DK1254162T3 - Kahalalid F og beslægtede forbindelser - Google Patents

Kahalalid F og beslægtede forbindelser

Info

Publication number
DK1254162T3
DK1254162T3 DK01904169T DK01904169T DK1254162T3 DK 1254162 T3 DK1254162 T3 DK 1254162T3 DK 01904169 T DK01904169 T DK 01904169T DK 01904169 T DK01904169 T DK 01904169T DK 1254162 T3 DK1254162 T3 DK 1254162T3
Authority
DK
Denmark
Prior art keywords
kahalalid
related compounds
kahalalide
leads
preparing
Prior art date
Application number
DK01904169T
Other languages
English (en)
Inventor
Fernando Albericio
Ernest Giralt
Jose Carlos Jimenez
Angel Lopez
Ignacio Manzanares
Ignacio Rodrigues
Miriam Royo
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of DK1254162T3 publication Critical patent/DK1254162T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Optical Record Carriers And Manufacture Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Detergent Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
DK01904169T 2000-02-09 2001-02-09 Kahalalid F og beslægtede forbindelser DK1254162T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0002952.0A GB0002952D0 (en) 2000-02-09 2000-02-09 Process for producing kahalalide F compounds
PCT/GB2001/000576 WO2001058934A2 (en) 2000-02-09 2001-02-09 Kahalalide f and related compounds

Publications (1)

Publication Number Publication Date
DK1254162T3 true DK1254162T3 (da) 2008-01-02

Family

ID=9885232

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01904169T DK1254162T3 (da) 2000-02-09 2001-02-09 Kahalalid F og beslægtede forbindelser

Country Status (28)

Country Link
US (2) US7482429B2 (da)
EP (3) EP1829889A3 (da)
JP (1) JP5188665B2 (da)
KR (1) KR100871489B1 (da)
CN (2) CN101597326B (da)
AT (1) ATE371667T1 (da)
AU (1) AU783542B2 (da)
BG (1) BG65926B1 (da)
BR (1) BR0108213A (da)
CA (1) CA2399187C (da)
CY (1) CY1106992T1 (da)
CZ (1) CZ304258B6 (da)
DE (1) DE60130192T2 (da)
DK (1) DK1254162T3 (da)
ES (1) ES2292558T3 (da)
GB (1) GB0002952D0 (da)
HK (1) HK1047290A1 (da)
HU (1) HUP0301817A3 (da)
IL (2) IL150981A0 (da)
MX (1) MXPA02007760A (da)
NO (1) NO331847B1 (da)
NZ (1) NZ520488A (da)
PL (1) PL207121B1 (da)
PT (1) PT1254162E (da)
RU (1) RU2280039C2 (da)
SK (1) SK11242002A3 (da)
UA (1) UA76949C2 (da)
WO (1) WO2001058934A2 (da)

Families Citing this family (24)

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US6274551B1 (en) * 1994-02-03 2001-08-14 Pharmamar, S.A. Cytotoxic and antiviral compound
GB0002952D0 (en) * 2000-02-09 2000-03-29 Pharma Mar Sa Process for producing kahalalide F compounds
KR100834138B1 (ko) 2000-10-31 2008-06-02 파르마 마르, 에스.에이. 카할라리드 에프
US20050054555A1 (en) * 2001-10-19 2005-03-10 Jose Jimeno Kahalalide compounds for use in cancer therapy
GB0304367D0 (en) * 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
GB0321066D0 (en) 2003-09-09 2003-10-08 Pharma Mar Sau New antitumoral compounds
GB0408958D0 (en) * 2004-04-22 2004-05-26 Pharma Mar Sa Convergent synthesis for kahalalide compounds
CN100396696C (zh) * 2004-04-23 2008-06-25 中国科学院海洋研究所 一种海洋绿藻在提取抗肿瘤活性环肽组分中的应用
US20100226919A1 (en) * 2007-10-19 2010-09-09 Pharma Mar, S.A. Antitumoral Treatments
US20100323021A1 (en) * 2008-01-30 2010-12-23 Pharma Mar, S.A. Antitumoral treatments
US20110015135A1 (en) * 2008-03-07 2011-01-20 Pharma Mar S.A. Antitumoral Treatments
CN103641891B (zh) * 2013-05-23 2017-03-22 深圳翰宇药业股份有限公司 一种制备Kahalalide F的方法
WO2017050259A1 (en) * 2015-09-23 2017-03-30 Xw Laboratories Inc. Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof
CN110709386B (zh) 2017-03-30 2022-06-07 凯瑞康宁生物工程（武汉）有限公司 双环杂芳基衍生物及其制备与用途
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN114042070A (zh) 2018-09-30 2022-02-15 凯瑞康宁生物工程（武汉）有限公司 作为神经元组胺受体-3拮抗剂的化合物及其用途
AU2020405133B2 (en) 2019-12-20 2023-04-27 XWPharma Ltd. Methods of synthesizing 4-valyloxybutyric acid
CA3183185A1 (en) 2020-06-18 2021-12-23 Jia-Ning Xiang Pharmaceutical granulations of water-soluble active pharmaceutical ingredients
WO2021257886A1 (en) 2020-06-18 2021-12-23 XWPharma Ltd. Controlled release granulations of water-soluble active pharmaceutical ingredients
CN116261451A (zh) 2020-07-24 2023-06-13 凯瑞康宁生物工程有限公司 γ-羟基丁酸衍生物的药物组合物和药物动力学
CA3194665A1 (en) 2020-10-05 2022-04-14 Jia-Ning Xiang Modified release compositions of a gamma-hydroxybutyric acid derivative
CN117098533A (zh) 2021-03-19 2023-11-21 凯瑞康宁公司 γ-羟基丁酸衍生物的组合释放型制剂的药物动力学
WO2023205233A1 (en) * 2022-04-21 2023-10-26 Zevra Therapeutics, Inc. Gamma-hydroxybutyrate delivering compounds and processes for making and using them

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US4943533A (en) * 1984-03-01 1990-07-24 The Regents Of The University Of California Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
JPS6178719A (ja) * 1984-09-25 1986-04-22 Tanabe Seiyaku Co Ltd 総合輸液剤
GR870129B (en) * 1987-01-27 1987-02-04 Giatzidis Ippokratis Stable bicarbonate - glycylglycine dialysate for hemodialysis and peritoneal dialysis
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
HU219537B (hu) * 1991-03-06 2001-05-28 Merck Patent Gmbh. Humanizált és kiméra monoklonális antitestek, azokat tartalmazó gyógyászati készítmények, az antitesteket kódoló szekvenciát tartalmazó expressziós vektorok, valamint eljárás az antitestek előállítására
US5849704A (en) * 1991-12-20 1998-12-15 Novo Nordisk A/S Pharmaceutical formulation
AU661533B2 (en) * 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
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US6274551B1 (en) * 1994-02-03 2001-08-14 Pharmamar, S.A. Cytotoxic and antiviral compound
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UA74803C2 (uk) * 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
GB0002952D0 (en) * 2000-02-09 2000-03-29 Pharma Mar Sa Process for producing kahalalide F compounds
CA2406743A1 (en) * 2000-04-28 2001-11-08 The Trustees Of The University Of Pennsylvania Recombinant aav vectors with aav5 capsids and aav5 vectors pseudotyped in heterologous capsids
US6440465B1 (en) * 2000-05-01 2002-08-27 Bioderm, Inc. Topical composition for the treatment of psoriasis and related skin disorders
KR100834138B1 (ko) 2000-10-31 2008-06-02 파르마 마르, 에스.에이. 카할라리드 에프
US20050054555A1 (en) 2001-10-19 2005-03-10 Jose Jimeno Kahalalide compounds for use in cancer therapy
GB0304367D0 (en) * 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
GB0321066D0 (en) * 2003-09-09 2003-10-08 Pharma Mar Sau New antitumoral compounds
GB0408958D0 (en) * 2004-04-22 2004-05-26 Pharma Mar Sa Convergent synthesis for kahalalide compounds

Also Published As

Publication number Publication date
JP2003522198A (ja) 2003-07-22
CY1106992T1 (el) 2012-09-26
CN101597326B (zh) 2014-07-09
NO331847B1 (no) 2012-04-23
ATE371667T1 (de) 2007-09-15
DE60130192D1 (de) 2007-10-11
BG65926B1 (bg) 2010-05-31
AU3208601A (en) 2001-08-20
NO20023749D0 (no) 2002-08-08
KR20020092951A (ko) 2002-12-12
PL207121B1 (pl) 2010-11-30
SK11242002A3 (sk) 2003-06-03
ES2292558T3 (es) 2008-03-16
EP1254162B1 (en) 2007-08-29
BR0108213A (pt) 2003-03-05
US20040214755A1 (en) 2004-10-28
PT1254162E (pt) 2007-12-03
US7482429B2 (en) 2009-01-27
MXPA02007760A (es) 2002-10-23
RU2002123877A (ru) 2004-01-10
WO2001058934A3 (en) 2002-03-21
EP2258715A1 (en) 2010-12-08
US20080318849A1 (en) 2008-12-25
IL150981A (en) 2013-05-30
RU2280039C2 (ru) 2006-07-20
GB0002952D0 (en) 2000-03-29
NZ520488A (en) 2005-03-24
CA2399187A1 (en) 2001-08-16
PL356800A1 (en) 2004-07-12
AU783542B2 (en) 2005-11-10
CA2399187C (en) 2011-04-19
CN1422278A (zh) 2003-06-04
EP1829889A2 (en) 2007-09-05
IL150981A0 (en) 2003-02-12
HK1047290A1 (en) 2003-02-14
HUP0301817A2 (hu) 2003-09-29
CN101597326A (zh) 2009-12-09
EP1254162A2 (en) 2002-11-06
KR100871489B1 (ko) 2008-12-05
CZ304258B6 (cs) 2014-02-05
WO2001058934A2 (en) 2001-08-16
HUP0301817A3 (en) 2011-10-28
EP1829889A3 (en) 2007-09-26
DE60130192T2 (de) 2008-05-21
NO20023749L (no) 2002-10-07
UA76949C2 (en) 2006-10-16
BG107020A (bg) 2003-05-30
JP5188665B2 (ja) 2013-04-24
CZ20022740A3 (cs) 2003-01-15

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