PT2427467E - Profármacos de triptólido - Google Patents
Profármacos de triptólido Download PDFInfo
- Publication number
- PT2427467E PT2427467E PT107191884T PT10719188T PT2427467E PT 2427467 E PT2427467 E PT 2427467E PT 107191884 T PT107191884 T PT 107191884T PT 10719188 T PT10719188 T PT 10719188T PT 2427467 E PT2427467 E PT 2427467E
- Authority
- PT
- Portugal
- Prior art keywords
- compound
- cancer
- formula
- triptolide
- alkyl
- Prior art date
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- DFBIRQPKNDILPW-CIVMWXNOSA-N Triptolide Chemical compound O=C1OCC([C@@H]2C3)=C1CC[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1(C(C)C)[C@@H](O)[C@]21[C@H]3O1 DFBIRQPKNDILPW-CIVMWXNOSA-N 0.000 title description 96
- YKUJZZHGTWVWHA-UHFFFAOYSA-N triptolide Natural products COC12CC3OC3(C(C)C)C(O)C14OC4CC5C6=C(CCC25C)C(=O)OC6 YKUJZZHGTWVWHA-UHFFFAOYSA-N 0.000 title description 86
- 229940002612 prodrug Drugs 0.000 title description 49
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- 150000001875 compounds Chemical class 0.000 claims description 156
- 206010028980 Neoplasm Diseases 0.000 claims description 119
- 201000011510 cancer Diseases 0.000 claims description 50
- 150000003839 salts Chemical class 0.000 claims description 43
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- -1 pyrrolidino, piperidino, piperazino Chemical group 0.000 claims description 19
- 101710163595 Chaperone protein DnaK Proteins 0.000 claims description 16
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- 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 claims description 16
- 239000011734 sodium Substances 0.000 claims description 16
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 14
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 14
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- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical group CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 12
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 10
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Classifications
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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| US9150600B2 (en) | 2009-05-07 | 2015-10-06 | Regents Of The University Of Minnesota | Triptolide prodrugs |
| KR20150059746A (ko) | 2012-08-23 | 2015-06-02 | 세네스텍 인코포레이티드 | 포유동물의 번식 능력을 감소시키는 방법 |
| WO2014047783A1 (zh) * | 2012-09-25 | 2014-04-03 | 鼎泓国际投资（香港）有限公司 | 含有雷公藤甲素及雷公藤甲素类衍生物和Bcl-2抑制剂的药物组合物及其应用 |
| WO2014167581A2 (en) * | 2013-04-01 | 2014-10-16 | Laurus Labs Private Limited | An improved process for the preparation of triptolide prodrugs |
| SG11201802915WA (en) * | 2015-09-11 | 2018-05-30 | Ys Ac Co Ltd | Cancer treatment composition combining anti-cd26 antibody and other anticancer agent |
| CN109942665B (zh) * | 2018-04-02 | 2021-04-06 | 欣凯医药化工中间体（上海）有限公司 | 雷公藤内酯醇衍生物及其制备方法和应用 |
| CN110551171B (zh) * | 2018-05-31 | 2021-07-27 | 欣凯医药化工中间体（上海）有限公司 | 一种雷公藤内酯醇衍生物的制备方法 |
| WO2020056174A1 (en) | 2018-09-13 | 2020-03-19 | Minneamrita Therapeutics, LLC | Triptolide and prodrugs thereof for use in methods to treat fibrosis, nash, and nafld |
| WO2021221179A1 (ja) * | 2020-04-28 | 2021-11-04 | 国立大学法人高知大学 | ヒト膵癌オルガノイドを用いたマウスモデルの樹立 |
| JP2023538424A (ja) | 2020-08-21 | 2023-09-07 | ルヤン コーポレイション | トリプトリドコンジュゲートおよびその使用 |
| CN115227829B (zh) * | 2022-02-22 | 2023-10-13 | 成都中医药大学 | 酸敏感性适配体雷公藤甲素偶联物及应用 |
| WO2024186320A1 (en) | 2023-03-09 | 2024-09-12 | Minneamrita Therapeutics Llc | Drug combination for treatment of pancreatic cancer |
| WO2024187139A1 (en) | 2023-03-09 | 2024-09-12 | Minneamrita Therapeutics Llc | Drug combination for treatment of gastric cancer |
| JP7759145B2 (ja) | 2023-03-09 | 2025-10-23 | ミネアムリタ セラピューティクス， エルエルシー | 胃癌の治療のための薬物の組み合わせ |
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| US5759550A (en) | 1993-05-06 | 1998-06-02 | Pharmagenesis, Inc. | Method for suppressing xenograft rejection |
| US5609991A (en) | 1995-02-10 | 1997-03-11 | Morton International, Inc. | Photoimageable composition having improved alkaline process resistance and tack-free surface for contact imaging |
| US5663335A (en) | 1996-03-01 | 1997-09-02 | Pharmagenesis, Inc. | Immunosuppressive compounds and methods |
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-
2010
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- 2010-05-07 AU AU2010245669A patent/AU2010245669B2/en active Active
- 2010-05-07 MX MX2011011776A patent/MX2011011776A/es active IP Right Grant
- 2010-05-07 MY MYPI2011005335A patent/MY160392A/en unknown
- 2010-05-07 CN CN201080031839.1A patent/CN102596977B/zh active Active
- 2010-05-07 ES ES10719188.4T patent/ES2552163T3/es active Active
- 2010-05-07 PT PT107191884T patent/PT2427467E/pt unknown
- 2010-05-07 US US13/319,316 patent/US8507552B2/en active Active
- 2010-05-07 EA EA201190293A patent/EA021135B1/ru unknown
- 2010-05-07 DK DK10719188.4T patent/DK2427467T3/en active
- 2010-05-07 JP JP2012510027A patent/JP6000122B2/ja active Active
- 2010-05-07 KR KR1020117029123A patent/KR101821823B1/ko active Active
- 2010-05-07 CA CA2964631A patent/CA2964631A1/en not_active Abandoned
- 2010-05-07 CA CA2760953A patent/CA2760953C/en active Active
- 2010-05-07 BR BRPI1014802A patent/BRPI1014802B8/pt active IP Right Grant
- 2010-05-07 WO PCT/US2010/034117 patent/WO2010129918A1/en not_active Ceased
- 2010-05-07 EP EP10719188.4A patent/EP2427467B1/en active Active
- 2010-05-07 SG SG2011081122A patent/SG175885A1/en unknown
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2014
- 2014-07-03 JP JP2014137661A patent/JP2014185181A/ja not_active Withdrawn
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2016
- 2016-01-08 JP JP2016002236A patent/JP2016065099A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| SG175885A1 (en) | 2011-12-29 |
| CN102596977A (zh) | 2012-07-18 |
| EP2427467A1 (en) | 2012-03-14 |
| KR101821823B1 (ko) | 2018-01-24 |
| BRPI1014802B8 (pt) | 2021-05-25 |
| HK1168107A1 (en) | 2012-12-21 |
| US8507552B2 (en) | 2013-08-13 |
| BRPI1014802B1 (pt) | 2020-09-24 |
| EP2427467B1 (en) | 2015-08-05 |
| DK2427467T3 (en) | 2015-11-09 |
| JP6000122B2 (ja) | 2016-09-28 |
| MX2011011776A (es) | 2012-08-03 |
| US20120238529A1 (en) | 2012-09-20 |
| CA2760953C (en) | 2017-05-30 |
| EA021135B1 (ru) | 2015-04-30 |
| WO2010129918A8 (en) | 2011-01-20 |
| CA2964631A1 (en) | 2010-11-11 |
| MY160392A (en) | 2017-03-15 |
| EA201190293A1 (ru) | 2012-11-30 |
| KR20120015339A (ko) | 2012-02-21 |
| AU2010245669A1 (en) | 2011-12-01 |
| BRPI1014802A2 (pt) | 2016-04-05 |
| WO2010129918A1 (en) | 2010-11-11 |
| CA2760953A1 (en) | 2010-11-11 |
| JP2014185181A (ja) | 2014-10-02 |
| JP2012526148A (ja) | 2012-10-25 |
| ES2552163T3 (es) | 2015-11-26 |
| PL2427467T3 (pl) | 2016-04-29 |
| CN102596977B (zh) | 2016-06-29 |
| AU2010245669B2 (en) | 2015-11-26 |
| JP2016065099A (ja) | 2016-04-28 |
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