PT99683A - Processo para a preparacao de derivados de indoles 3-alquilados - Google Patents

Processo para a preparacao de derivados de indoles 3-alquilados

Info

Publication number
PT99683A
PT99683A PT99683A PT9968391A PT99683A PT 99683 A PT99683 A PT 99683A PT 99683 A PT99683 A PT 99683A PT 9968391 A PT9968391 A PT 9968391A PT 99683 A PT99683 A PT 99683A
Authority
PT
Portugal
Prior art keywords
preparation
alked
indole derivatives
afford
reacting
Prior art date
Application number
PT99683A
Other languages
English (en)
Other versions
PT99683B (pt
Inventor
Roberts Toms Jacobs
Gerard Francis Costello
Stephen Alan Brook
Peter John Harrison
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Plc filed Critical Ici Plc
Publication of PT99683A publication Critical patent/PT99683A/pt
Publication of PT99683B publication Critical patent/PT99683B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT99683A 1990-12-05 1991-12-04 Processo para a preparacao de derivados de indoles 3-alquilados PT99683B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909026427A GB9026427D0 (en) 1990-12-05 1990-12-05 Chemical process

Publications (2)

Publication Number Publication Date
PT99683A true PT99683A (pt) 1992-10-30
PT99683B PT99683B (pt) 1999-05-31

Family

ID=10686509

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99683A PT99683B (pt) 1990-12-05 1991-12-04 Processo para a preparacao de derivados de indoles 3-alquilados

Country Status (22)

Country Link
US (1) US5280125A (pt)
EP (1) EP0489547B1 (pt)
JP (1) JP3160040B2 (pt)
KR (1) KR100228328B1 (pt)
AT (1) ATE168998T1 (pt)
AU (1) AU652002B2 (pt)
CA (1) CA2056065C (pt)
CZ (1) CZ282019B6 (pt)
DE (1) DE69129894T2 (pt)
DK (1) DK0489547T3 (pt)
ES (1) ES2118743T3 (pt)
FI (1) FI102170B1 (pt)
GB (1) GB9026427D0 (pt)
HU (1) HU222123B1 (pt)
IE (1) IE913936A1 (pt)
IL (1) IL100055A (pt)
NO (1) NO175680C (pt)
NZ (1) NZ240624A (pt)
PT (1) PT99683B (pt)
RU (1) RU2054417C1 (pt)
SK (1) SK278987B6 (pt)
ZA (1) ZA919079B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9119001D0 (en) * 1991-09-05 1991-10-23 Ici Plc Pharmaceutical agents
WO1998015530A1 (fr) * 1996-10-08 1998-04-16 Fujisawa Pharmaceutical Co., Ltd. Derives d'indol
CN112457235B (zh) * 2020-12-02 2023-04-25 烟台凯博医药科技有限公司 一种7-甲基吲哚的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732245A (en) * 1970-11-04 1973-05-08 Hoffmann La Roche Process and intermediates for the preparation of indoles from ortho-nitrotoluenes
US3976639A (en) * 1970-11-04 1976-08-24 Hoffmann-La Roche Inc. Intermediates for indoles
US3979410A (en) * 1974-01-21 1976-09-07 Hoffmann-La Roche Inc. Intermediate α-acyl-β-dialkylamino-2-nitrostyrenes
US4137404A (en) * 1977-12-20 1979-01-30 Hoffmann-La Roche Inc. Synthesis of tryptophans
US4665087A (en) * 1982-02-22 1987-05-12 Ciba-Geigy Corporation 1-(carbamyl, thiocarbamyl, and iminocarbamyl)-indoline derivatives
GB8607294D0 (en) * 1985-04-17 1986-04-30 Ici America Inc Heterocyclic amide derivatives
GB8623429D0 (en) * 1985-10-17 1986-11-05 Ici America Inc Carboximide derivatives
US5180728A (en) * 1989-09-25 1993-01-19 Fujisawa Pharmaceutical Company, Ltd. Pyrimidoindole derivatives and processes for preparation thereof
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
GB9026425D0 (en) * 1990-12-05 1991-01-23 Ici Plc Process

Also Published As

Publication number Publication date
IL100055A (en) 1996-12-05
JP3160040B2 (ja) 2001-04-23
IL100055A0 (en) 1992-08-18
FI102170B (fi) 1998-10-30
NO175680C (no) 1994-11-16
EP0489547B1 (en) 1998-07-29
HUT60716A (en) 1992-10-28
NZ240624A (en) 1994-01-26
DE69129894T2 (de) 1998-12-10
US5280125A (en) 1994-01-18
KR920012029A (ko) 1992-07-25
ES2118743T3 (es) 1998-10-01
AU8794691A (en) 1992-06-11
ZA919079B (en) 1992-09-30
ATE168998T1 (de) 1998-08-15
IE913936A1 (en) 1992-06-17
NO175680B (no) 1994-08-08
CA2056065C (en) 2003-07-29
JPH04266870A (ja) 1992-09-22
PT99683B (pt) 1999-05-31
DK0489547T3 (da) 1999-04-26
NO914775D0 (no) 1991-12-04
HU222123B1 (hu) 2003-04-28
RU2054417C1 (ru) 1996-02-20
KR100228328B1 (ko) 1999-11-01
EP0489547A1 (en) 1992-06-10
FI915735A (fi) 1992-06-06
SK278987B6 (sk) 1998-05-06
CA2056065A1 (en) 1992-06-06
DE69129894D1 (de) 1998-09-03
FI915735A0 (fi) 1991-12-05
AU652002B2 (en) 1994-08-11
FI102170B1 (fi) 1998-10-30
HU913759D0 (en) 1992-02-28
GB9026427D0 (en) 1991-01-23
NO914775L (no) 1992-06-09
CS363391A3 (en) 1992-06-17
CZ282019B6 (cs) 1997-04-16

Similar Documents

Publication Publication Date Title
PT84075B (pt) Processo para a preparacao de derivados de indol
NL300181I1 (nl) N-(pyrroloÄ2,3-dÜpyrimidine-3-ylacyl)-glutaminezuurderivaten.
TR199600478A1 (tr) Antidiabetik maddeler olarak, ikame edilmis N-(indol-2-karbonil)-B-alanimamidler ve türevleri.
FI950859A (fi) Arylideeni- ja heteroarylideeni-oksindolijohdannaiset tyrosiinikinaasi-inhibiittoreina
ES2101063T3 (es) Derivados monofluorados de n-propargil-1-amino-indano y su utilizacion como inhibidores de la monoamin-oxidasa.
DE3861178D1 (de) Nachspannendes bohrfutter.
ES535469A0 (es) Procedimiento para la preparacion de derivados de n-(2-nitrofenil)-4-aminopirimidina
PT98205A (pt) Processo para a preparacao de novos derivados beta-lactamicos
MX162676A (es) Procedimiento para la preparacion de derivados de 2-(piridilalquensulfinii.)benzimidazoles n-substituidos
FI891252A0 (fi) 1,3,4,5-tetrahydrobenz /c,d/ indol.
ES2018177B3 (es) Procedimiento para el agotamiento de soluciones acuosas de aminas.
DE3682541D1 (de) Herbizid wirkende derivate des n-phenyl-3,4,5,6-tetrahydrophthalsaeureimides.
PT99683A (pt) Processo para a preparacao de derivados de indoles 3-alquilados
NO860733L (no) N-(2-klor-4-trifluormethylfenyl)-3-trifluormethyl-benzensulfonamidderivat, fremgangsmaate for fremstilling av dette, og fungicid middel inneholdende dette.
DK83984A (da) Phenylethylaminderivater, deres fremstilling og anvendelse som vaekstfremmende midler til dyr
BR9611683A (pt) Processo para a preparação de compostos
EE200000024A (et) Meetod alküüloksüfuranooni amiinderivaatide valmistamiseks, sel meetodil saadud ühendid ja nende kasutamine
DK0462837T3 (da) Fremstilling af indol-derivater
PT86771A (pt) Process for preparing 4-substituted benzamide derivatives with anticonvulsant activity
PT83253B (pt) Processo para a preparacao de p-acilaminobenzamidas
TR200001122T2 (tr) Farmasötikler olarak bifenil türevleri.
FI945414A0 (fi) Menetelmä N,N-disubstituoidun aminofenolin valmistamiseksi
DE69905376D1 (de) Enanthioauswählende synthese
DE69015123D1 (de) Herstellung aromatischer Amine.
ES516224A0 (es) "procedimiento para preparar derivados de anilina".

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920612

FG3A Patent granted, date of granting

Effective date: 19990210

PC3A Transfer or assignment

Free format text: ASTRAZENECA UK LIMITED GB

Effective date: 20040722

PD3A Change of proprietorship

Free format text: SYNGENTA LIMITED GB

Effective date: 20040722

MM3A Annulment or lapse

Effective date: 20050810