ATE61567T1 - Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern, verwendung zur synthese von carboxyalkyldipeptiden. - Google Patents
Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern, verwendung zur synthese von carboxyalkyldipeptiden.Info
- Publication number
- ATE61567T1 ATE61567T1 AT88402340T AT88402340T ATE61567T1 AT E61567 T1 ATE61567 T1 AT E61567T1 AT 88402340 T AT88402340 T AT 88402340T AT 88402340 T AT88402340 T AT 88402340T AT E61567 T1 ATE61567 T1 AT E61567T1
- Authority
- AT
- Austria
- Prior art keywords
- synthesis
- carboxyal
- dipeptide
- esters
- preparation
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
- 108010016626 Dipeptides Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8712902A FR2620700B1 (fr) | 1987-09-17 | 1987-09-17 | Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides |
| EP19880402340 EP0309324B1 (de) | 1987-09-17 | 1988-09-16 | Verfahren zur Herstellung von N-alkylierten Aminosäuren und deren Estern, Verwendung zur Synthese von Carboxyalkyldipeptiden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE61567T1 true ATE61567T1 (de) | 1991-03-15 |
Family
ID=9354994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88402340T ATE61567T1 (de) | 1987-09-17 | 1988-09-16 | Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern, verwendung zur synthese von carboxyalkyldipeptiden. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0309324B1 (de) |
| JP (2) | JPH0725723B2 (de) |
| AT (1) | ATE61567T1 (de) |
| AU (1) | AU607260B2 (de) |
| CA (1) | CA1341380C (de) |
| DE (1) | DE3862006D1 (de) |
| DK (1) | DK173730B1 (de) |
| ES (1) | ES2034324T3 (de) |
| FR (1) | FR2620700B1 (de) |
| GR (1) | GR3001874T3 (de) |
| HK (1) | HK55196A (de) |
| IE (1) | IE60995B1 (de) |
| NZ (1) | NZ226222A (de) |
| OA (1) | OA08941A (de) |
| PT (1) | PT88530B (de) |
| ZA (1) | ZA886933B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2620699B1 (fr) * | 1987-09-17 | 1990-06-01 | Adir | Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides |
| DE19804100C1 (de) | 1998-02-03 | 1999-05-12 | Daimler Chrysler Ag | Fahrzeugsitz |
| JP3892963B2 (ja) * | 1998-03-17 | 2007-03-14 | 住友化学株式会社 | Ｌ−バリンベンジルエステルｐ−トルエンスルホン酸塩の製造方法 |
| JP2000247934A (ja) * | 1999-02-23 | 2000-09-12 | Toray Ind Inc | 高光学純度アミノ酸ベンジルエステルの製造法 |
| US6706916B1 (en) | 1999-02-23 | 2004-03-16 | Toray Fine Chemicals Co., Ltd. | Optically active amino acid derivatives and processes for the preparation of the same |
| FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| FR2807430B1 (fr) * | 2000-04-11 | 2002-05-17 | Adir | Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril |
| AR036187A1 (es) * | 2001-07-24 | 2004-08-18 | Adir | Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario |
| ATE395913T1 (de) | 2003-02-28 | 2008-06-15 | Servier S A Lab | Verfahren zur herstellung von perindopril |
| SI21800A (sl) | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| EP1792896A1 (de) | 2005-12-01 | 2007-06-06 | KRKA, tovarna zdravil, d.d., Novo mesto | Verfahren zur Herstellung von Perindopril und deren Salze |
| JP4929938B2 (ja) | 2006-09-12 | 2012-05-09 | 住友化学株式会社 | 光学活性なα−アミノ酸ベンジルエステル類の製造方法 |
| JP5785045B2 (ja) * | 2011-10-06 | 2015-09-24 | エヌ・イーケムキャット株式会社 | 選択的脱ベンジル化方法およびこれに用いる選択水素化触媒 |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| US4296110A (en) * | 1980-10-28 | 1981-10-20 | E. I. Du Pont De Nemours And Company | Antihypertensive I-substituted cyclic lactam-2-carboxylic acids |
| JPS6058233B2 (ja) * | 1982-05-24 | 1985-12-19 | 田辺製薬株式会社 | ２−オキソイミダゾリジン誘導体及びその製法 |
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
-
1987
- 1987-09-17 FR FR8712902A patent/FR2620700B1/fr not_active Expired - Lifetime
-
1988
- 1988-09-07 CA CA000577079A patent/CA1341380C/fr not_active Expired - Fee Related
- 1988-09-15 DK DK198805152A patent/DK173730B1/da active IP Right Grant
- 1988-09-16 OA OA59436A patent/OA08941A/xx unknown
- 1988-09-16 DE DE8888402340T patent/DE3862006D1/de not_active Expired - Lifetime
- 1988-09-16 PT PT88530A patent/PT88530B/pt not_active IP Right Cessation
- 1988-09-16 JP JP63232122A patent/JPH0725723B2/ja not_active Expired - Lifetime
- 1988-09-16 ZA ZA886933A patent/ZA886933B/xx unknown
- 1988-09-16 AT AT88402340T patent/ATE61567T1/de not_active IP Right Cessation
- 1988-09-16 NZ NZ226222A patent/NZ226222A/xx unknown
- 1988-09-16 IE IE280788A patent/IE60995B1/en not_active IP Right Cessation
- 1988-09-16 AU AU22356/88A patent/AU607260B2/en not_active Expired
- 1988-09-16 ES ES198888402340T patent/ES2034324T3/es not_active Expired - Lifetime
- 1988-09-16 EP EP19880402340 patent/EP0309324B1/de not_active Expired - Lifetime
-
1991
- 1991-04-29 GR GR91400546T patent/GR3001874T3/el unknown
-
1994
- 1994-10-05 JP JP6241178A patent/JP2524489B2/ja not_active Expired - Lifetime
-
1996
- 1996-03-28 HK HK55196A patent/HK55196A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK515288D0 (da) | 1988-09-15 |
| PT88530B (pt) | 1992-11-30 |
| DK515288A (da) | 1989-03-18 |
| AU2235688A (en) | 1989-03-23 |
| EP0309324A1 (de) | 1989-03-29 |
| IE60995B1 (en) | 1994-09-07 |
| DE3862006D1 (de) | 1991-04-18 |
| FR2620700A1 (fr) | 1989-03-24 |
| DK173730B1 (da) | 2001-08-06 |
| PT88530A (pt) | 1988-10-01 |
| IE882807L (en) | 1989-03-17 |
| JPH07206792A (ja) | 1995-08-08 |
| FR2620700B1 (fr) | 1990-06-01 |
| CA1341380C (fr) | 2002-08-06 |
| ZA886933B (en) | 1989-05-30 |
| HK55196A (en) | 1996-04-03 |
| GR3001874T3 (en) | 1992-11-23 |
| EP0309324B1 (de) | 1991-03-13 |
| NZ226222A (en) | 1990-06-26 |
| AU607260B2 (en) | 1991-02-28 |
| JPH0725723B2 (ja) | 1995-03-22 |
| ES2034324T3 (es) | 1993-04-01 |
| OA08941A (fr) | 1989-10-31 |
| JP2524489B2 (ja) | 1996-08-14 |
| JPH01110651A (ja) | 1989-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |