PT1254162E - Kahalalide f e compostos relacionados - Google Patents
Kahalalide f e compostos relacionados Download PDFInfo
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- PT1254162E PT1254162E PT01904169T PT01904169T PT1254162E PT 1254162 E PT1254162 E PT 1254162E PT 01904169 T PT01904169 T PT 01904169T PT 01904169 T PT01904169 T PT 01904169T PT 1254162 E PT1254162 E PT 1254162E
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 66
- RCGXNDQKCXNWLO-GZEKAAEYSA-N kahalalide f Chemical compound CC1OC(=O)C(C(C)C)NC(=O)\C(=C\C)NC(=O)C(CC=2C=CC=CC=2)NC(=O)C(C(C)C)NC(=O)C(C(C)CC)NC(=O)C1NC(=O)C(C(C)CC)NC(=O)C(CCCN)NC(=O)C1CCCN1C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CCCC(C)C)C(C)C)C(C)O)C(C)C)C(C)C RCGXNDQKCXNWLO-GZEKAAEYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 31
- RCGXNDQKCXNWLO-WLEIXIPESA-N (2r)-n-[(2s)-5-amino-1-[[(2r,3r)-1-[[(3s,6z,9s,12r,15r,18r,19s)-9-benzyl-15-[(2r)-butan-2-yl]-6-ethylidene-19-methyl-2,5,8,11,14,17-hexaoxo-3,12-di(propan-2-yl)-1-oxa-4,7,10,13,16-pentazacyclononadec-18-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopent Chemical compound N([C@@H](CCCN)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H]1C(N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NC(/C(=O)N[C@H](C(=O)O[C@H]1C)C(C)C)=C\C)C(C)C)[C@H](C)CC)=O)C(=O)[C@H]1CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C RCGXNDQKCXNWLO-WLEIXIPESA-N 0.000 claims abstract description 28
- 108010091711 kahalalide F Proteins 0.000 claims abstract description 26
- 229930194861 kahalalide Natural products 0.000 claims abstract description 10
- -1 amino, carboxyl Chemical group 0.000 claims description 42
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- 125000002252 acyl group Chemical group 0.000 claims description 24
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- 125000001424 substituent group Chemical group 0.000 claims description 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 17
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 13
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- 125000003118 aryl group Chemical group 0.000 claims description 11
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- 125000004404 heteroalkyl group Chemical group 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
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- Molecular Biology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Optical Record Carriers And Manufacture Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
- Detergent Compositions (AREA)
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| GBGB0002952.0A GB0002952D0 (en) | 2000-02-09 | 2000-02-09 | Process for producing kahalalide F compounds |
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| PT1254162E true PT1254162E (pt) | 2007-12-03 |
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| PT01904169T PT1254162E (pt) | 2000-02-09 | 2001-02-09 | Kahalalide f e compostos relacionados |
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| US6274551B1 (en) * | 1994-02-03 | 2001-08-14 | Pharmamar, S.A. | Cytotoxic and antiviral compound |
| GB0002952D0 (en) * | 2000-02-09 | 2000-03-29 | Pharma Mar Sa | Process for producing kahalalide F compounds |
| US7473681B2 (en) | 2000-10-31 | 2009-01-06 | Pharma Mar, S.A. | Kahalalide F |
| US20050054555A1 (en) * | 2001-10-19 | 2005-03-10 | Jose Jimeno | Kahalalide compounds for use in cancer therapy |
| GB0304367D0 (en) * | 2003-02-26 | 2003-04-02 | Pharma Mar Sau | Methods for treating psoriasis |
| US7507708B2 (en) * | 2003-02-26 | 2009-03-24 | Pharma Mar, S.A.U. | Antitumoral compounds |
| GB0321066D0 (en) * | 2003-09-09 | 2003-10-08 | Pharma Mar Sau | New antitumoral compounds |
| GB0408958D0 (en) * | 2004-04-22 | 2004-05-26 | Pharma Mar Sa | Convergent synthesis for kahalalide compounds |
| CN100396696C (zh) * | 2004-04-23 | 2008-06-25 | 中国科学院海洋研究所 | 一种海洋绿藻在提取抗肿瘤活性环肽组分中的应用 |
| CN101861159A (zh) * | 2007-10-19 | 2010-10-13 | 马尔药品公司 | 改进的抗肿瘤治疗 |
| EP2252315A1 (en) * | 2008-01-30 | 2010-11-24 | Pharma Mar, S.A. | Improved antitumoral treatments |
| AU2009221120A1 (en) * | 2008-03-07 | 2009-09-11 | Pharma Mar, S.A. | Improved antitumoral treatments |
| CN103641891B (zh) * | 2013-05-23 | 2017-03-22 | 深圳翰宇药业股份有限公司 | 一种制备Kahalalide F的方法 |
| CN108283000B (zh) | 2015-09-23 | 2021-04-13 | 凯瑞康宁生物工程（武汉）有限公司 | γ-羟基丁酸的前药及其组合物和用途 |
| KR102510784B1 (ko) | 2017-03-30 | 2023-03-15 | 엑스더블유파마 리미티드 | 이환형 헤테로아릴 유도체 및 이의 제조 및 용도 |
| LT3615544T (lt) | 2017-04-27 | 2023-05-10 | Pharma Mar S.A. | Priešnavikiniai junginiai |
| CN114042070A (zh) | 2018-09-30 | 2022-02-15 | 凯瑞康宁生物工程（武汉）有限公司 | 作为神经元组胺受体-3拮抗剂的化合物及其用途 |
| WO2021127461A1 (en) | 2019-12-20 | 2021-06-24 | Xw Laboratories Limited | Methods of synthesizing 4-valyloxybutyric acid |
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| AU2021357705B2 (en) | 2020-10-05 | 2024-09-26 | XWPharma Ltd. | Modified release compositions of a gamma-hydroxybutyric acid derivative |
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- 2000-02-09 GB GBGB0002952.0A patent/GB0002952D0/en not_active Ceased
-
2001
- 2001-02-09 EP EP10178150A patent/EP2258715A1/en not_active Withdrawn
- 2001-02-09 DK DK01904169T patent/DK1254162T3/da active
- 2001-02-09 CZ CZ2002-2740A patent/CZ304258B6/cs not_active IP Right Cessation
- 2001-02-09 RU RU2002123877/04A patent/RU2280039C2/ru active
- 2001-02-09 NZ NZ520488A patent/NZ520488A/en not_active IP Right Cessation
- 2001-02-09 AU AU32086/01A patent/AU783542B2/en not_active Ceased
- 2001-02-09 US US10/182,881 patent/US7482429B2/en not_active Expired - Fee Related
- 2001-02-09 WO PCT/GB2001/000576 patent/WO2001058934A2/en not_active Ceased
- 2001-02-09 JP JP2001558081A patent/JP5188665B2/ja not_active Expired - Fee Related
- 2001-02-09 ES ES01904169T patent/ES2292558T3/es not_active Expired - Lifetime
- 2001-02-09 KR KR1020027010355A patent/KR100871489B1/ko not_active Expired - Fee Related
- 2001-02-09 HU HU0301817A patent/HUP0301817A3/hu unknown
- 2001-02-09 CN CN01807743A patent/CN1422278A/zh active Pending
- 2001-02-09 CN CN200810178807.9A patent/CN101597326B/zh not_active Expired - Fee Related
- 2001-02-09 BR BR0108213-2A patent/BR0108213A/pt not_active IP Right Cessation
- 2001-02-09 PT PT01904169T patent/PT1254162E/pt unknown
- 2001-02-09 DE DE60130192T patent/DE60130192T2/de not_active Expired - Lifetime
- 2001-02-09 EP EP01904169A patent/EP1254162B1/en not_active Expired - Lifetime
- 2001-02-09 EP EP07010878A patent/EP1829889A3/en not_active Withdrawn
- 2001-02-09 PL PL356800A patent/PL207121B1/pl unknown
- 2001-02-09 CA CA2399187A patent/CA2399187C/en not_active Expired - Fee Related
- 2001-02-09 AT AT01904169T patent/ATE371667T1/de active
- 2001-02-09 MX MXPA02007760A patent/MXPA02007760A/es active IP Right Grant
- 2001-02-09 IL IL15098101A patent/IL150981A0/xx unknown
- 2001-02-09 SK SK1124-2002A patent/SK11242002A3/sk not_active Application Discontinuation
- 2001-09-02 UA UA2002097267A patent/UA76949C2/uk unknown
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2002
- 2002-07-30 IL IL150981A patent/IL150981A/en not_active IP Right Cessation
- 2002-08-08 NO NO20023749A patent/NO331847B1/no not_active IP Right Cessation
- 2002-08-21 BG BG107020A patent/BG65926B1/bg unknown
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2007
- 2007-11-08 CY CY20071101442T patent/CY1106992T1/el unknown
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2008
- 2008-08-25 US US12/198,013 patent/US20080318849A1/en not_active Abandoned
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