PT1572641E - Processo para a preparação do estereoisómero de glicopirrónio de configuração r,r (ou s,s) - Google Patents
Processo para a preparação do estereoisómero de glicopirrónio de configuração r,r (ou s,s) Download PDFInfo
- Publication number
- PT1572641E PT1572641E PT03782435T PT03782435T PT1572641E PT 1572641 E PT1572641 E PT 1572641E PT 03782435 T PT03782435 T PT 03782435T PT 03782435 T PT03782435 T PT 03782435T PT 1572641 E PT1572641 E PT 1572641E
- Authority
- PT
- Portugal
- Prior art keywords
- formula
- diastereomers
- isomer
- mixtures
- quaternization
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0189602A AT412088B (de) | 2002-12-18 | 2002-12-18 | Verfahren zur herstellung der r,r oder s,s konfigurierten glycopyrronium-isomere |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1572641E true PT1572641E (pt) | 2012-06-15 |
Family
ID=31192804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT03782435T PT1572641E (pt) | 2002-12-18 | 2003-12-18 | Processo para a preparação do estereoisómero de glicopirrónio de configuração r,r (ou s,s) |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7569598B2 (https=) |
| EP (1) | EP1572641B1 (https=) |
| JP (1) | JP2007524565A (https=) |
| CN (1) | CN100349867C (https=) |
| AT (2) | AT412088B (https=) |
| AU (1) | AU2003290075B2 (https=) |
| CA (1) | CA2510280C (https=) |
| DK (1) | DK1572641T3 (https=) |
| ES (1) | ES2383799T3 (https=) |
| NO (1) | NO330851B1 (https=) |
| NZ (1) | NZ541098A (https=) |
| PL (1) | PL214802B1 (https=) |
| PT (1) | PT1572641E (https=) |
| RU (1) | RU2337096C2 (https=) |
| WO (1) | WO2004054971A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0504463D0 (en) * | 2005-03-03 | 2005-04-13 | Arakis Ltd | Method of crystallisation and purification |
| WO2010115937A1 (en) * | 2009-04-09 | 2010-10-14 | Novartis Ag | Process for preparing pyrrolidinium salts |
| ES2528957T3 (es) * | 2010-06-14 | 2015-02-13 | Chiesi Farmaceutici S.P.A. | Forma cristalina del cloruro de glicopirronio |
| CN103159659A (zh) * | 2011-12-19 | 2013-06-19 | 沈阳药科大学 | 一种毒蕈碱受体拮抗剂格隆溴铵的制备方法 |
| RS55996B1 (sr) * | 2011-12-22 | 2017-09-29 | Cerbios-Pharma S A | Kontinuirani postupak za alkilaciju cikličnih tercijarnih amina |
| CN102627595A (zh) * | 2012-03-09 | 2012-08-08 | 徐奎 | 一种制备格隆溴铵的方法 |
| US8558008B2 (en) | 2013-02-28 | 2013-10-15 | Dermira, Inc. | Crystalline glycopyrrolate tosylate |
| EP3473615B1 (en) | 2013-02-28 | 2022-01-19 | Journey Medical Corporation | Glycopyrrolate salts |
| US9006462B2 (en) | 2013-02-28 | 2015-04-14 | Dermira, Inc. | Glycopyrrolate salts |
| CN104586841A (zh) * | 2013-10-30 | 2015-05-06 | 中国药科大学 | (3r,2’r)-格隆溴铵作为m3毒蕈碱性受体拮抗剂在制药中的用途 |
| CN107304178B (zh) * | 2016-04-21 | 2020-03-27 | 辽宁药联制药有限公司 | 一种毒蕈碱受体拮抗剂格隆溴铵手性对映体的制备方法 |
| CN107345945B (zh) * | 2016-05-05 | 2019-12-17 | 辽宁药联制药有限公司 | 一种拆分格隆溴铵对映体及杂质检查的高效液相色谱方法 |
| CN113234003B (zh) * | 2021-04-23 | 2024-02-02 | 广东嘉博制药有限公司 | 一种格隆溴铵及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0937041T3 (da) * | 1996-11-11 | 2003-08-11 | Christian R Noe | Anvendelse af et farmaceutisk egnet salt af (3R,2'R)-3-[(cyclopentil-hydroxyphenylacetyl)oxyl]-1,1-dimethyl-pyrrolidinium til fremstilling af et lægemiddel |
-
2002
- 2002-12-18 AT AT0189602A patent/AT412088B/de not_active IP Right Cessation
-
2003
- 2003-12-18 EP EP03782435A patent/EP1572641B1/de not_active Expired - Lifetime
- 2003-12-18 NZ NZ541098A patent/NZ541098A/en not_active IP Right Cessation
- 2003-12-18 DK DK03782435.6T patent/DK1572641T3/da active
- 2003-12-18 WO PCT/EP2003/014432 patent/WO2004054971A1/de not_active Ceased
- 2003-12-18 PT PT03782435T patent/PT1572641E/pt unknown
- 2003-12-18 ES ES03782435T patent/ES2383799T3/es not_active Expired - Lifetime
- 2003-12-18 US US10/540,187 patent/US7569598B2/en not_active Expired - Lifetime
- 2003-12-18 CN CNB2003801098187A patent/CN100349867C/zh not_active Expired - Fee Related
- 2003-12-18 JP JP2004560470A patent/JP2007524565A/ja active Pending
- 2003-12-18 AU AU2003290075A patent/AU2003290075B2/en not_active Ceased
- 2003-12-18 AT AT03782435T patent/ATE548348T1/de active
- 2003-12-18 CA CA2510280A patent/CA2510280C/en not_active Expired - Fee Related
- 2003-12-18 PL PL377441A patent/PL214802B1/pl unknown
- 2003-12-18 RU RU2005122497/04A patent/RU2337096C2/ru active
-
2005
- 2005-07-15 NO NO20053473A patent/NO330851B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL377441A1 (pl) | 2006-02-06 |
| DK1572641T3 (da) | 2012-07-02 |
| CA2510280C (en) | 2011-09-27 |
| CN100349867C (zh) | 2007-11-21 |
| ATE548348T1 (de) | 2012-03-15 |
| US7569598B2 (en) | 2009-08-04 |
| NZ541098A (en) | 2008-08-29 |
| EP1572641A1 (de) | 2005-09-14 |
| WO2004054971A1 (de) | 2004-07-01 |
| NO330851B1 (no) | 2011-08-01 |
| US20060167275A1 (en) | 2006-07-27 |
| PL214802B1 (pl) | 2013-09-30 |
| AU2003290075B2 (en) | 2009-01-29 |
| AT412088B (de) | 2004-09-27 |
| EP1572641B1 (de) | 2012-03-07 |
| ATA18962002A (de) | 2004-02-15 |
| AU2003290075A1 (en) | 2004-07-09 |
| NO20053473L (no) | 2005-09-19 |
| JP2007524565A (ja) | 2007-08-30 |
| CA2510280A1 (en) | 2004-07-01 |
| RU2005122497A (ru) | 2006-01-20 |
| ES2383799T3 (es) | 2012-06-26 |
| NO20053473D0 (no) | 2005-07-15 |
| RU2337096C2 (ru) | 2008-10-27 |
| CN1751022A (zh) | 2006-03-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2407135T3 (es) | Uso de (3S,2'R)-glicopirronio como medicamento | |
| PT1572641E (pt) | Processo para a preparação do estereoisómero de glicopirrónio de configuração r,r (ou s,s) | |
| US20110130463A1 (en) | Deuterium-enriched bupropion | |
| ES2375920T3 (es) | Procedimiento para resolver derivados de isoquinole�?na. | |
| BRPI0613945A2 (pt) | método de preparo de esomeprazol e sais do mesmo | |
| JP5503546B2 (ja) | ４，５−ジメトキシ−１−（メチルアミノメチル）−ベンゾシクロブタンの分離 | |
| WO1999002500A1 (es) | Resolucion de aminas | |
| WO2008157658A1 (en) | Deuterium-enriched montelukast | |
| US20090082387A1 (en) | Deuterium-enriched nvp-bez234 | |
| JP2007524565A5 (https=) | ||
| EP0004494B1 (fr) | Nouveaux dérivés de 1,3-dihydro 3-(1-(2-(2,3-dihydro 1,4-benzo-dioxin-2-yl)2-hydroxy éthyl)pipéridin-4-yl)2H-indol 2-one, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant | |
| US20090076087A1 (en) | Deuterium-enriched etoricoxib | |
| US8669268B2 (en) | Deuterium-enriched prasugrel | |
| EP0174358A1 (en) | Novel diastereomer salts of phenylalanine and n-acyl derivatives thereof and process for the separation of optically active phenylalanine and n-acyl derivatives thereof | |
| US20090076163A1 (en) | Deuterium-enriched dapoxetine | |
| KR20010079913A (ko) | (-)-α-(디플루오로메틸)오르니틴-모노히드로클로라이드일수화물의 제조 방법 | |
| WO2008157271A1 (en) | Deuterium-enriched escitalopram | |
| US20090082436A1 (en) | Deuterium-enriched rivastigmine | |
| BR112019018847A2 (pt) | processo para a preparação dos isômeros ópticos de pureza enantiomericamente elevada, implementação do processo, sais, e, aminas opticamente ativas | |
| US20090227623A1 (en) | Deuterium-enriched palosetron | |
| US20090082469A1 (en) | Deuterium-enriched terbinafine | |
| FR2527210A1 (fr) | Enantiomeres d'hexahydro-2,3,3a,4,5,6 1h-indolo(3,2,1-de) (naphtyridine-1,5), leur procede de separation et leur application en therapeutique | |
| BE499168A (https=) | ||
| US20090076154A1 (en) | Deuterium-enriched vorinostat | |
| US20090076048A1 (en) | Deuterium-enriched xaliproden |