RO85818B - PROCEDEU PENTRU PREPARAREA ACIZILOR ALCANOICI SUBSTITUITI îN ALFA CU UN SUBSTITUENT AROMATIC SI A ESTERILOR ACESTORA - Google Patents

PROCEDEU PENTRU PREPARAREA ACIZILOR ALCANOICI SUBSTITUITI îN ALFA CU UN SUBSTITUENT AROMATIC SI A ESTERILOR ACESTORA

Info

Publication number
RO85818B
RO85818B RO110733A RO11073381A RO85818B RO 85818 B RO85818 B RO 85818B RO 110733 A RO110733 A RO 110733A RO 11073381 A RO11073381 A RO 11073381A RO 85818 B RO85818 B RO 85818B
Authority
RO
Romania
Prior art keywords
radical
alpha
alkali
represent
aromatic
Prior art date
Application number
RO110733A
Other languages
English (en)
Other versions
RO85818A (ro
Inventor
Genichi Tsuchihashi
Shuichi Mitamura
Kouji Kitajima
Original Assignee
Sagami Chemical Research Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27519313&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RO85818(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP55125355A external-priority patent/JPS5750956A/ja
Priority claimed from JP55143042A external-priority patent/JPS5767535A/ja
Priority claimed from JP55157049A external-priority patent/JPS5798232A/ja
Priority claimed from JP1170081A external-priority patent/JPS57128661A/ja
Priority claimed from JP9097981A external-priority patent/JPS5810537A/ja
Application filed by Sagami Chemical Research Center filed Critical Sagami Chemical Research Center
Publication of RO85818A publication Critical patent/RO85818A/ro
Publication of RO85818B publication Critical patent/RO85818B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/307—Compounds having groups having acetal carbon atoms bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unui acid alcanonic, avînd un substituent alfa-aromatic sau esterul sau, cu formula generala I: (vezi formula) în care Ar reprezinta un substituent aromatic si R1 reprezinta un a tom de hidrogen sau un radical alifatic saturat sau Ar si R1, împreuna cu atomul de carbon la care sînt legati, pot forma un inel condensat si R2 reprezinta un atom de hidrogen, un radical alcalin sau un substituent hidroxialchil, conform caruia, un acetat de alfa-sulfoniloxicetona, cu formula generala II: (vezi formula) în care R3 si R4, în mod independent unul de altul, reprezinta un radical alcalin sau, luati împreuna, reprezinta radical alhilen, R5 reprezinta un radical alchil substituit sau nesubstituit sau un radical aromatic, si Ar si R1 sînt definiti mai sus, este tratat cu un agent avînd afinitate pentru oxigen, ales, de exemplu, din grupul format din trialchiliodsilani, perfluoralchilsulfonati si trialchilsilil, si acizi Lewis, de preferinta trimetiliodsilan, trifluormetansulfonat de trimetilsilil, clorura de aluminiu, clorura de staniu si clorura de fier, agentul avînd afinitate pentru oxigen, fiind folosit de preferinta, într-o cantitate de 0,2 pîna la 5 mol per mol de compus avînd formula Ii, la o temperatura între circa -40 si circa 150 degree C si, de preferinta, între -20 si circa 100 degree C.
RO110733A 1980-09-11 1981-09-11 PROCEDEU PENTRU PREPARAREA ACIZILOR ALCANOICI SUBSTITUITI îN ALFA CU UN SUBSTITUENT AROMATIC SI A ESTERILOR ACESTORA RO85818B (ro)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP55125355A JPS5750956A (en) 1980-09-11 1980-09-11 Alpha-sulfonyloxyalkanophenone acetal
JP55143042A JPS5767535A (en) 1980-10-15 1980-10-15 Preparation of alpha-aromatic group substituted alkanecarboxylic acid
JP55157049A JPS5798232A (en) 1980-11-10 1980-11-10 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal
JP1170081A JPS57128661A (en) 1981-01-30 1981-01-30 1-(4-substituted aminophenyl)-2-oxy-1-alkanone acetal
JP9097981A JPS5810537A (ja) 1981-06-15 1981-06-15 α−芳香族基置換アルカン酸類の製造方法

Publications (2)

Publication Number Publication Date
RO85818A RO85818A (ro) 1984-11-25
RO85818B true RO85818B (ro) 1984-11-30

Family

ID=27519313

Family Applications (3)

Application Number Title Priority Date Filing Date
RO81105287A RO82085A (ro) 1980-09-11 1981-09-11 Procedeu pentru prepararea acizilor alcanoici avind un substituent alfa aromatic sau esteric
RO110733A RO85818B (ro) 1980-09-11 1981-09-11 PROCEDEU PENTRU PREPARAREA ACIZILOR ALCANOICI SUBSTITUITI îN ALFA CU UN SUBSTITUENT AROMATIC SI A ESTERILOR ACESTORA
RO110734A RO86227B (ro) 1980-09-11 1981-09-11 Procedeu de preparare a unor acetali de alfa-sulfoniloxifenone substituite

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RO81105287A RO82085A (ro) 1980-09-11 1981-09-11 Procedeu pentru prepararea acizilor alcanoici avind un substituent alfa aromatic sau esteric

Family Applications After (1)

Application Number Title Priority Date Filing Date
RO110734A RO86227B (ro) 1980-09-11 1981-09-11 Procedeu de preparare a unor acetali de alfa-sulfoniloxifenone substituite

Country Status (22)

Country Link
EP (2) EP0048136B1 (ro)
AR (1) AR228067A1 (ro)
AU (1) AU599006B2 (ro)
CA (1) CA1186318A (ro)
DD (1) DD202866A5 (ro)
DE (1) DE3174810D1 (ro)
DK (3) DK161020C (ro)
FI (1) FI73195C (ro)
GR (1) GR75077B (ro)
HK (1) HK20589A (ro)
IE (1) IE53333B1 (ro)
IL (3) IL74744A (ro)
IN (1) IN155107B (ro)
MY (1) MY8700825A (ro)
NO (1) NO157616C (ro)
NZ (1) NZ198271A (ro)
PH (3) PH17798A (ro)
PL (1) PL133927B1 (ro)
PT (1) PT73624B (ro)
RO (3) RO82085A (ro)
SG (1) SG98187G (ro)
YU (2) YU43500B (ro)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2423863A (en) * 1940-11-16 1947-07-15 George F Wales Sheet metal compartment with shelf supports and method of manufacture
IL65629A (en) * 1981-04-30 1987-08-31 Syntex Pharma Int Preparation of alpha-arylalkanoic acids and esters and salts thereof
JPS5810525A (ja) * 1981-06-15 1983-01-21 Sagami Chem Res Center 光学活性な１−芳香族基置換−１−アルカノン類の製造方法
FI82680C (fi) * 1981-12-11 1991-04-10 Syntex Pharma Int Framstaellning av - arylalkansyror.
IT1173216B (it) * 1984-02-03 1987-06-18 Zambon Spa Processo per la preparazione di acidi alfa-idrossiaril-alcanoici
US4649213A (en) * 1984-04-14 1987-03-10 Kyowa Hakko Kogyo Co. Ltd. Process for producing an α-aromatic group substituted alkanoic acid derivative
IT1188181B (it) * 1985-07-31 1988-01-07 Zambon Spa Processo per la preparazione di acidi carbossilici otticamente attivi e relativi intermedi
JPS62263153A (ja) * 1986-05-28 1987-11-16 エフ・ホフマン―ラ　ロシユ　アーゲー カルバゾ−ル誘導体
IT1197800B (it) * 1986-08-01 1988-12-06 Zambon Spa Processo per la sintesi di acidi carbossilici
IT1240228B (it) * 1989-01-25 1993-11-27 Syntex Inc Preparazione di acidi alfa-metilarenacetici.
IT1251958B (it) * 1991-10-18 1995-05-27 Zambon Spa Processo per la dealogenazione di derivati del naftalene
JP2011511782A (ja) 2008-02-12 2011-04-14 アボット・ラボラトリーズ 長期放出性ヒドロコドンアセトアミノフェンならびにその関連方法および用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1109200B (it) * 1979-02-20 1985-12-16 Montedison Spa Processo per la preparazione di esteri di acidi arilacetici da alfa-alo-alchilarilchetoni
IE50897B1 (en) * 1980-02-26 1986-08-06 Blaschim Spa Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals
IL65629A (en) * 1981-04-30 1987-08-31 Syntex Pharma Int Preparation of alpha-arylalkanoic acids and esters and salts thereof
FI82680C (fi) * 1981-12-11 1991-04-10 Syntex Pharma Int Framstaellning av - arylalkansyror.

Also Published As

Publication number Publication date
IL63791A0 (en) 1981-12-31
DK396581A (da) 1982-03-12
CA1186318A (en) 1985-04-30
RO86227A (ro) 1985-03-15
FI73195B (fi) 1987-05-29
HK20589A (en) 1989-03-17
DK161020C (da) 1991-10-28
AR228067A1 (es) 1983-01-14
IE812057L (en) 1982-03-11
DK55790A (da) 1990-03-02
EP0151702A3 (en) 1985-10-02
EP0048136A2 (en) 1982-03-24
IL74744A0 (en) 1985-06-30
NO813088L (no) 1982-03-12
EP0151702B1 (en) 1987-11-25
DK163179C (da) 1992-06-22
RO85818A (ro) 1984-11-25
SG98187G (en) 1993-02-19
DK161020B (da) 1991-05-21
FI73195C (fi) 1987-09-10
YU216181A (en) 1983-12-31
EP0151702A2 (en) 1985-08-21
GR75077B (ro) 1984-07-13
PT73624B (pt) 1982-11-17
PH21751A (en) 1988-02-18
PL232991A1 (en) 1983-01-31
MY8700825A (en) 1987-12-31
IN155107B (ro) 1985-01-05
RO82085B (ro) 1983-06-30
DK55690A (da) 1990-03-02
RO86227B (ro) 1985-04-02
DK55690D0 (da) 1990-03-02
DE3174810D1 (en) 1986-07-17
PL133927B1 (en) 1985-07-31
DK163056C (da) 1992-06-15
YU228886A (en) 1988-02-29
YU45076B (en) 1991-08-31
PH17798A (en) 1984-12-13
NO157616C (no) 1988-04-20
DD202866A5 (de) 1983-10-05
IE53333B1 (en) 1988-10-26
RO82085A (ro) 1983-07-07
EP0048136B1 (en) 1986-06-11
IL74744A (en) 1986-02-28
EP0048136A3 (en) 1982-10-27
YU43500B (en) 1989-08-31
NZ198271A (en) 1985-05-31
DK163056B (da) 1992-01-13
FI812820L (fi) 1982-03-12
AU599006B2 (en) 1990-07-12
NO157616B (no) 1988-01-11
PH21746A (en) 1988-02-10
AU4588985A (en) 1986-01-02
DK163179B (da) 1992-02-03
PT73624A (pt) 1981-10-01
DK55790D0 (da) 1990-03-02

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