PT819122E - Derivados de 1,3-di-hidro-1-(fenilalquil)-2h-imidazol-2-ona com actividade de pde iv e de citoquina - Google Patents
Derivados de 1,3-di-hidro-1-(fenilalquil)-2h-imidazol-2-ona com actividade de pde iv e de citoquinaInfo
- Publication number
- PT819122E PT819122E PT96909150T PT96909150T PT819122E PT 819122 E PT819122 E PT 819122E PT 96909150 T PT96909150 T PT 96909150T PT 96909150 T PT96909150 T PT 96909150T PT 819122 E PT819122 E PT 819122E
- Authority
- PT
- Portugal
- Prior art keywords
- phenylalquil
- ona
- pde
- cytokine
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95200868 | 1995-04-06 | ||
EP95202898 | 1995-10-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT819122E true PT819122E (pt) | 2002-08-30 |
Family
ID=26139205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT96909150T PT819122E (pt) | 1995-04-06 | 1996-03-28 | Derivados de 1,3-di-hidro-1-(fenilalquil)-2h-imidazol-2-ona com actividade de pde iv e de citoquina |
Country Status (27)
Country | Link |
---|---|
US (2) | US5994376A (pt) |
EP (1) | EP0819122B1 (pt) |
JP (1) | JP4562101B2 (pt) |
KR (1) | KR100406628B1 (pt) |
CN (1) | CN1068591C (pt) |
AR (1) | AR002732A1 (pt) |
AT (1) | ATE214052T1 (pt) |
AU (1) | AU702947B2 (pt) |
CA (1) | CA2216653C (pt) |
CY (1) | CY2328B1 (pt) |
CZ (1) | CZ293127B6 (pt) |
DE (1) | DE69619661T2 (pt) |
DK (1) | DK0819122T3 (pt) |
ES (1) | ES2174064T3 (pt) |
HK (1) | HK1007880A1 (pt) |
HR (1) | HRP960155A2 (pt) |
HU (1) | HU223324B1 (pt) |
IL (1) | IL117807A (pt) |
MX (1) | MX9707652A (pt) |
MY (1) | MY119254A (pt) |
NO (1) | NO314339B1 (pt) |
NZ (1) | NZ304877A (pt) |
PL (1) | PL187375B1 (pt) |
PT (1) | PT819122E (pt) |
SI (1) | SI0819122T1 (pt) |
TW (1) | TW332201B (pt) |
WO (1) | WO1996031485A1 (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5703098A (en) * | 1994-12-30 | 1997-12-30 | Celgene Corporation | Immunotherapeutic imides/amides |
TW332201B (en) | 1995-04-06 | 1998-05-21 | Janssen Pharmaceutica Nv | 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives |
ATE236884T1 (de) * | 1996-10-02 | 2003-04-15 | Janssen Pharmaceutica Nv | Pde-iv hemmende 2-cyanoiminoimidazol-derivate |
ID24224A (id) * | 1997-07-10 | 2000-07-13 | Janssen Pharmaceutica Nv | Turunan-turunan 6-azaurasil sebagai inhibitor il-5 |
US6017926A (en) * | 1997-12-17 | 2000-01-25 | Merck & Co., Inc. | Integrin receptor antagonists |
TR200002801T2 (tr) * | 1998-04-01 | 2000-12-21 | Janssen Pharmaceutica N.V. | PDE IV engelleyici piridin türevleri |
US6118017A (en) * | 1998-04-14 | 2000-09-12 | Smithkline Beecham Corporation | Substituted-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylcyanocyclobutan-1-one |
JP2002511438A (ja) * | 1998-04-14 | 2002-04-16 | スミスクライン・ビーチャム・コーポレイション | ホスホジエステラーゼアイソザイム4(pde4)の阻害性化合物 |
DE69907254T2 (de) | 1998-11-23 | 2004-04-01 | Janssen Pharmaceutica N.V. | 6-azauracilderivate als il-5 inhibitoren |
EA004806B1 (ru) | 1998-12-18 | 2004-08-26 | Янссен Фармацевтика Н.В. | Производные 6-азаурацила, ингибирующие il-5 |
EP1322310A4 (en) * | 2000-09-13 | 2004-09-15 | Merck & Co Inc | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS |
JP4510383B2 (ja) * | 2001-05-23 | 2010-07-21 | 田辺三菱製薬株式会社 | 軟骨疾患修復治療用組成物 |
US20040146561A1 (en) | 2001-05-23 | 2004-07-29 | Naoki Sakurai | Compositions for promoting healing of bone fracture |
US6706739B2 (en) * | 2001-08-21 | 2004-03-16 | National Health Research Institute | Imidazolidinone compounds |
SE0200667D0 (sv) * | 2002-03-05 | 2002-03-05 | A & Science Invest Ab | Novel use of cytokine inhibitors |
GB0326407D0 (en) * | 2003-11-12 | 2003-12-17 | Glaxo Group Ltd | Chemical compounds |
GB0412865D0 (en) * | 2004-06-09 | 2004-07-14 | Glaxo Group Ltd | Chemical compounds |
US20080200526A1 (en) * | 2004-07-05 | 2008-08-21 | Jin Soo Lee | Composition for the Prevention and Treatment of Allergic Inflammatory Disease |
AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
US8354434B2 (en) * | 2006-01-30 | 2013-01-15 | Purdue Pharma L.P. | Cyclourea compounds as calcium channel blockers |
EP1834953A1 (en) | 2006-03-14 | 2007-09-19 | Ranbaxy Laboratories Limited | Tetrahydropyrane derivatives as 5-lipoxygenase inhibitors |
US7390772B2 (en) * | 2006-05-18 | 2008-06-24 | International Flavor & Fragrances Inc. | 1-phenyl-spiro[2.5]octane-1-carbonitrile analogues their use in fragrance formulations |
WO2008157425A2 (en) * | 2007-06-14 | 2008-12-24 | The Regents Of The University Of California | Compounds for inhibiting protein aggregation, and methods for making and using them |
NZ601967A (en) * | 2010-03-12 | 2015-03-27 | Omeros Corp | Pde10 inhibitors and related compositions and methods |
NZ630810A (en) | 2014-04-28 | 2016-03-31 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
NZ716462A (en) | 2014-04-28 | 2017-11-24 | Omeros Corp | Optically active pde10 inhibitor |
EP3285760A4 (en) | 2015-04-24 | 2018-09-26 | Omeros Corporation | Pde10 inhibitors and related compositions and methods |
JP2018535969A (ja) | 2015-11-04 | 2018-12-06 | オメロス コーポレーション | Pde10阻害剤の固体状態形態 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL285394A (pt) * | 1961-11-17 | |||
US3184060A (en) | 1963-02-13 | 1965-05-18 | Owens Illinois Glass Co | Packaging tacky latex emulsion paints in containers manufactured from polyolefinic maerials |
WO1992007567A1 (en) * | 1990-11-06 | 1992-05-14 | Smithkline Beecham Corporation | Imidazolidinone compounds |
ATE234270T1 (de) * | 1992-12-02 | 2003-03-15 | Pfizer | Cathecoldiether als selektive pde iv hemmungsmittel |
TW263495B (pt) * | 1992-12-23 | 1995-11-21 | Celltech Ltd | |
GB9304920D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
TW332201B (en) | 1995-04-06 | 1998-05-21 | Janssen Pharmaceutica Nv | 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives |
-
1996
- 1996-03-22 TW TW085103447A patent/TW332201B/zh not_active IP Right Cessation
- 1996-03-28 NZ NZ304877A patent/NZ304877A/en not_active IP Right Cessation
- 1996-03-28 PT PT96909150T patent/PT819122E/pt unknown
- 1996-03-28 DK DK96909150T patent/DK0819122T3/da active
- 1996-03-28 CN CN96193101A patent/CN1068591C/zh not_active Expired - Lifetime
- 1996-03-28 PL PL96322654A patent/PL187375B1/pl unknown
- 1996-03-28 JP JP52995996A patent/JP4562101B2/ja not_active Expired - Lifetime
- 1996-03-28 MX MX9707652A patent/MX9707652A/es unknown
- 1996-03-28 AU AU52755/96A patent/AU702947B2/en not_active Expired
- 1996-03-28 US US08/930,296 patent/US5994376A/en not_active Expired - Lifetime
- 1996-03-28 DE DE69619661T patent/DE69619661T2/de not_active Expired - Lifetime
- 1996-03-28 EP EP96909150A patent/EP0819122B1/en not_active Expired - Lifetime
- 1996-03-28 WO PCT/EP1996/001394 patent/WO1996031485A1/en active IP Right Grant
- 1996-03-28 CA CA002216653A patent/CA2216653C/en not_active Expired - Lifetime
- 1996-03-28 SI SI9630434T patent/SI0819122T1/xx unknown
- 1996-03-28 AT AT96909150T patent/ATE214052T1/de active
- 1996-03-28 CZ CZ19973149A patent/CZ293127B6/cs not_active IP Right Cessation
- 1996-03-28 KR KR1019970706853A patent/KR100406628B1/ko not_active IP Right Cessation
- 1996-03-28 ES ES96909150T patent/ES2174064T3/es not_active Expired - Lifetime
- 1996-03-28 HU HU9801575A patent/HU223324B1/hu active IP Right Grant
- 1996-04-02 HR HR95202898.3A patent/HRP960155A2/hr not_active Application Discontinuation
- 1996-04-03 AR ARP960102076A patent/AR002732A1/es active IP Right Grant
- 1996-04-03 IL IL11780796A patent/IL117807A/en not_active IP Right Cessation
- 1996-04-05 MY MYPI96001300A patent/MY119254A/en unknown
-
1997
- 1997-10-06 NO NO19974602A patent/NO314339B1/no not_active IP Right Cessation
-
1998
- 1998-07-07 HK HK98108913A patent/HK1007880A1/xx not_active IP Right Cessation
-
1999
- 1999-07-27 US US09/362,007 patent/US6403805B1/en not_active Expired - Lifetime
-
2002
- 2002-07-15 CY CY0200043A patent/CY2328B1/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT819122E (pt) | Derivados de 1,3-di-hidro-1-(fenilalquil)-2h-imidazol-2-ona com actividade de pde iv e de citoquina | |
DE68929305D1 (de) | Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel | |
NO308740B1 (no) | Kinazolinderivater, anvendelse derav og farmasøytisk blanding | |
DE69629988D1 (de) | Pharmazeutisches Grundbestandteil und seine Verwendung | |
HK1012193A1 (en) | Lactone derivatives of 17.beta.-carboxy, carbothio and amide androstane derivatives | |
ATE380794T1 (de) | 1,3-dihydro-1-(phenylalkenyl)-2h-imidazol-2 on- derivate mit pde iv und cytokin-inhibirendes aktivität | |
MX9203459A (es) | Nuevos derivados de 2'-halometilideno, 2'-etenilideno y 2'-etinilcitidina, uridina y guanosina. | |
DE68918215D1 (de) | 2'-Halomethyliden, 2'-Ethenyliden und 2'-Ethynyl-Adenosinderivate. | |
MA22916A1 (fr) | Derives de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides. | |
NO960699L (no) | Antimigren 1,2,5-tiadiazolderivater av indolylalkylpyridinyl- og -pyrimidinylpiperaziner | |
PL327686A1 (en) | Derivatives of @-amino 5,6-dichlorobenzimidazole exhibiting antiviral activity | |
ATE305455T1 (de) | 1,3-dihydro-2h-imidazol-2-on-derivate mit pdeiv und cytokin inhibierender aktivität | |
FR2735776B1 (fr) | Derives de 2,3-dihydro-1h-indole, leur preparation et leur application en therapeutique | |
FR2731707B1 (fr) | Derives de benzimidazole, leur preparation et leur application en therapeutique | |
DE4493151T1 (de) | Pyrimidinderivate und Arzneimittel | |
FR2738567B1 (fr) | Derives de alpha-phenylpiperidine-1-propanol, leur preparation et leur application en therapeutique | |
BR9508669A (pt) | Novos derivados de taizoloÚ3,2-a¾quinolina e naftirina | |
IT1275866B1 (it) | Derivati oligonucleotidici ad attivita' farmacologica e procedimento per la loro preparazione | |
MX9203071A (es) | Derivados de fenetilaminea y tritptofano-fenilalanina-n n-cicloalquil substituidos y policicloalquil alfa-substituidos. | |
HUP9903260A3 (en) | 2,4-diaminopyrimidine derivatives with antibiotic activity, preparation and use thereof | |
FR2739858B1 (fr) | Derives de n-sulfonyl- et n-sulfamoylpeptidylprolinamide, leur preparation et leur application en therapeutique | |
MX15190A (es) | Complejo de derivados de telurio y silenio. |