RU93045577A - Слитные полипептиды - Google Patents
Слитные полипептидыInfo
- Publication number
- RU93045577A RU93045577A RU93045577/04A RU93045577A RU93045577A RU 93045577 A RU93045577 A RU 93045577A RU 93045577/04 A RU93045577/04 A RU 93045577/04A RU 93045577 A RU93045577 A RU 93045577A RU 93045577 A RU93045577 A RU 93045577A
- Authority
- RU
- Russia
- Prior art keywords
- protein
- terminus
- fragment
- dpp
- extension
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 102000037240 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 101700062901 DPP Proteins 0.000 claims 1
- 102100012353 DPP4 Human genes 0.000 claims 1
- 101700039720 DPP4 Proteins 0.000 claims 1
- 102000007079 Peptide Fragments Human genes 0.000 claims 1
- 108010033276 Peptide Fragments Proteins 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Claims (1)
- Описан слитой белок, не встречающийся в природе, и содержащий удлиняющий пептидный фрагмент, который своим С-концом ковалентно связан с N-концом биологически активного фрагмента белка. Указанный удлиняющий фрагмент белка может быть удален посредством DPP IV-расщепления. Раскрывается также использование слитых белков, содержащих DPP IV-отщепляемые удлиняющие пептидные фрагменты, для изготовления лекарственных препаратов. Предлагается также способ выделения нужных белков из смеси, содержащей указанный слитой белок.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62672790A | 1990-12-13 | 1990-12-13 | |
| US07/626727 | 1990-12-13 | ||
| US07/626,727 | 1990-12-13 | ||
| PCT/US1991/009152 WO1992010576A1 (en) | 1990-12-13 | 1991-12-12 | Fusion polypeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93045577A true RU93045577A (ru) | 1996-02-27 |
| RU2114119C1 RU2114119C1 (ru) | 1998-06-27 |
Family
ID=24511577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93045577A RU2114119C1 (ru) | 1990-12-13 | 1991-12-12 | Слитой белок и способ выделения слитого белка |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0561971A1 (ru) |
| JP (1) | JPH06503473A (ru) |
| AU (1) | AU662508B2 (ru) |
| CA (1) | CA2094512A1 (ru) |
| CZ (1) | CZ109393A3 (ru) |
| FI (1) | FI932680A0 (ru) |
| HU (1) | HUT69963A (ru) |
| IE (1) | IE914347A1 (ru) |
| NO (1) | NO932148L (ru) |
| RU (1) | RU2114119C1 (ru) |
| SK (1) | SK60893A3 (ru) |
| TW (1) | TW213923B (ru) |
| WO (1) | WO1992010576A1 (ru) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050272652A1 (en) | 1999-03-29 | 2005-12-08 | Gault Victor A | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
| US6759393B1 (en) | 1999-04-12 | 2004-07-06 | Pfizer Inc. | Growth hormone and growth hormone releasing hormone compositions |
| CA2303702A1 (en) * | 1999-04-12 | 2000-10-12 | Pfizer Products Inc. | Growth hormone and growth hormone releasing hormone compositions |
| JP2003514532A (ja) * | 1999-11-19 | 2003-04-22 | トランスカーヨティック セラピーズ インコーポレイテッド | 生成物の産生量を最適化するための核酸構築体 |
| EP1205551A1 (en) * | 2000-11-09 | 2002-05-15 | Pfizer Products Inc. | Growth hormone and growth hormone releasing hormone compositions |
| JP4865565B2 (ja) | 2003-12-09 | 2012-02-01 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１アゴニストを用いた食物選択の制御 |
| EP2316446A1 (en) | 2004-06-11 | 2011-05-04 | Novo Nordisk A/S | Counteracting drug-induced obesity using GLP-1 agonists |
| US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| WO2006086769A2 (en) | 2005-02-11 | 2006-08-17 | Amylin Pharmaceuticals, Inc. | Gip analog and hybrid polypeptides with selectable properties |
| US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| EP1996220B2 (en) † | 2006-03-06 | 2023-08-16 | Amunix Operating Inc. | Unstructured recombinant polymers and uses thereof |
| US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
| DK2393828T3 (en) | 2009-02-03 | 2017-01-23 | Amunix Operating Inc | Extended recombinant polypeptides and compositions comprising same |
| US20120263701A1 (en) | 2009-08-24 | 2012-10-18 | Volker Schellenberger | Coagulation factor vii compositions and methods of making and using same |
| EP2573103B1 (en) * | 2010-01-29 | 2017-07-05 | Archer-Daniels-Midland Company | Peptide domains that bind small molecules of industrial significance |
| US10370430B2 (en) | 2012-02-15 | 2019-08-06 | Bioverativ Therapeutics Inc. | Recombinant factor VIII proteins |
| SG11201404885RA (en) | 2012-02-15 | 2014-09-26 | Amunix Operating Inc | Factor viii compositions and methods of making and using same |
| US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
| AU2016301303B2 (en) | 2015-08-03 | 2021-10-07 | Bioverativ Therapeutics Inc. | Factor IX fusion proteins and methods of making and using same |
| CN111051338A (zh) * | 2017-06-29 | 2020-04-21 | 乌雷卡有限公司 | 具有改进的药物学性能的前药肽 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4703004A (en) * | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
| US4569794A (en) * | 1984-12-05 | 1986-02-11 | Eli Lilly And Company | Process for purifying proteins and compounds useful in such process |
| CA1340522C (en) * | 1987-03-10 | 1999-05-04 | Heinz Dobeli | Fusion proteins containing neighbouring histidines for improved purification |
| DE69014115T2 (de) * | 1989-06-16 | 1995-05-24 | Upjohn Co | Stabilisierte, starke grf-analoga. |
| DK0527778T3 (da) * | 1990-04-09 | 1996-10-21 | Upjohn Co | Forbedret fremgangsmåde til rensning af rekombinante proteiner og forbindelser, som er anvendelige ved en sådan fremgangsmåde |
-
1991
- 1991-12-12 AU AU91165/91A patent/AU662508B2/en not_active Ceased
- 1991-12-12 RU RU93045577A patent/RU2114119C1/ru active
- 1991-12-12 CA CA002094512A patent/CA2094512A1/en not_active Abandoned
- 1991-12-12 EP EP92901817A patent/EP0561971A1/en not_active Withdrawn
- 1991-12-12 HU HU9301705A patent/HUT69963A/hu unknown
- 1991-12-12 WO PCT/US1991/009152 patent/WO1992010576A1/en not_active Application Discontinuation
- 1991-12-12 JP JP4501996A patent/JPH06503473A/ja active Pending
- 1991-12-12 CZ CS931093A patent/CZ109393A3/cs unknown
- 1991-12-12 SK SK60893A patent/SK60893A3/sk unknown
- 1991-12-13 IE IE434791A patent/IE914347A1/en not_active Application Discontinuation
- 1991-12-17 TW TW080109839A patent/TW213923B/zh active
-
1993
- 1993-06-11 NO NO93932148A patent/NO932148L/no unknown
- 1993-06-11 FI FI932680A patent/FI932680A0/fi not_active Application Discontinuation
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