NO175680C - Fremgangsmåte for fremstilling av en 3-alkylert indol - Google Patents

Fremgangsmåte for fremstilling av en 3-alkylert indol

Info

Publication number
NO175680C
NO175680C NO914775A NO914775A NO175680C NO 175680 C NO175680 C NO 175680C NO 914775 A NO914775 A NO 914775A NO 914775 A NO914775 A NO 914775A NO 175680 C NO175680 C NO 175680C
Authority
NO
Norway
Prior art keywords
alkylated indole
afford
preparing
reacting
imine salt
Prior art date
Application number
NO914775A
Other languages
English (en)
Other versions
NO175680B (no
NO914775D0 (no
NO914775L (no
Inventor
Robert Toms Jacobs
Gerard Francis Costello
Stephen Alan Brook
Peter John Harrison
Original Assignee
Zeneca Ltd
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd, Ici Plc filed Critical Zeneca Ltd
Publication of NO914775D0 publication Critical patent/NO914775D0/no
Publication of NO914775L publication Critical patent/NO914775L/no
Publication of NO175680B publication Critical patent/NO175680B/no
Publication of NO175680C publication Critical patent/NO175680C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06Preparation of nitro compounds
    • C07C201/12Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04Formation of amino groups in compounds containing carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO914775A 1990-12-05 1991-12-04 Fremgangsmåte for fremstilling av en 3-alkylert indol NO175680C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909026427A GB9026427D0 (en) 1990-12-05 1990-12-05 Chemical process

Publications (4)

Publication Number Publication Date
NO914775D0 NO914775D0 (no) 1991-12-04
NO914775L NO914775L (no) 1992-06-09
NO175680B NO175680B (no) 1994-08-08
NO175680C true NO175680C (no) 1994-11-16

Family

ID=10686509

Family Applications (1)

Application Number Title Priority Date Filing Date
NO914775A NO175680C (no) 1990-12-05 1991-12-04 Fremgangsmåte for fremstilling av en 3-alkylert indol

Country Status (22)

Country Link
US (1) US5280125A (no)
EP (1) EP0489547B1 (no)
JP (1) JP3160040B2 (no)
KR (1) KR100228328B1 (no)
AT (1) ATE168998T1 (no)
AU (1) AU652002B2 (no)
CA (1) CA2056065C (no)
CZ (1) CZ282019B6 (no)
DE (1) DE69129894T2 (no)
DK (1) DK0489547T3 (no)
ES (1) ES2118743T3 (no)
FI (1) FI102170B1 (no)
GB (1) GB9026427D0 (no)
HU (1) HU222123B1 (no)
IE (1) IE913936A1 (no)
IL (1) IL100055A (no)
NO (1) NO175680C (no)
NZ (1) NZ240624A (no)
PT (1) PT99683B (no)
RU (1) RU2054417C1 (no)
SK (1) SK278987B6 (no)
ZA (1) ZA919079B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9119001D0 (en) * 1991-09-05 1991-10-23 Ici Plc Pharmaceutical agents
WO1998015530A1 (fr) * 1996-10-08 1998-04-16 Fujisawa Pharmaceutical Co., Ltd. Derives d'indol
CN112457235B (zh) * 2020-12-02 2023-04-25 烟台凯博医药科技有限公司 一种7-甲基吲哚的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732245A (en) * 1970-11-04 1973-05-08 Hoffmann La Roche Process and intermediates for the preparation of indoles from ortho-nitrotoluenes
US3976639A (en) * 1970-11-04 1976-08-24 Hoffmann-La Roche Inc. Intermediates for indoles
US3979410A (en) * 1974-01-21 1976-09-07 Hoffmann-La Roche Inc. Intermediate α-acyl-β-dialkylamino-2-nitrostyrenes
US4137404A (en) * 1977-12-20 1979-01-30 Hoffmann-La Roche Inc. Synthesis of tryptophans
US4665087A (en) * 1982-02-22 1987-05-12 Ciba-Geigy Corporation 1-(carbamyl, thiocarbamyl, and iminocarbamyl)-indoline derivatives
GB8607294D0 (en) * 1985-04-17 1986-04-30 Ici America Inc Heterocyclic amide derivatives
GB8623429D0 (en) * 1985-10-17 1986-11-05 Ici America Inc Carboximide derivatives
US5180728A (en) * 1989-09-25 1993-01-19 Fujisawa Pharmaceutical Company, Ltd. Pyrimidoindole derivatives and processes for preparation thereof
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
GB9026425D0 (en) * 1990-12-05 1991-01-23 Ici Plc Process

Also Published As

Publication number Publication date
CZ282019B6 (cs) 1997-04-16
US5280125A (en) 1994-01-18
NO175680B (no) 1994-08-08
DE69129894D1 (de) 1998-09-03
JPH04266870A (ja) 1992-09-22
ES2118743T3 (es) 1998-10-01
AU8794691A (en) 1992-06-11
SK278987B6 (sk) 1998-05-06
IE913936A1 (en) 1992-06-17
CA2056065A1 (en) 1992-06-06
HU913759D0 (en) 1992-02-28
NO914775D0 (no) 1991-12-04
JP3160040B2 (ja) 2001-04-23
CA2056065C (en) 2003-07-29
FI915735A (fi) 1992-06-06
EP0489547A1 (en) 1992-06-10
FI915735A0 (fi) 1991-12-05
EP0489547B1 (en) 1998-07-29
HUT60716A (en) 1992-10-28
PT99683A (pt) 1992-10-30
DK0489547T3 (da) 1999-04-26
ZA919079B (en) 1992-09-30
NO914775L (no) 1992-06-09
CS363391A3 (en) 1992-06-17
IL100055A (en) 1996-12-05
PT99683B (pt) 1999-05-31
IL100055A0 (en) 1992-08-18
HU222123B1 (hu) 2003-04-28
ATE168998T1 (de) 1998-08-15
KR920012029A (ko) 1992-07-25
KR100228328B1 (ko) 1999-11-01
FI102170B (fi) 1998-10-30
AU652002B2 (en) 1994-08-11
GB9026427D0 (en) 1991-01-23
RU2054417C1 (ru) 1996-02-20
NZ240624A (en) 1994-01-26
FI102170B1 (fi) 1998-10-30
DE69129894T2 (de) 1998-12-10

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