PT2443104E - Antagonistas do caminho hedgehog de ftalazina dissubstituída - Google Patents
Antagonistas do caminho hedgehog de ftalazina dissubstituída Download PDFInfo
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- PT2443104E PT2443104E PT107267569T PT10726756T PT2443104E PT 2443104 E PT2443104 E PT 2443104E PT 107267569 T PT107267569 T PT 107267569T PT 10726756 T PT10726756 T PT 10726756T PT 2443104 E PT2443104 E PT 2443104E
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- Prior art keywords
- cancer
- methyl
- pharmaceutically acceptable
- acceptable salt
- compound according
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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Landscapes
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- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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| CA2742539C (en) * | 2008-11-03 | 2014-05-06 | Eli Lilly And Company | Disubstituted phthalazine hedgehog pathway antagonists |
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| EA018372B1 (ru) * | 2008-11-17 | 2013-07-30 | Эли Лилли Энд Компани | Тетразамещенные пиридазины в качестве антагонистов пути hedgehog |
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| CN105017140B (zh) * | 2014-04-28 | 2017-12-29 | 复旦大学 | 邻氨基苯甲酰胺化合物及其制备方法和用途 |
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| CN106279114B (zh) * | 2016-08-04 | 2019-01-29 | 东南大学 | 一种Taladegib的合成方法 |
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| CN106831718B (zh) * | 2016-12-30 | 2019-05-07 | 上海科技大学 | 平滑受体配体及其应用 |
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| JP5221952B2 (ja) | 2004-05-08 | 2013-06-26 | ノバルティス・インターナショナル・ファーマシューティカル・リミテッド | ３−アリール−５，６−ジ置換ピリダジン類 |
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| WO2010017240A2 (en) * | 2008-08-04 | 2010-02-11 | Amgen Inc. | Aurora kinase modulators and methods of use |
| CA2742539C (en) | 2008-11-03 | 2014-05-06 | Eli Lilly And Company | Disubstituted phthalazine hedgehog pathway antagonists |
| ES2392759T3 (es) | 2008-11-17 | 2012-12-13 | Eli Lilly And Company | Piridazina tetrasustituida como antagonistas de la vía Hedgehog. |
| EA018372B1 (ru) | 2008-11-17 | 2013-07-30 | Эли Лилли Энд Компани | Тетразамещенные пиридазины в качестве антагонистов пути hedgehog |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
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