PT99389A - Processo de preparacao de derivados de muramildipeptido e de vacina para a gripe contendo os derivados - Google Patents

Processo de preparacao de derivados de muramildipeptido e de vacina para a gripe contendo os derivados Download PDF

Info

Publication number
PT99389A
PT99389A PT99389A PT9938991A PT99389A PT 99389 A PT99389 A PT 99389A PT 99389 A PT99389 A PT 99389A PT 9938991 A PT9938991 A PT 9938991A PT 99389 A PT99389 A PT 99389A
Authority
PT
Portugal
Prior art keywords
group
carbon atoms
compound
substituted
formula
Prior art date
Application number
PT99389A
Other languages
English (en)
Portuguese (pt)
Inventor
Masaharu Oki
Hideya Tsuge
Kunio Ohkuma
Tetsuya Oka
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of PT99389A publication Critical patent/PT99389A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/5555—Muramyl dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/812—Liposome comprising an antibody, antibody fragment, antigen, or other specific or nonspecific immunoeffector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
PT99389A 1990-10-30 1991-10-30 Processo de preparacao de derivados de muramildipeptido e de vacina para a gripe contendo os derivados PT99389A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP29333590 1990-10-30
JP29333690 1990-10-30

Publications (1)

Publication Number Publication Date
PT99389A true PT99389A (pt) 1992-09-30

Family

ID=26559366

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99389A PT99389A (pt) 1990-10-30 1991-10-30 Processo de preparacao de derivados de muramildipeptido e de vacina para a gripe contendo os derivados

Country Status (16)

Country Link
US (1) US5292506A (forum.php)
EP (2) EP0680974A1 (forum.php)
KR (1) KR920008064A (forum.php)
CN (1) CN1062146A (forum.php)
AU (1) AU642048B2 (forum.php)
CA (1) CA2054228A1 (forum.php)
FI (1) FI915089L (forum.php)
HU (1) HUT62199A (forum.php)
IE (1) IE913765A1 (forum.php)
IL (1) IL99851A (forum.php)
MX (1) MX9101820A (forum.php)
NO (1) NO914233D0 (forum.php)
NZ (1) NZ240369A (forum.php)
PT (1) PT99389A (forum.php)
RU (1) RU2074192C1 (forum.php)
TW (1) TW207545B (forum.php)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612037A (en) * 1994-07-26 1997-03-18 Connaught Laboratories, Inc. Influenza virus subunit conjugates
JP2004531578A (ja) * 2001-06-29 2004-10-14 ベクトン・ディキンソン・アンド・カンパニー ワクチンおよび遺伝子治療剤のマイクロカニューレによる皮内送達
US20040247661A1 (en) * 2002-07-03 2004-12-09 Dov Michaeli Liposomal vaccine
US20050169979A1 (en) * 2002-07-03 2005-08-04 Dov Michaeli Liposomal vaccine
US20040208920A1 (en) * 2002-07-03 2004-10-21 Dov Michaeli Liposomal vaccine
US7588774B2 (en) * 2003-05-12 2009-09-15 Becton, Dickinson And Company Molecules enhancing dermal delivery of influenza vaccines
US20050123550A1 (en) * 2003-05-12 2005-06-09 Laurent Philippe E. Molecules enhancing dermal delivery of influenza vaccines
TWI329130B (en) 2003-06-19 2010-08-21 Bestewil Holding Bv Functionally reconstituted viral membranes containing adjuvant
WO2005074460A2 (en) * 2003-12-05 2005-08-18 Becton Dickinson And Company Methods of enhancing immune response in the intradermal compartment and compounds useful in the methods
PT1789084E (pt) 2004-09-09 2011-02-22 Novartis Vaccines & Diagnostic Redução de riscos iatrogénicos pontenciais associados às vacinas contra a gripe
WO2006062637A2 (en) 2004-11-03 2006-06-15 Novartis Vaccines And Diagnostics Inc. Influenza vaccination
US20060121055A1 (en) * 2004-12-06 2006-06-08 Becton, Dickinson And Company, Inc. Compositions with enhanced immunogenicity
CN101100483B (zh) * 2006-07-07 2011-12-07 中国医学科学院药物研究所 胞壁酰二肽的类似物
WO2008024075A1 (en) 2006-08-25 2008-02-28 Agency For Science, Technology And Research Modulators of candida hyphal morphogenesis and uses thereof
US20090060889A1 (en) * 2007-03-12 2009-03-05 Von Hofe Eric Ii-RNAi involved Ii suppression in cancer immunotherapy
US9657359B2 (en) 2010-09-07 2017-05-23 Novartis Ag Generic assays for detection of mamalian reovirus
WO2013172517A1 (ko) 2012-05-16 2013-11-21 서울대학교산학협력단 뮤라밀-다이펩타이드를 포함하는 골소실 예방, 골재생 또는 골형성 촉진용 약학 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6042398A (ja) * 1983-08-18 1985-03-06 Toshiyuki Hamaoka ムラミルジペプチド活性エステル誘導体
JPH0688911B2 (ja) * 1985-06-06 1994-11-09 国立予防衛生研究所長 インフルエンザワクチン及びその製造方法
US4895835A (en) * 1987-11-20 1990-01-23 Nisshin Oil Mills, Ltd. Muramyl peptide derivatives and use thereof
HU205147B (en) * 1989-06-29 1992-03-30 Sandoz Ag Process for producing muramyl dipeptide derivative and pharmaceutical compostions comprising same

Also Published As

Publication number Publication date
AU8684991A (en) 1992-05-07
NO914233D0 (no) 1991-10-29
MX9101820A (es) 1992-06-05
FI915089A7 (fi) 1992-05-01
CN1062146A (zh) 1992-06-24
CA2054228A1 (en) 1992-05-01
KR920008064A (ko) 1992-05-27
RU2074192C1 (ru) 1997-02-27
EP0487909A2 (en) 1992-06-03
IE913765A1 (en) 1992-05-22
AU642048B2 (en) 1993-10-07
HUT62199A (en) 1993-04-28
IL99851A (en) 1996-06-18
IL99851A0 (en) 1992-08-18
EP0487909A3 (en) 1992-08-12
EP0680974A1 (en) 1995-11-08
TW207545B (forum.php) 1993-06-11
US5292506A (en) 1994-03-08
NZ240369A (en) 1993-09-27
FI915089L (fi) 1992-05-01
FI915089A0 (fi) 1991-10-29
HU913398D0 (en) 1992-01-28

Similar Documents

Publication Publication Date Title
RU2074192C1 (ru) Мурамилдипептидные производные, противогриппозная вакцина
US5100591A (en) Process for preparing lipid microparticles
US4619794A (en) Spontaneous preparation of small unilamellar liposomes
KR940001373B1 (ko) 인플루엔자 백신의 제조방법
PT1991266E (pt) Novas composições adjuvantes glicolipídicas
JPH08208486A (ja) スタウロスポリン誘導体の静脈内投与のための医薬組成物
JPH0378371B2 (forum.php)
CA2131442A1 (en) Oral vaccine
Sunamoto et al. Synthesis and characterization of 1, 2-dimyristoylamido-1, 2-deoxyphosphatidylcholine as an artificial boundary lipid
EP0004512A1 (fr) Composés esters de muramyl-peptide et leurs applications dans les compositions pharmaceutiques et réactifs de laboratoire
BRPI0512757B1 (pt) Método de estabilização de lipossomos catiônicos em formulações aquosas, produto de lipossomo, adjuvante de vacina, vacina contra clamídia, malária ou tuberculose e sistema de distribuição
JP2011102321A (ja) 配糖体含有リポソーム
USRE35706E (en) Lipophila derivatives of muramylpeptides having properties of activating macrophages and compositions containing them
GB1564500A (en) Biological preparations
EL‐HARIRI et al. The mitigating effects of phosphatidylcholines on bile salt‐and lysophosphatidylcholine‐induced membrane damage
AU2016273638B2 (en) Adjuvant composition containing aluminum and vaccine composition containing the same
JP3498339B2 (ja) リン脂質誘導体
CA1283359C (en) Compositions of neocarzinostatin derivative for non-injection administration
JPH05229960A (ja) 新規インフルエンザワクチン
JP2004532068A (ja) リン脂質製剤の安定化および最終滅菌
RU2825571C1 (ru) Липидное соединение и композиция на его основе
JP5004464B2 (ja) 糖鎖修飾リポソーム
JP3539739B2 (ja) 新規ムラミルジペプチド誘導体
PT98321A (pt) Processo para a preparacao de uma dispersao de lipossomas injectavel
WO2025146125A1 (zh) 用于递送的脂质化合物和脂质纳米颗粒

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920512

FC3A Refusal

Effective date: 19990119