PT3250592T - Anticorpos anti-transtirretina - Google Patents

Anticorpos anti-transtirretina

Info

Publication number
PT3250592T
PT3250592T PT167028125T PT16702812T PT3250592T PT 3250592 T PT3250592 T PT 3250592T PT 167028125 T PT167028125 T PT 167028125T PT 16702812 T PT16702812 T PT 16702812T PT 3250592 T PT3250592 T PT 3250592T
Authority
PT
Portugal
Prior art keywords
transthyretin antibodies
transthyretin
antibodies
Prior art date
Application number
PT167028125T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Univ Health Network
Prothena Biosciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Health Network, Prothena Biosciences Ltd filed Critical Univ Health Network
Publication of PT3250592T publication Critical patent/PT3250592T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT167028125T 2015-01-28 2016-01-28 Anticorpos anti-transtirretina PT3250592T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562109002P 2015-01-28 2015-01-28
US201562266556P 2015-12-11 2015-12-11

Publications (1)

Publication Number Publication Date
PT3250592T true PT3250592T (pt) 2022-12-28

Family

ID=55299694

Family Applications (1)

Application Number Title Priority Date Filing Date
PT167028125T PT3250592T (pt) 2015-01-28 2016-01-28 Anticorpos anti-transtirretina

Country Status (31)

Country Link
US (1) US20160251418A1 (enExample)
EP (2) EP3250592B1 (enExample)
JP (2) JP6748086B2 (enExample)
KR (2) KR102677203B1 (enExample)
CN (1) CN107406499B (enExample)
AU (1) AU2016210888C1 (enExample)
CA (1) CA2974912A1 (enExample)
CL (2) CL2017001924A1 (enExample)
CO (1) CO2017008476A2 (enExample)
CU (1) CU24480B1 (enExample)
DK (1) DK3250592T3 (enExample)
EA (1) EA036080B1 (enExample)
ES (1) ES2934656T3 (enExample)
FI (1) FI3250592T3 (enExample)
HR (1) HRP20221538T1 (enExample)
HU (1) HUE060878T2 (enExample)
IL (1) IL253633B (enExample)
LT (1) LT3250592T (enExample)
MX (1) MX394170B (enExample)
PE (1) PE20180217A1 (enExample)
PH (1) PH12017501318A1 (enExample)
PL (1) PL3250592T3 (enExample)
PT (1) PT3250592T (enExample)
RS (1) RS63906B1 (enExample)
SA (1) SA517382002B1 (enExample)
SG (2) SG10202101763VA (enExample)
SI (1) SI3250592T1 (enExample)
TW (2) TWI786505B (enExample)
UA (1) UA122142C2 (enExample)
WO (1) WO2016120810A1 (enExample)
ZA (1) ZA201705663B (enExample)

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US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
US9879080B2 (en) 2015-01-28 2018-01-30 Prothena Biosciences Limited Anti-transthyretin antibodies
US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
WO2018007922A2 (en) * 2016-07-02 2018-01-11 Prothena Biosciences Limited Anti-transthyretin antibodies
MX2020003041A (es) 2017-10-06 2020-10-05 Prothena Biosciences Ltd Anticuerpos anti-transtiretina.
PE20210042A1 (es) 2017-10-06 2021-01-08 Prothena Biosciences Ltd Metodos para detectar transtiretina
CU20200042A7 (es) 2017-11-29 2021-03-11 Prothena Biosciences Ltd Formulación liofilizada de un anticuerpo monoclonal contra la transtirretina
CA3118618A1 (en) 2018-11-09 2020-05-14 Neurimmune Ag Patient-derived amyloid xenograft non-human animal model
JP7728788B2 (ja) 2020-03-18 2025-08-25 アーエルエス ファルマ アクチェン ゲゼルシャフト ミスフォールドsod1アッセイ
WO2021228987A1 (en) 2020-05-12 2021-11-18 Neurimmune Ag Combination therapy for ttr amyloidosis
US20230340089A1 (en) * 2020-05-14 2023-10-26 City Of Hope Smc1a antibodies and uses thereof
US20230391859A1 (en) * 2020-10-28 2023-12-07 Novo Nordisk A/S Anti-transthyretin antibodies and methods of use thereof
CN113845593B (zh) * 2021-10-27 2023-03-10 福州迈新生物技术开发有限公司 抗α-SMA蛋白单克隆抗体、细胞系及其应用
US20250019425A1 (en) * 2021-11-12 2025-01-16 Adrx, Inc. Transthyretin (ttr) monomer binding antibodies
CA3239708A1 (en) 2021-12-03 2023-06-08 Aubin MICHALON Novel potency assay for antibody-based drugs and useful means therefor
US20240228637A9 (en) * 2022-10-19 2024-07-11 Ibio, Inc. Chemokine receptor 8 (ccr8) antibodies
JP2025537802A (ja) 2022-11-15 2025-11-20 ニューリミューン アーゲー トランスサイレチン媒介アミロイドーシスを治療又は予防する方法
WO2024197157A1 (en) * 2023-03-21 2024-09-26 Biograph 55, Inc. Cd19/cd38 multispecific antibodies
WO2024240562A1 (en) 2023-05-19 2024-11-28 Neurimmune Ag Novel immunotherapy for musculoskeletal disorders and conditions
TW202528347A (zh) 2023-11-15 2025-07-16 瑞士商紐立慕公司 抗運甲狀腺素蛋白抗體、包含所述抗體之組成物及用於治療或預防運甲狀腺素蛋白介導之澱粉樣變性的方法
WO2025125544A1 (en) 2023-12-15 2025-06-19 Novo Nordisk A/S Stable liquid formulations
WO2025238147A1 (en) 2024-05-15 2025-11-20 Neurimmune Ag Maintenance treatment of cardiac ttr amyloidosis using anti-transthyretin antibodies

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PE20210042A1 (es) 2017-10-06 2021-01-08 Prothena Biosciences Ltd Metodos para detectar transtiretina

Also Published As

Publication number Publication date
DK3250592T3 (en) 2023-01-09
KR20170106469A (ko) 2017-09-20
ZA201705663B (en) 2018-08-29
CN107406499A (zh) 2017-11-28
EP3250592B1 (en) 2022-10-05
US20160251418A1 (en) 2016-09-01
CO2017008476A2 (es) 2018-01-16
RS63906B1 (sr) 2023-02-28
ES2934656T3 (es) 2023-02-23
PH12017501318B1 (en) 2018-02-05
PL3250592T3 (pl) 2023-06-19
UA122142C2 (uk) 2020-09-25
NZ733896A (en) 2024-11-29
SG11201706124VA (en) 2017-08-30
AU2016210888C1 (en) 2022-06-02
SG10202101763VA (en) 2021-04-29
EP3250592A1 (en) 2017-12-06
KR102598180B1 (ko) 2023-11-03
TW202124436A (zh) 2021-07-01
KR20230156164A (ko) 2023-11-13
MX2017009806A (es) 2018-08-15
WO2016120810A1 (en) 2016-08-04
FI3250592T3 (fi) 2023-01-13
MX394170B (es) 2025-03-24
JP2020185009A (ja) 2020-11-19
EP4134379A1 (en) 2023-02-15
CN107406499B (zh) 2021-10-22
EA036080B1 (ru) 2020-09-23
IL253633B (en) 2021-06-30
BR112017016330A2 (en) 2018-04-03
JP7028923B2 (ja) 2022-03-02
TWI718122B (zh) 2021-02-11
SA517382002B1 (ar) 2021-11-25
EA201791712A1 (ru) 2017-12-29
PH12017501318A1 (en) 2018-02-05
IL253633A0 (en) 2017-09-28
HUE060878T2 (hu) 2023-04-28
HRP20221538T1 (hr) 2023-03-03
TW201632554A (zh) 2016-09-16
SI3250592T1 (sl) 2023-03-31
CU20170097A7 (es) 2018-03-13
JP2018506277A (ja) 2018-03-08
AU2016210888B2 (en) 2021-11-04
KR102677203B1 (ko) 2024-06-20
CL2017001924A1 (es) 2018-04-27
PE20180217A1 (es) 2018-01-31
TWI786505B (zh) 2022-12-11
CA2974912A1 (en) 2016-08-04
LT3250592T (lt) 2023-02-10
AU2016210888A1 (en) 2017-08-10
CU24480B1 (es) 2020-03-04
JP6748086B2 (ja) 2020-09-02
CL2022003027A1 (es) 2023-06-09

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