PT95111A - Processo para a preparacao de proteinas de fusao - Google Patents
Processo para a preparacao de proteinas de fusaoInfo
- Publication number
- PT95111A PT95111A PT95111A PT9511190A PT95111A PT 95111 A PT95111 A PT 95111A PT 95111 A PT95111 A PT 95111A PT 9511190 A PT9511190 A PT 9511190A PT 95111 A PT95111 A PT 95111A
- Authority
- PT
- Portugal
- Prior art keywords
- proteins
- manner
- fuseo
- preparation
- fusion protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39987489A | 1989-08-29 | 1989-08-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT95111A true PT95111A (pt) | 1991-05-22 |
| PT95111B PT95111B (pt) | 1998-10-30 |
Family
ID=23581315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95111A PT95111B (pt) | 1989-08-29 | 1990-08-28 | Processo para a preparacao de proteinas de fusao |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0489780B1 (pt) |
| JP (1) | JP3043803B2 (pt) |
| KR (1) | KR0159786B1 (pt) |
| AT (1) | ATE173018T1 (pt) |
| AU (1) | AU638277B2 (pt) |
| CA (1) | CA2065146C (pt) |
| CY (1) | CY2168B1 (pt) |
| DE (1) | DE69032743T2 (pt) |
| DK (1) | DK0489780T3 (pt) |
| ES (1) | ES2124216T3 (pt) |
| FI (1) | FI113183B (pt) |
| GR (1) | GR1005153B (pt) |
| HK (1) | HK1012026A1 (pt) |
| HU (1) | HU216069B (pt) |
| IE (1) | IE903120A1 (pt) |
| IL (1) | IL95495A (pt) |
| NO (1) | NO308667B1 (pt) |
| PT (1) | PT95111B (pt) |
| WO (1) | WO1991003550A1 (pt) |
| ZA (1) | ZA906839B (pt) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5426036A (en) * | 1987-05-05 | 1995-06-20 | Hoechst Aktiengesellschaft | Processes for the preparation of foreign proteins in streptomycetes |
| DK0600372T3 (da) | 1992-12-02 | 1997-08-11 | Hoechst Ag | Fremgangsmåde til fremstilling af proinsulin med korrekt forbundne cystinbroer. |
| DE59409816D1 (de) * | 1993-04-27 | 2001-09-13 | Hoechst Ag | Amorphe monosphärische Formen von Insulinderivaten |
| WO1995009914A1 (fr) * | 1993-10-05 | 1995-04-13 | Asahi Glass Company Ltd. | Vecteur de multiclonage, vecteur d'expression, et production d'une proteine exogene au moyen dudit vecteur d'expression |
| US6001604A (en) * | 1993-12-29 | 1999-12-14 | Bio-Technology General Corp. | Refolding of proinsulins without addition of reducing agents |
| DE4405179A1 (de) * | 1994-02-18 | 1995-08-24 | Hoechst Ag | Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken |
| US5683987A (en) * | 1994-07-12 | 1997-11-04 | The Board Of Regents Of The University Of Nebraska | Therapeutic oligonucleotides targeting the human MDR1 and MRP genes |
| DE59711533D1 (de) | 1996-07-26 | 2004-05-27 | Aventis Pharma Gmbh | Insulinderivate mit erhöhter Zinkbindung |
| DE19735711C2 (de) | 1997-08-18 | 2001-04-26 | Aventis Pharma Gmbh | Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken |
| DE19825447A1 (de) | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
| DE19915938A1 (de) | 1999-04-09 | 2000-10-19 | Aventis Pharma Gmbh | Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung |
| DE19930676B4 (de) | 1999-07-02 | 2006-01-19 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln |
| US7638618B2 (en) | 2001-02-20 | 2009-12-29 | Sanofi-Aventis Deutschland Gmbh | Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest |
| US7202059B2 (en) | 2001-02-20 | 2007-04-10 | Sanofi-Aventis Deutschland Gmbh | Fusion proteins capable of being secreted into a fermentation medium |
| DE10235168A1 (de) * | 2002-08-01 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Verfahren zur Reinigung von Preproinsulin |
| AU2003280870A1 (en) * | 2002-11-12 | 2004-06-03 | Ckd Bio Corp. | Plasmids expressing human insulin and the preparation method for human insuling thereby |
| DE102008025007A1 (de) | 2008-05-24 | 2009-11-26 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| AU2009203810B2 (en) | 2008-01-09 | 2013-07-25 | Sanofi-Aventis Deutschland Gmbh | Novel insulin derivatives having an extremely delayed time-action profile |
| AU2009203809B2 (en) | 2008-01-09 | 2013-07-25 | Sanofi-Aventis Deutschland Gmbh | Novel insulin derivatives having an extremely delayed time-action profile |
| DE102008003568A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| DE102008025008A1 (de) | 2008-05-24 | 2009-11-26 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| DE102008003566A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| EP3228320B1 (de) | 2008-10-17 | 2019-12-18 | Sanofi-Aventis Deutschland GmbH | Kombination von einem insulin und einem glp-1-agonisten |
| UY33025A (es) | 2009-11-13 | 2011-06-30 | Sanofi Aventis Deustschland Gmbh | Composicion farmaceutica que comprende un agonista de glp-1 metionina |
| AR080669A1 (es) | 2009-11-13 | 2012-05-02 | Sanofi Aventis Deutschland | Composicion farmaceutica que comprende un agonista de glp-1, una insulina y metionina |
| MX339614B (es) | 2010-08-30 | 2016-06-02 | Sanofi - Aventis Deutschland GmbH | Uso de ave0010 para la fabricacion de un medicamento para el tratamiento de la diabetes mellitus tipo 2. |
| DK2739646T3 (en) | 2011-05-10 | 2018-02-26 | Stefan Hermann | COMPREHENSIVE BUFFER SYSTEM FOR RENATURING HUMAN PROINSULIN OR PROINSULIN DERIVATIVES |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| RU2650616C2 (ru) | 2011-08-29 | 2018-04-16 | Санофи-Авентис Дойчланд Гмбх | Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| JP5858945B2 (ja) | 2012-03-15 | 2016-02-10 | アークレイ株式会社 | 酵素を用いた測定方法 |
| CN107206058A (zh) | 2014-12-12 | 2017-09-26 | 赛诺菲-安万特德国有限公司 | 甘精胰岛素/利西拉来固定比率配制剂 |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| EP3927825A4 (en) * | 2019-02-19 | 2023-05-31 | The Trustees of Princeton University | SYSTEM AND METHODS FOR LIGHT-REGULATED OLIGOMERIZATION AND PHASE SEPARATION OF FOLDED DOMAINS AND PROTEIN DOMAINS ASSOCIATED WITH RNA GRANULATION |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4366246A (en) * | 1977-11-08 | 1982-12-28 | Genentech, Inc. | Method for microbial polypeptide expression |
| US4431739A (en) * | 1979-11-05 | 1984-02-14 | Genentech, Inc. | Transformant bacterial culture capable of expressing heterologous protein |
| US4769326A (en) * | 1980-02-29 | 1988-09-06 | The Regents Of The University Of California | Expression linkers |
| US4652639A (en) * | 1982-05-06 | 1987-03-24 | Amgen | Manufacture and expression of structural genes |
| JPS61264000A (ja) * | 1985-03-21 | 1986-11-21 | イミユネツクス コ−ポレイシヨン | 標識ペプチドによるタンパク質の合成 |
| DE3526995A1 (de) * | 1985-07-27 | 1987-02-05 | Hoechst Ag | Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung |
-
1990
- 1990-08-27 IL IL9549590A patent/IL95495A/en active IP Right Grant
- 1990-08-27 GR GR900100635A patent/GR1005153B/el not_active IP Right Cessation
- 1990-08-28 DE DE69032743T patent/DE69032743T2/de not_active Expired - Lifetime
- 1990-08-28 AU AU62872/90A patent/AU638277B2/en not_active Expired
- 1990-08-28 AT AT90912715T patent/ATE173018T1/de not_active IP Right Cessation
- 1990-08-28 IE IE312090A patent/IE903120A1/en not_active IP Right Cessation
- 1990-08-28 WO PCT/US1990/004840 patent/WO1991003550A1/en active IP Right Grant
- 1990-08-28 PT PT95111A patent/PT95111B/pt not_active IP Right Cessation
- 1990-08-28 EP EP90912715A patent/EP0489780B1/en not_active Expired - Lifetime
- 1990-08-28 KR KR1019920700456A patent/KR0159786B1/ko not_active IP Right Cessation
- 1990-08-28 CA CA002065146A patent/CA2065146C/en not_active Expired - Lifetime
- 1990-08-28 DK DK90912715T patent/DK0489780T3/da active
- 1990-08-28 ES ES90912715T patent/ES2124216T3/es not_active Expired - Lifetime
- 1990-08-28 HU HUP9200674A patent/HU216069B/hu unknown
- 1990-08-28 JP JP2512297A patent/JP3043803B2/ja not_active Expired - Lifetime
- 1990-09-28 ZA ZA906839A patent/ZA906839B/xx unknown
-
1992
- 1992-02-27 NO NO920774A patent/NO308667B1/no not_active IP Right Cessation
- 1992-02-28 FI FI920923A patent/FI113183B/fi active
-
1998
- 1998-12-11 HK HK98113231A patent/HK1012026A1/xx not_active IP Right Cessation
-
2000
- 2000-05-03 CY CY0000013A patent/CY2168B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05501799A (ja) | 1993-04-08 |
| DE69032743D1 (de) | 1998-12-10 |
| HU9200674D0 (en) | 1992-08-28 |
| AU638277B2 (en) | 1993-06-24 |
| GR1005153B (el) | 2006-03-13 |
| GR900100635A (el) | 1991-12-30 |
| ZA906839B (en) | 1991-06-26 |
| DK0489780T3 (da) | 1999-07-19 |
| ES2124216T3 (es) | 1999-02-01 |
| IE903120A1 (en) | 1991-03-13 |
| HU216069B (hu) | 1999-04-28 |
| CY2168B1 (en) | 2002-08-23 |
| DE69032743T2 (de) | 1999-06-17 |
| EP0489780B1 (en) | 1998-11-04 |
| JP3043803B2 (ja) | 2000-05-22 |
| IL95495A (en) | 1996-10-16 |
| HK1012026A1 (en) | 1999-07-23 |
| EP0489780A4 (en) | 1992-08-12 |
| NO920774L (no) | 1992-04-28 |
| HUT60327A (en) | 1992-08-28 |
| CA2065146A1 (en) | 1991-03-01 |
| WO1991003550A1 (en) | 1991-03-21 |
| NO920774D0 (no) | 1992-02-27 |
| ATE173018T1 (de) | 1998-11-15 |
| KR0159786B1 (ko) | 1998-11-16 |
| EP0489780A1 (en) | 1992-06-17 |
| FI920923A0 (fi) | 1992-02-28 |
| FI113183B (fi) | 2004-03-15 |
| CA2065146C (en) | 2002-07-23 |
| AU6287290A (en) | 1991-04-08 |
| PT95111B (pt) | 1998-10-30 |
| NO308667B1 (no) | 2000-10-09 |
| IL95495A0 (en) | 1991-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19901207 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19980709 |
|
| PC3A | Transfer or assignment |
Free format text: 20010322 AVENTIS PHARMA DEUTSCHLAND GMBH DE |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20130709 |