RO117150B1 - Metodă pentru tratamentul afecţiunilor provocate de abuzul faţă de drog sau altă substanţă - Google Patents
Metodă pentru tratamentul afecţiunilor provocate de abuzul faţă de drog sau altă substanţăInfo
- Publication number
- RO117150B1 RO117150B1 RO94-01692A RO9401692A RO117150B1 RO 117150 B1 RO117150 B1 RO 117150B1 RO 9401692 A RO9401692 A RO 9401692A RO 117150 B1 RO117150 B1 RO 117150B1
- Authority
- RO
- Romania
- Prior art keywords
- atoms
- carbon
- alkyl
- hydrogen
- halogen
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000126 substance Substances 0.000 title abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 8
- 125000004429 atom Chemical group 0.000 abstract 8
- 229910052799 carbon Inorganic materials 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 230000037396 body weight Effects 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
Prezenta invenţie se referă la metodă pentru tratamentul afecţiunilor provocate de abuzul faţă de drog sau altă substanţă. Metoda pentru tratamentul afecţiunilor provocate de abuzul faţă de drog sau altă substanţă constă în aceea că se administrează între 1 şi 5 ori pe zi, o cantitate eficientă, cuprinsă între 0,01 şi 10 mg/kg corp, de preferinţă, între 0,01 şi 1 mg/kg corp, de bisfenilalchilpiperazine cu formula generală:(I)şi sărurile lor de adiţie acide, acceptabile farmaceutic, în care, Rşi Rsunt aceiaşi sau diferiţi, şi sunt aleşi dintre hidrogen sau halogen; Rşi Rsunt aceiaşi sau diferiţi şi sunt aleşi dintre hidrogen sau alchil având 1 la 5 atomi de carbon, n este 2 sau 3, A este ales dintre următoarele grupări pirimidil sau piridil:în care Reste ales dintre hidrogen, alchil cu 1 la 5 atomi de carbon sau halogen; Rşi Rsunt aceiaşi sau diferiţi, şi aleşi dintre hidrogen, halogen, alchil cu 1 la 5 atomi de carbon, alcoxi cu 1 la 5 atomi de carbon, hidroxi, ciano, nitro, triflormetil, COOR; CONRRsau COB, unde Reste hidrogen sau alchil cu 1 la 5 atomi de carbon; Rşi Rsunt aceiaşi sau diferiţi şi sunt aleşi dintre hidrogen, alchil cu 1 la 5 atomi de carbon sau cicloalchil cu 3 la 8 atomi de carbon; B este ales dintre:în care m este 1, 2, 3 sau 4; Reste ales dintre hidrogen sau alchil cu 1 la 5 atomi de carbon şi atunci când este folosit în definiţiile de mai sus, termenul alchil include grupări de hidrocarburi liniare şi ramificate, termenul alcoxi include grupări alcoxi liniare şi ramificate; termenul halogen include fluor, clor şi brom.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9201239A SE9201239D0 (sv) | 1992-04-21 | 1992-04-21 | Agents for treating substance abuse disorders |
| PCT/SE1993/000339 WO1993020821A1 (en) | 1992-04-21 | 1993-04-19 | Agents for treating substance abuse disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO117150B1 true RO117150B1 (ro) | 2001-11-30 |
Family
ID=20386004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO94-01692A RO117150B1 (ro) | 1992-04-21 | 1993-04-19 | Metodă pentru tratamentul afecţiunilor provocate de abuzul faţă de drog sau altă substanţă |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5565455A (ro) |
| EP (1) | EP0637242B1 (ro) |
| JP (1) | JP3245642B2 (ro) |
| KR (1) | KR100321319B1 (ro) |
| AT (1) | ATE184484T1 (ro) |
| AU (1) | AU659941B2 (ro) |
| BG (1) | BG62154B1 (ro) |
| BR (1) | BR9306361A (ro) |
| CA (1) | CA2118512C (ro) |
| CZ (1) | CZ281296B6 (ro) |
| DE (1) | DE69326459T2 (ro) |
| DK (1) | DK0637242T3 (ro) |
| EE (1) | EE02974B1 (ro) |
| ES (1) | ES2139007T3 (ro) |
| GR (1) | GR3032030T3 (ro) |
| HU (1) | HU223463B1 (ro) |
| IL (1) | IL105449A (ro) |
| NO (2) | NO308827B1 (ro) |
| PH (1) | PH31051A (ro) |
| RO (1) | RO117150B1 (ro) |
| RU (1) | RU2126254C1 (ro) |
| SE (1) | SE9201239D0 (ro) |
| SK (1) | SK279940B6 (ro) |
| UA (1) | UA27884C2 (ro) |
| WO (1) | WO1993020821A1 (ro) |
| ZA (1) | ZA932757B (ro) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5316759A (en) * | 1986-03-17 | 1994-05-31 | Robert J. Schaap | Agonist-antagonist combination to reduce the use of nicotine and other drugs |
| SE9201956D0 (sv) * | 1992-06-25 | 1992-06-25 | Kabi Pharmacia Ab | Novel nicotinicacid esters |
| SE9601708D0 (sv) * | 1996-05-06 | 1996-05-06 | Pharmacia Ab | Pyridyl- and pyrimidyl-piperazines in the treatment of substance abuse disorders |
| JP4570773B2 (ja) | 1997-10-27 | 2010-10-27 | ニューロサーチ、アクティーゼルスカブ | ニコチン性アセチルコリンレセプターに於けるコリン作動性リガンドとしてのヘテロアリールジアザシクロアルカン |
| US6632823B1 (en) * | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
| US6358060B2 (en) | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
| US6344222B1 (en) | 1998-09-03 | 2002-02-05 | Jsr Llc | Medicated chewing gum delivery system for nicotine |
| US6090780A (en) * | 1999-04-07 | 2000-07-18 | Chandon Prasad | Histidyl-proline diketopiperazine and method of use |
| TW518218B (en) * | 1999-05-27 | 2003-01-21 | Merck Patent Gmbh | Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders |
| RU2215527C2 (ru) * | 2001-09-28 | 2003-11-10 | Областная наркологическая больница | Способ купирования алкогольного абстинентного синдрома, алкогольного делирия, острого алкогольного галлюциноза |
| SI1551372T1 (en) | 2002-09-20 | 2018-08-31 | Alpharma Pharmaceuticals Llc | SUBVENCATION DATA AND RELATED CONSTRUCTIONS AND PROCEDURES |
| EP2719378B1 (en) | 2006-06-19 | 2016-08-31 | Alpharma Pharmaceuticals LLC | Pharmaceutical compositions |
| US8642016B2 (en) | 2006-07-21 | 2014-02-04 | Jsrnti, Llc | Medicinal delivery system, and related methods |
| US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
| BRPI1003506B1 (pt) | 2010-09-24 | 2019-12-03 | Ache Int Bvi Ltd | composto alquil-piperazino-fenil-4(3h)quinazolinonas e uso do composto alquil-piperazino-fenil-4(3h)quinazolinonas associado aos receptores serotoninérgicos 5-ht1a e 5-ht2a |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2958694A (en) * | 1959-06-22 | 1960-11-01 | Janssen Paul Adriaan Jan | 1-(aroylalkyl)-4-(2'-pyridyl) piperazines |
| US2985657A (en) * | 1959-10-12 | 1961-05-23 | Paul A J Janssen | 1-(aroylalkyl)-4-heterocyclylpiperazines |
| US2979508A (en) * | 1959-10-12 | 1961-04-11 | Paul A J Janssen | Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols |
| NO154582C (no) * | 1978-10-20 | 1986-11-05 | Ferrosan Ab | Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider. |
| US4605655A (en) * | 1984-03-06 | 1986-08-12 | Bristol-Myers Company | Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives |
| US4766215A (en) * | 1987-02-27 | 1988-08-23 | American Home Products Corporation | Histamine H1 -receptor antagonists |
| SE8701375D0 (sv) * | 1987-04-02 | 1987-04-02 | Leo Ab | Novel pyridyl- and pyrimidyl derivatives |
| US5217987A (en) * | 1989-10-30 | 1993-06-08 | Berger Stephen P | Dopamine uptake inhibitors in reducing substance abuse and/or craving |
| SE9100860D0 (sv) * | 1991-03-22 | 1991-03-22 | Kabi Pharmacia Ab | New use |
-
1992
- 1992-04-21 SE SE9201239A patent/SE9201239D0/xx unknown
-
1993
- 1993-04-19 AT AT93911554T patent/ATE184484T1/de not_active IP Right Cessation
- 1993-04-19 WO PCT/SE1993/000339 patent/WO1993020821A1/en not_active Ceased
- 1993-04-19 EP EP93911554A patent/EP0637242B1/en not_active Expired - Lifetime
- 1993-04-19 AU AU40437/93A patent/AU659941B2/en not_active Ceased
- 1993-04-19 SK SK1269-94A patent/SK279940B6/sk not_active IP Right Cessation
- 1993-04-19 JP JP51825193A patent/JP3245642B2/ja not_active Expired - Fee Related
- 1993-04-19 US US08/325,212 patent/US5565455A/en not_active Expired - Lifetime
- 1993-04-19 IL IL105449A patent/IL105449A/en not_active IP Right Cessation
- 1993-04-19 RO RO94-01692A patent/RO117150B1/ro unknown
- 1993-04-19 CZ CZ942606A patent/CZ281296B6/cs not_active IP Right Cessation
- 1993-04-19 RU RU94045866A patent/RU2126254C1/ru active
- 1993-04-19 CA CA002118512A patent/CA2118512C/en not_active Expired - Fee Related
- 1993-04-19 ES ES93911554T patent/ES2139007T3/es not_active Expired - Lifetime
- 1993-04-19 UA UA94105949A patent/UA27884C2/uk unknown
- 1993-04-19 BR BR9306361A patent/BR9306361A/pt not_active Application Discontinuation
- 1993-04-19 DE DE69326459T patent/DE69326459T2/de not_active Expired - Fee Related
- 1993-04-19 DK DK93911554T patent/DK0637242T3/da active
- 1993-04-19 HU HU9403020A patent/HU223463B1/hu not_active IP Right Cessation
- 1993-04-20 ZA ZA932757A patent/ZA932757B/xx unknown
- 1993-04-21 PH PH46084A patent/PH31051A/en unknown
-
1994
- 1994-10-19 BG BG99129A patent/BG62154B1/bg unknown
- 1994-10-20 NO NO943977A patent/NO308827B1/no not_active IP Right Cessation
- 1994-10-21 KR KR1019940703758A patent/KR100321319B1/ko not_active Expired - Fee Related
- 1994-11-17 EE EE9400398A patent/EE02974B1/xx not_active IP Right Cessation
-
1999
- 1999-12-02 GR GR990403117T patent/GR3032030T3/el unknown
-
2000
- 2000-08-21 NO NO20004169A patent/NO318461B1/no not_active IP Right Cessation
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