AU2235688A - Process for the synthesis of alpha n alkylated amino acids and esters thereof. application to the synthesis of carboxyalkyl dipeptides. - Google Patents

Process for the synthesis of alpha n alkylated amino acids and esters thereof. application to the synthesis of carboxyalkyl dipeptides.

Info

Publication number
AU2235688A
AU2235688A AU22356/88A AU2235688A AU2235688A AU 2235688 A AU2235688 A AU 2235688A AU 22356/88 A AU22356/88 A AU 22356/88A AU 2235688 A AU2235688 A AU 2235688A AU 2235688 A AU2235688 A AU 2235688A
Authority
AU
Australia
Prior art keywords
synthesis
application
alpha
esters
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU22356/88A
Other versions
AU607260B2 (en
Inventor
Jean Baliarda
Bernard Marchand
Georges Remond
Michel Vincent
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Publication of AU2235688A publication Critical patent/AU2235688A/en
Application granted granted Critical
Publication of AU607260B2 publication Critical patent/AU607260B2/en
Assigned to LES LABORATOIRES SERVIER reassignment LES LABORATOIRES SERVIER Alteration of Name(s) in Register under S187 Assignors: ADIR ET COMPAGNIE
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Process for industrial synthesis of the derivative of formula (I): <IMAGE> and their addition salts with an inorganic or organic acid or base, in which: R1 is linear or branched lower alkyl (of 1 to 6 carbon atoms), R2 is hydrogen or a linear or branched lower alkyl group (of 1 to 4 carbon atoms). Application to the industrial synthesis of carboxyalkyl dipeptides.
AU22356/88A 1987-09-17 1988-09-16 Process for the synthesis of alpha n alkylated amino acids and esters thereof. application to the synthesis of carboxyalkyl dipeptides. Expired AU607260B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8712902 1987-09-17
FR8712902A FR2620700B1 (en) 1987-09-17 1987-09-17 PROCESS FOR THE SYNTHESIS OF ALPHA AMINO ACIDS N ALKYLS AND THEIR ESTERS. APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES

Publications (2)

Publication Number Publication Date
AU2235688A true AU2235688A (en) 1989-03-23
AU607260B2 AU607260B2 (en) 1991-02-28

Family

ID=9354994

Family Applications (1)

Application Number Title Priority Date Filing Date
AU22356/88A Expired AU607260B2 (en) 1987-09-17 1988-09-16 Process for the synthesis of alpha n alkylated amino acids and esters thereof. application to the synthesis of carboxyalkyl dipeptides.

Country Status (16)

Country Link
EP (1) EP0309324B1 (en)
JP (2) JPH0725723B2 (en)
AT (1) ATE61567T1 (en)
AU (1) AU607260B2 (en)
CA (1) CA1341380C (en)
DE (1) DE3862006D1 (en)
DK (1) DK173730B1 (en)
ES (1) ES2034324T3 (en)
FR (1) FR2620700B1 (en)
GR (1) GR3001874T3 (en)
HK (1) HK55196A (en)
IE (1) IE60995B1 (en)
NZ (1) NZ226222A (en)
OA (1) OA08941A (en)
PT (1) PT88530B (en)
ZA (1) ZA886933B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU606992B2 (en) * 1987-09-17 1991-02-21 Les Laboratoires Servier Process for the synthesis of alpha n alkylated amino acids and esters thereof. application to the synthesis of carboxyalkyl dipeptides.

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19804100C1 (en) 1998-02-03 1999-05-12 Daimler Chrysler Ag Automobile seat with incorporated ventilation
JP3892963B2 (en) * 1998-03-17 2007-03-14 住友化学株式会社 Method for producing L-valine benzyl ester p-toluenesulfonate
JP2000247934A (en) * 1999-02-23 2000-09-12 Toray Ind Inc Production of amino acid benzyl ester having high optical purity
US6706916B1 (en) 1999-02-23 2004-03-16 Toray Fine Chemicals Co., Ltd. Optically active amino acid derivatives and processes for the preparation of the same
FR2807431B1 (en) * 2000-04-06 2002-07-19 Adir NOVEL PROCESS FOR THE SYNTHESIS OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
FR2807430B1 (en) * 2000-04-11 2002-05-17 Adir NOVEL PROCESS FOR THE SYNTHESIS OF N - [(S) -1- CARBOXYBUTYL] - (S) -ALANINE ESTERS AND APPLICATION TO THE SYNTHESIS OF PERINDOPRIL
AR036187A1 (en) * 2001-07-24 2004-08-18 Adir A PROCESS FOR THE PREPARATION OF PERINDOPRIL, ANALOG COMPOUNDS AND ITS SALTS, INTERMEDIARY COMPOUND 2,5-DIOXO-OXAZOLIDINE AND PROCESS TO PREPARE A INTERMEDIARY
DK1603558T3 (en) 2003-02-28 2008-09-01 Servier S A Lab Process for the preparation of perindopril and its salts
SI21800A (en) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto New procedure of synthesis of perindopril
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
JP4929938B2 (en) 2006-09-12 2012-05-09 住友化学株式会社 Process for producing optically active α-amino acid benzyl esters
JP5785045B2 (en) * 2011-10-06 2015-09-24 エヌ・イーケムキャット株式会社 Selective debenzylation method and selective hydrogenation catalyst used therefor
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (en) * 1980-10-02 1982-10-08 Science Union & Cie NOVEL SUBSTITUTED IMINO DIACIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4296110A (en) * 1980-10-28 1981-10-20 E. I. Du Pont De Nemours And Company Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
JPS6058233B2 (en) * 1982-05-24 1985-12-19 田辺製薬株式会社 2-oxoimidazolidine derivative and its production method
FR2620709B1 (en) * 1987-09-17 1990-09-07 Adir PROCESS FOR THE INDUSTRIAL SYNTHESIS OF PERINDOPRIL AND ITS MAIN INTERMEDIATE SYNTHESIS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU606992B2 (en) * 1987-09-17 1991-02-21 Les Laboratoires Servier Process for the synthesis of alpha n alkylated amino acids and esters thereof. application to the synthesis of carboxyalkyl dipeptides.

Also Published As

Publication number Publication date
ZA886933B (en) 1989-05-30
NZ226222A (en) 1990-06-26
IE60995B1 (en) 1994-09-07
FR2620700A1 (en) 1989-03-24
EP0309324A1 (en) 1989-03-29
AU607260B2 (en) 1991-02-28
HK55196A (en) 1996-04-03
JPH0725723B2 (en) 1995-03-22
DK515288A (en) 1989-03-18
DK173730B1 (en) 2001-08-06
DK515288D0 (en) 1988-09-15
IE882807L (en) 1989-03-17
CA1341380C (en) 2002-08-06
JP2524489B2 (en) 1996-08-14
GR3001874T3 (en) 1992-11-23
ES2034324T3 (en) 1993-04-01
EP0309324B1 (en) 1991-03-13
PT88530B (en) 1992-11-30
JPH01110651A (en) 1989-04-27
DE3862006D1 (en) 1991-04-18
ATE61567T1 (en) 1991-03-15
JPH07206792A (en) 1995-08-08
PT88530A (en) 1988-10-01
OA08941A (en) 1989-10-31
FR2620700B1 (en) 1990-06-01

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Legal Events

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PC Assignment registered

Owner name: LES LABORATOIRES SERVIER

Free format text: FORMER OWNER WAS: ADIR ET CIE