CY1108258T1 - Διεργασια για την παρασκευη της περινδοπριλης και των αλατων της - Google Patents

Διεργασια για την παρασκευη της περινδοπριλης και των αλατων της

Info

Publication number
CY1108258T1
CY1108258T1 CY20081100857T CY081100857T CY1108258T1 CY 1108258 T1 CY1108258 T1 CY 1108258T1 CY 20081100857 T CY20081100857 T CY 20081100857T CY 081100857 T CY081100857 T CY 081100857T CY 1108258 T1 CY1108258 T1 CY 1108258T1
Authority
CY
Cyprus
Prior art keywords
perindopril
formula
salts
procedure
preparation
Prior art date
Application number
CY20081100857T
Other languages
English (en)
Inventor
Debashish Datta
Girij Pal Singh
Himanshu Madhav Godbole
Rajinder Singh Siyan
Original Assignee
Les Laboratoires Servier S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier S.A. filed Critical Les Laboratoires Servier S.A.
Publication of CY1108258T1 publication Critical patent/CY1108258T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons

Abstract

Μία διεργασία για την παρασκευή της περινδοπρίλης του τύπου (Π) και των αλάτων της η οποία είναι απλή, ασφαλής, εύκολη και οικονομικά αποδοτική. Η διεργασία περιλαμβάνει την αντίδραση της ένωσης του τύπου (I), όπου το Χ είναι χλώριο ή βρώμιο με την ένωση του τύπου (VII) όπου το Α υποδηλώνει ότι ο έξη μελών δακτύλιος του δικυκλικού συστήματος είναι είτε κορεσμένος είτε ακόρεστος, ακολουθούμενη από την καταλυτική υδρογόνωση για να αποδώσει την περίνδοπρίλη του τύπου (II).
CY20081100857T 2003-02-28 2008-08-13 Διεργασια για την παρασκευη της περινδοπριλης και των αλατων της CY1108258T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IN2003/000042 WO2004075889A1 (en) 2003-02-28 2003-02-28 Process for preparation of perindopril and salts thereof
EP03720846A EP1603558B1 (en) 2003-02-28 2003-02-28 Process for preparation of perindopril and salts thereof

Publications (1)

Publication Number Publication Date
CY1108258T1 true CY1108258T1 (el) 2014-02-12

Family

ID=32922925

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100857T CY1108258T1 (el) 2003-02-28 2008-08-13 Διεργασια για την παρασκευη της περινδοπριλης και των αλατων της

Country Status (13)

Country Link
US (1) US7521566B2 (el)
EP (1) EP1603558B1 (el)
JP (1) JP4461027B2 (el)
AT (1) ATE395913T1 (el)
AU (1) AU2003224420B2 (el)
CA (1) CA2517205C (el)
CY (1) CY1108258T1 (el)
DE (1) DE60321233D1 (el)
DK (1) DK1603558T3 (el)
ES (1) ES2307923T3 (el)
PT (1) PT1603558E (el)
SI (1) SI1603558T1 (el)
WO (1) WO2004075889A1 (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2603856T3 (es) * 2004-03-29 2017-03-01 Les Laboratoires Servier Procedimiento para preparar una composición farmacéutica sólida
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
PT1861367E (pt) 2005-03-14 2009-10-08 Servier Lab Um processo melhorado para a purificação de perindoril
US7291745B2 (en) 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
WO2007004165A2 (en) * 2005-06-30 2007-01-11 Ranbaxy Laboratories Limited Process for the preparation of perindopril
AU2009263737B2 (en) * 2008-06-24 2013-10-24 Mylan Laboratories Ltd. Novel polymorphic forms of Perindopril (L)-Arginine and process for the preparation thereof
FR2935141B1 (fr) * 2008-08-21 2010-10-08 Sanofi Aventis Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate
GB0910692D0 (en) 2009-06-20 2009-08-05 Teva Pharma Compound
ES2670854T3 (es) * 2012-10-10 2018-06-01 Piramal Enterprises Limited Un proceso mejorado para la preparación de perindoprilo intermedio
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508729A (en) 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
IN156096B (el) 1981-03-19 1985-05-11 Usv Pharma Corp
FR2546886B2 (fr) 1983-06-06 1986-05-16 Adir Derives d'acides isoindoledicarboxyliques, leur preparation et compositions pharmaceutiques les contenant
FR2620699B1 (fr) 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620700B1 (fr) 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
SI9500140A (en) 1995-04-24 1996-10-31 Genesis Para La Investigacion Novel n-sulfoxy anhydrides, process for the preparation thereof and its use for the preparation of bioactive substances having ace inhibitory action
SI9600169A (en) 1996-05-22 1997-12-31 Krka Tovarna Zdravil Process for preparation of compounds with ace inhibitory effect
FR2807037B1 (fr) 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
FR2827860B1 (fr) 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
AR036187A1 (es) 2001-07-24 2004-08-18 Adir Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario

Also Published As

Publication number Publication date
AU2003224420A1 (en) 2004-09-17
ES2307923T3 (es) 2008-12-01
EP1603558B1 (en) 2008-05-21
US20060276659A1 (en) 2006-12-07
US7521566B2 (en) 2009-04-21
JP4461027B2 (ja) 2010-05-12
CA2517205C (en) 2010-08-24
DK1603558T3 (da) 2008-09-01
AU2003224420B2 (en) 2009-08-06
DE60321233D1 (de) 2008-07-03
CA2517205A1 (en) 2004-09-10
SI1603558T1 (sl) 2008-12-31
PT1603558E (pt) 2008-08-19
EP1603558A1 (en) 2005-12-14
ATE395913T1 (de) 2008-06-15
JP2006519168A (ja) 2006-08-24
WO2004075889A1 (en) 2004-09-10

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