KR100871489B1 - 카할라이드 화합물 - Google Patents

카할라이드 화합물 Download PDF

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Publication number
KR100871489B1
KR100871489B1 KR1020027010355A KR20027010355A KR100871489B1 KR 100871489 B1 KR100871489 B1 KR 100871489B1 KR 1020027010355 A KR1020027010355 A KR 1020027010355A KR 20027010355 A KR20027010355 A KR 20027010355A KR 100871489 B1 KR100871489 B1 KR 100871489B1
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KR
South Korea
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thr
ile
group
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Expired - Fee Related
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KR1020027010355A
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English (en)
Korean (ko)
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KR20020092951A (ko
Inventor
페르난도 알베리시오
어네스트 히랄트
호세 깔로스 히메네즈
안헬 로페즈
이그나시오 만자나레스
이그나시오 로드리게스
미리암 로요
Original Assignee
파르마 마르, 에스.에이.
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Application filed by 파르마 마르, 에스.에이. filed Critical 파르마 마르, 에스.에이.
Publication of KR20020092951A publication Critical patent/KR20020092951A/ko
Application granted granted Critical
Publication of KR100871489B1 publication Critical patent/KR100871489B1/ko
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Optical Record Carriers And Manufacture Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Detergent Compositions (AREA)
KR1020027010355A 2000-02-09 2001-02-09 카할라이드 화합물 Expired - Fee Related KR100871489B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0002952.0 2000-02-09
GBGB0002952.0A GB0002952D0 (en) 2000-02-09 2000-02-09 Process for producing kahalalide F compounds

Publications (2)

Publication Number Publication Date
KR20020092951A KR20020092951A (ko) 2002-12-12
KR100871489B1 true KR100871489B1 (ko) 2008-12-05

Family

ID=9885232

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027010355A Expired - Fee Related KR100871489B1 (ko) 2000-02-09 2001-02-09 카할라이드 화합물

Country Status (27)

Country Link
US (2) US7482429B2 (enExample)
EP (3) EP2258715A1 (enExample)
JP (1) JP5188665B2 (enExample)
KR (1) KR100871489B1 (enExample)
CN (2) CN1422278A (enExample)
AT (1) ATE371667T1 (enExample)
AU (1) AU783542B2 (enExample)
BG (1) BG65926B1 (enExample)
BR (1) BR0108213A (enExample)
CA (1) CA2399187C (enExample)
CY (1) CY1106992T1 (enExample)
CZ (1) CZ304258B6 (enExample)
DE (1) DE60130192T2 (enExample)
DK (1) DK1254162T3 (enExample)
ES (1) ES2292558T3 (enExample)
GB (1) GB0002952D0 (enExample)
HU (1) HUP0301817A3 (enExample)
IL (2) IL150981A0 (enExample)
MX (1) MXPA02007760A (enExample)
NO (1) NO331847B1 (enExample)
NZ (1) NZ520488A (enExample)
PL (1) PL207121B1 (enExample)
PT (1) PT1254162E (enExample)
RU (1) RU2280039C2 (enExample)
SK (1) SK11242002A3 (enExample)
UA (1) UA76949C2 (enExample)
WO (1) WO2001058934A2 (enExample)

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US6274551B1 (en) * 1994-02-03 2001-08-14 Pharmamar, S.A. Cytotoxic and antiviral compound
GB0002952D0 (en) * 2000-02-09 2000-03-29 Pharma Mar Sa Process for producing kahalalide F compounds
US7473681B2 (en) 2000-10-31 2009-01-06 Pharma Mar, S.A. Kahalalide F
US20050054555A1 (en) * 2001-10-19 2005-03-10 Jose Jimeno Kahalalide compounds for use in cancer therapy
GB0304367D0 (en) * 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) * 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
GB0321066D0 (en) * 2003-09-09 2003-10-08 Pharma Mar Sau New antitumoral compounds
GB0408958D0 (en) * 2004-04-22 2004-05-26 Pharma Mar Sa Convergent synthesis for kahalalide compounds
CN100396696C (zh) * 2004-04-23 2008-06-25 中国科学院海洋研究所 一种海洋绿藻在提取抗肿瘤活性环肽组分中的应用
CN101861159A (zh) * 2007-10-19 2010-10-13 马尔药品公司 改进的抗肿瘤治疗
EP2252315A1 (en) * 2008-01-30 2010-11-24 Pharma Mar, S.A. Improved antitumoral treatments
AU2009221120A1 (en) * 2008-03-07 2009-09-11 Pharma Mar, S.A. Improved antitumoral treatments
CN103641891B (zh) * 2013-05-23 2017-03-22 深圳翰宇药业股份有限公司 一种制备Kahalalide F的方法
CN108283000B (zh) 2015-09-23 2021-04-13 凯瑞康宁生物工程（武汉）有限公司 γ-羟基丁酸的前药及其组合物和用途
KR102510784B1 (ko) 2017-03-30 2023-03-15 엑스더블유파마 리미티드 이환형 헤테로아릴 유도체 및 이의 제조 및 용도
LT3615544T (lt) 2017-04-27 2023-05-10 Pharma Mar S.A. Priešnavikiniai junginiai
CN114042070A (zh) 2018-09-30 2022-02-15 凯瑞康宁生物工程（武汉）有限公司 作为神经元组胺受体-3拮抗剂的化合物及其用途
WO2021127461A1 (en) 2019-12-20 2021-06-24 Xw Laboratories Limited Methods of synthesizing 4-valyloxybutyric acid
KR102982616B1 (ko) 2020-06-18 2026-06-26 엑스더블유파마 리미티드 수용성 원료의약품의 약학적 과립화제
AU2021292406B2 (en) 2020-06-18 2024-03-14 XWPharma Ltd. Controlled release granulations of water-soluble active pharmaceutical ingredients
WO2022020621A1 (en) 2020-07-24 2022-01-27 XWPharma Ltd. Pharmaceutical compositions and pharmacokinetics of a gamma-hydroxybutyric acid derivative
AU2021357705B2 (en) 2020-10-05 2024-09-26 XWPharma Ltd. Modified release compositions of a gamma-hydroxybutyric acid derivative
DK4308086T3 (da) 2021-03-19 2025-11-17 Xwpharma Ltd Farmakokinetik af formuleringer med kombineret frigivelse af et gamma-hydroxysmørsyrederivat
JP2025513295A (ja) * 2022-04-21 2025-04-24 ゼブラ セラピューティクス， インコーポレイテッド ガンマ－ヒドロキシブチラート送達化合物ならびにその作製および使用のためのプロセス

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GB0304367D0 (en) 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) * 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
GB0321066D0 (en) * 2003-09-09 2003-10-08 Pharma Mar Sau New antitumoral compounds
GB0408958D0 (en) * 2004-04-22 2004-05-26 Pharma Mar Sa Convergent synthesis for kahalalide compounds

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Tetrahedron Lett. Vol.41:9765-9769 (2000.12.)
Tetrahedron Lett. Vol.55:7739-7746 (1999)

Also Published As

Publication number Publication date
BG107020A (bg) 2003-05-30
JP2003522198A (ja) 2003-07-22
SK11242002A3 (sk) 2003-06-03
WO2001058934A3 (en) 2002-03-21
BG65926B1 (bg) 2010-05-31
EP1254162A2 (en) 2002-11-06
CN101597326A (zh) 2009-12-09
CY1106992T1 (el) 2012-09-26
DK1254162T3 (da) 2008-01-02
AU783542B2 (en) 2005-11-10
ES2292558T3 (es) 2008-03-16
GB0002952D0 (en) 2000-03-29
IL150981A0 (en) 2003-02-12
IL150981A (en) 2013-05-30
CZ304258B6 (cs) 2014-02-05
US20040214755A1 (en) 2004-10-28
RU2280039C2 (ru) 2006-07-20
WO2001058934A2 (en) 2001-08-16
RU2002123877A (ru) 2004-01-10
NO20023749L (no) 2002-10-07
PL207121B1 (pl) 2010-11-30
UA76949C2 (en) 2006-10-16
AU3208601A (en) 2001-08-20
HK1047290A1 (en) 2003-02-14
DE60130192D1 (de) 2007-10-11
EP2258715A1 (en) 2010-12-08
CA2399187A1 (en) 2001-08-16
HUP0301817A2 (hu) 2003-09-29
US7482429B2 (en) 2009-01-27
NO20023749D0 (no) 2002-08-08
MXPA02007760A (es) 2002-10-23
NO331847B1 (no) 2012-04-23
PL356800A1 (en) 2004-07-12
CA2399187C (en) 2011-04-19
BR0108213A (pt) 2003-03-05
CN1422278A (zh) 2003-06-04
EP1829889A2 (en) 2007-09-05
US20080318849A1 (en) 2008-12-25
DE60130192T2 (de) 2008-05-21
KR20020092951A (ko) 2002-12-12
CZ20022740A3 (cs) 2003-01-15
EP1829889A3 (en) 2007-09-26
NZ520488A (en) 2005-03-24
PT1254162E (pt) 2007-12-03
CN101597326B (zh) 2014-07-09
JP5188665B2 (ja) 2013-04-24
EP1254162B1 (en) 2007-08-29
ATE371667T1 (de) 2007-09-15
HUP0301817A3 (en) 2011-10-28

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