PT1603558E - Processo para a preparação de perindopril e dos seus sais - Google Patents
Processo para a preparação de perindopril e dos seus sais Download PDFInfo
- Publication number
- PT1603558E PT1603558E PT03720846T PT03720846T PT1603558E PT 1603558 E PT1603558 E PT 1603558E PT 03720846 T PT03720846 T PT 03720846T PT 03720846 T PT03720846 T PT 03720846T PT 1603558 E PT1603558 E PT 1603558E
- Authority
- PT
- Portugal
- Prior art keywords
- formula
- perindopril
- compound
- preparation
- manufacture
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 9
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title abstract 8
- 229960002582 perindopril Drugs 0.000 title abstract 6
- 150000003839 salts Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 2
- AUVAVXHAOCLQBF-YUMQZZPRSA-N (2s)-2-[[(2s)-1-ethoxy-1-oxopentan-2-yl]azaniumyl]propanoate Chemical compound OC(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC AUVAVXHAOCLQBF-YUMQZZPRSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000007822 coupling agent Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/34—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2003/000042 WO2004075889A1 (en) | 2003-02-28 | 2003-02-28 | Process for preparation of perindopril and salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1603558E true PT1603558E (pt) | 2008-08-19 |
Family
ID=32922925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT03720846T PT1603558E (pt) | 2003-02-28 | 2003-02-28 | Processo para a preparação de perindopril e dos seus sais |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7521566B2 (pt) |
| EP (1) | EP1603558B1 (pt) |
| JP (1) | JP4461027B2 (pt) |
| AT (1) | ATE395913T1 (pt) |
| AU (1) | AU2003224420B2 (pt) |
| CA (1) | CA2517205C (pt) |
| CY (1) | CY1108258T1 (pt) |
| DE (1) | DE60321233D1 (pt) |
| DK (1) | DK1603558T3 (pt) |
| ES (1) | ES2307923T3 (pt) |
| PT (1) | PT1603558E (pt) |
| SI (1) | SI1603558T1 (pt) |
| WO (1) | WO2004075889A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1729739T3 (en) * | 2004-03-29 | 2016-10-31 | Servier Lab | PROCESS FOR THE PREPARATION OF A solid pharmaceutical composition. |
| SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| EP1861367B1 (en) | 2005-03-14 | 2009-07-15 | Les Laboratoires Servier | An improved process for the purification of perindopril |
| US7291745B2 (en) | 2005-03-21 | 2007-11-06 | Glenmark Pharmaceuticals Limited | Process for the preparation of perindopril |
| WO2007004165A2 (en) * | 2005-06-30 | 2007-01-11 | Ranbaxy Laboratories Limited | Process for the preparation of perindopril |
| DK2318365T3 (en) * | 2008-06-24 | 2015-11-23 | Mylan Lab Ltd | NOVEL polymorphic forms of perindopril (L) -arginine AND PROCESS FOR PREPARATION THEREOF |
| FR2935141B1 (fr) * | 2008-08-21 | 2010-10-08 | Sanofi Aventis | Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate |
| GB0910692D0 (en) | 2009-06-20 | 2009-08-05 | Teva Pharma | Compound |
| US20150252001A1 (en) * | 2012-10-10 | 2015-09-10 | Piramal Enterprises Limited | Process for preparation of perindopril intermediate |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
| FR3050380B1 (fr) | 2016-04-20 | 2020-07-10 | Les Laboratoires Servier | Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains. |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4508729A (en) | 1979-12-07 | 1985-04-02 | Adir | Substituted iminodiacids, their preparation and pharmaceutical compositions containing them |
| IN156096B (pt) | 1981-03-19 | 1985-05-11 | Usv Pharma Corp | |
| FR2546886B2 (fr) | 1983-06-06 | 1986-05-16 | Adir | Derives d'acides isoindoledicarboxyliques, leur preparation et compositions pharmaceutiques les contenant |
| FR2620709B1 (fr) | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| FR2620700B1 (fr) | 1987-09-17 | 1990-06-01 | Adir | Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides |
| FR2620699B1 (fr) | 1987-09-17 | 1990-06-01 | Adir | Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides |
| SI9500140A (en) | 1995-04-24 | 1996-10-31 | Genesis Para La Investigacion | Novel n-sulfoxy anhydrides, process for the preparation thereof and its use for the preparation of bioactive substances having ace inhibitory action |
| SI9600169A (en) | 1996-05-22 | 1997-12-31 | Krka Tovarna Zdravil | Process for preparation of compounds with ace inhibitory effect |
| FR2807037B1 (fr) | 2000-03-31 | 2002-05-10 | Adir | NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL |
| FR2807431B1 (fr) | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| FR2807430B1 (fr) | 2000-04-11 | 2002-05-17 | Adir | Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril |
| AR036187A1 (es) | 2001-07-24 | 2004-08-18 | Adir | Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario |
| FR2827860B1 (fr) | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
-
2003
- 2003-02-28 CA CA2517205A patent/CA2517205C/en not_active Expired - Fee Related
- 2003-02-28 AU AU2003224420A patent/AU2003224420B2/en not_active Ceased
- 2003-02-28 US US10/547,243 patent/US7521566B2/en not_active Expired - Fee Related
- 2003-02-28 AT AT03720846T patent/ATE395913T1/de active
- 2003-02-28 PT PT03720846T patent/PT1603558E/pt unknown
- 2003-02-28 JP JP2004568714A patent/JP4461027B2/ja not_active Expired - Fee Related
- 2003-02-28 DE DE60321233T patent/DE60321233D1/de not_active Expired - Lifetime
- 2003-02-28 EP EP03720846A patent/EP1603558B1/en not_active Expired - Lifetime
- 2003-02-28 DK DK03720846T patent/DK1603558T3/da active
- 2003-02-28 SI SI200331316T patent/SI1603558T1/sl unknown
- 2003-02-28 ES ES03720846T patent/ES2307923T3/es not_active Expired - Lifetime
- 2003-02-28 WO PCT/IN2003/000042 patent/WO2004075889A1/en active IP Right Grant
-
2008
- 2008-08-13 CY CY20081100857T patent/CY1108258T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1603558T3 (da) | 2008-09-01 |
| EP1603558B1 (en) | 2008-05-21 |
| EP1603558A1 (en) | 2005-12-14 |
| ATE395913T1 (de) | 2008-06-15 |
| WO2004075889A1 (en) | 2004-09-10 |
| SI1603558T1 (sl) | 2008-12-31 |
| DE60321233D1 (de) | 2008-07-03 |
| US20060276659A1 (en) | 2006-12-07 |
| CA2517205A1 (en) | 2004-09-10 |
| ES2307923T3 (es) | 2008-12-01 |
| JP2006519168A (ja) | 2006-08-24 |
| US7521566B2 (en) | 2009-04-21 |
| AU2003224420A1 (en) | 2004-09-17 |
| CA2517205C (en) | 2010-08-24 |
| AU2003224420B2 (en) | 2009-08-06 |
| JP4461027B2 (ja) | 2010-05-12 |
| CY1108258T1 (el) | 2014-02-12 |
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