PT3008172T - Composições de meio de cultura para maturar cardiomicóticos derivados de células estaminais pluripotentes de mamíferos - Google Patents
Composições de meio de cultura para maturar cardiomicóticos derivados de células estaminais pluripotentes de mamíferosInfo
- Publication number
- PT3008172T PT3008172T PT147324461T PT14732446T PT3008172T PT 3008172 T PT3008172 T PT 3008172T PT 147324461 T PT147324461 T PT 147324461T PT 14732446 T PT14732446 T PT 14732446T PT 3008172 T PT3008172 T PT 3008172T
- Authority
- PT
- Portugal
- Prior art keywords
- maturating
- culture medium
- stem cells
- mammalian stem
- medium compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
- C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/395—Thyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2010953 | 2013-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3008172T true PT3008172T (pt) | 2020-07-21 |
Family
ID=50981826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT147324461T PT3008172T (pt) | 2013-06-11 | 2014-06-06 | Composições de meio de cultura para maturar cardiomicóticos derivados de células estaminais pluripotentes de mamíferos |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10696947B2 (pt) |
| EP (2) | EP3708655A1 (pt) |
| JP (4) | JP6682429B2 (pt) |
| CN (1) | CN105473708A (pt) |
| CA (2) | CA3135208A1 (pt) |
| DK (1) | DK3008172T3 (pt) |
| ES (1) | ES2806698T3 (pt) |
| HU (1) | HUE049916T2 (pt) |
| PL (1) | PL3008172T3 (pt) |
| PT (1) | PT3008172T (pt) |
| WO (1) | WO2014200339A1 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105473708A (zh) * | 2013-06-11 | 2016-04-06 | 普鲁瑞欧米克斯有限公司 | 用于使衍生自多能哺乳动物干细胞的心肌细胞成熟的培养基组合物 |
| EP3152300A1 (en) | 2014-06-06 | 2017-04-12 | Pluriomics B.v. | Cardiomyocyte maturation |
| WO2016055519A1 (en) * | 2014-10-07 | 2016-04-14 | Max-Delbrück-Centrum für Molekulare Medizin | Endogenous retrovirus transcription as a marker for primate naïve pluripotent stem cells |
| US10613078B2 (en) | 2015-02-20 | 2020-04-07 | Ncardia B.V. | Assays for measuring cardiotoxicity |
| PT3344758T (pt) | 2015-09-01 | 2021-10-28 | Ncardia B V | Um método in vitro para diferenciação de uma população de células estaminais pluripotentes humanas numa população de células de cardiomiócitos |
| CN105567635A (zh) * | 2016-02-21 | 2016-05-11 | 中国医科大学附属第一医院 | 一种改良的Neurobasal B27培养基、制备方法及应用 |
| AU2017314870B2 (en) * | 2016-08-26 | 2023-11-30 | The Council Of The Queensland Institute Of Medical Research | Cardiomyocyte maturation |
| CN106754663A (zh) * | 2016-11-30 | 2017-05-31 | 中国人民解放军第三军医大学第三附属医院 | 促进成年哺乳动物心肌细胞存活的体外培养方法及监测成年哺乳动物心肌细胞增殖的方法 |
| CN106957815B (zh) * | 2017-03-16 | 2021-05-07 | 杨涛 | 一种用于人类多潜能干细胞的无血清培养基的配方 |
| NL2019618B1 (en) | 2017-09-22 | 2019-03-28 | Ncardia B V | In vitro method for providing stem cell derived cardiomyocytes |
| CN108456654A (zh) * | 2018-02-22 | 2018-08-28 | 上海产业技术研究院 | 用于促进干细胞来源心肌细胞成熟的无血清培养体系 |
| IL277340B2 (en) * | 2018-03-30 | 2024-07-01 | Univ Kyoto | Modified isoindolinone-benzimidazole compounds, a cardiomyocyte maturation promoter, and a method for preparing an adult cardiomyocyte |
| CN111918961B (zh) * | 2018-03-30 | 2023-10-24 | 国立大学法人京都大学 | 心肌细胞成熟促进剂 |
| JP2022535141A (ja) * | 2019-06-06 | 2022-08-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 心筋細胞及び組成物ならびにそれらを生成する方法 |
| CN111454886A (zh) * | 2020-05-12 | 2020-07-28 | 广东源心再生医学有限公司 | 一种增强型心肌细胞培养液及其应用 |
| CN112708591B (zh) * | 2020-12-24 | 2022-04-29 | 南京周子未来食品科技有限公司 | 一种用于肌肉干细胞体外分化的化学成分明确的培养基 |
| CN113073076B (zh) * | 2021-04-24 | 2022-09-09 | 华中科技大学同济医学院附属协和医院 | 一种将多能干细胞分化为瓣膜内皮细胞与瓣膜间质细胞的分化方法 |
| CN113215085B (zh) * | 2021-05-07 | 2024-05-10 | 澳门大学 | 一种脂类物质添加剂及其应用 |
| WO2023114274A1 (en) * | 2021-12-14 | 2023-06-22 | Agex Therapeutics, Inc. | Improved methods for inducing the maturation of mammalian cells |
| WO2023136229A1 (ja) * | 2022-01-11 | 2023-07-20 | 三井化学株式会社 | 薬剤の、心筋細胞に対する作用を評価する方法 |
| WO2024004960A1 (ja) * | 2022-06-27 | 2024-01-04 | 武田薬品工業株式会社 | 細胞の培養方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3871206D1 (de) | 1987-03-24 | 1992-06-25 | Grace W R & Co | Basisnaehrmedium fuer eine zellkultur. |
| WO1990003430A1 (en) | 1988-09-23 | 1990-04-05 | Cetus Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| JPH03180176A (ja) * | 1989-11-16 | 1991-08-06 | W R Grace & Co | 細胞培養のための基礎栄養培地 |
| US6221911B1 (en) * | 1995-06-07 | 2001-04-24 | Karo Bio Ab | Uses for thyroid hormone compounds or thyroid hormone-like compounds |
| US7425448B2 (en) * | 2001-07-12 | 2008-09-16 | Geron Corporation | Cardiomyocyte precursors from human embryonic stem cells |
| US7169610B2 (en) | 2002-01-25 | 2007-01-30 | Genzyme Corporation | Serum-free media for chondrocytes and methods of use thereof |
| EP2361966A1 (en) * | 2002-05-17 | 2011-08-31 | Mount Sinai School of Medicine of New York University | Mesoderm and definitive endoderm cell populations |
| CA2391118A1 (en) * | 2002-06-21 | 2003-12-21 | Universite Du Quebec A Montreal | Oxytocin as cardiomyogenesis inducer and uses thereof |
| WO2007016366A2 (en) | 2005-07-29 | 2007-02-08 | Yale University | Defined culture conditions of human embryonic stem cells |
| JP2007124982A (ja) * | 2005-11-07 | 2007-05-24 | Toray Ind Inc | 細胞培養液および細胞培養方法 |
| JP2007228815A (ja) | 2006-02-27 | 2007-09-13 | Gifu Univ | 胚性幹細胞の維持方法 |
| GB0622394D0 (en) | 2006-11-09 | 2006-12-20 | Univ Cambridge Tech | Differentiation of pluripotent cells |
| GB0622395D0 (en) | 2006-11-09 | 2006-12-20 | Univ Cambridge Tech | Methods relating to pluripotent cells |
| CN100540659C (zh) | 2006-12-22 | 2009-09-16 | 北京维通达生物技术有限公司 | 一种培养小鼠胚胎干细胞的方法及其专用培养基 |
| EP2118278A4 (en) * | 2007-01-19 | 2010-04-14 | Sinai School Medicine | TARGETED GENE MODIFICATION OF STEM CELLS |
| WO2008094597A2 (en) * | 2007-01-30 | 2008-08-07 | University Of Georgia Research Foundation, Inc. | Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc) |
| EP2139988A1 (en) | 2007-03-15 | 2010-01-06 | California Stem Cell, Inc. | Cardiomyocytes and methods of producing and purifying cardiomyocytes |
| WO2010007031A2 (en) * | 2008-07-14 | 2010-01-21 | Novartis Ag | Methods for improving cardiac differentiation of human embryonic stem cells |
| US10894944B2 (en) | 2009-04-10 | 2021-01-19 | Monash University | Cell culture media |
| US10913929B2 (en) * | 2009-10-13 | 2021-02-09 | Stemcell Technologies Inc. | Method of differentiating stem cells |
| EP4166652A1 (en) * | 2009-11-12 | 2023-04-19 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
| WO2011100286A2 (en) * | 2010-02-09 | 2011-08-18 | The Johns Hopkins University | Compositions and methods of generating a differentiated mesodermal cell |
| US8773594B2 (en) * | 2010-09-29 | 2014-07-08 | Sharp Kabushiki Kaisha | Signal processing device, and integrated circuit including oblique lowpass filtering and multiple sharpening components |
| US20140178894A1 (en) | 2011-04-20 | 2014-06-26 | Novartis Forschungsstiftung, Zweigniederlassung | Culture medium suitable for the culture of undifferentiated cells |
| DK2737056T3 (en) | 2011-07-29 | 2018-05-22 | Cellular Dynamics Int Inc | Metabolic maturation in stem cell-derived tissue cells |
| US9587220B2 (en) | 2012-01-27 | 2017-03-07 | Kyoto University | Method for inducing cardiac differentiation of pluripotent stem cell |
| CN103365555A (zh) * | 2012-03-31 | 2013-10-23 | 国际商业机器公司 | 数据处理方法和系统、数据收集方法和系统 |
| CN105473708A (zh) * | 2013-06-11 | 2016-04-06 | 普鲁瑞欧米克斯有限公司 | 用于使衍生自多能哺乳动物干细胞的心肌细胞成熟的培养基组合物 |
-
2014
- 2014-06-06 CN CN201480033355.9A patent/CN105473708A/zh active Pending
- 2014-06-06 CA CA3135208A patent/CA3135208A1/en active Pending
- 2014-06-06 EP EP20172600.7A patent/EP3708655A1/en active Pending
- 2014-06-06 CA CA2914922A patent/CA2914922C/en active Active
- 2014-06-06 ES ES14732446T patent/ES2806698T3/es active Active
- 2014-06-06 WO PCT/NL2014/050366 patent/WO2014200339A1/en active Application Filing
- 2014-06-06 HU HUE14732446A patent/HUE049916T2/hu unknown
- 2014-06-06 EP EP14732446.1A patent/EP3008172B1/en active Active
- 2014-06-06 US US14/897,314 patent/US10696947B2/en active Active
- 2014-06-06 PT PT147324461T patent/PT3008172T/pt unknown
- 2014-06-06 DK DK14732446.1T patent/DK3008172T3/da active
- 2014-06-06 PL PL14732446T patent/PL3008172T3/pl unknown
- 2014-06-06 JP JP2016519470A patent/JP6682429B2/ja active Active
-
2019
- 2019-09-20 JP JP2019171164A patent/JP2020022460A/ja not_active Withdrawn
-
2020
- 2020-06-11 US US16/899,121 patent/US12043846B2/en active Active
-
2021
- 2021-11-05 JP JP2021180863A patent/JP2022031684A/ja active Pending
-
2023
- 2023-12-01 JP JP2023203668A patent/JP2024040143A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024040143A (ja) | 2024-03-25 |
| EP3008172A1 (en) | 2016-04-20 |
| EP3708655A1 (en) | 2020-09-16 |
| JP2016521571A (ja) | 2016-07-25 |
| DK3008172T3 (da) | 2020-07-20 |
| EP3008172B1 (en) | 2020-05-06 |
| PL3008172T3 (pl) | 2020-09-21 |
| ES2806698T3 (es) | 2021-02-18 |
| US20160122718A1 (en) | 2016-05-05 |
| US10696947B2 (en) | 2020-06-30 |
| US12043846B2 (en) | 2024-07-23 |
| CA2914922A1 (en) | 2014-12-18 |
| HUE049916T2 (hu) | 2020-11-30 |
| CN105473708A (zh) | 2016-04-06 |
| JP2022031684A (ja) | 2022-02-22 |
| US20200370018A1 (en) | 2020-11-26 |
| JP2020022460A (ja) | 2020-02-13 |
| JP6682429B2 (ja) | 2020-04-15 |
| CA3135208A1 (en) | 2014-12-18 |
| CA2914922C (en) | 2021-11-30 |
| WO2014200339A1 (en) | 2014-12-18 |
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