PT2221298E - Derivados de fenilpirazole - Google Patents

Derivados de fenilpirazole

Info

Publication number
PT2221298E
PT2221298E PT88497250T PT08849725T PT2221298E PT 2221298 E PT2221298 E PT 2221298E PT 88497250 T PT88497250 T PT 88497250T PT 08849725 T PT08849725 T PT 08849725T PT 2221298 E PT2221298 E PT 2221298E
Authority
PT
Portugal
Prior art keywords
alkyl
halogen
heterocyclic ring
saturated heterocyclic
formula
Prior art date
Application number
PT88497250T
Other languages
English (en)
Portuguese (pt)
Inventor
Toshio Nakamura
Shigeyuki Chaki
Hiroshi Ohta
Makoto Tatsuzuki
Dai Nozawa
Tomoko Tamita
Seiji Masuda
Shuhei Kashiwa
Aya Fujino
Toshiharu Shimazaki
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of PT2221298E publication Critical patent/PT2221298E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38Nitrogen atoms
    • C07D231/40Acylated on said nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT88497250T 2007-11-13 2008-11-13 Derivados de fenilpirazole PT2221298E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007294040 2007-11-13
JP2008153736 2008-06-12

Publications (1)

Publication Number Publication Date
PT2221298E true PT2221298E (pt) 2013-12-03

Family

ID=40638800

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88497250T PT2221298E (pt) 2007-11-13 2008-11-13 Derivados de fenilpirazole

Country Status (24)

Country Link
US (3) US7888354B2 (cg-RX-API-DMAC7.html)
EP (1) EP2221298B1 (cg-RX-API-DMAC7.html)
JP (2) JP4543344B2 (cg-RX-API-DMAC7.html)
KR (1) KR101571176B1 (cg-RX-API-DMAC7.html)
CN (1) CN101855211B (cg-RX-API-DMAC7.html)
AU (1) AU2008321823B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0820432B8 (cg-RX-API-DMAC7.html)
CA (1) CA2705502C (cg-RX-API-DMAC7.html)
CY (1) CY1114877T1 (cg-RX-API-DMAC7.html)
DK (1) DK2221298T3 (cg-RX-API-DMAC7.html)
ES (1) ES2436146T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20131060T1 (cg-RX-API-DMAC7.html)
IL (2) IL205509A (cg-RX-API-DMAC7.html)
MX (1) MX2010005225A (cg-RX-API-DMAC7.html)
MY (1) MY173546A (cg-RX-API-DMAC7.html)
NZ (1) NZ585661A (cg-RX-API-DMAC7.html)
PH (1) PH12012501917A1 (cg-RX-API-DMAC7.html)
PL (1) PL2221298T3 (cg-RX-API-DMAC7.html)
PT (1) PT2221298E (cg-RX-API-DMAC7.html)
RS (1) RS53125B (cg-RX-API-DMAC7.html)
RU (1) RU2480456C2 (cg-RX-API-DMAC7.html)
SI (1) SI2221298T1 (cg-RX-API-DMAC7.html)
WO (1) WO2009063953A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201003111B (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008072724A1 (ja) * 2006-12-14 2008-06-19 Taisho Pharmaceutical Co., Ltd. ピラゾール誘導体
CA2705502C (en) * 2007-11-13 2016-01-26 Taisho Pharmaceutical Co., Ltd. Phenylpyrazole derivatives
JP5740838B2 (ja) * 2009-05-12 2015-07-01 大正製薬株式会社 フェニルピラゾール誘導体
EP2789608A4 (en) * 2011-12-08 2015-07-01 Taisho Pharmaceutical Co Ltd PHENYLPYRROLDERIVAT
US20150045553A1 (en) * 2011-12-27 2015-02-12 Taisho Pharmaceutical Co., Ltd Phenyltriazole derivative
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
MX2015007051A (es) * 2012-12-07 2016-01-12 Chemocentryx Inc Diazol lactamas.
BR112015016323A2 (pt) * 2013-01-17 2017-07-11 Hoffmann La Roche agonistas de receptor de oxitocina para tratamento de doenças de cns
PL3439653T3 (pl) 2016-04-07 2021-07-05 Chemocentryx, Inc. Zmniejszenie obciążenia guzem przez podawanie antagonistów ccr1 w skojarzeniu z inhibitorami pd-1 lub inhibitorami pd-l1

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL104311A (en) * 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HUP0302893A3 (en) 2000-08-08 2006-04-28 Ortho Mcneil Pharm Inc Non-imidazole aryloxypiperidines and pharmaceutical compositions containing them and their use
US6316475B1 (en) * 2000-11-17 2001-11-13 Abbott Laboratories Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications
MXPA03008319A (es) * 2001-03-16 2003-12-11 Abbott Lab Nuevas aminas como ligantes del receptor de histamina-3 y sus aplicaciones terapeuticas.
US7595316B2 (en) 2003-06-27 2009-09-29 Banyu Pharmaceutical Co., Ltd. Heteroaryloxy nitrogenous saturated heterocyclic derivative
CA2561791A1 (en) 2004-03-31 2005-10-20 Janssen Pharmaceutica, N.V. Non-imidazole heterocyclic compounds
GB0408083D0 (en) 2004-04-08 2004-05-12 Glaxo Group Ltd Novel compounds
FR2870846B1 (fr) 2004-05-25 2006-08-04 Sanofi Synthelabo Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique
SE0401971D0 (sv) 2004-08-02 2004-08-02 Astrazeneca Ab Piperidne derivatives
AU2005277518B2 (en) 2004-08-23 2011-08-04 Eli Lilly And Company Histamine H3 receptor agents, preparation and therapeutic uses
CN101044135B (zh) 2004-10-19 2011-11-23 霍夫曼-拉罗奇有限公司 喹啉衍生物
WO2006046131A1 (en) 2004-10-29 2006-05-04 Pfizer Products Inc. Tetralin histamine-3 receptor antagonists
WO2006059778A1 (ja) * 2004-12-01 2006-06-08 Banyu Pharmaceutical Co., Ltd. 置換ピリドン誘導体
JP2008523006A (ja) 2004-12-07 2008-07-03 グラクソ グループ リミテッド インデニル誘導体および神経学的障害の治療のためのそれらの使用
JP2008534542A (ja) * 2005-03-31 2008-08-28 ユセベ ファルマ ソシエテ アノニム オキサゾール部分又はチアゾール部分を含む化合物、それらの製造方法及びそれらの使用
JP5072827B2 (ja) 2005-04-01 2012-11-14 イーライ リリー アンド カンパニー ヒスタミンh3受容体薬剤、製剤及び治療的使用
DE102005033448A1 (de) * 2005-07-18 2007-01-25 Josef Gail Druckgas-Zylinderläufermotor
GB0514811D0 (en) * 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
GB0514812D0 (en) * 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
DK1988777T3 (da) 2006-02-09 2012-01-16 Athersys Inc Pyrazoler til behandling af fedme og andre cns-lidelser
WO2008072724A1 (ja) 2006-12-14 2008-06-19 Taisho Pharmaceutical Co., Ltd. ピラゾール誘導体
EP2134673A1 (en) * 2007-04-12 2009-12-23 DSM Fine Chemicals Austria Nfg GmbH & Co KG Improved process for preparing o-chloromethylphenylglyoxylic esters, improved process for preparing (e)-2-(2-chloromethylphenyl)-2-alkoximinoacetic esters, and novel intermediates for their preparation
CA2705502C (en) * 2007-11-13 2016-01-26 Taisho Pharmaceutical Co., Ltd. Phenylpyrazole derivatives

Also Published As

Publication number Publication date
AU2008321823A1 (en) 2009-05-22
CA2705502C (en) 2016-01-26
US20110065667A1 (en) 2011-03-17
US8183387B2 (en) 2012-05-22
EP2221298A1 (en) 2010-08-25
US7888354B2 (en) 2011-02-15
IL205509A0 (en) 2010-12-30
MY173546A (en) 2020-02-04
RU2010123924A (ru) 2011-12-20
EP2221298A4 (en) 2011-09-21
CA2705502A1 (en) 2009-05-22
ES2436146T3 (es) 2013-12-27
PL2221298T3 (pl) 2014-05-30
KR101571176B1 (ko) 2015-11-23
NZ585661A (en) 2012-04-27
ZA201003111B (en) 2011-08-31
BRPI0820432B8 (pt) 2021-05-25
CN101855211A (zh) 2010-10-06
BRPI0820432A2 (pt) 2015-05-26
JP2010143943A (ja) 2010-07-01
MX2010005225A (es) 2010-05-27
RS53125B (sr) 2014-06-30
US20110065668A1 (en) 2011-03-17
WO2009063953A1 (ja) 2009-05-22
JPWO2009063953A1 (ja) 2011-03-31
RU2480456C2 (ru) 2013-04-27
IL205509A (en) 2015-09-24
HK1145834A1 (en) 2011-05-06
BRPI0820432B1 (pt) 2020-01-14
CY1114877T1 (el) 2016-12-14
JP5375639B2 (ja) 2013-12-25
CN101855211B (zh) 2013-06-12
US8193176B2 (en) 2012-06-05
EP2221298B1 (en) 2013-11-06
KR20100083795A (ko) 2010-07-22
IL236083A (en) 2016-12-29
HRP20131060T1 (hr) 2013-12-20
AU2008321823B2 (en) 2013-03-07
IL236083A0 (en) 2015-01-29
DK2221298T3 (da) 2013-11-18
PH12012501917A1 (en) 2014-10-17
SI2221298T1 (sl) 2013-12-31
JP4543344B2 (ja) 2010-09-15
US20100267687A1 (en) 2010-10-21

Similar Documents

Publication Publication Date Title
PT2221298E (pt) Derivados de fenilpirazole
MX2011008336A (es) Derivados de dihidroquinolinona.
CY1121543T1 (el) Ενωση πυριδυλαμινοοξεικου οξεος
NO20082136L (no) 1,5-substituerte indol-2-yl-amidderivater
ATE545413T1 (de) Antagonisten des opioidrezeptors
MX2010005717A (es) Derivados de isoxazolo-piridina.
NO20090166L (no) Amino-imidazoloner og deres anvendelse som et medikament for behandling av kognitiv svekkelse, Alzheimers sykdom, neurodegenerering og demens
NO20076134L (no) Benzamidderivater og anvendelser derav
NO20075086L (no) Behandling av Parkinsons sykdom, obstruktiv sovn apne, demens med Lewy legemer, vaskulaer demens med ikke-imidazol alkylamin histamin H3-reseptor ligander
MX2011011489A (es) Derivados de isoxazol-piridina.
NZ617334A (en) Cyclopropyl amine derivatives
NO20083058L (no) Cykloheksylsulfonamidderivater med H3 reseptor aktivitet
DK1778673T3 (da) Nye hydantoin-derivater til behandling af obstruktive luftvejssygdomme
CA2702933A1 (en) Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof
NO20084516L (no) Terfenylderivater for behandling av alzheimers sykdom
ATE544756T1 (de) Substituierte carbinolverbindungen
MX2011011273A (es) Derivados de isoxazol-pirazol.
ATE512961T1 (de) Amorphes nebivolol hydrochlorid und seine herstellung
WO2007057790A3 (en) Substituted bicyclic pyrimidone derivatives
ATE495159T1 (de) Diaminocyclohexan- und diaminocyclopentanderivate
EA201171229A1 (ru) Терапевтическое применение производных хиназолиндиона при сердечно-сосудистых заболеваниях
EA201070367A1 (ru) Производное 6-пиримидинилпиримид-4-она
PH12014501293A1 (en) Phenylpyrrole derivative
ATE449776T1 (de) Pyrroloä2,3-cüpyridinderivate
EA200700707A1 (ru) Производные 2-ациламинотиазола