DE69129894T2 - Ein Verfahren zur Darstellung eines 3-alkylierten Indols, Intermediate und ein Verfahren zur Darstellung eines Derivats - Google Patents

Ein Verfahren zur Darstellung eines 3-alkylierten Indols, Intermediate und ein Verfahren zur Darstellung eines Derivats

Info

Publication number
DE69129894T2
DE69129894T2 DE69129894T DE69129894T DE69129894T2 DE 69129894 T2 DE69129894 T2 DE 69129894T2 DE 69129894 T DE69129894 T DE 69129894T DE 69129894 T DE69129894 T DE 69129894T DE 69129894 T2 DE69129894 T2 DE 69129894T2
Authority
DE
Germany
Prior art keywords
preparation
intermediates
derivative
alkylated indole
afford
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69129894T
Other languages
English (en)
Other versions
DE69129894D1 (de
Inventor
Robert Toms Jacobs
Gerard Francis Costello
Stephen Alan Brook
Peter John Harrison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of DE69129894D1 publication Critical patent/DE69129894D1/de
Publication of DE69129894T2 publication Critical patent/DE69129894T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
DE69129894T 1990-12-05 1991-11-29 Ein Verfahren zur Darstellung eines 3-alkylierten Indols, Intermediate und ein Verfahren zur Darstellung eines Derivats Expired - Fee Related DE69129894T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909026427A GB9026427D0 (en) 1990-12-05 1990-12-05 Chemical process

Publications (2)

Publication Number Publication Date
DE69129894D1 DE69129894D1 (de) 1998-09-03
DE69129894T2 true DE69129894T2 (de) 1998-12-10

Family

ID=10686509

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69129894T Expired - Fee Related DE69129894T2 (de) 1990-12-05 1991-11-29 Ein Verfahren zur Darstellung eines 3-alkylierten Indols, Intermediate und ein Verfahren zur Darstellung eines Derivats

Country Status (22)

Country Link
US (1) US5280125A (de)
EP (1) EP0489547B1 (de)
JP (1) JP3160040B2 (de)
KR (1) KR100228328B1 (de)
AT (1) ATE168998T1 (de)
AU (1) AU652002B2 (de)
CA (1) CA2056065C (de)
CZ (1) CZ282019B6 (de)
DE (1) DE69129894T2 (de)
DK (1) DK0489547T3 (de)
ES (1) ES2118743T3 (de)
FI (1) FI102170B (de)
GB (1) GB9026427D0 (de)
HU (1) HU222123B1 (de)
IE (1) IE913936A1 (de)
IL (1) IL100055A (de)
NO (1) NO175680C (de)
NZ (1) NZ240624A (de)
PT (1) PT99683B (de)
RU (1) RU2054417C1 (de)
SK (1) SK278987B6 (de)
ZA (1) ZA919079B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9119001D0 (en) * 1991-09-05 1991-10-23 Ici Plc Pharmaceutical agents
AU4400597A (en) * 1996-10-08 1998-05-05 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives
CN112457235B (zh) * 2020-12-02 2023-04-25 烟台凯博医药科技有限公司 一种7-甲基吲哚的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732245A (en) * 1970-11-04 1973-05-08 Hoffmann La Roche Process and intermediates for the preparation of indoles from ortho-nitrotoluenes
US3976639A (en) * 1970-11-04 1976-08-24 Hoffmann-La Roche Inc. Intermediates for indoles
US3979410A (en) * 1974-01-21 1976-09-07 Hoffmann-La Roche Inc. Intermediate α-acyl-β-dialkylamino-2-nitrostyrenes
US4137404A (en) * 1977-12-20 1979-01-30 Hoffmann-La Roche Inc. Synthesis of tryptophans
US4665087A (en) * 1982-02-22 1987-05-12 Ciba-Geigy Corporation 1-(carbamyl, thiocarbamyl, and iminocarbamyl)-indoline derivatives
GB8607294D0 (en) * 1985-04-17 1986-04-30 Ici America Inc Heterocyclic amide derivatives
GB8623429D0 (en) * 1985-10-17 1986-11-05 Ici America Inc Carboximide derivatives
US5180728A (en) * 1989-09-25 1993-01-19 Fujisawa Pharmaceutical Company, Ltd. Pyrimidoindole derivatives and processes for preparation thereof
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
GB9026425D0 (en) * 1990-12-05 1991-01-23 Ici Plc Process

Also Published As

Publication number Publication date
JP3160040B2 (ja) 2001-04-23
FI102170B1 (fi) 1998-10-30
PT99683A (pt) 1992-10-30
NZ240624A (en) 1994-01-26
EP0489547A1 (de) 1992-06-10
ES2118743T3 (es) 1998-10-01
CS363391A3 (en) 1992-06-17
KR100228328B1 (ko) 1999-11-01
NO175680C (no) 1994-11-16
JPH04266870A (ja) 1992-09-22
CA2056065C (en) 2003-07-29
NO914775D0 (no) 1991-12-04
CZ282019B6 (cs) 1997-04-16
NO175680B (no) 1994-08-08
SK278987B6 (sk) 1998-05-06
ATE168998T1 (de) 1998-08-15
GB9026427D0 (en) 1991-01-23
IE913936A1 (en) 1992-06-17
ZA919079B (en) 1992-09-30
HUT60716A (en) 1992-10-28
EP0489547B1 (de) 1998-07-29
DK0489547T3 (da) 1999-04-26
US5280125A (en) 1994-01-18
AU8794691A (en) 1992-06-11
CA2056065A1 (en) 1992-06-06
NO914775L (no) 1992-06-09
RU2054417C1 (ru) 1996-02-20
DE69129894D1 (de) 1998-09-03
PT99683B (pt) 1999-05-31
FI102170B (fi) 1998-10-30
IL100055A (en) 1996-12-05
IL100055A0 (en) 1992-08-18
AU652002B2 (en) 1994-08-11
FI915735A (fi) 1992-06-06
HU913759D0 (en) 1992-02-28
FI915735A0 (fi) 1991-12-05
HU222123B1 (hu) 2003-04-28
KR920012029A (ko) 1992-07-25

Similar Documents

Publication Publication Date Title
HU9203162D0 (en) Method for diastereoselective reductive pinacolic binding of homoquiralic alpha-amino-aldehydes
DE19882893T1 (de) Herstellung von 3-substituierten Adeninen
DE3852959T2 (de) Verfahren zur Herstellung von N-substituiertes Amin.
DK81993D0 (da) Fremgangsmaade til fremstilling af 2-thioalkoxy-6-alkoxy-7-iod-7-deazapuriner
DE69133509D1 (de) Verfahren zur herstellung von beta-lactamen
DE69129894D1 (de) Ein Verfahren zur Darstellung eines 3-alkylierten Indols, Intermediate und ein Verfahren zur Darstellung eines Derivats
DE59105224D1 (de) Verfahren zur Herstellung von N-substituierten Pyrrolidonen.
ATE277887T1 (de) Verfahren zur herstellung von 1,4-bis((2- (dimethylamino)ethyl amino)-5,8- dihydroxyanthracene-9,10-dion
DE69105812D1 (de) Verfahren zur Herstellung von sekundärem Amin und Katalysatoren dafür.
EE03873B1 (et) Meetod alküüloksüfuranooni amiinderivaatide valmistamiseks, sel meetodil saadud ühendid ja nende kasutamine
PT82536A (de) Verfahren zur herstellung von 17alpha-ethinyl-17 beta-hydroxy-18-methyl-4,15-estradien-3-on und die neuen ausgangsverbindungenfur dieses verfahren
DE69701104T2 (de) Verfahren zur Herstellung von tertiären Amin-Derivaten
DE59202953D1 (de) Verfahren zur Herstellung von Aminen durch katalytische Hydrierung von Nitrilen.
DE69816944D1 (de) Verfahren zur Herstellung von einem aliphatischen Aminderivat
DE59303525D1 (de) Verfahren zur Herstellung von N-(2-Hydroxypropyl)-2,6-dimethylmorpholin
DE59600522D1 (de) Verfahren zur Herstellung aromatischer Amine
DE69708011D1 (de) Verfahren zur Herstellung primärer Amine
ATE183994T1 (de) Verfahren zur herstellung n-z-geschützter n- alkylierter aminosäuren
DE60001468T2 (de) Verfahren zur Herstellung von 2-Azabicyclo[2.2.1]hept-5-en-3-on

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SYNGENTA LTD., GUILDFORD, SURREY, GB

8327 Change in the person/name/address of the patent owner

Owner name: ZENECA LIMITED, LONDON, GB

8327 Change in the person/name/address of the patent owner

Owner name: ASTRAZENECA UK LTD., LONDON, GB

8339 Ceased/non-payment of the annual fee