PT88530A - Procede de synthese d'alpha amino acides n alkyles et de leurs esters application a la synthese de carboxyalkyl dipeptides - Google Patents

Procede de synthese d'alpha amino acides n alkyles et de leurs esters application a la synthese de carboxyalkyl dipeptides

Info

Publication number
PT88530A
PT88530A PT88530A PT8853088A PT88530A PT 88530 A PT88530 A PT 88530A PT 88530 A PT88530 A PT 88530A PT 8853088 A PT8853088 A PT 8853088A PT 88530 A PT88530 A PT 88530A
Authority
PT
Portugal
Prior art keywords
synthese
alkyles
procede
alpha amino
carboxyalkyl dipeptides
Prior art date
Application number
PT88530A
Other languages
English (en)
Other versions
PT88530B (pt
Inventor
Michel Vincent
Jean Baliarda
Bernard Marchand
Georges Remond
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of PT88530A publication Critical patent/PT88530A/pt
Publication of PT88530B publication Critical patent/PT88530B/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30Preparation of optical isomers
    • C07C227/32Preparation of optical isomers by stereospecific synthesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
PT88530A 1987-09-17 1988-09-16 Processo para a sintese de alfa-aminoacidos n-alquilados e dos seus esteres e sua aplicacao para a sintese de carboxialquil-dipeotidos PT88530B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8712902A FR2620700B1 (fr) 1987-09-17 1987-09-17 Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides

Publications (2)

Publication Number Publication Date
PT88530A true PT88530A (pt) 1988-10-01
PT88530B PT88530B (pt) 1992-11-30

Family

ID=9354994

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88530A PT88530B (pt) 1987-09-17 1988-09-16 Processo para a sintese de alfa-aminoacidos n-alquilados e dos seus esteres e sua aplicacao para a sintese de carboxialquil-dipeotidos

Country Status (16)

Country Link
EP (1) EP0309324B1 (pt)
JP (2) JPH0725723B2 (pt)
AT (1) ATE61567T1 (pt)
AU (1) AU607260B2 (pt)
CA (1) CA1341380C (pt)
DE (1) DE3862006D1 (pt)
DK (1) DK173730B1 (pt)
ES (1) ES2034324T3 (pt)
FR (1) FR2620700B1 (pt)
GR (1) GR3001874T3 (pt)
HK (1) HK55196A (pt)
IE (1) IE60995B1 (pt)
NZ (1) NZ226222A (pt)
OA (1) OA08941A (pt)
PT (1) PT88530B (pt)
ZA (1) ZA886933B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
DE19804100C1 (de) 1998-02-03 1999-05-12 Daimler Chrysler Ag Fahrzeugsitz
JP3892963B2 (ja) * 1998-03-17 2007-03-14 住友化学株式会社 L−バリンベンジルエステルp−トルエンスルホン酸塩の製造方法
US6706916B1 (en) 1999-02-23 2004-03-16 Toray Fine Chemicals Co., Ltd. Optically active amino acid derivatives and processes for the preparation of the same
JP2000247934A (ja) * 1999-02-23 2000-09-12 Toray Ind Inc 高光学純度アミノ酸ベンジルエステルの製造法
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
AR036187A1 (es) * 2001-07-24 2004-08-18 Adir Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario
US7521566B2 (en) 2003-02-28 2009-04-21 Les Laboratoires Servier Process for preparation of perindopril and salts thereof
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
JP4929938B2 (ja) 2006-09-12 2012-05-09 住友化学株式会社 光学活性なα−アミノ酸ベンジルエステル類の製造方法
JP5785045B2 (ja) * 2011-10-06 2015-09-24 エヌ・イーケムキャット株式会社 選択的脱ベンジル化方法およびこれに用いる選択水素化触媒
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4296110A (en) * 1980-10-28 1981-10-20 E. I. Du Pont De Nemours And Company Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
JPS6058233B2 (ja) * 1982-05-24 1985-12-19 田辺製薬株式会社 2−オキソイミダゾリジン誘導体及びその製法
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese

Also Published As

Publication number Publication date
JPH07206792A (ja) 1995-08-08
EP0309324B1 (fr) 1991-03-13
EP0309324A1 (fr) 1989-03-29
DE3862006D1 (de) 1991-04-18
HK55196A (en) 1996-04-03
CA1341380C (fr) 2002-08-06
JP2524489B2 (ja) 1996-08-14
DK515288D0 (da) 1988-09-15
AU2235688A (en) 1989-03-23
FR2620700B1 (fr) 1990-06-01
JPH01110651A (ja) 1989-04-27
PT88530B (pt) 1992-11-30
FR2620700A1 (fr) 1989-03-24
IE882807L (en) 1989-03-17
ES2034324T3 (es) 1993-04-01
ZA886933B (en) 1989-05-30
JPH0725723B2 (ja) 1995-03-22
OA08941A (fr) 1989-10-31
IE60995B1 (en) 1994-09-07
GR3001874T3 (en) 1992-11-23
DK515288A (da) 1989-03-18
DK173730B1 (da) 2001-08-06
ATE61567T1 (de) 1991-03-15
NZ226222A (en) 1990-06-26
AU607260B2 (en) 1991-02-28

Similar Documents

Publication Publication Date Title
PT88530A (pt) Procede de synthese d'alpha amino acides n alkyles et de leurs esters application a la synthese de carboxyalkyl dipeptides
PT780386E (pt) Inibidores de metaloprotease de matriz
KR930000486A (ko) 광학활성 퀴놀린메발론산의 디아스테레오머염
FR2590567B1 (fr) Nouveau procede de synthese de (meth)acrylamide de n-dialkylaminoalkyle
FR2620699B1 (fr) Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
ZA904495B (en) Peptide derivatives,process for preparing them and pharmaceutical compositions containing them
BR9606092A (pt) Derivados de ácido 3-amino-2-mercaptobenzóico e processos para sua preparação
IS3828A (is) Hliðstæð aðferð til tilreiðslu á nýjum afleiðum thiazolidinone og oxazolidinone sem gagnlegar eru til æðaútvíkkunar
LV11030A (lv) Morfolinolsavienojums ta iegusana un pielietosana
DE3867986D1 (de) 1,2,5,6-tetrahydropyridin-3-carboxaldehydoxim-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel und diese enthaltende zusammensetzungen.
AU2522692A (en) Imidazol-1-yl methyl pyridine derivatives, processes for their production and their use as pharmaceuticals
DE68917211D1 (de) N-(5,6,7,8-Tetrahydropyrido(2,3-d)pyrimidin-6-yl-alkanoyl)-glutaminsäure-Derivate.
PT87734A (pt) Procede de preparation de nouveaux tripeptides a structure polycyclique azotee et de compositions pharmaceutiques les contenant
DE69113338T2 (de) Pyranobenzoxadiazolderivate.
ATE86629T1 (de) 4-piperidincarboxamid-derivate.
ATE92461T1 (de) Gegen die zerebrale insuffizienz wirksame verbindungen.
ES2056721A1 (es) Mejoras en el objeto de la patente de invencion n{ 9101355 que se refiere a procedimiento de obtencion de nuevos derivados de platino con aminopirrolidinas.
ATE115132T1 (de) Derivate des 1,2,5,6-tetrahydropyridin-3- caboxaldehydoxims, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
TH13243EX (th) อนุพันธ์ไธอะโซลิดิโนนและออกซาโซลิดิโนนและการเตรียมสารนั้นและการใช้เป็นยาทำให้หลอดเลือดขยายตัว

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920506

PC3A Transfer or assignment

Free format text: 20011105 LES LABORATOIRES SERVIER FR

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20080916