PT2621891T - Polimorfos de cloridrato de 4-metilbenzoato de 4-[2- dimetilamino-1-(1-hidroxiciclohexil)etil]fenilo, métodos para a preparação dos mesmos e utilização dos mesmos - Google Patents
Polimorfos de cloridrato de 4-metilbenzoato de 4-[2- dimetilamino-1-(1-hidroxiciclohexil)etil]fenilo, métodos para a preparação dos mesmos e utilização dos mesmosInfo
- Publication number
- PT2621891T PT2621891T PT118279116T PT11827911T PT2621891T PT 2621891 T PT2621891 T PT 2621891T PT 118279116 T PT118279116 T PT 118279116T PT 11827911 T PT11827911 T PT 11827911T PT 2621891 T PT2621891 T PT 2621891T
- Authority
- PT
- Portugal
- Prior art keywords
- same
- hydroxycyclohexyl
- polymorphs
- dimethylamino
- phenyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
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-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Psychology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010503737 | 2010-10-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2621891T true PT2621891T (pt) | 2020-02-04 |
Family
ID=45891856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT118279116T PT2621891T (pt) | 2010-10-01 | 2011-09-28 | Polimorfos de cloridrato de 4-metilbenzoato de 4-[2- dimetilamino-1-(1-hidroxiciclohexil)etil]fenilo, métodos para a preparação dos mesmos e utilização dos mesmos |
Country Status (17)
Country | Link |
---|---|
US (2) | US8741952B2 (zh) |
EP (1) | EP2621891B1 (zh) |
JP (7) | JP2014500234A (zh) |
KR (3) | KR101640808B1 (zh) |
CN (3) | CN103588653B (zh) |
AU (1) | AU2011307952B2 (zh) |
BR (3) | BR122014004636B1 (zh) |
CA (3) | CA2860747C (zh) |
CY (1) | CY1122772T1 (zh) |
DK (1) | DK2621891T3 (zh) |
ES (1) | ES2769581T3 (zh) |
MY (1) | MY160607A (zh) |
PL (1) | PL2621891T3 (zh) |
PT (1) | PT2621891T (zh) |
RU (1) | RU2576665C2 (zh) |
SG (1) | SG188637A1 (zh) |
WO (1) | WO2012041013A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104672097B (zh) * | 2013-12-03 | 2016-06-29 | 山东绿叶制药有限公司 | 化合物对甲基苯甲酸4-(2-二甲胺基-1-环己烯基乙基)苯酯制备方法及应用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4535186A (en) | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
WO1999002522A1 (fr) * | 1997-07-11 | 1999-01-21 | Dainippon Pharmaceutical Co., Ltd. | (r)-n-(1-ethyl-1h-hexahydroazepine-3-yl)-6-methoxy-1h-benzotriazole-5-carbooxamide monofumarate monohydrate et son procede de production |
PL350924A1 (en) * | 1999-04-06 | 2003-02-10 | Sepracor Inc | Derivatives of venlafaxine and methods of preparing and using the same |
US20020022662A1 (en) | 1999-06-15 | 2002-02-21 | American Home Products Corporation | Enantiomers of O-desmethyl venlafaxine |
US7291646B2 (en) | 1999-11-24 | 2007-11-06 | Wyeth | Ethers of O-desmethyl venlafaxine |
NZ519130A (en) * | 1999-11-24 | 2003-09-26 | Wyeth Corp | Ethers of O-desmethyl venlafaxine useful for treating central nervous system disorders |
US6348494B1 (en) * | 2000-11-21 | 2002-02-19 | American Home Products Corporation | Ethers of o-desmethyl venlafaxine |
SK5762003A3 (en) * | 2000-10-19 | 2003-11-04 | Teva Pharma | Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof |
WO2002046140A1 (en) * | 2000-12-07 | 2002-06-13 | Dr. Reddy's Laboratories Ltd. | Novel crystalline polymorphic forms of venlafaxine hydrochloride and a process for their preparation |
ES2290281T5 (es) | 2001-02-12 | 2017-09-11 | Wyeth Llc | Sal de succinato de O-desmetil-venlafaxina |
WO2003042162A1 (en) * | 2001-11-17 | 2003-05-22 | Neurosearch A/S | Prodrugs of antidepressants and their use for treating depressions |
RU2004120285A (ru) | 2001-12-05 | 2005-04-10 | Уайт (Us) | Новый кристаллический полиморф гидрохлорида венлафаксина и способы его получения |
WO2003082806A1 (en) | 2002-03-28 | 2003-10-09 | Synthon B.V. | Venlafaxine base |
CN101024654A (zh) * | 2002-04-11 | 2007-08-29 | 特瓦制药工业有限公司 | 利塞膦酸钠的新多晶型物和假多晶型物 |
US7875642B2 (en) * | 2004-01-26 | 2011-01-25 | Merck Sharp & Dohme Corp. | Crystalline forms of an inhibitor of 11-β-hydroxysteroid dehydrogenase type 1 |
CN100455560C (zh) * | 2004-06-09 | 2009-01-28 | 中国人民解放军军事医学科学院放射医学研究所 | 含长链脂肪酰基取代的文拉法辛前体药物及其制备方法和用途 |
CN1955159B (zh) * | 2005-06-17 | 2010-11-24 | 山东绿叶制药有限公司 | 用于阻断5-羟色胺以及去甲基肾上腺素再摄取的化合物,其制备方法及其用途 |
GT200600397A (es) * | 2005-09-07 | 2007-08-28 | Formulas topicas conteniendo o-desmetil venlafaxina (odv) o sus sales |
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2011
- 2011-09-28 CA CA2860747A patent/CA2860747C/en active Active
- 2011-09-28 ES ES11827911T patent/ES2769581T3/es active Active
- 2011-09-28 JP JP2013530528A patent/JP2014500234A/ja active Pending
- 2011-09-28 EP EP11827911.6A patent/EP2621891B1/en active Active
- 2011-09-28 CA CA2812227A patent/CA2812227C/en active Active
- 2011-09-28 CN CN201310464696.9A patent/CN103588653B/zh active Active
- 2011-09-28 PT PT118279116T patent/PT2621891T/pt unknown
- 2011-09-28 KR KR1020137011253A patent/KR101640808B1/ko active IP Right Grant
- 2011-09-28 DK DK11827911.6T patent/DK2621891T3/da active
- 2011-09-28 BR BR122014004636-7A patent/BR122014004636B1/pt active IP Right Grant
- 2011-09-28 WO PCT/CN2011/001637 patent/WO2012041013A1/en active Application Filing
- 2011-09-28 CA CA2860748A patent/CA2860748C/en active Active
- 2011-09-28 PL PL11827911T patent/PL2621891T3/pl unknown
- 2011-09-28 MY MYPI2013001148A patent/MY160607A/en unknown
- 2011-09-28 CN CN201310462622.1A patent/CN103588652B/zh active Active
- 2011-09-28 BR BR122014004640-5A patent/BR122014004640B1/pt active IP Right Grant
- 2011-09-28 KR KR1020147007372A patent/KR101477155B1/ko active IP Right Grant
- 2011-09-28 AU AU2011307952A patent/AU2011307952B2/en active Active
- 2011-09-28 RU RU2013119806/04A patent/RU2576665C2/ru active
- 2011-09-28 SG SG2013021472A patent/SG188637A1/en unknown
- 2011-09-28 BR BR112013008664-5A patent/BR112013008664B1/pt active IP Right Grant
- 2011-09-28 CN CN201180036015.8A patent/CN103025705B/zh active Active
- 2011-09-28 KR KR1020147007371A patent/KR101477154B1/ko active IP Right Grant
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2013
- 2013-03-18 US US13/846,773 patent/US8741952B2/en active Active
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2014
- 2014-04-23 US US14/259,964 patent/US9199912B2/en active Active
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2015
- 2015-08-07 JP JP2015156966A patent/JP2015205932A/ja active Pending
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2016
- 2016-06-23 JP JP2016124043A patent/JP2016188233A/ja active Pending
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2017
- 2017-09-08 JP JP2017172815A patent/JP2017210494A/ja active Pending
- 2017-09-08 JP JP2017172806A patent/JP6434591B2/ja active Active
- 2017-12-14 JP JP2017239299A patent/JP6522094B2/ja active Active
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2019
- 2019-07-19 JP JP2019133324A patent/JP6908657B2/ja active Active
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2020
- 2020-02-03 CY CY20201100094T patent/CY1122772T1/el unknown
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