PT2978859T - Marcadores genéticos para previsão da capacidade de resposta à terapêutica - Google Patents
Marcadores genéticos para previsão da capacidade de resposta à terapêuticaInfo
- Publication number
- PT2978859T PT2978859T PT14714628T PT14714628T PT2978859T PT 2978859 T PT2978859 T PT 2978859T PT 14714628 T PT14714628 T PT 14714628T PT 14714628 T PT14714628 T PT 14714628T PT 2978859 T PT2978859 T PT 2978859T
- Authority
- PT
- Portugal
- Prior art keywords
- therapy
- genetic markers
- predicting responsiveness
- responsiveness
- predicting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13161386 | 2013-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2978859T true PT2978859T (pt) | 2018-10-04 |
Family
ID=47997187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT14714628T PT2978859T (pt) | 2013-03-27 | 2014-03-24 | Marcadores genéticos para previsão da capacidade de resposta à terapêutica |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US9909178B2 (hu) |
| EP (2) | EP3404115A1 (hu) |
| JP (2) | JP6449235B2 (hu) |
| KR (1) | KR102153557B1 (hu) |
| CN (2) | CN111073974B (hu) |
| BR (1) | BR112015024116A2 (hu) |
| CA (1) | CA2897420C (hu) |
| DK (1) | DK2978859T3 (hu) |
| ES (1) | ES2685269T3 (hu) |
| HK (1) | HK1213602A1 (hu) |
| HR (1) | HRP20181358T1 (hu) |
| HU (1) | HUE039973T2 (hu) |
| LT (1) | LT2978859T (hu) |
| MX (2) | MX370538B (hu) |
| PL (1) | PL2978859T3 (hu) |
| PT (1) | PT2978859T (hu) |
| RS (1) | RS57640B1 (hu) |
| RU (1) | RU2707533C2 (hu) |
| SI (1) | SI2978859T1 (hu) |
| WO (1) | WO2014154606A1 (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2676984C (en) | 2007-02-01 | 2015-03-17 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular diseases |
| JP5795304B2 (ja) | 2009-03-18 | 2015-10-14 | レスバーロジックス コーポレイション | 新規抗炎症剤 |
| RU2707533C2 (ru) * | 2013-03-27 | 2019-11-27 | Ф. Хоффманн-Ля Рош Аг | Генетические маркеры для прогнозирования восприимчивости к терапии |
| CN106559998B (zh) * | 2014-07-30 | 2022-01-25 | 豪夫迈·罗氏有限公司 | 预测对hdl升高剂或hdl模拟剂疗法的应答性的遗传标记 |
| CA2977308A1 (en) | 2015-03-13 | 2016-09-22 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
| US20190070178A1 (en) | 2017-08-29 | 2019-03-07 | Dalcor Pharma Uk Ltd., Stockport Zug Branch | Methods for treating or preventing cardiovascular disorders and lowering risk of cardiovascular events |
| CN108004312B (zh) * | 2017-12-20 | 2019-01-01 | 德诺杰亿（北京）生物科技有限公司 | 检测心血管疾病相关基因多态性的引物组、试剂盒及方法 |
| SG11202101086YA (en) * | 2018-08-09 | 2021-03-30 | Dalcor Pharma Uk Ltd Leatherhead | Methods for delaying occurrence of new-onset type 2 diabetes and for slowing progression of and treating type 2 diabetes |
| CA3126323A1 (en) | 2019-03-07 | 2020-09-10 | Jean-Claude Tardif | Methods for treating or preventing heart failure and reducing risk of heart failure |
| WO2021140358A1 (en) * | 2020-01-08 | 2021-07-15 | Universitatea De Medicina Şi Farmacie "Victor Babes" (In English: University Of Medicine And Pharmacy "Victor Babes") | Method to identify patients who would respond favourably to hypolipidemic treatment |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2894445B2 (ja) | 1997-02-12 | 1999-05-24 | 日本たばこ産業株式会社 | Ｃｅｔｐ活性阻害剤として有効な化合物 |
| ES2265945T3 (es) | 1999-06-04 | 2007-03-01 | Consejo Superior De Investigaciones Cientificas | Plantas, semillas y aceites de girasol con un contenido alto de oleico y alto de estearico. |
| US20030092647A1 (en) | 2001-08-08 | 2003-05-15 | Crooke Rosanne M. | Antisense modulation of cholesteryl ester transfer protein expression |
| AU2002323270A1 (en) | 2001-08-18 | 2003-03-03 | Myriad Genetics, Inc | Composition and method for treating hiv infection |
| US20040180370A1 (en) * | 2003-01-27 | 2004-09-16 | The Regents Of The University Of Colorado, A Body Corporate | Genetic diagnosis of alcoholism subtypes |
| CA2519458A1 (en) | 2003-03-17 | 2004-09-30 | Japan Tobacco Inc. | Method for increasing the oral bioavailability of s-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]-2-methylpropanethioate |
| TWI393560B (zh) | 2003-05-02 | 2013-04-21 | Japan Tobacco Inc | 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合 |
| WO2005007111A2 (en) | 2003-07-11 | 2005-01-27 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives as cannabinoid receptor modulators |
| US7326706B2 (en) | 2003-08-15 | 2008-02-05 | Bristol-Myers Squibb Company | Pyrazine modulators of cannabinoid receptors |
| CA2554982A1 (en) | 2003-09-26 | 2005-04-07 | Japan Tobacco Inc. | Method of inhibiting remnant lipoprotein production |
| US7517900B2 (en) | 2003-10-10 | 2009-04-14 | Bristol-Myers Squibb Company | Pyrazole derivatives as cannabinoid receptor modulators |
| US7420059B2 (en) | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
| PL1697371T3 (pl) | 2003-12-19 | 2007-09-28 | Bristol Myers Squibb Co | Azabicykliczne heterocykle jako modulatory receptora kanabinoidowego |
| CA2550435A1 (en) | 2003-12-19 | 2005-07-14 | Bristol-Myers Squibb Company | Azabicyclic heterocycles as cannabinoid receptor modulators |
| US20050261201A1 (en) | 2004-03-30 | 2005-11-24 | Rejuvenon Corporation | Method of reducing C-reactive protein using growth hormone secretagogues |
| WO2006072172A1 (en) | 2005-01-05 | 2006-07-13 | Medicure International Inc. | Compounds and methods for regulating triglyceride levels |
| WO2006099142A2 (en) * | 2005-03-10 | 2006-09-21 | The Trustees Of Boston University | Prognostic method for vascular diseases |
| JP2006288279A (ja) * | 2005-04-11 | 2006-10-26 | Otsuka Pharmaceut Co Ltd | 出血時間延長傾向判定方法 |
| AU2006304836A1 (en) | 2005-10-21 | 2007-04-26 | Novartis Ag | Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent |
| US7435849B2 (en) | 2005-10-31 | 2008-10-14 | Hoffmann-La Roche Inc. | Process for the production of acid chlorides |
| KR101329112B1 (ko) | 2005-11-08 | 2013-11-14 | 랜박시 래보러터리스 리미티드 | (3ｒ,5ｒ)-7-〔2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-〔(4-히드록시 메틸 페닐 아미노)카르보닐〕-피롤-1-일〕-3,5-디히드록시 헵탄산 헤미 칼슘염의 제조 방법 |
| US20070213274A1 (en) * | 2005-12-20 | 2007-09-13 | Oy Jurilab Ltd | Novel genes and markers associated with high-density lipoprotein-cholesterol (HDL-C) |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| US20090035306A1 (en) | 2006-11-29 | 2009-02-05 | Kalypsys, Inc. | Quinazolinone modulators of tgr5 |
| EP1935867A1 (en) | 2006-12-20 | 2008-06-25 | F. Hoffmann-La Roche Ag | Process for preparing 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid |
| WO2008097976A1 (en) | 2007-02-09 | 2008-08-14 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 for treatment of disease |
| JP5314671B2 (ja) | 2007-04-25 | 2013-10-16 | エフ．ホフマン−ラ ロシュ アーゲー | 酸塩化物の新規合成方法 |
| US20090054304A1 (en) | 2007-08-23 | 2009-02-26 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 for treatment of disease |
| US20090105124A1 (en) | 2007-08-23 | 2009-04-23 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 |
| CN101981001B (zh) | 2008-04-04 | 2016-06-08 | 弗·哈夫曼-拉罗切有限公司 | 制备环己烷甲酸衍生物的新方法 |
| ES2460900T3 (es) | 2008-04-04 | 2014-05-14 | F. Hoffmann-La Roche Ag | Nuevo procedimiento para la preparación de derivados de ácido ciclohexanocarboxílico mediante el correspondiente derivado ciclohexanocarboxamida |
| AU2009259495B2 (en) | 2008-06-17 | 2014-04-03 | F. Hoffmann-La Roche Ag | 1-(2-ethyl-butyl) -cyclohexanecarboxylic acid ester as an intermediate in the preparation of pharmaceutically active amides |
| EP2177615A1 (en) * | 2008-10-10 | 2010-04-21 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Method for a genome wide identification of expression regulatory sequences and use of genes and molecules derived thereof for the diagnosis and therapy of metabolic and/or tumorous diseases |
| WO2010056910A2 (en) | 2008-11-12 | 2010-05-20 | Carolus Therapeutics, Inc. | Methods of treating cardiovascular disorders |
| BRPI0922888A2 (pt) | 2008-12-08 | 2019-09-24 | Hoffmann La Roche | administração combinada de fármaco |
| NZ624963A (en) | 2009-04-29 | 2016-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| US20110004011A1 (en) | 2009-07-01 | 2011-01-06 | Declan Costello | Novel process |
| JP2012533560A (ja) | 2009-07-15 | 2012-12-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 細胞における取り込みが制御可能なペプチド |
| EP2598158A4 (en) | 2010-07-28 | 2014-03-12 | Inst Cardiologie Montreal | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION COMPRISING A PEPTIDE / PHOSPHOLIPID COMPLEX OF APOLIPOPROTEINS |
| MX2013002656A (es) | 2010-09-16 | 2013-04-08 | Hoffmann La Roche | Nuevo proceso. |
| EA025649B1 (ru) | 2010-11-04 | 2017-01-30 | Ф.Хоффманн-Ля Рош Аг | Таблетка, содержащая s-[2-([[1-(2-этилбутил)циклогексил]карбонил]амино)фенил]-2-метилпропантиоат и кроскарамеллозу натрия |
| MX2013006031A (es) | 2010-12-08 | 2013-07-15 | Hoffmann La Roche | Formulacion liposomal de dalcetrapib. |
| TR201818880T4 (tr) | 2010-12-16 | 2019-01-21 | Hoffmann La Roche | Disülfürlerin hidrojenasyonu yoluyla aromatik tiyol türevlerinin hazırlanması prosesi. |
| WO2012112720A2 (en) * | 2011-02-15 | 2012-08-23 | The Ohio University Research Foundaton | Methods for predicting cardiovascular risks and responsiveness to statin therapy using snps |
| KR20140006879A (ko) * | 2011-02-17 | 2014-01-16 | 에프. 호프만-라 로슈 아게 | 고온 용융 압출에 의해 활성 약학 성분을 과냉된 액체 상태로부터 제어되는 방식으로 결정화시키는 방법 |
| WO2012136272A1 (en) | 2011-04-08 | 2012-10-11 | Zora Biosciences Oy | Biomarkers for sensitive detection of statin-induced muscle toxicity |
| US9541565B2 (en) | 2011-04-08 | 2017-01-10 | Zora Biosciences Oy | Biomarkers for sensitive detection of statin-induced muscle toxicity |
| US20120301439A1 (en) | 2011-05-24 | 2012-11-29 | Washington University | Inhibition of choroidal neovascularization |
| US8975438B2 (en) | 2011-07-13 | 2015-03-10 | Hoffmann-La Roche Inc. | Process for the preparation of cyclohexanecarboxylic acid derivatives |
| AR089853A1 (es) | 2012-02-01 | 2014-09-24 | Boehringer Ingelheim Int | Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso |
| TW201350475A (zh) | 2012-03-06 | 2013-12-16 | Boehringer Ingelheim Int | 用於組合療法之白三烯素生成之苯并二噁烷抑制劑 |
| JP2015515498A (ja) | 2012-04-30 | 2015-05-28 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規製剤 |
| MX351059B (es) | 2012-08-17 | 2017-09-29 | Laboratorios Senosiain S A De C V Star | Composicion farmaceutica oral en forma de microesferas y proceso de elaboracion. |
| RU2707533C2 (ru) | 2013-03-27 | 2019-11-27 | Ф. Хоффманн-Ля Рош Аг | Генетические маркеры для прогнозирования восприимчивости к терапии |
| RU2016127357A (ru) | 2013-12-19 | 2018-01-24 | Ф. Хоффманн-Ля Рош Аг | Модулятор сетр для применения в лечении заболеваний глаз |
| CN106559998B (zh) * | 2014-07-30 | 2022-01-25 | 豪夫迈·罗氏有限公司 | 预测对hdl升高剂或hdl模拟剂疗法的应答性的遗传标记 |
| US20190070178A1 (en) * | 2017-08-29 | 2019-03-07 | Dalcor Pharma Uk Ltd., Stockport Zug Branch | Methods for treating or preventing cardiovascular disorders and lowering risk of cardiovascular events |
| SG11202101086YA (en) * | 2018-08-09 | 2021-03-30 | Dalcor Pharma Uk Ltd Leatherhead | Methods for delaying occurrence of new-onset type 2 diabetes and for slowing progression of and treating type 2 diabetes |
-
2014
- 2014-03-24 RU RU2015145133A patent/RU2707533C2/ru active
- 2014-03-24 LT LTEP14714628.6T patent/LT2978859T/lt unknown
- 2014-03-24 PL PL14714628T patent/PL2978859T3/pl unknown
- 2014-03-24 WO PCT/EP2014/055790 patent/WO2014154606A1/en active Application Filing
- 2014-03-24 EP EP18176394.7A patent/EP3404115A1/en not_active Withdrawn
- 2014-03-24 CA CA2897420A patent/CA2897420C/en active Active
- 2014-03-24 CN CN201911328044.6A patent/CN111073974B/zh active Active
- 2014-03-24 CN CN201480017986.1A patent/CN105164276B/zh active Active
- 2014-03-24 SI SI201430853T patent/SI2978859T1/sl unknown
- 2014-03-24 KR KR1020157026058A patent/KR102153557B1/ko active IP Right Grant
- 2014-03-24 JP JP2016504603A patent/JP6449235B2/ja active Active
- 2014-03-24 MX MX2015013505A patent/MX370538B/es active IP Right Grant
- 2014-03-24 HU HUE14714628A patent/HUE039973T2/hu unknown
- 2014-03-24 RS RS20180997A patent/RS57640B1/sr unknown
- 2014-03-24 EP EP14714628.6A patent/EP2978859B1/en active Active
- 2014-03-24 PT PT14714628T patent/PT2978859T/pt unknown
- 2014-03-24 DK DK14714628.6T patent/DK2978859T3/en active
- 2014-03-24 BR BR112015024116A patent/BR112015024116A2/pt not_active Application Discontinuation
- 2014-03-24 ES ES14714628.6T patent/ES2685269T3/es active Active
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2015
- 2015-09-22 MX MX2019015058A patent/MX2019015058A/es unknown
- 2015-09-23 US US14/863,148 patent/US9909178B2/en active Active
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2016
- 2016-02-11 HK HK16101496.9A patent/HK1213602A1/zh unknown
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2018
- 2018-01-22 US US15/877,019 patent/US20180155784A1/en not_active Abandoned
- 2018-08-22 US US16/109,447 patent/US10711303B2/en active Active
- 2018-08-24 HR HRP20181358TT patent/HRP20181358T1/hr unknown
- 2018-12-05 JP JP2018228045A patent/JP2019058180A/ja active Pending
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2020
- 2020-06-03 US US16/891,493 patent/US11549142B2/en active Active
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