
EP0059688B1 (de) * 1981-03-04 1985-05-15 Ciba-Geigy Ag Pyridazinone, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen und deren Verwendung
JPS58113180A (ja) * 1981-12-28 1983-07-05 Mitsui Toatsu Chem Inc ピリダジノン誘導体
JPS58140076A (ja) * 1982-02-09 1983-08-19 Mitsubishi Chem Ind Ltd ピリダジノン誘導体又はその塩類
DE3204375C2 (de) * 1982-02-09 1983-12-01 J. Rettenmaier & Söhne GmbH + Co, 7091 Holzmühle Verfahren zur Herabsetzung der Saugfähigkeit von Holz
DE3302021A1 (de) * 1983-01-22 1984-07-26 Basf Ag, 6700 Ludwigshafen 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung
AU581324B2 (en) * 1985-07-05 1989-02-16 Smith Kline & French Laboratories Limited Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones

Also Published As

Publication number Publication date
ZA85251B (en) 1986-08-27
AU572252B2 (en) 1988-05-05
NO850129L (no) 1985-07-15
KR920006781B1 (ko) 1992-08-17
ES8703846A1 (es) 1987-03-01
FI850140A7 (fi) 1985-07-14
EP0150937B1 (en) 1988-09-14
PL147123B1 (en) 1989-04-29
GR850068B (enEXAMPLES) 1985-05-03
DK9185D0 (da) 1985-01-08
JPS63313776A (ja) 1988-12-21
PT79819B (en) 1987-01-07
DD231350A5 (de) 1985-12-24
JO1351B1 (en) 1986-11-30
DK9185A (da) 1985-07-14
ATE37179T1 (de) 1988-09-15
WO1985003076A1 (en) 1985-07-18
ES549629A0 (es) 1987-03-01
DE3564941D1 (en) 1988-10-20
IE850069L (en) 1985-07-13
HUT37128A (en) 1985-11-28
HU193591B (en) 1987-11-30
EP0150937A2 (en) 1985-08-07
CN85101722A (zh) 1987-01-31
CS248731B2 (en) 1987-02-12
CA1260471A (en) 1989-09-26
CA1251209A (en) 1989-03-14
SU1396963A3 (ru) 1988-05-15
ES539446A0 (es) 1986-06-01
DK162519B (da) 1991-11-11
JPS60158181A (ja) 1985-08-19
ZW385A1 (en) 1985-08-07
GB8400863D0 (en) 1984-02-15
EP0150937A3 (en) 1985-08-21
PL251516A1 (en) 1985-12-17
US4654342A (en) 1987-03-31
ES8607949A1 (es) 1986-06-01
AU3761185A (en) 1985-07-18
PT79819A (en) 1985-02-01
NZ210816A (en) 1987-06-30
ES8706645A1 (es) 1987-07-01
ES554965A0 (es) 1987-07-01
DK162519C (da) 1992-03-30
FI850140L (fi) 1985-07-14
IE57969B1 (en) 1993-06-02
PH22136A (en) 1988-06-01
MY100124A (en) 1989-12-18
IL74031A (en) 1988-07-31
IL74031A0 (en) 1985-04-30
CA1260471C (enEXAMPLES) 1989-09-26
KR850005417A (ko) 1985-08-26
FI850140A0 (fi) 1985-01-11
JPS63313775A (ja) 1988-12-21

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